Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
June-2024 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2024 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Radiocontrast medium induces histamine release in association with upregulation of miR‑19a‑3p and miR‑362‑3p expression

  • Authors:
    • Wei-Fang Chang
    • Po-Wei Huang
    • Chia-Ling Li
    • Hung-Sen Huang
    • Ting-Yu Chou
    • En-Chih Liao
    • Sheng-Jie Yu
  • View Affiliations / Copyright

    Affiliations: Department of Radiology and Nuclear Medicine, Zuoying Armed Forces General Hospital, Kaohsiung 813, Taiwan, R.O.C., Division of Urology, Department of Surgery, Zuoying Armed Forces General Hospital, Kaohsiung 813, Taiwan, R.O.C., Children's Medical Center, Taichung Veterans General Hospital, Taichung 407, Taiwan, R.O.C., Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan, R.O.C., Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan, R.O.C., Department of Medicine, MacKay Medical College, New Taipei City 252, Taiwan, R.O.C.
    Copyright: © Chang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 93
    |
    Published online on: April 19, 2024
       https://doi.org/10.3892/br.2024.1780
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In Taiwan, the use of radiocontrast medium for clinical image diagnosis recently surpassed one million times and the overall prevalence of radiocontrast hypersensitivity was ~7%. A microRNA (miRNA/miRs) is a small non‑coding RNA molecule that mostly plays a suppressor role in cells. However, the roles of miRNA expression in radiocontrast‑induced mast cells activation remains to be elucidated. The aim of the present study was to investigate the role of miRNA on radiocontrast‑induced mast cell activation. Computed tomography radiocontrast, ultravist and mouse mast cell line, P815, were used in the present study. Cell viability was detected by CCK‑8 experiment. Levels of histamine and β‑hexosaminidase were measured by ELISA. miRNA expression was detected by miRNA sequencing and reverse transcription‑quantitative PCR. The results showed that ultravist could increase histamine release and reduce intracellular β‑hexosaminidase levels of mast cells. A total of 102 miRNAs could be significantly upregulated by ultravist stimulation. Selected candidate miRNAs for the validation included miR‑19a‑3p and miR‑362‑3p which were also increased expression following stimulation with ultravist. In conclusion, ultravist could induce mast cell activation through upregulation of miR‑19a‑3p and miR‑362‑3p. Thus, miR‑19a‑3p and miR‑362‑3p could be promising candidates for development as novel targets for preventing radiocontrast‑induced allergy in the future.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Bae KT: Intravenous contrast medium administration and scan timing at CT: Considerations and approaches. Radiology. 256:32–61. 2010.PubMed/NCBI View Article : Google Scholar

2 

Bottinor W, Polkampally P and Jovin I: Adverse reactions to iodinated contrast media. Int J Angiol. 22:149–154. 2013.PubMed/NCBI View Article : Google Scholar

3 

Zhang B, Dong Y, Liang L, Lian Z, Liu J, Luo X, Chen W, Li X, Liang C and Zhang S: The incidence, classification, and management of acute adverse reactions to the low-osmolar iodinated contrast media isovue and ultravist in contrast-enhanced computed tomography scanning. Medicine (Baltimore). 95(e3170)2016.PubMed/NCBI View Article : Google Scholar

4 

Bannon GA: Hypersensitivity: Anaphylactic (Type I). In Van Nostrand's Scientific Encyclopedia. G.D. Considine (ed.). Wiley & Sons, Inc., Hoboken NJ, 2007. https://doi.org/10.1002/9780471743989.vse9966.

5 

Nakamura T: The roles of lipid mediators in type I hypersensitivity. J Pharmacol Sci. 147:126–131. 2021.PubMed/NCBI View Article : Google Scholar

6 

Nagata Y and Suzuki R: FcεRI: A master regulator of mast cell functions. Cells. 11(622)2022.PubMed/NCBI View Article : Google Scholar

7 

Kanagaratham C, El Ansari YS, Lewis OL and Oettgen HC: IgE and IgG antibodies as regulators of mast cell and basophil functions in food allergy. Front Immunol. 11(603050)2020.PubMed/NCBI View Article : Google Scholar

8 

Gilfillan AM and Rivera J: The tyrosine kinase network regulating mast cell activation. Immunol Rev. 228:149–169. 2009.PubMed/NCBI View Article : Google Scholar

9 

Shefler I, Salamon P and Mekori YA: MicroRNA involvement in allergic and non-allergic mast cell activation. Int J Mol Sci. 20(2145)2019.PubMed/NCBI View Article : Google Scholar

