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Myeloid‑derived suppressor cell accumulation induces Treg expansion and modulates lung malignancy progression

  • Authors:
    • Yinghua Wan
    • Xiangdong Mu
    • Jingquan Zhao
    • Li Li
    • Wenshuai Xu
    • Mingqiang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, P.R. China
    Copyright: © Wan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 68
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    Published online on: March 1, 2024
       https://doi.org/10.3892/br.2024.1754
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Abstract

Myeloid‑derived suppressor cells (MDSCs) are a heterogeneous family of myeloid cells that suppress T cell immunity in tumor‑bearing hosts. The present study aimed to examine roles of T and MDSC subsets in lung malignancy. The study analyzed 102 cases with lung malignancy and 34 healthy individuals. Flow cytometry was performed for identification of T cell and MDSC subsets and their phenotypic characteristics in peripheral blood. The lung malignancy cases exhibited lower frequencies of granulocyte‑like MDSCs (G‑MDSCs) expressing PD‑L2 and PD‑L1 than healthy controls (P=0.013 and P<0.001, respectively). Additionally, there was a higher frequency of monocyte‑like MDSCs (M‑MDSCs) expressing PD‑L1 in the peripheral blood of patients with lung malignancy than healthy controls (P<0.001). The frequencies of G‑MDSCs and M‑MDSCs were positively correlated with proportions of PD‑1+ and CTLA‑4+ regulatory T cells (Tregs). In vitro co‑culture assay demonstrated M‑MDSCs of lung malignancy enhanced naive T cell apoptosis and promoted Treg subset differentiation compared with M‑MDSCs of healthy controls. The findings suggested accumulation of MDSC subsets in lung malignancy and MDSCs expressing PD‑L2 and PD‑L1 induced Treg expansion by binding to PD‑1 on the surface of Tregs.
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Copy and paste a formatted citation
Spandidos Publications style
Wan Y, Mu X, Zhao J, Li L, Xu W and Zhang M: Myeloid‑derived suppressor cell accumulation induces Treg expansion and modulates lung malignancy progression. Biomed Rep 20: 68, 2024.
APA
Wan, Y., Mu, X., Zhao, J., Li, L., Xu, W., & Zhang, M. (2024). Myeloid‑derived suppressor cell accumulation induces Treg expansion and modulates lung malignancy progression. Biomedical Reports, 20, 68. https://doi.org/10.3892/br.2024.1754
MLA
Wan, Y., Mu, X., Zhao, J., Li, L., Xu, W., Zhang, M."Myeloid‑derived suppressor cell accumulation induces Treg expansion and modulates lung malignancy progression". Biomedical Reports 20.4 (2024): 68.
Chicago
Wan, Y., Mu, X., Zhao, J., Li, L., Xu, W., Zhang, M."Myeloid‑derived suppressor cell accumulation induces Treg expansion and modulates lung malignancy progression". Biomedical Reports 20, no. 4 (2024): 68. https://doi.org/10.3892/br.2024.1754
Copy and paste a formatted citation
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Spandidos Publications style
Wan Y, Mu X, Zhao J, Li L, Xu W and Zhang M: Myeloid‑derived suppressor cell accumulation induces Treg expansion and modulates lung malignancy progression. Biomed Rep 20: 68, 2024.
APA
Wan, Y., Mu, X., Zhao, J., Li, L., Xu, W., & Zhang, M. (2024). Myeloid‑derived suppressor cell accumulation induces Treg expansion and modulates lung malignancy progression. Biomedical Reports, 20, 68. https://doi.org/10.3892/br.2024.1754
MLA
Wan, Y., Mu, X., Zhao, J., Li, L., Xu, W., Zhang, M."Myeloid‑derived suppressor cell accumulation induces Treg expansion and modulates lung malignancy progression". Biomedical Reports 20.4 (2024): 68.
Chicago
Wan, Y., Mu, X., Zhao, J., Li, L., Xu, W., Zhang, M."Myeloid‑derived suppressor cell accumulation induces Treg expansion and modulates lung malignancy progression". Biomedical Reports 20, no. 4 (2024): 68. https://doi.org/10.3892/br.2024.1754
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