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Assessment of the effects of amphiphilic poly (N‑vinylpyrrolidone) nanoparticles loaded with bortezomib on glioblastoma cell lines and zebrafish embryos

  • Authors:
    • Anne V. Yagolovich
    • Andrey N. Kuskov
    • Pavel P. Kulikov
    • Dmitry V. Bagrov
    • Polina A. Petrova
    • Ekaterina V. Kukovyakina
    • Alina A. Isakova
    • Irina I. Khan
    • Vadim S. Pokrovsky
    • Alexander E. Nosyrev
    • Polyxeni C. Stamati
    • Elena A. Markvicheva
    • Marine E. Gasparian
    • Demetrios A. Spandidos
    • Aristidis M. Tsatsakis
  • View Affiliations / Copyright

    Affiliations: Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russian Federation, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russian Federation, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, 115478 Moscow, Russian Federation, Center of Bioanalytical Research and Molecular Design, Sechenov First Moscow State Medical University, 119991 Moscow, Russian Federation, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, Greece, Shemyakin‑Ovchinnikov Institute of Bioorganic Chemistry of The Russian Academy of Sciences, 117997 Moscow, Russian Federation, Laboratory of Clinical Virology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece
    Copyright: © Yagolovich et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 37
    |
    Published online on: January 17, 2024
       https://doi.org/10.3892/br.2024.1725
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Abstract

Proteasome inhibitor bortezomib is an anticancer agent approved for treatment of multiple myeloma and mantle cell lymphoma. However, its application in other types of cancer, primarily in solid tumors, is limited due to poor pharmacokinetics, inefficient tissue penetration, low stability and frequent adverse effects. In the present study, a novel micellar nano‑scaled delivery system was manufactured, composed of amphiphilic poly(N‑vinylpyrrolidone) nanoparticles loaded with bortezomib. Similar nanoparticles loaded with prothionamide, a drug without anticancer effect, were used as control. The size and zeta potential of the obtained polymeric micelles were measured by dynamic light scattering. Bortezomib‑loaded micelles exhibited significant cytotoxic activity in vitro in monolayer tumor cell cultures (IC50 ~6.5 µg/ml) and in 3D multicellular tumor spheroids (IC50 ~8.5 µg/ml) of human glioblastoma cell lines U87 and T98G. Additionally, the toxic effects in vivo were studied in zebrafish Danio rerio embryos, with an estimated 50% lethal concentration of 0.1 mg/ml. Considering that bortezomib and other molecules from the class of proteasome inhibitors are potent antitumor agents, nanodelivery approach can help reduce adverse effects and expand the range of its applications for treatment of various oncological diseases.
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1 

Zavrski I, Jakob C, Schmid P, Krebbel H, Kaiser M, Fleissner C, Rosche M, Possinger K and Sezer O: Proteasome: An emerging target for cancer therapy. Anticancer Drugs. 16:475–481. 2005.PubMed/NCBI View Article : Google Scholar

2 

Adams J and Kauffman M: Development of the proteasome inhibitor Velcade (Bortezomib). Cancer Invest. 22:304–311. 2004.PubMed/NCBI View Article : Google Scholar

3 

Raedler L: Velcade (Bortezomib) receives 2 new FDA indications: For retreatment of patients with multiple myeloma and for first-line treatment of patients with mantle-cell lymphoma. Am Health Drug Benefits. 8:135–140. 2015.PubMed/NCBI

4 

Cengiz Seval G and Beksac M: The safety of bortezomib for the treatment of multiple myeloma. Expert Opin Drug Saf. 17:953–962. 2018.PubMed/NCBI View Article : Google Scholar

5 

Yamamoto S and Egashira N: Pathological mechanisms of bortezomib-induced peripheral neuropathy. Int J Mol Sci. 22(888)2021.PubMed/NCBI View Article : Google Scholar

6 

Tan CRC, Abdul-Majeed S, Cael B and Barta SK: Clinical pharmacokinetics and pharmacodynamics of bortezomib. Clin Pharmacokinet. 58:157–168. 2019.PubMed/NCBI View Article : Google Scholar

7 

Liu J, Zhao R, Jiang X, Li Z and Zhang B: Progress on the application of bortezomib and bortezomib-based nanoformulations. Biomolecules. 12(51)2021.PubMed/NCBI View Article : Google Scholar

8 

Wen R, Umeano AC, Chen P and Farooqi AA: Polymer-based drug delivery systems for cancer. Crit Rev Ther Drug Carrier Syst. 35:521–553. 2018.PubMed/NCBI View Article : Google Scholar

9 

Waleka E, Stojek Z and Karbarz M: Activity of povidone in recent biomedical applications with emphasis on micro- and nano drug delivery systems. Pharmaceutics. 13(654)2021.PubMed/NCBI View Article : Google Scholar

