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Cerium oxide nanoparticles: Chemical properties, biological effects and potential therapeutic opportunities (Review)

  • Authors:
    • Mariane Brandão Da Silva Assis
    • Gabriela Nestal De Moraes
    • Kátia Regina De Souza
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    Affiliations: Laboratory of Physical‑Chemistry of Materials, Military Institute of Engineering (IME), Rio de Janeiro 22 290 270, Brazil, Laboratory of Cellular and Molecular Hemato‑Oncology, Molecular Hemato‑Oncology Program, National Cancer Institute (INCA), Rio de Janeiro 20 230 130, Brazil
    Copyright: © Brandão Da Silva Assis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 48
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    Published online on: January 29, 2024
       https://doi.org/10.3892/br.2024.1736
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Abstract

The chemistry of pure cerium oxide (CeO2‑x) nanoparticles has been widely studied since the 1970s, especially for chemical catalysis. CeO2‑x nanoparticles have been included in an important class of industrial metal oxide nanoparticles and have been attributed a range of wide applications, such as ultraviolet absorbers, gas sensors, polishing agents, cosmetics, consumer products, high‑tech devices and fuel cell conductors. Despite these early applications in the field of chemistry, the biological effects of CeO2‑x nanoparticles were only explored in the 2000s. Since then, CeO2‑x nanoparticles have gained a spot in research related to various diseases, especially the ones in which oxidative stress plays a part. Due to an innate oxidation state variation on their surface, CeO2‑x nanoparticles have exhibited redox activities in diseases, such as cancer, acting either as an oxidizing agent, or as an antioxidant. In biological models, CeO2‑x nanoparticles have been shown to modulate cancer cell viability and, more recently, cell death pathways. However, a deeper understanding on how the chemical structure of CeO2‑x nanoparticles (including nanoparticle size, shape, suspension, agglomeration in the medium used, pH of the medium, type of synthesis and crystallite size) influences the cellular effects observed remains to be elucidated. In the present review, the chemistry of CeO2‑x nanoparticles and their impact on biological models and modulation of cell signalling, particularly focusing on oxidative and cell death pathways, were investigated. The deeper understanding of the chemical activity of CeO2‑x nanoparticles may provide the rationale for further biomedical applications towards disease treatment and drug delivery purposes.
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1 

Montini T, Melchionna M, Monai M and Fornasiero P: Fundamentals and Catalytic Applications of CeO2 -Based Materials. Chem Rev. 116:5987–6041. 2016.PubMed/NCBI View Article : Google Scholar

2 

Choudhury B and Choudhury A: Ce3+ and oxygen vacancy mediated tuning of structural and optical properties of CeO2 nanoparticles. Mater Chem Phys. 131:666–671. 2012.

3 

Gangopadhyay S, Frolov DD, Masunov AE and Seal S: Structure and properties of cerium oxides in bulk and nanoparticulate forms. J Alloys Compd. 584:199–208. 2014.

4 

Guo W, Zhang M, Lou Z, Zhou M, Wang P and Wei H: Engineering nanoceria for enhanced peroxidase mimics: A solid solution strategy. ChemCatChem. 11:737–743. 2019.

5 

Sisubalan N, Ramkumar VS, Pugazhendhi A, Karthikeyan C, Indira K, Gopinath K, Hameed ASH and Basha MHG: ROS-Mediated Cytotoxic Activity of ZnO and CeO2 Nanoparticles Synthesized Using the Rubia Cordifolia L. Leaf Extract on MG-63 Human Osteosarcoma Cell Lines. Environ Sci Pollut Res. 25:10482–10492. 2018.PubMed/NCBI View Article : Google Scholar

6 

Da Silva JLF: Stability of the Ce2O3 Phases: A DFT + U Investigation. Phys Rev B. 76(193108)2007.

7 

Trovarelli Alessandro Catalysis by Ceria and Related Materials; 2002; Vol. 2; ISBN 978-1-78326-131-4.

8 

Gangavarapu RR and Mishra B: Structural, Redox and Catalytic Chemistry of Ceria Based Materials. Bull Catal Soc India. 2:122–134. 2003.

9 

Deshpande S, Patil S, Kuchibhatla SV and Seal S: Size dependency variation in lattice parameter and valency states in nanocrystalline cerium oxide. Appl Phys Lett. 87(133113)2005.

