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miRNA‑mRNA network contributes to HBV‑related hepatocellular carcinoma via immune infiltration induced by GRB2

  • Authors:
    • Chuqian Zheng
    • Hongmeng Su
    • Min Liu
    • Yanyan Qian
    • Hong Fan
  • View Affiliations / Copyright

    Affiliations: Department of Medical Genetics and Developmental Biology, School of Medicine, The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, P.R. China, School of Life Science and Technology, Southeast University, Nanjing, Jiangsu 210009, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 90
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    Published online on: April 11, 2024
       https://doi.org/10.3892/br.2024.1777
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Abstract

Chronic hepatitis B virus (HBV) infection is a critical causative factor in the tumorigenesis and progression of hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) serve a critical role in the process of viral infection. However, there has been insufficient evaluation of HBV‑associated miRNA‑mRNA regulatory networks in HCC. The differential expression levels of miRNAs were compared in HBV‑associated HCC tumor and normal tissues using the Gene Expression Omnibus database. The present study evaluated potential target genes of differentially expressed miRNAs using protein‑protein interaction network, hub gene, Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, gene set enrichment and immune infiltration analysis. A total of five miRNAs and seven target genes were identified in the HBV‑associated miRNA‑mRNA network. miRNA‑93 could positively regulate the growth factor receptor bound protein 2 (GRB2) gene, while there was a positive correlation between GRB2 and cancer immune infiltrate function in Tumor Immune Estimation Resource. Collectively, the present study investigated the miRNA‑mRNA regulatory network in HCC with HBV infection and showed that miRNA‑93 positively regulated immune infiltration‑related GRB2. Restoring GRB2 may be a candidate strategy for the treatment of HBV‑related HCC.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

2 

Younes R and Bugianesi E: Should we undertake surveillance for HCC in patients with NAFLD? J Hepatol. 68:326–334. 2018.PubMed/NCBI View Article : Google Scholar

3 

Sartorius K, Makarova J, Sartorius B, An P, Winkler C, Chuturgoon A and Kramvis A: The regulatory role of MicroRNA in hepatitis-B virus-associated hepatocellular carcinoma (HBV-HCC) pathogenesis. Cells. 8(1504)2019.PubMed/NCBI View Article : Google Scholar

4 

El-Serag HB: Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 142:1264–1273.e1. 2012.PubMed/NCBI View Article : Google Scholar

5 

Sagnelli C, Macera M, Pisaturo M, Zampino R, Coppola M and Sagnelli E: Occult HBV infection in the oncohematological setting. Infection. 44:575–582. 2016.PubMed/NCBI View Article : Google Scholar

6 

Ringelhan M, O'Connor T, Protzer U and Heikenwalder M: The direct and indirect roles of HBV in liver cancer: Prospective markers for HCC screening and potential therapeutic targets. J Pathol. 235:355–367. 2015.PubMed/NCBI View Article : Google Scholar

7 

Szpakowski JL and Tucker LY: Causes of death in patients with hepatitis B: A natural history cohort study in the United States. Hepatology. 58:21–30. 2013.PubMed/NCBI View Article : Google Scholar

8 

Choi YM, Lee SY and Kim BJ: Naturally occurring hepatitis B virus mutations leading to endoplasmic reticulum stress and their contribution to the progression of hepatocellular carcinoma. Int J Mol Sci. 20(597)2019.PubMed/NCBI View Article : Google Scholar

9 

Kim CM, Koike K, Saito I, Miyamura T and Jay G: HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature. 351:317–320. 1991.PubMed/NCBI View Article : Google Scholar

10 

Sadri Nahand J, Bokharaei-Salim F, Karimzadeh M, Moghoofei M, Karampoor S, Mirzaei HR, Tabibzadeh A, Jafari A, Ghaderi A, Asemi Z, et al: MicroRNAs and exosomes: Key players in HIV pathogenesis. HIV Med. 21:246–278. 2020.PubMed/NCBI View Article : Google Scholar

11 

Petrini E, Caviglia GP, Abate ML, Fagoonee S, Smedile A and Pellicano R: MicroRNAs in HBV-related hepatocellular carcinoma: Functions and potential clinical applications. Panminerva Med. 57:201–209. 2015.PubMed/NCBI

12 

Pu C, Wang J, Wei Q and Han P: Commentary on ‘Asymptomatic prostatic inflammation in men with clinical BPH and erectile dysfunction affects the positive predictive value of prostate-specific antigen’. Agnihotri S, Mittal RD, Kapoor R, Mandhani A, Department of Urology & Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India: Urol Oncol 2014; [Epub ahead of print]. doi: 10.1016/j.urolonc.2014.03.004. Urol Oncol. 33:103–104. 2015.PubMed/NCBI View Article : Google Scholar

