Interleukin‑18 binding protein: Biological properties and roles in human and animal immune regulation (Review)
- Authors:
- Fengxue Wang
-
Affiliations: College of Veterinary Medicine, Key Laboratory for Clinical Diagnosis and Treatment of Animal Disease at the Ministry of Agriculture, Inner Mongolia Agricultural University, Inner Mongolia Autonomous Region, Huhhot 010018, P.R. China - Published online on: April 9, 2024 https://doi.org/10.3892/br.2024.1775
- Article Number: 87
-
Copyright: © Wang . This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
|
Dinarello CA, Novick D, Rubinstein M and Lonnemann G: Interleukin 18 and interleukin 18 binding protein: Possible role in immunosuppression of chronic renal failure. Blood Purif. 21:258–270. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Kim YM, Kang HS, Paik GS, Pyun GH, Anderson KL, Torbett BE and Choi I: Roles of IFN consensus sequence binding protein and PU.1 in regulating IL-18 gene expression. J Immunol. 163:2000–2007. 1999.PubMed/NCBI | |
|
Muhl H, Kampfer H, Bosmann M, Frank S, Radeke H and Pfeilschifter J: Interferon-gamma mediates gene expression of IL-18 binding protein in nonleukocytic cells. Biochem Biophys Res Commun. 267:960–963. 2000.PubMed/NCBI View Article : Google Scholar | |
|
Mazodier K, Marin V, Novick D, Farnarier C, Robitail S, Schleinitz N, Veit V, Paul P, Rubinstein M, Dinarello CA, et al: Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome. Blood. 106:3483–3489. 2005.PubMed/NCBI View Article : Google Scholar | |
|
Chirathaworn C, Rianthavorn P, Wuttirattanakowit N and Poovorawan Y: Serum IL-18 and IL-18BP levels in patients with Chikungunya virus infection. Viral Immunol. 23:113–117. 2010.PubMed/NCBI View Article : Google Scholar | |
|
Migliorini P, Anzilotti C, Pratesi F, Quattroni P, Bargagna M, Dinarello CA and Boraschi D: Serum and urinary levels of IL-18 and its inhibitor IL-18BP in systemic lupus erythematosus. Eur Cytokine Netw. 21:264–271. 2010.PubMed/NCBI View Article : Google Scholar | |
|
Shan NN, Wang X, Zhu XJ, Peng J and Hou M: Role of IL-18/IL-18BP balance in spleen of patients with primary immune thrombocytopenia. Zhonghua Yi Xue Za Zhi. 91:239–242. 2011.PubMed/NCBI(In Chinese). | |
|
Ha CT, Li X, Fu D and Xiao M: Circulating IL-18 Binding Protein (IL-18BP) and IL-18 as dual biomarkers of total-body irradiation in mice. Radiat Res. 185:375–383. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Zhang H, Wang J, Wang L, Xie H, Chen L and He S: Role of IL-18 in atopic asthma is determined by balance of IL-18/IL-18BP/IL-18R. J Cell Mol Med. 22:354–373. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Mochol M, Tauboll E, Aukrust P, Ueland T, Andreassen OA and Svalheim S: Interleukin 18 (IL-18) and its binding protein (IL-18BP) are increased in patients with epilepsy suggesting low-grade systemic inflammation. Seizure. 80:221–225. 2020.PubMed/NCBI View Article : Google Scholar | |
|
Yoshino O, Osuga Y, Koga K, Tsutsumi O, Yano T, Fujii T, Kugu K, Momoeda M, Fujiwara T, Tomita K and Taketani Y: Evidence for the expression of interleukin (IL)-18, IL-18 receptor and IL-18 binding protein in the human endometrium. Mol Hum Reprod. 7:649–654. 2001.PubMed/NCBI View Article : Google Scholar | |
|
Torigoe K, Ushio S, Okura T, Kobayashi S, Taniai M, Kunikata T, Murakami T, Sanou O, Kojima H, Fujii M, et al: Purification and characterization of the human interleukin-18 receptor. J Biol Chem. 272:25737–25742. 1997.PubMed/NCBI View Article : Google Scholar | |
|
Hoshino K, Tsutsui H, Kawai T, Takeda K, Nakanishi K, Takeda Y and Akira S: Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J Immunol. 162:5041–5044. 1999.PubMed/NCBI | |
|
Thomassen E, Bird TA, Renshaw BR, Kennedy MK and Sims JE: Binding of interleukin-18 to the interleukin-1 receptor homologous receptor IL-1Rrp1 leads to activation of signaling pathways similar to those used by interleukin-1. J Interferon Cytokine Res. 18:1077–1088. 1998.PubMed/NCBI View Article : Google Scholar | |