10 

Bao Y, Wang S, Gao Y, Zhang W, Jin H, Yang Y and Li J: MicroRNA-126 accelerates IgE-mediated mast cell degranulation associated with the PI3K/Akt signaling pathway by promoting Ca(2+) influx. Exp Ther Med. 16:2763–2769. 2018.PubMed/NCBI View Article : Google Scholar

11 

Xiao L, Jiang L, Hu Q and Li Y: MiR-302e attenuates allergic inflammation in vitro model by targeting RelA. Biosci Rep. 38:2018.PubMed/NCBI View Article : Google Scholar

12 

Griffiths-Jones S: miRBase: The microRNA sequence database. Methods Mol Biol. 342:129–138. 2006.PubMed/NCBI View Article : Google Scholar

13 

Langmead B and Salzberg SL: Fast gapped-read alignment with Bowtie 2. Nat Methods. 9:357–359. 2012.PubMed/NCBI View Article : Google Scholar

14 

Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G and Durbin R: 1000 Genome Project Data Processing Subgroup. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 25:2078–2079. 2009.PubMed/NCBI View Article : Google Scholar

15 

Robinson MD, McCarthy DJ and Smyth GK: edgeR: A Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010.PubMed/NCBI View Article : Google Scholar

16 

Wang L, Feng Z, Wang X, Wang X and Zhang X: DEGseq: An R package for identifying differentially expressed genes from RNA-seq data. Bioinformatics. 26:136–138. 2010.PubMed/NCBI View Article : Google Scholar

17 

Enright AJ, John B, Gaul U, Tuschl T, Sander C and Marks DS: MicroRNA targets in Drosophila. Genome Biol. 5(R1)2003.PubMed/NCBI View Article : Google Scholar

18 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. Elife. 4(e05005)2015.PubMed/NCBI View Article : Google Scholar

19 

Kertesz M, Iovino N, Unnerstall U, Gaul U and Segal E: The role of site accessibility in microRNA target recognition. Nat Genet. 39:1278–1284. 2007.PubMed/NCBI View Article : Google Scholar

20 

Yu G, Wang LG, Han Y and He QY: ClusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012.PubMed/NCBI View Article : Google Scholar

21 

Luo W, Pant G, Bhavnasi YK, Blanchard Jr SG and Brouwer C: Pathview Web: User friendly pathway visualization and data integration. Nucleic Acids Res. 45(W1):W501–W508. 2017.PubMed/NCBI View Article : Google Scholar

22 

Chang L, Zhou G, Soufan O and Xia J: miRNet 2.0: Network-based visual analytics for miRNA functional analysis and systems biology. Nucleic Acids Res. 48(W1):W244–W251. 2020.PubMed/NCBI View Article : Google Scholar

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

24 

Gil-Martínez M, Lorente-Sorolla C, Naharro S, Rodrigo-Muñoz JM and del Pozo V: Advances and Highlights of miRNAs in Asthma: Biomarkers for diagnosis and treatment. Int J Mol Sci. 24(1628)2023.PubMed/NCBI View Article : Google Scholar

25 

Kulkarni KN, Hegde RG, Balani A and Joshi AR: Transient angioedema of small bowel secondary to intravenous iodinated contrast medium. Indian J Radiol Imaging. 24:303–305. 2014.PubMed/NCBI View Article : Google Scholar

26 

Zou W, Yang S, Chen L, Hu S, Hao G and Hu C: Iodixanol activation of mast cells: Implications in the pathogenesis of iodixanol-induced delayed cutaneous adverse reactions. Toxicology. 465(153034)2022.PubMed/NCBI View Article : Google Scholar

27 

Lee SH, Park JW and Hwang BM: Anaphylactic shock following nonionic contrast medium during caudal epidural injection. Korean J Pain. 28:280–283. 2015.PubMed/NCBI View Article : Google Scholar

28 

Li Y, Liu J, Zhang J, Zhang W and Wu Z: Characterization of microRNA profile in IgE-mediated mouse BMMCs degranulation. J Microbiol Immunol Infect. 53:550–560. 2020.PubMed/NCBI View Article : Google Scholar

29 

Teng Y, Zhang R, Yu H, Wang H, Hong Z, Zhuang W and Huang Y: Altered MicroRNA expression profiles in activated mast cells following IgE-FcεRI cross-linking with antigen. Cell Physiol Biochem. 35:2098–2110. 2015.PubMed/NCBI View Article : Google Scholar

30 

Zhu X, Guo Q, Zou J, Wang B, Zhang Z, Wei R, Zhao L, Zhang Y, Chu C, Fu X and Li X: MiR-19a-3p Suppresses M1 macrophage polarization by inhibiting STAT1/IRF1 pathway. Front Pharmacol. 12(614044)2021.PubMed/NCBI View Article : Google Scholar