13 

Kelly EJ and Russell SJ: MicroRNAs and the regulation of vector tropism. Mol Ther. 17:409–416. 2009.PubMed/NCBI View Article : Google Scholar

14 

Li LM, Hu ZB, Zhou ZX, Chen X, Liu FY, Zhang JF, Shen HB, Zhang CY and Zen K: Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Cancer Res. 70:9798–9807. 2010.PubMed/NCBI View Article : Google Scholar

15 

Bertoli G, Cava C and Castiglioni I: MicroRNAs: New biomarkers for diagnosis, prognosis, therapy prediction and therapeutic tools for breast cancer. Theranostics. 5:1122–1143. 2015.PubMed/NCBI View Article : Google Scholar

16 

Ma X, Feng J, Lu M, Tang W, Han J, Luo X, Zhao Q and Yang L: microRNA-501-5p promotes cell proliferation and migration in gastric cancer by downregulating LPAR1. J Cell Biochem. 121:1911–1922. 2020.PubMed/NCBI View Article : Google Scholar

17 

Vautrot V, Chanteloup G, Elmallah M, Cordonnier M, Aubin F, Garrido C and Gobbo J: Exosomal miRNA: Small molecules, big impact in colorectal cancer. J Oncol. 2019(8585276)2019.PubMed/NCBI View Article : Google Scholar

18 

Sur S, Steele R, Shi X and Ray RB: miRNA-29b inhibits prostate tumor growth and induces apoptosis by increasing bim expression. Cells. 8(1455)2019.PubMed/NCBI View Article : Google Scholar

19 

Vienberg S, Geiger J, Madsen S and Dalgaard LT: MicroRNAs in metabolism. Acta Physiol (Oxf). 219:346–361. 2017.PubMed/NCBI View Article : Google Scholar

20 

Portal-Núñez S, Esbrit P, Alcaraz MJ and Largo R: Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis. Biochem Pharmacol. 108:1–10. 2016.PubMed/NCBI View Article : Google Scholar

21 

Guo D, Liu J, Wang W, Hao F, Sun X, Wu X, Bu P, Zhang Y, Liu Y, Liu F, et al: Alteration in abundance and compartmentalization of inflammation-related miRNAs in plasma after intracerebral hemorrhage. Stroke. 44:1739–1742. 2013.PubMed/NCBI View Article : Google Scholar

22 

Ura S, Honda M, Yamashita T, Ueda T, Takatori H, Nishino R, Sunakozaka H, Sakai Y, Horimoto K and Kaneko S: Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. Hepatology. 49:1098–1112. 2009.PubMed/NCBI View Article : Google Scholar

23 

Giray BG, Emekdas G, Tezcan S, Ulger M, Serin MS, Sezgin O, Altintas E and Tiftik EN: Profiles of serum microRNAs; miR-125b-5p and miR223-3p serve as novel biomarkers for HBV-positive hepatocellular carcinoma. Mol Biol Rep. 41:4513–4519. 2014.PubMed/NCBI View Article : Google Scholar

24 

Ninomiya M, Kondo Y, Kimura O, Funayama R, Nagashima T, Kogure T, Morosawa T, Tanaka Y, Nakayama K and Shimosegawa T: The expression of miR-125b-5p is increased in the serum of patients with chronic hepatitis B infection and inhibits the detection of hepatitis B virus surface antigen. J Viral Hepat. 23:330–339. 2016.PubMed/NCBI View Article : Google Scholar

25 

Xu J, An P, Winkler CA and Yu Y: Dysregulated microRNAs in hepatitis B virus-related hepatocellular carcinoma: Potential as biomarkers and therapeutic targets. Front Oncol. 10(1271)2020.PubMed/NCBI View Article : Google Scholar

26 

Morishita A, Fujita K, Iwama H, Chiyo T, Fujihara S, Oura K, Tadokoro T, Mimura S, Nomura T, Tani J, et al: Role of microRNA-210-3p in hepatitis B virus-related hepatocellular carcinoma. Am J Physiol Gastrointest Liver Physiol. 318:G401–G409. 2020.PubMed/NCBI View Article : Google Scholar