|
Debets R, Timans JC, Churakowa T, Zurawski S, de Waal Malefyt R, Moore KW, Abrams JS, O'Garra A, Bazan JF and Kastelein RA: IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18. J Immunol. 165:4950–4956. 2000.PubMed/NCBI View Article : Google Scholar | |
|
Shao XT, Feng L, Gu LJ, Wu LJ, Feng TT, Yang YM, Wu NP and Yao HP: Expression of interleukin-18, IL-18BP, and IL-18R in serum, synovial fluid, and synovial tissue in patients with rheumatoid arthritis. Clin Exp Med. 9:215–221. 2009.PubMed/NCBI View Article : Google Scholar | |
|
Corbaz A, ten Hove T, Herren S, Graber P, Schwartsburd B, Belzer I, Harrison J, Plitz T, Kosco-Vilbois MH, Kim SH, et al: IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease. J Immunol. 168:3608–3616. 2002.PubMed/NCBI View Article : Google Scholar | |
|
Medina L, Rabinovich A, Piura B, Dyomin V, Levy RS and Huleihel M: Expression of IL-18, IL-18 binding protein, and IL-18 receptor by normal and cancerous human ovarian tissues: Possible implication of IL-18 in the pathogenesis of ovarian carcinoma. Mediators Inflamm. 2014(914954)2014.PubMed/NCBI View Article : Google Scholar | |
|
Hu Y, Wang J, Zhang H, Xie H, Song W, Jiang Q, Zhao N and He S: Enhanced Expression of IL-18 and IL-18BP in Plasma of Patients with Eczema: Altered Expression of IL-18BP and IL-18 receptor on mast cells. Mediators Inflamm. 2017(3090782)2017.PubMed/NCBI View Article : Google Scholar | |
|
Wawrocki S, Kielnierowski G, Rudnicka W, Seweryn M and Druszczynska M: Interleukin-18, Functional IL-18 Receptor and IL-18 binding protein expression in active and latent tuberculosis. Pathogens. 9(451)2020.PubMed/NCBI View Article : Google Scholar | |
|
Kaur D, Chachi L, Gomez E, Sylvius N and Brightling CE: Interleukin-18, IL-18 binding protein and IL-18 receptor expression in asthma: A hypothesis showing IL-18 promotes epithelial cell differentiation. Clin Transl Immunology. 10(e1301)2021.PubMed/NCBI View Article : Google Scholar | |
|
Prencipe G, Bracaglia C and De Benedetti F: Interleukin-18 in pediatric rheumatic diseases. Curr Opin Rheumatol. 31:421–427. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Novick D, Elbirt D, Dinarello CA, Rubinstein M and Sthoeger ZM: Interleukin-18 binding protein in the sera of patients with Wegener's granulomatosis. J Clin Immunol. 29:38–45. 2009.PubMed/NCBI View Article : Google Scholar | |
|
Novick D, Schwartsburd B, Pinkus R, Suissa D, Belzer I, Sthoeger Z, Keane WF, Chvatchko Y, Kim SH, Fantuzzi G, et al: A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18. Cytokine. 14:334–342. 2001.PubMed/NCBI View Article : Google Scholar | |
|
Tschoeke SK, Oberholzer A and Moldawer LL: Interleukin-18: A novel prognostic cytokine in bacteria-induced sepsis. Crit Care Med. 34:1225–1233. 2006.PubMed/NCBI View Article : Google Scholar | |
|
Chen O, Shan N, Zhu X, Wang Y, Ren P, Wei D and Sun R: The imbalance of IL-18/IL-18BP in patients with systemic juvenile idiopathic arthritis. Acta Biochim Biophys Sin (Shanghai). 45:339–341. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Harel M, Girard-Guyonvarc'h C, Rodriguez E, Palmer G and Gabay C: Production of IL-18 binding protein by radiosensitive and radioresistant cells in CpG-Induced macrophage activation syndrome. J Immunol. 205:1167–1175. 2020.PubMed/NCBI View Article : Google Scholar | |
|
McCurdy S, Yap J, Irei J, Lozano J and Boisvert WA: IL-37-a putative therapeutic agent in cardiovascular diseases. QJM. 115:719–725. 2022.PubMed/NCBI View Article : Google Scholar | |
|
