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Review Open Access

Treatment approaches in autoimmune pancreatitis (Review)

  • Authors:
    • Vlad Pădureanu
    • Alice Nicoleta Drăgoescu
    • Rodica Pădureanu
    • Maria Magdalena Roșu
    • Dumitru Rădulescu
    • Dalia Dop
    • Mircea Cătălin Forțofoiu
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Anaesthesiology and Intensive Care, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Diabetes, Nutrition and Metabolic Diseases, County Clinical Emergency Hospital of Craiova, Craiova 200642, Romania, Department of Pediatrics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
    Copyright: © Pădureanu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 26
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    Published online on: December 21, 2023
       https://doi.org/10.3892/br.2023.1714
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Abstract

Autoimmune pancreatitis (AIP) is a rare disease. There are two distinct types of AIP: AIP type 1 (AIP-1), a pancreatic manifestation of a multi-organ disease linked to immunoglobulin (Ig)G4, and AIP type 2 (AIP-2), a pancreas-specific disease unrelated to IgG4. The usual course of treatment for AIP is oral corticosteroid medication. Rituximab has also been recommended for recurrent AIP-1 in order to initiate remission and provide ongoing treatment. Immunomodulators such as azathioprine are used to keep certain patients in remission. Evaluation also takes into account a number of pharmacological alternatives, including biologic drugs like anti-tumor necrosis factor therapy, a safe and efficient second‑line treatment for AIP‑2 relapse or steroid dependence. Corticosteroids and immunosuppressants, which are poorly tolerated due to considerable side effects, are being replaced by other biologic drugs, which may offer a beneficial therapeutic alternative.
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Copy and paste a formatted citation
Spandidos Publications style
Pădureanu V, Drăgoescu A, Pădureanu R, Roșu M, Rădulescu D, Dop D and Forțofoiu M: Treatment approaches in autoimmune pancreatitis (Review). Biomed Rep 20: 26, 2024.
APA
Pădureanu, V., Drăgoescu, A., Pădureanu, R., Roșu, M., Rădulescu, D., Dop, D., & Forțofoiu, M. (2024). Treatment approaches in autoimmune pancreatitis (Review). Biomedical Reports, 20, 26. https://doi.org/10.3892/br.2023.1714
MLA
Pădureanu, V., Drăgoescu, A., Pădureanu, R., Roșu, M., Rădulescu, D., Dop, D., Forțofoiu, M."Treatment approaches in autoimmune pancreatitis (Review)". Biomedical Reports 20.2 (2024): 26.
Chicago
Pădureanu, V., Drăgoescu, A., Pădureanu, R., Roșu, M., Rădulescu, D., Dop, D., Forțofoiu, M."Treatment approaches in autoimmune pancreatitis (Review)". Biomedical Reports 20, no. 2 (2024): 26. https://doi.org/10.3892/br.2023.1714
Copy and paste a formatted citation
x
Spandidos Publications style
Pădureanu V, Drăgoescu A, Pădureanu R, Roșu M, Rădulescu D, Dop D and Forțofoiu M: Treatment approaches in autoimmune pancreatitis (Review). Biomed Rep 20: 26, 2024.
APA
Pădureanu, V., Drăgoescu, A., Pădureanu, R., Roșu, M., Rădulescu, D., Dop, D., & Forțofoiu, M. (2024). Treatment approaches in autoimmune pancreatitis (Review). Biomedical Reports, 20, 26. https://doi.org/10.3892/br.2023.1714
MLA
Pădureanu, V., Drăgoescu, A., Pădureanu, R., Roșu, M., Rădulescu, D., Dop, D., Forțofoiu, M."Treatment approaches in autoimmune pancreatitis (Review)". Biomedical Reports 20.2 (2024): 26.
Chicago
Pădureanu, V., Drăgoescu, A., Pădureanu, R., Roșu, M., Rădulescu, D., Dop, D., Forțofoiu, M."Treatment approaches in autoimmune pancreatitis (Review)". Biomedical Reports 20, no. 2 (2024): 26. https://doi.org/10.3892/br.2023.1714
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