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Article

Atrial natriuretic peptide T2238C gene polymorphism and the risk of cardiovascular diseases: A meta‑analysis

  • Authors:
    • Jiao Wang
    • Yuchun Yang
    • Meijuan Zheng
    • Lei Zhang
    • Muhuyati Wulasihan
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China, Xinjiang Medical University, Urumqi, Xinjiang 830017, P.R. China
  • Article Number: 41
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    Published online on: January 18, 2024
       https://doi.org/10.3892/br.2024.1730
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Abstract

The present study aimed to investigate the association between atrial natriuretic peptide (ANP) T2238C (rs5065) gene polymorphism and the risk of cardiovascular disease. Relevant literature was obtained by searching databases. The odds ratios (ORs) of the ANP T2238C locus genotype distribution in the case group of cardiovascular diseases and the control group of a non‑cardiovascular population were pooled using R software. Sensitivity analysis was used to verify the stability of the results. Egger's linear regression test was used to assess the publication bias of the included literature. Studies were classified according to quality assessment score of the Newcastle‑Ottawa scale, year, region, sample size and underlying disease for subgroup analysis, and meta‑regression analysis was performed. A total of 12 studies comprising 45,619 patients were included. ANP rs5065 mutant gene C allele was a significant risk factor for myocardial infarction relative to T allele (OR=2.55, 95%CI=1.47‑4.43, P=0.0008), CC+CT genotype was a significant risk factor for cerebrovascular events relative to TT (OR=1.14, 95%CI=1.04‑1.26, P=0.0048) and the mutant CC genotype was a potential risk factor for the composite cardio‑cerebral vascular events (CVE) relative to CT+TT (OR=1.40, 95%CI=0.96‑2.04, P=0.081). In studies fulfilling the Hardy‑Weinberg equilibrium, the CC genotype was a significant risk factor for the composite CVE relative to TT (OR=2.39, 95%CI=1.40‑4.10, P=0.0018) and the CC genotype was a significant risk factor for composite CVE relative to CT+TT (OR=2.41, 95%CI=1.41‑4.13, P=0.0015). The P‑value of the Egger's test for publication bias was 0.436, which was not statistically significant. The results of the sensitivity analysis were relatively stable. Subgroup analysis indicated that the publication year was a potential source of heterogeneity. Regression analysis was performed for the recessive model in the composite CVE and the results showed that the study region (Europe) was one of the sources of heterogeneity (P=0.016). In conclusion, ANP 2238T/C mutation may increase the risk of myocardial infarction, cerebrovascular events and composite CVE.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Yang Y, Zheng M, Zhang L and Wulasihan M: Atrial natriuretic peptide T2238C gene polymorphism and the risk of cardiovascular diseases: A meta‑analysis. Biomed Rep 20: 41, 2024.
APA
Wang, J., Yang, Y., Zheng, M., Zhang, L., & Wulasihan, M. (2024). Atrial natriuretic peptide T2238C gene polymorphism and the risk of cardiovascular diseases: A meta‑analysis. Biomedical Reports, 20, 41. https://doi.org/10.3892/br.2024.1730
MLA
Wang, J., Yang, Y., Zheng, M., Zhang, L., Wulasihan, M."Atrial natriuretic peptide T2238C gene polymorphism and the risk of cardiovascular diseases: A meta‑analysis". Biomedical Reports 20.3 (2024): 41.
Chicago
Wang, J., Yang, Y., Zheng, M., Zhang, L., Wulasihan, M."Atrial natriuretic peptide T2238C gene polymorphism and the risk of cardiovascular diseases: A meta‑analysis". Biomedical Reports 20, no. 3 (2024): 41. https://doi.org/10.3892/br.2024.1730
Copy and paste a formatted citation
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Spandidos Publications style
Wang J, Yang Y, Zheng M, Zhang L and Wulasihan M: Atrial natriuretic peptide T2238C gene polymorphism and the risk of cardiovascular diseases: A meta‑analysis. Biomed Rep 20: 41, 2024.
APA
Wang, J., Yang, Y., Zheng, M., Zhang, L., & Wulasihan, M. (2024). Atrial natriuretic peptide T2238C gene polymorphism and the risk of cardiovascular diseases: A meta‑analysis. Biomedical Reports, 20, 41. https://doi.org/10.3892/br.2024.1730
MLA
Wang, J., Yang, Y., Zheng, M., Zhang, L., Wulasihan, M."Atrial natriuretic peptide T2238C gene polymorphism and the risk of cardiovascular diseases: A meta‑analysis". Biomedical Reports 20.3 (2024): 41.
Chicago
Wang, J., Yang, Y., Zheng, M., Zhang, L., Wulasihan, M."Atrial natriuretic peptide T2238C gene polymorphism and the risk of cardiovascular diseases: A meta‑analysis". Biomedical Reports 20, no. 3 (2024): 41. https://doi.org/10.3892/br.2024.1730
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