10 

Kuskov A, Nikitovic D, Berdiaki A, Shtilman M and Tsatsakis A: Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for nonsteroidal, anti-inflammatory drugs: Pharmacokinetic, anti-inflammatory, and ulcerogenic activity study. Pharmaceutics. 14(925)2022.PubMed/NCBI View Article : Google Scholar

11 

Berdiaki A, Kuskov AN, Kulikov PP, Thrapsanioti LN, Giatagana EM, Stivaktakis P, Shtilman MI, Tsatsakis A and Nikitovic D: In vitro assessment of poly-N-Vinylpyrrolidone/acrylic acid nanoparticles biocompatibility in a microvascular endothelium model. Int J Mol Sci. 23(12446)2022.PubMed/NCBI View Article : Google Scholar

12 

Villemson AL, Kuskov AN, Shtilman MI, Galebskaya LV, Ryumina EV and Larionova NI: Interaction of polymer aggregates based on stearoyl-poly-N-vinylpyrrolidone with blood components. Biochemistry (Mosc). 69:621–628. 2004.PubMed/NCBI View Article : Google Scholar

13 

Berdiaki A, Perisynaki E, Stratidakis A, Kulikov PP, Kuskov AN, Stivaktakis P, Henrich-Noack P, Luss AL, Shtilman MM, Tzanakakis GN, et al: Assessment of amphiphilic poly-N-vinylpyrrolidone nanoparticles' biocompatibility with endothelial cells in vitro and delivery of an anti-inflammatory drug. Mol Pharm. 17:4212–4225. 2020.PubMed/NCBI View Article : Google Scholar

14 

Yagolovich A, Kuskov A, Kulikov P, Kurbanova L, Bagrov D, Artykov A, Gasparian M, Sizova S, Oleinikov V, Gileva A, et al: Amphiphilic poly(N-vinylpyrrolidone) nanoparticles conjugated with dr5-specific antitumor cytokine dr5-b for targeted delivery to cancer cells. Pharmaceutics. 13(1413)2021.PubMed/NCBI View Article : Google Scholar

15 

Teng Y, Morrison ME, Munk P, Webber SE and Procházka K: Release kinetics studies of aromatic molecules into water from block polymer micelles. Macromolecules. 31:3578–3587. 1998.

16 

Akasov R, Zaytseva-Zotova D, Burov S, Leko M, Dontenwill M, Chiper M, Vandamme T and Markvicheva E: Formation of multicellular tumor spheroids induced by cyclic RGD-peptides and use for anticancer drug testing in vitro. Int J Pharm. 506:148–157. 2016.PubMed/NCBI View Article : Google Scholar

17 

Kulikov PP, Kuskov AN, Goryachaya AV, Luss AN and Shtil'man MI: Amphiphilic poly-n-vinyl-2-pyrrolidone: Synthesis, properties, nanoparticles. Polym Sci Ser D. 10:263–268. 2017.

18 

Kuskov AN, Kulikov PP, Luss AL, Goryachaya AV and Shtil'man MI: Preparation of polymer nanoparticles by self-assembling of amphiphilic poly-N-vinylpyrrolidone derivatives in aqueous media. Russ J Appl Chem. 89:1461–1468. 2016.

19 

Kozulitsyna TI and Zemskova ZS: Therapeutic efficiency of ethionamide and prothionamide. Probl Tuberk. 47:66–69. 1969.PubMed/NCBI(In Russian).

20 

Radu IC, Hudita A, Zaharia C, Galateanu B, Iovu H, Tanasa EV, Georgiana Nitu S, Ginghina O, Negrei C, Tsatsakis A, et al: Poly(3-hydroxybutyrate-CO-3-hydroxyvalerate) PHBHV biocompatible nanocarriers for 5-FU delivery targeting colorectal cancer. Drug Deliv. 26:318–327. 2019.PubMed/NCBI View Article : Google Scholar

21 

Ginghină O, Hudiță A, Zaharia C, Tsatsakis A, Mezhuev Y, Costache M and Gălățeanu B: Current landscape in organic nanosized materials advances for improved management of colorectal cancer patients. Materials (Basel). 14(2440)2021.PubMed/NCBI View Article : Google Scholar

22 

Hudiță A, Radu IC, Zaharia C, Ion AC, Ginghină O, Gălățeanu B, Măruțescu L, Grama F, Tsatsakis A, Gurevich L and Costache M: Bio- and hemo-compatible silk fibroin PEGylated nanocarriers for 5-fluorouracil chemotherapy in colorectal cancer: In vitro studies. Pharmaceutics. 13(755)2021.PubMed/NCBI View Article : Google Scholar

23 

Cicek B, Hacimuftuoglu A, Kuzucu M, Cetin A, Yeni Y, Genc S, Yildirim S, Bolat I, Kantarci M, Gul M, et al: Sorafenib alleviates inflammatory signaling of tumor microenvironment in precancerous lung injuries. Pharmaceuticals (Basel). 16(221)2023.PubMed/NCBI View Article : Google Scholar