Belkaya S, Michailidis E, Korol CB, Kabbani M, Cobat A, Bastard P, Lee YS, Hernandez N, Drutman S, de Jong YP, et al: Inherited IL-18BP deficiency in human fulminant viral hepatitis. J Exp Med. 216:1777–1790. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Bufler P, Azam T, Gamboni-Robertson F, Reznikov LL, Kumar S, Dinarello CA and Kim SH: A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. Proc Natl Acad Sci USA. 99:13723–13728. 2002.PubMed/NCBI View Article : Google Scholar | |
|
Liu W, Liu G, Qin X and Wang G: Recombinant cIL-18-binding protein as an antagonist to cIL-18 enhanced PBMCs secreting IFN-gamma. Wei Sheng Wu Xue Bao. 50:506–511. 2010.PubMed/NCBI(In Chinese). | |
|
Reznikov LL, Kim SH, Westcott JY, Frishman J, Fantuzzi G, Novick D, Rubinstein M and Dinarello CA: IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma. Proc Natl Acad Sci USA. 97:2174–2179. 2000.PubMed/NCBI View Article : Google Scholar | |
|
Faggioni R, Cattley RC, Guo J, Flores S, Brown H, Qi M, Yin S, Hill D, Scully S, Chen C, et al: IL-18-binding protein protects against lipopolysaccharide-induced lethality and prevents the development of Fas/Fas ligand-mediated models of liver disease in mice. J Immunol. 167:5913–5920. 2001.PubMed/NCBI View Article : Google Scholar | |
|
Plitz T, Saint-Mezard P, Satho M, Herren S, Waltzinger C, de Carvalho Bittencourt M, Kosco-Vilbois MH and Chvatchko Y: IL-18 binding protein protects against contact hypersensitivity. J Immunol. 171:1164–1171. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Lin XL, Zhu J, Wang LM, Yan F, Sha WP and Yang HL: MiR-92b-5p inhibitor suppresses IL-18 mediated inflammatory amplification after spinal cord injury via IL-18BP up-regulation. Eur Rev Med Pharmacol Sci. 23:1891–1898. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Yatsiv I, Morganti-Kossmann MC, Perez D, Dinarello CA, Novick D, Rubinstein M, Otto VI, Rancan M, Kossmann T, Redaelli CA, et al: Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury. J Cereb Blood Flow Metab. 22:971–978. 2002.PubMed/NCBI View Article : Google Scholar | |
|
Shan NN, Ji XB, Wang X, Li Y, Liu X, Zhu XJ and Hou M: In vitro recovery of Th1/Th2 balance in PBMCs from patients with immune thrombocytopenia through the actions of IL-18BPa/Fc. Thromb Res. 128:e119–e124. 2011.PubMed/NCBI View Article : Google Scholar | |
|
Ushio S, Namba M, Okura T, Hattori K, Nukada Y, Akita K, Tanabe F, Konishi K, Micallef M, Fujii M, et al: Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J Immunol. 156:4274–4279. 1996.PubMed/NCBI | |
|
Alboni S, Benatti C, Montanari C, Tascedda F and Brunello N: Chronic antidepressant treatments resulted in altered expression of genes involved in inflammation in the rat hypothalamus. Eur J Pharmacol. 721:158–167. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA and Rubinstein M: Interleukin-18 binding protein: A novel modulator of the Th1 cytokine response. Immunity. 10:127–136. 1999.PubMed/NCBI View Article : Google Scholar | |
|
Dinarello CA: Novel targets for interleukin 18 binding protein. Ann Rheum Dis. 60 (Suppl 3):iii18–iii24. 2001.PubMed/NCBI View Article : Google Scholar | |
|
Aizawa Y, Akita K, Taniai M, Torigoe K, Mori T, Nishida Y, Ushio S, Nukada Y, Tanimoto T, Ikegami H, et al: Cloning and expression of interleukin-18 binding protein. FEBS Lett. 445:338–342. 1999.PubMed/NCBI View Article : Google Scholar | |
|
Maiti PK, Im SH, Souroujon MC and Fuchs S: A monoclonal antibody specific for rat IL-18BP and its application in determining serum IL-18BP. Immunol Lett. 85:65–70. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Kim SH, Eisenstein M, Reznikov L, Fantuzzi G, Novick D, Rubinstein M and Dinarello CA: Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. Proc Natl Acad Sci USA. 97:1190–1195. 2000.PubMed/NCBI View Article : Google Scholar | |
|
Lee S, Kim S, Bae S, Choi J, Hong J, Ryoo S, Jhun H, Hong K, Kim E, Jo S, et al: Development of isoform-specific monoclonal antibodies against human IL-18 binding protein. Hybridoma (Larchmt). 29:517–524. 2010.PubMed/NCBI View Article : Google Scholar | |