27 

Meng FL, Wang W and Jia WD: Diagnostic and prognostic significance of serum miR-24-3p in HBV-related hepatocellular carcinoma. Med Oncol. 31(177)2014.PubMed/NCBI View Article : Google Scholar

28 

Xie KL, Zhang YG, Liu J, Zeng Y and Wu H: MicroRNAs associated with HBV infection and HBV-related HCC. Theranostics. 4:1176–1192. 2014.PubMed/NCBI View Article : Google Scholar

29 

Wang C, Su K, Lin H, Cen B, Zheng S and Xu X: Identification and verification of a novel MAGI2-AS3/miRNA-374-5p/FOXO1 network associated with HBV-related HCC. Cells. 11(3466)2022.PubMed/NCBI View Article : Google Scholar

30 

Ranjpour M, Katare DP, Wajid S and Jain SK: HCC specific protein network involving interactions of EGFR with A-Raf and transthyretin: experimental analysis and computational biology correlates. Anticancer Agents Med Chem. 18:1163–1176. 2018.PubMed/NCBI View Article : Google Scholar

31 

Liu H, Lei C, He Q, Pan Z, Xiao D and Tao Y: Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer. Mol Cancer. 17(64)2018.PubMed/NCBI View Article : Google Scholar

32 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009.PubMed/NCBI View Article : Google Scholar

33 

Huang V and Li LC: miRNA goes nuclear. RNA Biol. 9:269–273. 2012.PubMed/NCBI View Article : Google Scholar

34 

Chen C, Chen H, Zhang Y, Thomas HR, Frank MH, He Y and Xia R: TBtools: An integrative toolkit developed for interactive analyses of big biological data. Mol Plant. 13:1194–1202. 2020.PubMed/NCBI View Article : Google Scholar

35 

Fan Y, Siklenka K, Arora SK, Ribeiro P, Kimmins S and Xia J: miRNet-dissecting miRNA-target interactions and functional associations through network-based visual analysis. Nucleic Acids Res. 44 (W1):W135–W141. 2016.PubMed/NCBI View Article : Google Scholar

36 

Zhu HR, Yu XN, Zhang GC, Shi X, Bilegsaikhan E, Guo HY, Liu LL, Cai Y, Song GQ, Liu TT, et al: Comprehensive analysis of long non-coding RNA-messenger RNA-microRNA co-expression network identifies cell cycle-related lncRNA in hepatocellular carcinoma. Int J Mol Med. 44:1844–1854. 2019.PubMed/NCBI View Article : Google Scholar

37 

Hensel KO, Cantner F, Bangert F, Wirth S and Postberg J: Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx. Epigenetics Chromatin. 11(34)2018.PubMed/NCBI View Article : Google Scholar

38 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and Varambally S: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 19:649–658. 2017.PubMed/NCBI View Article : Google Scholar

39 

Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS, Li B and Liu XS: TIMER: A web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 77:e108–e110. 2017.PubMed/NCBI View Article : Google Scholar

40 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

41 

Wang X, Hu H, Hu B, Xia H, Cheng X, Zheng J, Zhang Z and Liu H: Dihydromyricetin inhibits Hepatitis B virus replication by activating NF-κB, MAPKs, and autophagy in HepG2.2.15 cells. Mol Biol Rep. 50:1403–1414. 2023.PubMed/NCBI View Article : Google Scholar

42 

Lou W, Liu J, Ding B, Chen D, Xu L, Ding J, Jiang D, Zhou L, Zheng S and Fan W: Identification of potential miRNA-mRNA regulatory network contributing to pathogenesis of HBV-related HCC. J Transl Med. 17(7)2019.PubMed/NCBI View Article : Google Scholar

43 

Ren M, Qin D, Li K, Qu J, Wang L, Wang Z, Huang A and Tang H: Correlation between hepatitis B virus protein and microRNA processor Drosha in cells expressing HBV. Antiviral Res. 94:225–231. 2012.PubMed/NCBI View Article : Google Scholar

44 

Zhang M, Bai X, Zeng X, Liu J, Liu F and Zhang Z: circRNA-miRNA-mRNA in breast cancer. Clin Chim Acta. 523:120–130. 2021.PubMed/NCBI View Article : Google Scholar

45 

Ma J, Wang P, Huang L, Qiao J and Li J: Bioinformatic analysis reveals an exosomal miRNA-mRNA network in colorectal cancer. BMC Med Genomics. 14(60)2021.PubMed/NCBI View Article : Google Scholar