24 

Gu Z, Wang X, Cheng R, Cheng L and Zhong Z: Hyaluronic acid shell and disulfide-crosslinked core micelles for in vivo targeted delivery of bortezomib for the treatment of multiple myeloma. Acta Biomater. 80:288–295. 2018.PubMed/NCBI View Article : Google Scholar

25 

Zhang R, Liu Y, Yang Z, Li Y, Rong X, Wang L, Guo C, Li S, Liu J, Li M and Wu Y: Construction of nanoparticles based on amphiphilic PEI-PA polymers for bortezomib and paclitaxel co-delivery. RSC Adv. 5:15453–15460. 2015.

26 

Unsoy G, Yalcin S, Khodadust R, Mutlu P, Onguru O and Gunduz U: Chitosan magnetic nanoparticles for pH responsive Bortezomib release in cancer therapy. Biomed Pharmacother. 68:641–648. 2014.PubMed/NCBI View Article : Google Scholar

27 

De Santo M, Giovinazzo A, Fava M, Mazzotta E, De Napoli IE, Greco M, Comandé A, Nigro A, Argurio P, Perrotta I, et al: Engineered mesoporous silica-based nanoparticles as smart chemotherapy nanodevice for bortezomib administration†. Mater Chem Front. 7:216–229. 2023.

28 

Yadav S, Sharma AK and Kumar P: Nanoscale self-assembly for therapeutic delivery. Front Bioeng Biotechnol. 8(127)2020.PubMed/NCBI View Article : Google Scholar

29 

Shen S, Du XJ, Liu J, Sun R, Zhu YH and Wang J: Delivery of bortezomib with nanoparticles for basal-like triple-negative breast cancer therapy. J Control Release. 208:14–24. 2015.PubMed/NCBI View Article : Google Scholar

30 

Liu L, Wang S, Qi P, Song S, Yang Y, Shi J and Han G: Dopamine-modified poly(ε-caprolactone) micelles for pH controlled delivery of bortezomib. Int J Pharm. 590(119885)2020.PubMed/NCBI View Article : Google Scholar

31 

Liu S, Ono RJ, Yang C, Gao S, Ming Tan JY, Hedrick JL and Yang YY: Dual pH-responsive shell-cleavable polycarbonate micellar nanoparticles for in vivo anticancer drug delivery. ACS Appl Mater Interfaces. 10:19355–19364. 2018.PubMed/NCBI View Article : Google Scholar

32 

Toda M, Arima Y and Iwata H: Complement activation on degraded polyethylene glycol-covered surface. Acta Biomate. 6:2642–2649. 2010.PubMed/NCBI View Article : Google Scholar

33 

Xu H, Ye F, Hu M, Yin P, Zhang W, Li Y, Yu X and Deng Y: Influence of phospholipid types and animal models on the accelerated blood clearance phenomenon of PEGylated liposomes upon repeated injection. Drug Deliv. 22:598–607. 2015.PubMed/NCBI View Article : Google Scholar

34 

Asenjo-Sanz I, Del-Corte M, Pinacho-Olaciregui J, González-Burgos M, González E, Verde-Sesto E, Arbe A, Colmenero J and Pomposo JA: Preparation and preliminary evaluation of povidone single-chain nanoparticles as potential drug delivery nanocarriers. Med One:. 4(e190013)2019.

35 

Roth P, Mason WP, Richardson PG and Weller M: Proteasome inhibition for the treatment of glioblastoma. Expert Opin Investig Drugs. 29:1133–1141. 2020.PubMed/NCBI View Article : Google Scholar

36 

Tawfik M, Hadlak S, Götze C, Sokolov M, Kulikov P, Kuskov A, Shtilman M, Sabel BA and Henrich-Noack P: Live in-vivo neuroimaging reveals the transport of lipophilic cargo through the blood-retina barrier with modified amphiphilic poly-N-vinylpyrrolidone nanoparticles. J Biomed Nanotechnol. 17:846–858. 2021.PubMed/NCBI View Article : Google Scholar

37 

Pensado-López A, Fernández-Rey J, Reimunde P, Crecente-Campo J, Sánchez L and Torres Andón F: Zebrafish models for the safety and therapeutic testing of nanoparticles with a focus on macrophages. Nanomaterials (Basel). 11(1784)2021.PubMed/NCBI View Article : Google Scholar

38 

Gamble JT, Elson DJ, Greenwood JA, Tanguay RL and Kolluri SK: The zebrafish xenograft models for investigating cancer and cancer therapeutics. Biology (Basel). 10(252)2021.PubMed/NCBI View Article : Google Scholar