|
Nakamura K, Asano Y, Taniguchi T, Minatsuki S, Inaba T, Maki H, Hatano M, Yamashita T, Saigusa R, Ichimura Y, et al: Serum levels of interleukin-18-binding protein isoform a: Clinical association with inflammation and pulmonary hypertension in systemic sclerosis. J Dermatol. 43:912–918. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Zhou J, Ling J, Wang Y, Shang J and Ping F: Cross-talk between interferon-gamma and interleukin-18 in melanogenesis. J Photochem Photobiol B. 163:133–143. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Iannello A, Samarani S, Allam O, Jenabian MA, Mehraj V, Amre D, Routy JP, Tremblay C and Ahmad A: A potentially protective role of IL-18 Binding Protein in HIV-infected Long-Term Non-Progressors. Cytokine. 90:96–99. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Standing AS, Malinova D, Hong Y, Record J, Moulding D, Blundell MP, Nowak K, Jones H, Omoyinmi E, Gilmour KC, et al: Autoinflammatory periodic fever, immunodeficiency, and thrombocytopenia (PFIT) caused by mutation in actin-regulatory gene WDR1. J Exp Med. 214:59–71. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Liuqing W, Liping X, Hui S and Jing L: Elevated IL-37, IL-18 and IL-18BP serum concentrations in patients with primary Sjogren's syndrome. J Investig Med. 65:717–721. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Krumm B, Meng X, Xiang Y and Deng J: Identification of small molecule inhibitors of Interleukin-18. Sci Rep. 7(483)2017.PubMed/NCBI View Article : Google Scholar | |
|
Mele D, Mantovani S, Oliviero B, Grossi G, Lombardi A, Mondelli MU and Varchetta S: Monocytes inhibit hepatitis C virus-induced TRAIL expression on CD56bright NK cells. J Hepatol. 67:1148–1156. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Wang M and Feng Z: Mechanisms of hepatocellular injury in hepatitis A. Viruses. 13(861)2021.PubMed/NCBI View Article : Google Scholar | |
|
Kwiatkowski K, Piotrowska A, Rojewska E, Makuch W and Mika J: The RS504393 influences the level of nociceptive factors and enhances opioid analgesic potency in neuropathic rats. J Neuroimmune Pharmacol. 12:402–419. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Yasin S, Solomon K, Canna SW, Girard-Guyonvarc'h C, Gabay C, Schiffrin E, Sleight A, Grom AA and Schulert GS: IL-18 as therapeutic target in a patient with resistant systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome. Rheumatology (Oxford). 59:442–445. 2020.PubMed/NCBI View Article : Google Scholar | |
|
Gabay C, Fautrel B, Rech J, Spertini F, Feist E, Kotter I, Hachulla E, Morel J, Schaeverbeke T, Hamidou MA, et al: Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still's disease. Ann Rheum Dis. 77:840–847. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Girard-Guyonvarc'h C, Palomo J, Martin P, Rodriguez E, Troccaz S, Palmer G and Gabay C: Unopposed IL-18 signaling leads to severe TLR9-induced macrophage activation syndrome in mice. Blood. 131:1430–1441. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Horie K, Watanabe M, Chanbora C, Awada T, Kunimatsu R, Uchida T, Takata T and Tanimoto K: Bovine lactoferrin reduces extra-territorial facial allodynia/hyperalgesia following a trigeminal nerve injury in the rat. Brain Res. 1669:89–96. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Italiani P, Manca ML, Angelotti F, Melillo D, Pratesi F, Puxeddu I, Boraschi D and Migliorini P: IL-1 family cytokines and soluble receptors in systemic lupus erythematosus. Arthritis Res Ther. 20(27)2018.PubMed/NCBI View Article : Google Scholar | |
|
D'Angelo C, Reale M, Costantini E, Di Nicola M, Porfilio I, de Andres C, Fernandez-Paredes L, Sanchez-Ramon S and Pasquali L: Profiling of Canonical and Non-Traditional Cytokine Levels in Interferon-β-Treated relapsing-remitting-multiple sclerosis patients. Front Immunol. 9(1240)2018.PubMed/NCBI View Article : Google Scholar | |
