Granulomatous mastitis in accessory breast tissue: A rare presentation and surgical management

Salih,Abdulwahid M.; Pshtiwan,Lana RΑ.; Latif,Shaban; Ali,Halkawt O.; Abdullah,Ari M.; Baba,Hiwa O.; Hama,Jihad Ibrahim; Hassan,Shko H.; Hassan,Marwan N.; Mohammed,Shvan H.; Ahmed,Mohammed L.; Kakamad,Fahmi H.

doi:10.3892/br.2024.1750

April-2024 Volume 20 Issue 4

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April-2024 Volume 20 Issue 4

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Case Report Open Access

Granulomatous mastitis in accessory breast tissue: A rare presentation and surgical management

Authors:
- Abdulwahid M. Salih
- Lana RΑ. Pshtiwan
- Shaban Latif
- Halkawt O. Ali
- Ari M. Abdullah
- Hiwa O. Baba
- Jihad Ibrahim Hama
- Shko H. Hassan
- Marwan N. Hassan
- Shvan H. Mohammed
- Mohammed L. Ahmed
- Fahmi H. Kakamad
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Affiliations: Scientific Affairs Department, Smart Health Tower, Sulaimani, Kurdistan 46001, Republic of Iraq, Research Center, University of Halabja, Halabja, Kurdistan 46018, Republic of Iraq, Kscien Organization for Scientific Research, Sulaimani, Kurdistan 46001, Republic of Iraq

Copyright: © Salih et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 62
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Published online on: February 19, 2024

https://doi.org/10.3892/br.2024.1750
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Abstract

Granulomatous mastitis (GM) in accessory breast tissue is rare. The present study aimed to report a rare case of GM in accessory breast tissue. A 39‑year‑old female patient presented with right axillary discomfort and swelling for ~5 days. On clinical examination, a tender, firm lump was detected in the right axillary region. The ultrasound showed diffuse parenchymal heterogeneity and surrounding edema in the right accessory breast associated with reactive axillary lymph nodes. Following unresponsiveness to conservative treatment, a surgical procedure was performed in the form of an excisional biopsy and the lesion was diagnosed as GM. During the six‑month follow‑up, there were no recurrences. The exact cause of GM remains uncertain and the etiology within accessory breast tissue is even less understood. Proposed mechanisms suggest that it may result from an exaggerated immune response triggered by various factors, such as infection, autoimmunity or hormonal fluctuations. GM in accessory breast tissue is a rare and challenging clinical condition to be diagnosed. Due to the rarity of this condition, it highlights the importance of including GM in the differential diagnosis of axillary masses.

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1	Wolfrum A, Kümmel S, Theuerkauf I, Pelz E and Reinisch M: Granulomatous mastitis: A therapeutic and diagnostic challenge. Breast Care (Basel). 13:413–418. 2018.PubMed/NCBI View Article : Google Scholar
2	Alvand S, Hessami A, Makhmalbaf AO and Elahi A: Uncommon location of idiopathic granulomatous mastitis: A case report. Arch Breast Cancer. 9 (3-SI):320–324. 2022.
3	Kessler E and Wolloch Y: Granulomatous mastitis: A lesion clinically simulating carcinoma. Am J Clin Pathol. 58:642–646. 1972.PubMed/NCBI View Article : Google Scholar
4	Cohen C: Granulomatous mastitis-a review of 5 cases. S Afr Med J. 52:14–16. 1977.PubMed/NCBI
5	Brennan ME, Morgan M, Heilat GB and Kanesalingam K: Granulomatous lobular mastitis: Clinical update and case study. Aust J Gen Pract. 49:44–47. 2020.PubMed/NCBI View Article : Google Scholar
6	Carmalt HL and Ramsey-Stewart G: Granulomatous mastitis. Med J Aust. 1:356–359. 1981.PubMed/NCBI View Article : Google Scholar
7	Deng Y, Xiong Y, Ning P, Wang X, Han XR, Tu GF and He PY: A case management model for patients with granulomatous mastitis: A prospective study. BMC Womens Health. 22(143)2022.PubMed/NCBI View Article : Google Scholar
8	Nakamura J, Tanaka F, Ohtaka K, Sato K and Iyama A: A rare case of granulomatous mastitis in the accessory axillary breast of a pregnant woman successfully treated by surgery. Eur J Breast Health. 18:195–198. 2022.PubMed/NCBI View Article : Google Scholar
9	Yılmaz MA, Kaya TI, Demirel M and Yuyucu Karabulut Y: Pregnancy-associated granulomatous mastitis of accessory breast: A novel clinical presentation. Dermatol Ther. 34(e14729)2021.PubMed/NCBI View Article : Google Scholar
10	Muhialdeen AS, Ahmed JO, Baba HO, Abdullah IY, Hassan HA, Najar KA, Mikael TM, Mustafa MQ, Mohammed DA, Omer DA, et al: Kscien's list; a new strategy to discourage predatory journals and publishers (second version). Barw Med J. 1:30–32. 2023.
11	Altintoprak F, Kivilcim T and Ozkan OV: Aetiology of idiopathic granulomatous mastitis. World J Clin Cases. 2:852–858. 2014.PubMed/NCBI View Article : Google Scholar
12	Camargo MD PhD A, F B, B DF, L S, J M, Ramilo MD T and Balcarce MD TG: Is it possible to avoid the late diagnosis of idiopathic granulomatous mastitis? Obstet Gynecol Int J. 12:408–413. 2021.
13	Kumar MA, Pankaja S, Kumar NG and Sunayana K: Varied clinical presentation of granulomatous mastitis-a retrospective cohort study. Int J Anat Radiol Surg. 11:SO19–SO24. 2022.
14	Chirappapha P, Thaweepworadej P, Supsamutchai C, Biadul N and Lertsithichai P: Idiopathic granulomatous mastitis: A retrospective cohort study between 44 patients with different treatment modalities. Ann Med Surg (Lond). 36:162–167. 2018.PubMed/NCBI View Article : Google Scholar
15	Bani-Hani KE, Yaghan RJ, Matalka II and Shatnawi NJ: Idiopathic granulomatous mastitis: Time to avoid unnecessary mastectomies. Breast J. 10:318–322. 2004.PubMed/NCBI View Article : Google Scholar
16	Diesing D, Axt-Fliedner R, Hornung D, Weiss JM, Diedrich K and Friedrich M: Granulomatous mastitis. Arch Gynecol Obstet. 269:233–236. 2004.PubMed/NCBI View Article : Google Scholar
17	Kiyak G, Dumlu EG, Kilinc I, Tokaç M, Akbaba S, Gurer A, Ozkardes AB and Kilic M: Management of idiopathic granulomatous mastitis: Dilemmas in diagnosis and treatment. BMC Surg. 14(66)2014.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Granulomatous mastitis in accessory breast tissue: A rare presentation and surgical management

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