10 

Das S, Dowding JM, Klump KE, McGinnis JF, Self W and Seal S: Cerium Oxide Nanoparticles: Applications and prospects in nanomedicine. Nanomedicine (Lond). 8:1483–1508. 2013.PubMed/NCBI View Article : Google Scholar

11 

Ganduglia-Pirovano MV, Da Silva JL and Sauer J: Density-Functional calculations of the structure of near-surface oxygen vacancies and electron localization on CeO2 (111). Phys Rev Lett. 102(026101)2009.PubMed/NCBI View Article : Google Scholar

12 

Chen BH and Stephen Inbaraj B: Various physicochemical and surface properties controlling the bioactivity of cerium oxide nanoparticles. Crit Rev Biotechnol. 38:1003–1024. 2018.PubMed/NCBI View Article : Google Scholar

13 

Jerratsch JF, Shao X, Nilius N, Freund HJ, Popa C, Ganduglia-Pirovano MV, Burow AM and Sauer J: Electron Localization in Defective Ceria Films: A study with scanning-tunneling microscopy and density-functional theory. Phys Rev Lett. 106(246801)2011.PubMed/NCBI View Article : Google Scholar

14 

Skorodumova NV, Simak SI, Lundqvist BI, Abrikosov IA and Johansson B: Quantum origin of the oxygen storage capability of ceria. Phys Rev Lett. 89(166601)2002.PubMed/NCBI View Article : Google Scholar

15 

Pinto FM, Suzuki VY, Silva RC and La Porta FA: Oxygen defects and surface chemistry of reducible oxides. Front Mater. 6(260)2019.

16 

Sun C, Li H and Chen L: Nanostructured ceria-based materials: Synthesis, properties, and applications. Energy Environ Sci. 5:8475–8505. 2012.

17 

Calvache-Muñoz J, Prado FA and Rodríguez-Páez JE: Cerium oxide nanoparticles: Synthesis, characterization and tentative mechanism of particle formation. Colloids Surf Physicochem. Eng Asp. 529:146–159. 2017.

18 

Capdevila-Cortada M and López N: Entropic contributions enhance polarity compensation for CeO2(100) Surfaces. Nat Mater. 16:328–334. 2017.PubMed/NCBI View Article : Google Scholar

19 

Hussain SP, Hofseth LJ and Harris CC: Radical Causes of Cancer. Nat Rev Cancer. 3:276–285. 2003.PubMed/NCBI View Article : Google Scholar

20 

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, et al: Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 25:486–541. 2018.PubMed/NCBI View Article : Google Scholar

21 

Lord MS, Berret JF, Singh S, Vinu A and Karakoti AS: Redox active cerium oxide nanoparticles: Current status and burning issues. Small. 17(e2102342)2021.PubMed/NCBI View Article : Google Scholar

22 

Korsvik C, Patil S, Seal S and Self WT: superoxide dismutase mimetic properties exhibited by vacancy engineered ceria nanoparticles. Chem Commun (Camb). 1056-1058:2007.PubMed/NCBI View Article : Google Scholar

23 

Yadav N and Singh S: Polyoxometalate-Mediated vacancy-engineered cerium oxide nanoparticles exhibiting controlled biological enzyme-mimicking activities. Inorg Chem. 60:7475–7489. 2021.PubMed/NCBI View Article : Google Scholar

24 

Pirmohamed T, Dowding JM, Singh S, Wasserman B, Heckert E, Karakoti AS, King JES, Seal S and Self WT: Nanoceria exhibit redox state-dependent catalase mimetic activity. Chem Commun. 46(2736)2010.PubMed/NCBI View Article : Google Scholar

25 

Yadav N, Patel V, McCourt L, Ruppert M, Miller M, Inerbaev T, Mahasivam S, Bansal V, Vinu A, Singh S and Karakoti A: Tuning the enzyme-like activities of cerium oxide nanoparticles using a triethyl phosphite ligand. Biomater Sci. 10:3245–3258. 2022.PubMed/NCBI View Article : Google Scholar

26 

Karakoti AS, Singh S, Kumar A, Malinska M, Kuchibhatla SV, Wozniak K, Self WT and Seal S: PEGylated Nanoceria as Radical Scavenger with Tunable Redox Chemistry. J Am Chem Soc. 131:14144–14145. 2009.PubMed/NCBI View Article : Google Scholar

27 

Ikeda A, Nishina PM and Naggert JK: The tubby-like proteins, a family with roles in neuronal development and function. J Cell Sci. 115(Pt 1):9–14. 2002.PubMed/NCBI View Article : Google Scholar