|
Liu C, Chen J, Liu B, Yuan S, Shou D, Wen L, Wu X and Gong W: Role of IL-18 in transplant biology. Eur Cytokine Netw. 29:48–51. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Weiss ES, Girard-Guyonvarc'h C, Holzinger D, de Jesus AA, Tariq Z, Picarsic J, Schiffrin EJ, Foell D, Grom AA, Ammann S, et al: Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome. Blood. 131:1442–1455. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Dong M, Zhao M, Cui M, Sun J, Meng X, Sun W, Wang L and Du P: Interleukin-18 binding protein attenuates renal injury of adriamycin-induced mouse nephropathy. Int J Clin Exp Pathol. 12:3005–3012. 2019.PubMed/NCBI | |
|
Kim HS, Kim K, Lee H, Yang EA, Chun YH, Kim HH and Kim JT: Level of interleukin-18 binding protein is significantly different in patients with anaphylaxis than urticaria. Asian Pac J Allergy Immunol. 40:368–373. 2022.PubMed/NCBI View Article : Google Scholar | |
|
Zhang LM, Zhang Y, Fei C, Zhang J, Wang L, Yi ZW and Gao G: Neutralization of IL-18 by IL-18 binding protein ameliorates bleomycin-induced pulmonary fibrosis via inhibition of epithelial-mesenchymal transition. Biochem Biophys Res Commun. 508:660–666. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Liu X, Yang H, Liu Y, Jiao Y, Yang L, Wang X, Yu W, Su D and Tian J: Remifentanil upregulates hepatic IL-18 binding protein (IL-18BP) expression through transcriptional control. Lab Invest. 98:1588–1599. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Wang J, Long Q, Zhang W and Chen N: Protective effects of exogenous interleukin 18-binding protein in a rat model of acute renal ischemia-reperfusion injury. Shock. 37:333–340. 2012.PubMed/NCBI View Article : Google Scholar | |
|
O'Brien LC, Mezzaroma E, Van Tassell BW, Marchetti C, Carbone S, Abbate A and Toldo S: Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure. Mol Med. 20:221–229. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Harms RZ, Creer AJ, Lorenzo-Arteaga KM, Ostlund KR and Sarvetnick NE: Interleukin (IL)-18 binding protein deficiency disrupts natural killer cell maturation and diminishes circulating IL-18. Front Immunol. 8(1020)2017.PubMed/NCBI View Article : Google Scholar | |
|
Zhang LM, Zhang J, Zhang Y, Wang L, Fei C, Yi ZW and Dong L: Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway. Biochem Biophys Res Commun. 505:837–842. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Li YH, Wei X, Ji S, Gui SY and Zhang SM: In vivo effects of the NLRP1/NLRP3 inflammasome pathway on latent respiratory virus infection. Int J Mol Med. 41:3620–3628. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Doi K, Katagiri D, Negishi K, Hasegawa S, Hamasaki Y, Fujita T, Matsubara T, Ishii T, Yahagi N, Sugaya T and Noiri E: Mild elevation of urinary biomarkers in prerenal acute kidney injury. Kidney Int. 82:1114–1120. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Li X, Cui W, Hull L, Wang L, Yu T and Xiao M: IL-18 binding protein (IL-18BP) as a novel radiation countermeasure after radiation exposure in mice. Sci Rep. 10(18674)2020.PubMed/NCBI View Article : Google Scholar | |
|
Nakanishi Y, Horimasu Y, Yamaguchi K, Sakamoto S, Masuda T, Nakashima T, Miyamoto S, Iwamoto H, Ohshimo S, Fujitaka K, et al: IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis. PLoS One. 16(e0252594)2021.PubMed/NCBI View Article : Google Scholar | |
|
Berti A, Warner R, Johnson K, Cornec D, Schroeder D, Kabat B, Langford CA, Hoffman GS, Fervenza FC, Kallenberg CGM, et al: Brief Report: Circulating cytokine profiles and antineutrophil cytoplasmic antibody specificity in patients with antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheumatol. 70:1114–1121. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Ter Horst R, Jaeger M, van de Wijer L, van der Heijden WA, Janssen AMW, Smeekens SP, Brouwer MAE, van Cranenbroek B, Aguirre-Gamboa R, Netea-Maier RT, et al: Seasonal and nonseasonal longitudinal variation of immune function. J Immunol. 207:696–708. 2021.PubMed/NCBI View Article : Google Scholar | |
