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Effects of continuous intravenous infusion with propofol on intestinal metabolites in rats

  • Authors:
    • Jiaying Li
    • Zhongjie Zhang
    • Hongyu Liu
    • Xutong Qu
    • Xueqing Yin
    • Lu Chen
    • Nana Guo
    • Changsong Wang
    • Zhaodi Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, P.R. China, Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 25
    |
    Published online on: December 20, 2023
       https://doi.org/10.3892/br.2023.1713
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Abstract

Microbial metabolites play an important role in regulating intestinal homeostasis and immune responses. Propofol is a common anesthetic in clinic, but it is not clear whether it affects intestinal metabolites in rats. Tail vein puncture was performed after adaptive feeding for 1 month in eight 2‑month‑old rats and they were given continuous intravenous infusion of propofol for 3 h. The feces of rats were divided into different groups based on time periods, with before and after anesthesia with propofol on days 1, 3 and 7 labeled as groups P, A1, A3 and A7, respectively. The effect of continuous intravenous infusion with propofol on rat fecal metabolites was determined using the non‑targeted metabolomics technique gas chromatography coupled with a time‑of‑flight mass spectrometer analysis. The types and contents of metabolites in rat feces were changed after continuous intravenous infusion with propofol, but the changes were not statistically significant. The contents of the metabolites 3‑hydroxyphenylacetic acid and palmitic acid increased from day 3 to 7, and it was shown that the two metabolites were positively correlated at a statistically significant level. Linoleic acid decreased to its lowest level on day 3, and it returned to pre‑anesthesia level on day 7. At the same time, linoleic acid metabolism was a metabolic pathway that was co‑enriched 7 days after infusion with propofol. Spearman correlation analysis showed that there was significant correlation between some differential metabolites and differential microorganisms. It was observed that zymosterol 1, cytosin and elaidic acid were negatively correlated with Alloprevotella in the A3 vs. P group. In the A7 vs. P group, cortexolone 3 and coprostan‑3‑one were positively correlated with Faecalibacterium, whilst aconitic acid was negatively correlated with it. In conclusion, the present study revealed statistically insignificant effects of continuous intravenous propofol on the intestinal metabolites in rats.
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Copy and paste a formatted citation
Spandidos Publications style
Li J, Zhang Z, Liu H, Qu X, Yin X, Chen L, Guo N, Wang C and Zhang Z: Effects of continuous intravenous infusion with propofol on intestinal metabolites in rats. Biomed Rep 20: 25, 2024.
APA
Li, J., Zhang, Z., Liu, H., Qu, X., Yin, X., Chen, L. ... Zhang, Z. (2024). Effects of continuous intravenous infusion with propofol on intestinal metabolites in rats. Biomedical Reports, 20, 25. https://doi.org/10.3892/br.2023.1713
MLA
Li, J., Zhang, Z., Liu, H., Qu, X., Yin, X., Chen, L., Guo, N., Wang, C., Zhang, Z."Effects of continuous intravenous infusion with propofol on intestinal metabolites in rats". Biomedical Reports 20.2 (2024): 25.
Chicago
Li, J., Zhang, Z., Liu, H., Qu, X., Yin, X., Chen, L., Guo, N., Wang, C., Zhang, Z."Effects of continuous intravenous infusion with propofol on intestinal metabolites in rats". Biomedical Reports 20, no. 2 (2024): 25. https://doi.org/10.3892/br.2023.1713
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Zhang Z, Liu H, Qu X, Yin X, Chen L, Guo N, Wang C and Zhang Z: Effects of continuous intravenous infusion with propofol on intestinal metabolites in rats. Biomed Rep 20: 25, 2024.
APA
Li, J., Zhang, Z., Liu, H., Qu, X., Yin, X., Chen, L. ... Zhang, Z. (2024). Effects of continuous intravenous infusion with propofol on intestinal metabolites in rats. Biomedical Reports, 20, 25. https://doi.org/10.3892/br.2023.1713
MLA
Li, J., Zhang, Z., Liu, H., Qu, X., Yin, X., Chen, L., Guo, N., Wang, C., Zhang, Z."Effects of continuous intravenous infusion with propofol on intestinal metabolites in rats". Biomedical Reports 20.2 (2024): 25.
Chicago
Li, J., Zhang, Z., Liu, H., Qu, X., Yin, X., Chen, L., Guo, N., Wang, C., Zhang, Z."Effects of continuous intravenous infusion with propofol on intestinal metabolites in rats". Biomedical Reports 20, no. 2 (2024): 25. https://doi.org/10.3892/br.2023.1713
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