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Antibacterial and antioxidant activities in various parts of Artocarpus lacucha Buch. Ham. ethanolic extract

  • Authors:
    • Dewi Pertiwi
    • Rika Hartati
    • Elin Julianti
    • Irda Fidrianny
  • View Affiliations / Copyright

    Affiliations: Department of Pharmaceutical Biology, School of Pharmacy, Bandung Institute of Technology, Bandung, West Java 40132, Indonesia, Department of Pharmacochemistry, School of Pharmacy, Bandung Institute of Technology, Bandung, West Java 40132, Indonesia
    Copyright: © Pertiwi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 66
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    Published online on: February 23, 2024
       https://doi.org/10.3892/br.2024.1755
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Abstract

Artocarpus lacucha is an endemic plant to North Sumatera, Indonesia. This plant has pharmacological activities, including acting as an antioxidant and antibacterial. The aim of the present study was to analyze the antibacterial and antioxidant activities, and determine the flavonoid compounds from four parts of A. lachuca, namely leaves, barks, twigs and fruits. Antioxidant activity was investigated using the 2,2‑diphenyl 1‑picrylhydrazyl (DPPH) and cupric reducing antioxidant capacity (CUPRAC) methods. Antibacterial activity was analyzed using disk diffusion and microdilution methods. Several flavonoids, such as luteolin‑7‑O‑glucoside, rutin, quercetin, kaempferol and apigenin, were determined using high performance liquid chromatography. Based on the antioxidant activity test results using the DPPH method, the bark ethanolic extract provided the highest antioxidant capacity, while the CUPRAC method indicated that the twig ethanolic extract had the highest antioxidant capacity. The antibacterial activity test results demonstrated that at a low concentration of 750 µg/disk the bark ethanolic extract obtained the highest inhibition zone and minimum inhibitory concentration level against six of nine pathogenic bacteria. Therefore, A. lachuca bark ethanolic extract could be potentially developed as antioxidant and antibacterial agents.
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Copy and paste a formatted citation
Spandidos Publications style
Pertiwi D, Hartati R, Julianti E and Fidrianny I: Antibacterial and antioxidant activities in various parts of <em>Artocarpus</em> <em>lacucha</em> Buch. Ham. ethanolic extract. Biomed Rep 20: 66, 2024.
APA
Pertiwi, D., Hartati, R., Julianti, E., & Fidrianny, I. (2024). Antibacterial and antioxidant activities in various parts of <em>Artocarpus</em> <em>lacucha</em> Buch. Ham. ethanolic extract. Biomedical Reports, 20, 66. https://doi.org/10.3892/br.2024.1755
MLA
Pertiwi, D., Hartati, R., Julianti, E., Fidrianny, I."Antibacterial and antioxidant activities in various parts of <em>Artocarpus</em> <em>lacucha</em> Buch. Ham. ethanolic extract". Biomedical Reports 20.4 (2024): 66.
Chicago
Pertiwi, D., Hartati, R., Julianti, E., Fidrianny, I."Antibacterial and antioxidant activities in various parts of <em>Artocarpus</em> <em>lacucha</em> Buch. Ham. ethanolic extract". Biomedical Reports 20, no. 4 (2024): 66. https://doi.org/10.3892/br.2024.1755
Copy and paste a formatted citation
x
Spandidos Publications style
Pertiwi D, Hartati R, Julianti E and Fidrianny I: Antibacterial and antioxidant activities in various parts of <em>Artocarpus</em> <em>lacucha</em> Buch. Ham. ethanolic extract. Biomed Rep 20: 66, 2024.
APA
Pertiwi, D., Hartati, R., Julianti, E., & Fidrianny, I. (2024). Antibacterial and antioxidant activities in various parts of <em>Artocarpus</em> <em>lacucha</em> Buch. Ham. ethanolic extract. Biomedical Reports, 20, 66. https://doi.org/10.3892/br.2024.1755
MLA
Pertiwi, D., Hartati, R., Julianti, E., Fidrianny, I."Antibacterial and antioxidant activities in various parts of <em>Artocarpus</em> <em>lacucha</em> Buch. Ham. ethanolic extract". Biomedical Reports 20.4 (2024): 66.
Chicago
Pertiwi, D., Hartati, R., Julianti, E., Fidrianny, I."Antibacterial and antioxidant activities in various parts of <em>Artocarpus</em> <em>lacucha</em> Buch. Ham. ethanolic extract". Biomedical Reports 20, no. 4 (2024): 66. https://doi.org/10.3892/br.2024.1755
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