|
Min HK, Kim S, Lee JY, Kim KW, Lee SH and Kim HR: IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell/regulatory T cell imbalance in rheumatoid arthritis. J Transl Med. 19(392)2021.PubMed/NCBI View Article : Google Scholar | |
|
Otterdal K, Berg A, Michelsen AE, Yndestad A, Patel S, Gregersen I, Halvorsen B, Ueland T, Langeland N and Aukrust P: IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria. BMC Infect Dis. 21(1073)2021.PubMed/NCBI View Article : Google Scholar | |
|
Haghshenas MR, Saffarian A, Khademolhosseini A, Dehghanian A, Ghaderi A and Sotoodeh Jahromi A: Simultaneous Increase in Serum Levels of IL-37 and IL-18 binding protein in low-grade and high-grade brain tumors. Asian Pac J Cancer Prev. 23:2851–2856. 2022.PubMed/NCBI View Article : Google Scholar | |
|
Yang YC, Chen SN, Gan Z, Huang L, Li N, Wang KL and Nie P: Functional characterization of IL-18 receptor subunits, IL-18Rα and IL-18Rβ, and its natural inhibitor, IL-18 binding protein (IL-18BP) in rainbow trout Oncorhynchus mykiss. Dev Comp Immunol. 140(104610)2023.PubMed/NCBI View Article : Google Scholar | |
|
Zaccone P, Phillips J, Conget I, Cooke A and Nicoletti F: IL-18 binding protein fusion construct delays the development of diabetes in adoptive transfer and cyclophosphamide-induced diabetes in NOD mouse. Clin Immunol. 115:74–79. 2005.PubMed/NCBI View Article : Google Scholar | |
|
Thompson SR, Novick D, Stock CJ, Sanders J, Brull D, Cooper J, Woo P, Miller G, Rubinstein M and Humphries SE: Free Interleukin (IL)-18 levels, and the impact of IL18 and IL18BP genetic variation, in CHD patients and healthy men. Arterioscler Thromb Vasc Biol. 27:2743–2749. 2007.PubMed/NCBI View Article : Google Scholar | |
|
Cao Q, Cai W, Niu G, He L and Chen X: Multimodality imaging of IL-18-binding protein-Fc therapy of experimental lung metastasis. Clin Cancer Res. 14:6137–6145. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Kimura T, Kato Z, Ohnishi H, Tochio H, Shirakawa M and Kondo N: Expression, purification and structural analysis of human IL-18 binding protein: A potent therapeutic molecule for allergy. Allergol Int. 57:367–376. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Leach ST, Messina I, Lemberg DA, Novick D, Rubenstein M and Day AS: Local and systemic interleukin-18 and interleukin-18-binding protein in children with inflammatory bowel disease. Inflamm Bowel Dis. 14:68–74. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Dao T, Ohashi K, Kayano T, Kurimoto M and Okamura H: Interferon-gamma-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells. Cell Immunol. 173:230–235. 1996.PubMed/NCBI View Article : Google Scholar | |
|
Favilli F, Anzilotti C, Martinelli L, Quattroni P, De Martino S, Pratesi F, Neumann D, Beermann S, Novick D, Dinarello CA, et al: IL-18 activity in systemic lupus erythematosus. Ann N Y Acad Sci. 1173:301–309. 2009.PubMed/NCBI View Article : Google Scholar | |
|
Shimizu C, Fujita T, Fuke Y, Ito K, Satomura A, Matsumoto K and Soma M: High circulating levels of interleukin-18 binding protein indicate the severity of glomerular involvement in systemic lupus erythematosus. Mod Rheumatol. 22:73–79. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Yamamura M, Kawashima M, Taniai M, Yamauchi H, Tanimoto T, Kurimoto M, Morita Y, Ohmoto Y and Makino H: Interferon-gamma-inducing activity of interleukin-18 in the joint with rheumatoid arthritis. Arthritis Rheum. 44:275–285. 2001.PubMed/NCBI View Article : Google Scholar | |
|
Dinarello CA: Interleukin-18 and the treatment of rheumatoid arthritis. Rheum Dis Clin North Am. 30:417–434, ix. 2004.PubMed/NCBI View Article : Google Scholar | |