28 

Schwabe RF and Luedde T: Apoptosis and necroptosis in the liver: A matter of life and death. Nat Rev Gastroenterol Hepatol. 15:738–752. 2018.PubMed/NCBI View Article : Google Scholar

29 

Jiang L, Xie Y, Sun X and Yin Z: Relationship between apoptosis of brain cells and free radical scavenging ability in rats during acute intermittent hypoxia. Space Med Med Eng (Beijing). 11:83–86. 1998.PubMed/NCBI

30 

Eizirik DL, Colli ML and Ortis F: The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol. 5:219–226. 2009.PubMed/NCBI View Article : Google Scholar

31 

Li W, Khor TO, Xu C, Shen G, Jeong WS, Yu S and Kong AN: Activation of Nrf2-antioxidant signaling Attenuates NFkappaB-Inflammatory response and elicits apoptosis. Biochem Pharmacol. 76:1485–1489. 2008.PubMed/NCBI View Article : Google Scholar

32 

Carneiro BA and El-Deiry WS: Targeting Apoptosis in Cancer Therapy. Nat Rev Clin Oncol. 17:395–417. 2020.PubMed/NCBI View Article : Google Scholar

33 

Davis W Jr, Ronai Z and Tew KD: Cellular thiols and reactive oxygen species in drug-induced apoptosis. J Pharmacol Exp Ther. 296:1–6. 2001.PubMed/NCBI

34 

Fleury C, Mignotte B and Vayssière JL: Mitochondrial reactive oxygen species in cell death signaling. Biochimie. 84:131–141. 2002.PubMed/NCBI View Article : Google Scholar

35 

Redza-Dutordoir M and Averill-Bates DA: Activation of apoptosis signalling pathways by reactive oxygen species. Biochim Biophys Acta. 1863:2977–2992. 2016.PubMed/NCBI View Article : Google Scholar

36 

Hockenbery DM, Giedt CD, O'Neill JW, Manion MK and Banker DE: Mitochondria and apoptosis: New therapeutic targets. Adv Cancer Res. 85:203–242. 2002.PubMed/NCBI View Article : Google Scholar

37 

Henry-Mowatt J, Dive C, Martinou JC and James D: Role of mitochondrial membrane permeabilization in apoptosis and cancer. Oncogene. 23:2850–2860. 2004.PubMed/NCBI View Article : Google Scholar

38 

Aroui S, Brahim S, De Waard M, Bréard J and Kenani A: Efficient induction of apoptosis by doxorubicin coupled to cell-penetrating peptides compared to unconjugated doxorubicin in the human breast cancer cell line MDA-MB 231. Cancer Lett. 285:28–38. 2009.PubMed/NCBI View Article : Google Scholar

39 

Fulda S, Galluzzi L and Kroemer G: Targeting mitochondria for cancer therapy. Nat Rev Drug Discov. 9:447–464. 2010.PubMed/NCBI View Article : Google Scholar

40 

Kong L, Cai X, Zhou X, Wong LL, Karakoti AS, Seal S and McGinnis JF: Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathways. Neurobiol Dis. 42:514–523. 2011.PubMed/NCBI View Article : Google Scholar

41 

Oró D, Yudina T, Fernández-Varo G, Casals E, Reichenbach V, Casals G, González De La Presa B, Sandalinas S, Carvajal S, Puntes V and Jiménez W: Cerium oxide nanoparticles reduce steatosis, portal hypertension and display antiinflammatory properties in rats with liver fibrosis. J Hepatol. 64:691–698. 2016.PubMed/NCBI View Article : Google Scholar

42 

Khurana A, Tekula S and Godugu C: Nanoceria suppresses multiple low doses of streptozotocin-induced type 1 diabetes by inhibition of Nrf2/NF-κB pathway and reduction of apoptosis. Nanomedicine (Lond). 13:1905–1922. 2018.PubMed/NCBI View Article : Google Scholar

43 

Schwotzer D, Niehof M, Schaudien D, Kock H, Hansen T, Dasenbrock C and Creutzenberg O: cerium oxide and barium sulfate nanoparticle inhalation affects gene expression in alveolar epithelial cells type II. J Nanobiotechnology. 16(16)2018.PubMed/NCBI View Article : Google Scholar

