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Role of decompressive craniectomy in the management of acute ischemic stroke (Review)

  • Authors:
    • George Fotakopoulos
    • Charalambos Gatos
    • Vasiliki Epameinondas Georgakopoulou
    • Ioannis G. Lempesis
    • Demetrios A. Spandidos
    • Nikolaos Trakas
    • Pagona Sklapani
    • Kostas N. Fountas
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, General University Hospital of Larissa, 41221 Larissa, Greece, Department of Pathophysiology, National and Kapodistrian University of Athens, 11527 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Department of Biochemistry, Sismanogleio Hospital, 15126 Athens, Greece
    Copyright: © Fotakopoulos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 33
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    Published online on: January 3, 2024
       https://doi.org/10.3892/br.2024.1721
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Abstract

The application of decompressive craniectomy (DC) is thoroughly documented in the management of brain edema, particularly following traumatic brain injury. However, an increasing amount of concern is developing among the universal medical community as regards the application of DC in the treatment of other causes of brain edema, such as subarachnoid hemorrhage, cerebral hemorrhage, sinus thrombosis and encephalitis. Managing stroke continues to remain challenging, and demands the aggressive and intensive consulting of a number of medical specialties. Middle cerebral artery (MCA) infarcts, which consist of 1‑10% of all supratentorial infarcts, are often associated with mass effects, and high mortality and morbidity rates. Over the past three decades, a number of neurosurgical medical centers have reported their experience with the application of DC in the treatment of malignant MCA infarction with varying results. In addition, over the past decade, major efforts have been dedicated to multicenter randomized clinical trials. The present study reviews the pertinent literature to outline the use of DC in the management of malignant MCA infarction. The PubMed database was systematically searched for the following terms: ‘Malignant cerebral infarction’, ‘surgery for stroke’, ‘DC for cerebral infarction’, and all their combinations. Case reports were excluded from the review. The articles were categorized into a number of groups; the majority of these were human clinical studies, with a few animal experimental clinical studies. The surgical technique involved was DC, or hemicraniectomy. Other aspects that were included in the selection of articles were methodological characteristics and the number of patients. The multicenter randomized trials were promising. The mortality rate has unanimously decreased. As for the functional outcome, different scales were employed; the Glasgow Outcome Scale Extended was not sufficient; the Modified Rankin Scale and Bathel index, as well as other scales, were applied. Other aspects considered were demographics, statistics and the very interesting radiological ones. There is no doubt that DC decreases mortality rates, as shown in all clinical trials. Functional outcome appears to be the goal standard in modern‑era neurosurgery, and quality of life should be further discussed among the medical community and with patient consent.
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Copy and paste a formatted citation
Spandidos Publications style
Fotakopoulos G, Gatos C, Georgakopoulou VE, Lempesis IG, Spandidos DA, Trakas N, Sklapani P and Fountas KN: Role of decompressive craniectomy in the management of acute ischemic stroke (Review). Biomed Rep 20: 33, 2024.
APA
Fotakopoulos, G., Gatos, C., Georgakopoulou, V.E., Lempesis, I.G., Spandidos, D.A., Trakas, N. ... Fountas, K.N. (2024). Role of decompressive craniectomy in the management of acute ischemic stroke (Review). Biomedical Reports, 20, 33. https://doi.org/10.3892/br.2024.1721
MLA
Fotakopoulos, G., Gatos, C., Georgakopoulou, V. E., Lempesis, I. G., Spandidos, D. A., Trakas, N., Sklapani, P., Fountas, K. N."Role of decompressive craniectomy in the management of acute ischemic stroke (Review)". Biomedical Reports 20.2 (2024): 33.
Chicago
Fotakopoulos, G., Gatos, C., Georgakopoulou, V. E., Lempesis, I. G., Spandidos, D. A., Trakas, N., Sklapani, P., Fountas, K. N."Role of decompressive craniectomy in the management of acute ischemic stroke (Review)". Biomedical Reports 20, no. 2 (2024): 33. https://doi.org/10.3892/br.2024.1721
Copy and paste a formatted citation
x
Spandidos Publications style
Fotakopoulos G, Gatos C, Georgakopoulou VE, Lempesis IG, Spandidos DA, Trakas N, Sklapani P and Fountas KN: Role of decompressive craniectomy in the management of acute ischemic stroke (Review). Biomed Rep 20: 33, 2024.
APA
Fotakopoulos, G., Gatos, C., Georgakopoulou, V.E., Lempesis, I.G., Spandidos, D.A., Trakas, N. ... Fountas, K.N. (2024). Role of decompressive craniectomy in the management of acute ischemic stroke (Review). Biomedical Reports, 20, 33. https://doi.org/10.3892/br.2024.1721
MLA
Fotakopoulos, G., Gatos, C., Georgakopoulou, V. E., Lempesis, I. G., Spandidos, D. A., Trakas, N., Sklapani, P., Fountas, K. N."Role of decompressive craniectomy in the management of acute ischemic stroke (Review)". Biomedical Reports 20.2 (2024): 33.
Chicago
Fotakopoulos, G., Gatos, C., Georgakopoulou, V. E., Lempesis, I. G., Spandidos, D. A., Trakas, N., Sklapani, P., Fountas, K. N."Role of decompressive craniectomy in the management of acute ischemic stroke (Review)". Biomedical Reports 20, no. 2 (2024): 33. https://doi.org/10.3892/br.2024.1721
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