|
Woldbaek PR, Tonnessen T, Henriksen UL, Florholmen G, Lunde PK, Lyberg T and Christensen G: Increased cardiac IL-18 mRNA, pro-IL-18 and plasma IL-18 after myocardial infarction in the mouse; a potential role in cardiac dysfunction. Cardiovasc Res. 59:122–131. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Reznikov LL, Kim SH, Zhou L, Bufler P, Goncharov I, Tsang M and Dinarello CA: The combination of soluble IL-18Ralpha and IL-18Rbeta chains inhibits IL-18-induced IFN-gamma. J Interferon Cytokine Res. 22:593–601. 2002.PubMed/NCBI View Article : Google Scholar | |
|
Meng X, Leman M and Xiang Y: Variola virus IL-18 binding protein interacts with three human IL-18 residues that are part of a binding site for human IL-18 receptor alpha subunit. Virology. 358:211–220. 2007.PubMed/NCBI View Article : Google Scholar | |
|
Krumm B, Meng X, Li Y, Xiang Y and Deng J: Structural basis for antagonism of human interleukin 18 by poxvirus interleukin 18-binding protein. Proc Natl Acad Sci USA. 105:20711–20715. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Palomo J, Dietrich D, Martin P, Palmer G and Gabay C: The interleukin (IL)-1 cytokine family-Balance between agonists and antagonists in inflammatory diseases. Cytokine. 76:25–37. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Booker CS and Grattan DR: IL1R9 Is Evolutionarily Related to IL18BP and May Function as an IL-18 Receptor. J Immunol. 198:270–278. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Allam O, Samarani S, Jenabian MA, Routy JP, Tremblay C, Amre D and Ahmad A: Differential synthesis and release of IL-18 and IL-18 Binding Protein from human platelets and their implications for HIV infection. Cytokine. 90:144–154. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Bachmann M, Pfeilschifter J and Muhl H: Epigenetic regulation by CpG methylation splits strong from retarded IFNү-induced IL-18BP in epithelial versus monocytic cells. Biochim Biophys Acta Gene Regul Mech. 1861:191–199. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Wang Z, Liu Z, Wang L, Wang J, Chen L, Xie H, Zhang H and He S: Altered expression of IL-18 binding protein and IL-18 receptor in basophils and mast cells of asthma patients. Scand J Immunol. 87(e12658)2018.PubMed/NCBI View Article : Google Scholar | |
|
Gupta A, Fei YD, Kim TY, Xie A, Batai K, Greener I, Tang H, Ciftci-Yilmaz S, Juneman E, Indik JH, et al: IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias. Blood. 137:1208–1218. 2021.PubMed/NCBI View Article : Google Scholar | |
|
Shao Q, Liu N, Li GF, Meng QC, Yao JH and Wang N: IL-18 expression in clinical human pituitary adenoma. Technol Health Care. 30:11–16. 2022.PubMed/NCBI View Article : Google Scholar | |
|
Detry S, Andries J, Bloch Y, Gabay C, Clancy DM and Savvides SN: Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity. J Biol Chem. 298(101908)2022.PubMed/NCBI View Article : Google Scholar | |
|
Yang Y, Zhang ZX, Lian D, Haig A, Bhattacharjee RN and Jevnikar AM: IL-37 inhibits IL-18-induced tubular epithelial cell expression of pro-inflammatory cytokines and renal ischemia-reperfusion injury. Kidney Int. 87:396–408. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Tsuji-Takayama K, Aizawa Y, Okamoto I, Kojima H, Koide K, Takeuchi M, Ikegami H, Ohta T and Kurimoto M: Interleukin-18 induces interferon-gamma production through NF-kappaB and NFAT activation in murine T helper type 1 cells. Cell Immunol. 196:41–50. 1999.PubMed/NCBI View Article : Google Scholar | |
|
McIlroy A, Caron G, Blanchard S, Fremaux I, Duluc D, Delneste Y, Chevailler A and Jeannin P: Histamine and prostaglandin E up-regulate the production of Th2-attracting chemokines (CCL17 and CCL22) and down-regulate IFN-gamma-induced CXCL10 production by immature human dendritic cells. Immunology. 117:507–516. 2006.PubMed/NCBI View Article : Google Scholar | |