44 

Hanahan D: Hallmarks of cancer: New dimensions. Cancer Discov. 12:31–46. 2022.PubMed/NCBI View Article : Google Scholar

45 

Delbridge ARD, Grabow S, Strasser A and Vaux DL: Thirty Years of BCL-2: Translating cell death discoveries into novel cancer therapies. Nat Rev Cancer. 16:99–109. 2016.PubMed/NCBI View Article : Google Scholar

46 

Mohamed MS, Bishr MK, Almutairi FM and Ali AG: Inhibitors of apoptosis: Clinical implications in cancer. Apoptosis. 22:1487–1509. 2017.PubMed/NCBI View Article : Google Scholar

47 

Arfin S, Jha NK, Jha SK, Kesari KK, Ruokolainen J, Roychoudhury S, Rathi B and Kumar D: Oxidative stress in cancer cell metabolism. Antioxidants (Basel). 10(642)2021.PubMed/NCBI View Article : Google Scholar

48 

Waris G and Ahsan H: Reactive oxygen species: Role in the development of cancer and various chronic conditions. J Carcinog. 5(14)2006.PubMed/NCBI View Article : Google Scholar

49 

Perillo B, Di Donato M, Pezone A, Di Zazzo E, Giovannelli P, Galasso G, Castoria G and Migliaccio A: ROS in cancer therapy: The bright side of the moon. Exp Mol Med. 52:192–203. 2020.PubMed/NCBI View Article : Google Scholar

50 

Tarnuzzer RW, Colon J, Patil S and Seal S: Vacancy engineered ceria nanostructures for protection from radiation-induced cellular damage. Nano Lett. 5:2573–2577. 2005.PubMed/NCBI View Article : Google Scholar

51 

Robertson-Tessi M, Gillies RJ, Gatenby RA and Anderson ARA: Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes. Cancer Res. 75:1567–1579. 2015.PubMed/NCBI View Article : Google Scholar

52 

Asati A, Santra S, Kaittanis C and Perez JM: Surface-Charge-Dependent cell localization and cytotoxicity of cerium oxide nanoparticles. ACS Nano. 4:5321–5331. 2010.PubMed/NCBI View Article : Google Scholar

53 

Ali D, Alarifi S, Alkahtani S, AlKahtane AA and Almalik A: Cerium oxide nanoparticles induce oxidative stress and genotoxicity in human skin melanoma cells. Cell Biochem. Biophys. 71:1643–1651. 2015.PubMed/NCBI View Article : Google Scholar

54 

Xu C and Qu X: Cerium oxide nanoparticle: A remarkably versatile rare earth nanomaterial for biological applications. NPG Asia Mater. 6(e90)2014.

55 

Alili L, Sack M, Karakoti AS, Teuber S, Puschmann K, Hirst SM, Reilly CM, Zanger K, Stahl W, Das S, et al: Combined cytotoxic and anti-invasive properties of redox-active nanoparticles in tumor-stroma interactions. Biomaterials. 32:2918–2929. 2011.PubMed/NCBI View Article : Google Scholar

56 

Wason MS, Colon J, Das S, Seal S, Turkson J, Zhao J and Baker CH: Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production. Nanomedicine. 9:558–569. 2013.PubMed/NCBI View Article : Google Scholar

57 

Rubio L, Marcos R and Hernández A: Nanoceria acts as antioxidant in tumoral and transformed cells. Chem Biol Interact. 291:7–15. 2018.PubMed/NCBI View Article : Google Scholar

58 

Cheng G, Guo W, Han L, Chen E, Kong L, Wang L, Ai W, Song N, Li H and Chen H: Cerium oxide nanoparticles induce cytotoxicity in human hepatoma SMMC-7721 cells via oxidative stress and the activation of MAPK signaling pathways. Toxicol In Vitro. 27:1082–1088. 2013.PubMed/NCBI View Article : Google Scholar

59 

Xia T, Kovochich M, Liong M, Mädler L, Gilbert B, Shi H, Yeh JI, Zink JI and Nel AE: Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano. 2:2121–2134. 2008.PubMed/NCBI View Article : Google Scholar

60 

Fernández-Varo G, Perramón M, Carvajal S, Oró D, Casals E, Boix L, Oller L, Macías-Muñoz L, Marfà S, Casals G, et al: Bespoken Nanoceria: An effective treatment in experimental hepatocellular carcinoma. Hepatology. 72:1267–1282. 2020.PubMed/NCBI View Article : Google Scholar