31 

Xu G, Li J and Yu L: miR-19a-3p promotes tumor-relevant behaviors in bladder urothelial carcinoma via targeting THBS1. Comput Math Methods Med. 2021(2710231)2021.PubMed/NCBI View Article : Google Scholar

32 

Jiang L, Wang M, Sun R, Lin Z, Liu R, Cai H, Tang Z and Zhang R: Methylation of miR-19b-3p promoter exacerbates inflammatory responses in sepsis-induced ALI via targeting KLF7. Cell Biol Int. 45:1666–1675. 2021.PubMed/NCBI View Article : Google Scholar

33 

Ye L, Morse LR, Falci SP, Olson JK, Shrivastava M, Nguyen N, Linnman C, Troy KL and Battaglino RA: hsa-MiR-19a-3p and hsa-MiR-19b-3p Are Associated with Spinal Cord Injury-Induced Neuropathic Pain: Findings from a Genome-Wide MicroRNA Expression Profiling Screen. Neurotrauma Rep. 2:424–439. 2021.PubMed/NCBI View Article : Google Scholar

34 

Wang D, Wang H, Li Y and Li Q: MiR-362-3p functions as a tumor suppressor through targeting MCM5 in cervical adenocarcinoma. Biosci Rep. 38(BSR20180668)2018.PubMed/NCBI View Article : Google Scholar

35 

Cao S, Li N and Liao X: miR-362-3p acts as a tumor suppressor by targeting SERBP1 in ovarian cancer. J Ovarian Res. 14(23)2021.PubMed/NCBI View Article : Google Scholar

36 

Wang X and Chen P: Aberrant miR-362-3p is Associated with EBV-Infection and prognosis in nasopharyngeal carcinoma and involved in tumor progression by targeting JMJD2A. Onco Targets Ther. 15:121–131. 2022.PubMed/NCBI View Article : Google Scholar

37 

Omidbakhsh A, Saeedi M, Khoshnia M, Marjani A and Hakimi S: Micro-RNAs-106a and -362-3p in peripheral blood of inflammatory bowel disease patients. Open Biochem J. 12:78–86. 2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chang W, Huang P, Li C, Huang H, Chou T, Liao E and Yu S: Radiocontrast medium induces histamine release in association with upregulation of miR‑19a‑3p and miR‑362‑3p expression. Biomed Rep 20: 93, 2024.
APA
Chang, W., Huang, P., Li, C., Huang, H., Chou, T., Liao, E., & Yu, S. (2024). Radiocontrast medium induces histamine release in association with upregulation of miR‑19a‑3p and miR‑362‑3p expression. Biomedical Reports, 20, 93. https://doi.org/10.3892/br.2024.1780
MLA
Chang, W., Huang, P., Li, C., Huang, H., Chou, T., Liao, E., Yu, S."Radiocontrast medium induces histamine release in association with upregulation of miR‑19a‑3p and miR‑362‑3p expression". Biomedical Reports 20.6 (2024): 93.
Chicago
Chang, W., Huang, P., Li, C., Huang, H., Chou, T., Liao, E., Yu, S."Radiocontrast medium induces histamine release in association with upregulation of miR‑19a‑3p and miR‑362‑3p expression". Biomedical Reports 20, no. 6 (2024): 93. https://doi.org/10.3892/br.2024.1780
Copy and paste a formatted citation
x
Spandidos Publications style
Chang W, Huang P, Li C, Huang H, Chou T, Liao E and Yu S: Radiocontrast medium induces histamine release in association with upregulation of miR‑19a‑3p and miR‑362‑3p expression. Biomed Rep 20: 93, 2024.
APA
Chang, W., Huang, P., Li, C., Huang, H., Chou, T., Liao, E., & Yu, S. (2024). Radiocontrast medium induces histamine release in association with upregulation of miR‑19a‑3p and miR‑362‑3p expression. Biomedical Reports, 20, 93. https://doi.org/10.3892/br.2024.1780
MLA
Chang, W., Huang, P., Li, C., Huang, H., Chou, T., Liao, E., Yu, S."Radiocontrast medium induces histamine release in association with upregulation of miR‑19a‑3p and miR‑362‑3p expression". Biomedical Reports 20.6 (2024): 93.
Chicago
Chang, W., Huang, P., Li, C., Huang, H., Chou, T., Liao, E., Yu, S."Radiocontrast medium induces histamine release in association with upregulation of miR‑19a‑3p and miR‑362‑3p expression". Biomedical Reports 20, no. 6 (2024): 93. https://doi.org/10.3892/br.2024.1780
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team