|
Walker W and Rotondo D: Prostaglandin E2 is a potent regulator of interleukin-12- and interleukin-18-induced natural killer cell interferon-gamma synthesis. Immunology. 111:298–305. 2004.PubMed/NCBI View Article : Google Scholar | |
|
Liao TL, Chen YM, Hsieh CW, Chen HH, Lee HC, Hung WT, Tang KT and Chen DY: Upregulation of circulating microRNA-134 in adult-onset Still's disease and its use as potential biomarker. Sci Rep. 7(4214)2017.PubMed/NCBI View Article : Google Scholar | |
|
Shi L, Zhang S, Huang Z, Hu F, Zhang T, Wei M, Bai Q, Lu B and Ji L: Baicalin promotes liver regeneration after acetaminophen-induced liver injury by inducing NLRP3 inflammasome activation. Free Radic Biol Med. 160:163–177. 2020.PubMed/NCBI View Article : Google Scholar | |
|
Xiang Y and Moss B: Identification of human and mouse homologs of the MC51L-53L-54L family of secreted glycoproteins encoded by the Molluscum contagiosum poxvirus. Virology. 257:297–302. 1999.PubMed/NCBI View Article : Google Scholar | |
|
Xiang Y and Moss B: Molluscum contagiosum virus interleukin-18 (IL-18) binding protein is secreted as a full-length form that binds cell surface glycosaminoglycans through the C-terminal tail and a furin-cleaved form with only the IL-18 binding domain. J Virol. 77:2623–2630. 2003.PubMed/NCBI View Article : Google Scholar | |
|
Xiang Y and Moss B: IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins. Proc Natl Acad Sci USA. 96:11537–11542. 1999.PubMed/NCBI View Article : Google Scholar | |
|
Xiang Y and Moss B: Correspondence of the functional epitopes of poxvirus and human interleukin-18-binding proteins. J Virol. 75:9947–9954. 2001.PubMed/NCBI View Article : Google Scholar | |
|
Calderara S, Xiang Y and Moss B: Orthopoxvirus IL-18 binding proteins: Affinities and antagonist activities. Virology. 279:22–26. 2001.PubMed/NCBI View Article : Google Scholar | |
|
Esteban DJ, Nuara AA and Buller RML: Interleukin-18 and glycosaminoglycan binding by a protein encoded by Variola virus. J Gen Virol. 85(Pt 5):1291–1299. 2004.PubMed/NCBI View Article : Google Scholar | |
|
Krumm B, Meng X, Wang Z, Xiang Y and Deng J: A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein. PLoS Pathog. 8(e1002876)2012.PubMed/NCBI View Article : Google Scholar | |
|
Nazarian SH, Rahman MM, Werden SJ, Villeneuve D, Meng X, Brunetti C, Valeriano C, Wong C, Singh R, Barrett JW, et al: Yaba monkey tumor virus encodes a functional inhibitor of interleukin-18. J Virol. 82:522–528. 2008.PubMed/NCBI View Article : Google Scholar | |
|
Symons JA, Adams E, Tscharke DC, Reading PC, Waldmann H and Smith GL: The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model. J Gen Virol. 83(Pt 11):2833–2844. 2002.PubMed/NCBI View Article : Google Scholar | |
|
Smith VP, Bryant NA and Alcami A: Ectromelia, vaccinia and cowpox viruses encode secreted interleukin-18-binding proteins. J Gen Virol. 81(Pt 5):1223–1230. 2000.PubMed/NCBI View Article : Google Scholar | |
|
Esteban DJ and Buller RM: Identification of residues in an orthopoxvirus interleukin-18 binding protein involved in ligand binding and species specificity. Virology. 323:197–207. 2004.PubMed/NCBI View Article : Google Scholar | |
|
Afonso CL, Tulman ER, Lu Z, Zsak L, Kutish GF and Rock DL: The genome of fowlpox virus. J Virol. 74:3815–3831. 2000.PubMed/NCBI View Article : Google Scholar | |
|
Yan Y, Deng J, Niu L, Wang Q, Yu J, Shao H, Cao Q, Zhang Y and Tan X: Cloning and characterization of giant panda (Ailuropoda melanoleuca) IL-18 binding protein. Res Vet Sci. 106:170–172. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Gibson MS, Steyn A, Kealy D, Kaspers B and Fife MS: Molecular cloning and characterisation of chicken IL-18 binding protein. Dev Comp Immunol. 114(103850)2021.PubMed/NCBI View Article : Google Scholar |