61 

Cheng H, Liao ZL, Ning LH, Chen HY, Wei SS, Yang XC and Guo H: Alendronate-Anchored PEGylation of ceria nanoparticles promotes human hepatoma cell proliferation via AKT/ERK signaling pathways. Cancer Med. 6:374–381. 2017.PubMed/NCBI View Article : Google Scholar

62 

Pešić M, Podolski-Renić A, Stojković S, Matović B, Zmejkoski D, Kojić V, Bogdanović G, Pavićević A, Mojović M, Savić A, et al: Anti-Cancer effects of cerium oxide nanoparticles and its intracellular redox activity. Chem Biol Interact. 232:85–93. 2015.PubMed/NCBI View Article : Google Scholar

63 

Aplak E, Von Montfort C, Haasler L, Stucki D, Steckel B, Reichert AS, Stahl W and Brenneisen P: CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction. PLoS One. 15(e0227926)2020.PubMed/NCBI View Article : Google Scholar

64 

Datta A, Mishra S, Manna K, Saha KD, Mukherjee S and Roy S: Pro-Oxidant therapeutic activities of cerium oxide nanoparticles in colorectal carcinoma cells. ACS Omega. 5:9714–9723. 2020.PubMed/NCBI View Article : Google Scholar

65 

Hirst SM, Karakoti AS, Tyler RD, Sriranganathan N, Seal S and Reilly CM: Anti-Inflammatory Properties of Cerium Oxide Nanoparticles. Small. 5:2848–2856. 2009.PubMed/NCBI View Article : Google Scholar

66 

Zal Z, Ghasemi A, Azizi S, Asgarian-Omran H, Montazeri A and Hosseinimehr SJ: Radioprotective effect of cerium oxide nanoparticles against genotoxicity induced by ionizing radiation on human lymphocytes. Curr Radiopharm. 11:109–115. 2018.PubMed/NCBI View Article : Google Scholar

67 

Cai R, Xiao L, Qiu J, Zhao L, Li Z, Ju H, Sun M, Zhu W, Wang Z and Du F: Fabrication of cerium doped carbon dots with highly radical scavenging activity alleviates ferroptosis-induced oxidative damage. Nanotechnology. 32:2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Brandão Da Silva Assis M, De Moraes GN and De Souza KR: Cerium oxide nanoparticles: Chemical properties, biological effects and potential therapeutic opportunities (Review). Biomed Rep 20: 48, 2024.
APA
Brandão Da Silva Assis, M., De Moraes, G.N., & De Souza, K.R. (2024). Cerium oxide nanoparticles: Chemical properties, biological effects and potential therapeutic opportunities (Review). Biomedical Reports, 20, 48. https://doi.org/10.3892/br.2024.1736
MLA
Brandão Da Silva Assis, M., De Moraes, G. N., De Souza, K. R."Cerium oxide nanoparticles: Chemical properties, biological effects and potential therapeutic opportunities (Review)". Biomedical Reports 20.3 (2024): 48.
Chicago
Brandão Da Silva Assis, M., De Moraes, G. N., De Souza, K. R."Cerium oxide nanoparticles: Chemical properties, biological effects and potential therapeutic opportunities (Review)". Biomedical Reports 20, no. 3 (2024): 48. https://doi.org/10.3892/br.2024.1736
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Spandidos Publications style
Brandão Da Silva Assis M, De Moraes GN and De Souza KR: Cerium oxide nanoparticles: Chemical properties, biological effects and potential therapeutic opportunities (Review). Biomed Rep 20: 48, 2024.
APA
Brandão Da Silva Assis, M., De Moraes, G.N., & De Souza, K.R. (2024). Cerium oxide nanoparticles: Chemical properties, biological effects and potential therapeutic opportunities (Review). Biomedical Reports, 20, 48. https://doi.org/10.3892/br.2024.1736
MLA
Brandão Da Silva Assis, M., De Moraes, G. N., De Souza, K. R."Cerium oxide nanoparticles: Chemical properties, biological effects and potential therapeutic opportunities (Review)". Biomedical Reports 20.3 (2024): 48.
Chicago
Brandão Da Silva Assis, M., De Moraes, G. N., De Souza, K. R."Cerium oxide nanoparticles: Chemical properties, biological effects and potential therapeutic opportunities (Review)". Biomedical Reports 20, no. 3 (2024): 48. https://doi.org/10.3892/br.2024.1736
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