39 

Renieri EA, Sfakianakis DG, Alegakis AA, Safenkova IV, Buha A, Matović V, Tzardi M, Dzantiev BB, Divanach P, Kentouri M and Tsatsakis AM: Nonlinear responses to waterborne cadmium exposure in zebrafish. An in vivo study. Environ Res. 157:173–181. 2017.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yagolovich AV, Kuskov AN, Kulikov PP, Bagrov DV, Petrova PA, Kukovyakina EV, Isakova AA, Khan II, Pokrovsky VS, Nosyrev AE, Nosyrev AE, et al: Assessment of the effects of amphiphilic poly (N‑vinylpyrrolidone) nanoparticles loaded with bortezomib on glioblastoma cell lines and zebrafish embryos. Biomed Rep 20: 37, 2024.
APA
Yagolovich, A.V., Kuskov, A.N., Kulikov, P.P., Bagrov, D.V., Petrova, P.A., Kukovyakina, E.V. ... Tsatsakis, A.M. (2024). Assessment of the effects of amphiphilic poly (N‑vinylpyrrolidone) nanoparticles loaded with bortezomib on glioblastoma cell lines and zebrafish embryos. Biomedical Reports, 20, 37. https://doi.org/10.3892/br.2024.1725
MLA
Yagolovich, A. V., Kuskov, A. N., Kulikov, P. P., Bagrov, D. V., Petrova, P. A., Kukovyakina, E. V., Isakova, A. A., Khan, I. I., Pokrovsky, V. S., Nosyrev, A. E., Stamati, P. C., Markvicheva, E. A., Gasparian, M. E., Spandidos, D. A., Tsatsakis, A. M."Assessment of the effects of amphiphilic poly (N‑vinylpyrrolidone) nanoparticles loaded with bortezomib on glioblastoma cell lines and zebrafish embryos". Biomedical Reports 20.3 (2024): 37.
Chicago
Yagolovich, A. V., Kuskov, A. N., Kulikov, P. P., Bagrov, D. V., Petrova, P. A., Kukovyakina, E. V., Isakova, A. A., Khan, I. I., Pokrovsky, V. S., Nosyrev, A. E., Stamati, P. C., Markvicheva, E. A., Gasparian, M. E., Spandidos, D. A., Tsatsakis, A. M."Assessment of the effects of amphiphilic poly (N‑vinylpyrrolidone) nanoparticles loaded with bortezomib on glioblastoma cell lines and zebrafish embryos". Biomedical Reports 20, no. 3 (2024): 37. https://doi.org/10.3892/br.2024.1725
Copy and paste a formatted citation
x
Spandidos Publications style
Yagolovich AV, Kuskov AN, Kulikov PP, Bagrov DV, Petrova PA, Kukovyakina EV, Isakova AA, Khan II, Pokrovsky VS, Nosyrev AE, Nosyrev AE, et al: Assessment of the effects of amphiphilic poly (N‑vinylpyrrolidone) nanoparticles loaded with bortezomib on glioblastoma cell lines and zebrafish embryos. Biomed Rep 20: 37, 2024.
APA
Yagolovich, A.V., Kuskov, A.N., Kulikov, P.P., Bagrov, D.V., Petrova, P.A., Kukovyakina, E.V. ... Tsatsakis, A.M. (2024). Assessment of the effects of amphiphilic poly (N‑vinylpyrrolidone) nanoparticles loaded with bortezomib on glioblastoma cell lines and zebrafish embryos. Biomedical Reports, 20, 37. https://doi.org/10.3892/br.2024.1725
MLA
Yagolovich, A. V., Kuskov, A. N., Kulikov, P. P., Bagrov, D. V., Petrova, P. A., Kukovyakina, E. V., Isakova, A. A., Khan, I. I., Pokrovsky, V. S., Nosyrev, A. E., Stamati, P. C., Markvicheva, E. A., Gasparian, M. E., Spandidos, D. A., Tsatsakis, A. M."Assessment of the effects of amphiphilic poly (N‑vinylpyrrolidone) nanoparticles loaded with bortezomib on glioblastoma cell lines and zebrafish embryos". Biomedical Reports 20.3 (2024): 37.
Chicago
Yagolovich, A. V., Kuskov, A. N., Kulikov, P. P., Bagrov, D. V., Petrova, P. A., Kukovyakina, E. V., Isakova, A. A., Khan, I. I., Pokrovsky, V. S., Nosyrev, A. E., Stamati, P. C., Markvicheva, E. A., Gasparian, M. E., Spandidos, D. A., Tsatsakis, A. M."Assessment of the effects of amphiphilic poly (N‑vinylpyrrolidone) nanoparticles loaded with bortezomib on glioblastoma cell lines and zebrafish embryos". Biomedical Reports 20, no. 3 (2024): 37. https://doi.org/10.3892/br.2024.1725
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