46 

Guerrieri F, Belloni L, D'Andrea D, Pediconi N, Le Pera L, Testoni B, Scisciani C, Floriot O, Zoulim F, Tramontano A and Levrero M: Genome-wide identification of direct HBx genomic targets. BMC Genomics. 18(184)2017.PubMed/NCBI View Article : Google Scholar

47 

Su Q, Schröder CH, Hofmann WJ, Otto G, Pichlmayr R and Bannasch P: Expression of hepatitis B virus X protein in HBV-infected human livers and hepatocellular carcinomas. Hepatology. 27:1109–1120. 1998.PubMed/NCBI View Article : Google Scholar

48 

Liang XH, Stemler M, Will H, Braun R, Tang ZY and Schröder CH: Low incidence and high titers of antibodies to hepatitis B virus X-protein in sera of Chinese patients with hepatocellular carcinoma. J Med Virol. 25:329–337. 1988.PubMed/NCBI View Article : Google Scholar

49 

Levrero M and Zucman-Rossi J: Mechanisms of HBV-induced hepatocellular carcinoma. J Hepatol. 64 (Suppl 1):S84–S101. 2016.PubMed/NCBI View Article : Google Scholar

50 

Peng F, Xiao X, Jiang Y, Luo K, Tian Y, Peng M, Zhang M, Xu Y and Gong G: HBx down-regulated Gld2 plays a critical role in HBV-related dysregulation of miR-122. PLoS One. 9(e92998)2014.PubMed/NCBI View Article : Google Scholar

51 

Zhou SJ, Deng YL, Liang HF, Jaoude JC and Liu FY: Hepatitis B virus X protein promotes CREB-mediated activation of miR-3188 and Notch signaling in hepatocellular carcinoma. Cell Death Differ. 24:1577–1587. 2017.PubMed/NCBI View Article : Google Scholar

52 

Michlewski G and Cáceres JF: Post-transcriptional control of miRNA biogenesis. RNA. 25:1–16. 2019.PubMed/NCBI View Article : Google Scholar

53 

Bernardo BC, Ooi JYY, Lin RCY and McMullen JR: miRNA therapeutics: A new class of drugs with potential therapeutic applications in the heart. Future Med Chem. 7:1771–1792. 2015.PubMed/NCBI View Article : Google Scholar

54 

lyu Z, Mao Z, Wang H, Fang Y, Chen T, Wan Q, Wang M, Wang N, Xiao J, Wei H, et al: MiR-181b targets Six2 and inhibits the proliferation of metanephric mesenchymal cells in vitro. Biochem Biophys Res Commun. 440:495–501. 2013.PubMed/NCBI View Article : Google Scholar

55 

Schmiedel JM, Klemm SL, Zheng Y, Sahay A, Blüthgen N, Marks DS and van Oudenaarden A: Gene expression. MicroRNA control of protein expression noise. Science. 348:128–132. 2015.PubMed/NCBI View Article : Google Scholar

56 

Xiao M, Li J, Li W, Wang Y, Wu F, Xi Y, Zhang L, Ding C, Luo H, Li Y, et al: MicroRNAs activate gene transcription epigenetically as an enhancer trigger. RNA Biol. 14:1326–1334. 2017.PubMed/NCBI View Article : Google Scholar

57 

Suzuki HI, Young RA and Sharp PA: Super-enhancer-mediated RNA processing revealed by integrative MicroRNA network analysis. Cell. 168:1000–1014.e15. 2017.PubMed/NCBI View Article : Google Scholar

58 

Li N, Miao Y, Shan Y, Liu B, Li Y, Zhao L and Jia L: MiR-106b and miR-93 regulate cell progression by suppression of PTEN via PI3K/Akt pathway in breast cancer. Cell Death Dis. 8(e2796)2017.PubMed/NCBI View Article : Google Scholar

59 

Liang C, Xu Y, Ge H, Xing B, Li G, Li G and Wu J: miR-564 inhibits hepatocellular carcinoma cell proliferation and invasion by targeting the GRB2-ERK1/2-AKT axis. Oncotarget. 8:107543–107557. 2017.PubMed/NCBI View Article : Google Scholar

60 

Vaughan TY, Verma S and Bunting KD: Grb2-associated binding (Gab) proteins in hematopoietic and immune cell biology. Am J Blood Res. 1:130–134. 2011.PubMed/NCBI

61 

Li J, Lv M, Huang Q, Hu R, Zhong X, Sun X, Feng W, Han Z, Ma M, Zhang W and Zhou X: FAT4 expression in peripheral blood mononuclear cells is associated with prognosis and immune cell infiltration in hepatocellular carcinoma. Sci Rep. 13(15735)2023.PubMed/NCBI View Article : Google Scholar

62 

Dunn GP, Dunn IF and Curry WT: Focus on TILs: Prognostic significance of tumor infiltrating lymphocytes in human glioma. Cancer Immun. 7(12)2007.PubMed/NCBI

63 

Azimi F, Scolyer RA, Rumcheva P, Moncrieff M, Murali R, McCarthy SW, Saw RP and Thompson JF: Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma. J Clin Oncol. 30:2678–2683. 2012.PubMed/NCBI View Article : Google Scholar

64 

Zhang X and Zhang J, Gao F, Fan S, Dai L and Zhang J: KPNA2-associated immune analyses highlight the dysregulation and prognostic effects of GRB2, NRAS, and their RNA-binding proteins in hepatocellular carcinoma. Front Genet. 11(593273)2020.PubMed/NCBI View Article : Google Scholar

65 

Lee CC, Li IJ, Chen YC, Cheng JW, Wu HH, Weng CH, Fang JT and Tian YC: Comparable ten-year outcome in hemodialysis patients with hepatitis C virus and hepatitis B virus coinfection and single hepatitis B virus infection. Blood Purif. 32:89–95. 2011.PubMed/NCBI View Article : Google Scholar

66 

Tacke F: Targeting hepatic macrophages to treat liver diseases. J Hepatol. 66:1300–1312. 2017.PubMed/NCBI View Article : Google Scholar

67 

Maheshwari A: Innate immune memory in macrophages. Newborn (Clarksville). 2:60–79. 2023.PubMed/NCBI View Article : Google Scholar

68 

Kawasaki T, Ikegawa M, Yunoki K, Otani H, Ori D, Ishii KJ, Kuroda E, Takamura S, Kitabatake M, Ito T, et al: Alveolar macrophages instruct CD8+ T cell expansion by antigen cross-presentation in lung. Cell Rep. 41(111828)2022.PubMed/NCBI View Article : Google Scholar

69 

Dai H, Lan P, Zhao D, Abou-Daya K, Liu W, Chen W, Friday AJ, Williams AL, Sun T, Chen J, et al: PIRs mediate innate myeloid cell memory to nonself MHC molecules. Science. 368:1122–1127. 2020.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zheng C, Su H, Liu M, Qian Y and Fan H: miRNA‑mRNA network contributes to HBV‑related hepatocellular carcinoma via immune infiltration induced by GRB2. Biomed Rep 20: 90, 2024.
APA
Zheng, C., Su, H., Liu, M., Qian, Y., & Fan, H. (2024). miRNA‑mRNA network contributes to HBV‑related hepatocellular carcinoma via immune infiltration induced by GRB2. Biomedical Reports, 20, 90. https://doi.org/10.3892/br.2024.1777
MLA
Zheng, C., Su, H., Liu, M., Qian, Y., Fan, H."miRNA‑mRNA network contributes to HBV‑related hepatocellular carcinoma via immune infiltration induced by GRB2". Biomedical Reports 20.6 (2024): 90.
Chicago
Zheng, C., Su, H., Liu, M., Qian, Y., Fan, H."miRNA‑mRNA network contributes to HBV‑related hepatocellular carcinoma via immune infiltration induced by GRB2". Biomedical Reports 20, no. 6 (2024): 90. https://doi.org/10.3892/br.2024.1777
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng C, Su H, Liu M, Qian Y and Fan H: miRNA‑mRNA network contributes to HBV‑related hepatocellular carcinoma via immune infiltration induced by GRB2. Biomed Rep 20: 90, 2024.
APA
Zheng, C., Su, H., Liu, M., Qian, Y., & Fan, H. (2024). miRNA‑mRNA network contributes to HBV‑related hepatocellular carcinoma via immune infiltration induced by GRB2. Biomedical Reports, 20, 90. https://doi.org/10.3892/br.2024.1777
MLA
Zheng, C., Su, H., Liu, M., Qian, Y., Fan, H."miRNA‑mRNA network contributes to HBV‑related hepatocellular carcinoma via immune infiltration induced by GRB2". Biomedical Reports 20.6 (2024): 90.
Chicago
Zheng, C., Su, H., Liu, M., Qian, Y., Fan, H."miRNA‑mRNA network contributes to HBV‑related hepatocellular carcinoma via immune infiltration induced by GRB2". Biomedical Reports 20, no. 6 (2024): 90. https://doi.org/10.3892/br.2024.1777
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