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Article

Tumor necrosis factor‑α ‑308 G/A genetic polymorphism in patients with chronic obstructive pulmonary disease presenting with hyperactive airways

  • Authors:
    • Pia Monique D. Hipolito
    • Peter F. Quilala
    • Mark Pierre S. Dimamay
    • Veni R. Liles
    • Mica Xiena Yungca
    • Michael O. Baclig
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, St. Luke's Medical Center, Quezon City 1112, Philippines, Center for Basic Science Research, St. Luke's Medical Center, Quezon City 1112, Philippines, Department of Molecular Medicine, St. Luke's Medical Center College of Medicine‑William H. Quasha Memorial, Quezon City 1112, Philippines
  • Article Number: 113
    |
    Published online on: June 12, 2024
       https://doi.org/10.3892/br.2024.1802
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Abstract

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide. COPD is often diagnosed late in the disease leading to a delay in management. Notably, tumor necrosis factor‑α (TNF‑α) polymorphisms may serve an important role in the development of COPD. A single‑center, case‑control study was conducted to determine the presence of the TNF‑α ‑308 G/A polymorphism among patients diagnosed with COPD presenting with hyperactive airways, patients without COPD presenting with hyperactive airways, and normal study participants without pulmonary comorbidities. Three genotypes: G/G (94%; 157/167), G/A (5%; 9/167) and A/A (1%; 1/167) were detected by quantitative PCR. The present study showed that the presence of the TNF‑α ‑308 G/A polymorphism reduced the odds of having hyperactive airways with COPD by 29.3% and hyperactive airways without COPD by 26.3%. Multinomial logistic regression analysis showed that having the TNF‑α ‑308 G/A polymorphism did not significantly reduce the odds of having hyperactive airways with COPD and without COPD compared to those with the G/G genotype. In conclusion, the presence of the TNF‑α ‑308 G/A gene polymorphism showed no significant association with patients with COPD with or without hyperactive airways. The presence of the TNF‑α ‑308 G/A polymorphism instead had a weak association with the reduction in the development of COPD regardless of the presence or absence of airway hyperactivity.
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Copy and paste a formatted citation
Spandidos Publications style
Hipolito PD, Quilala PF, Dimamay MS, Liles VR, Yungca MX and Baclig MO: Tumor necrosis factor‑α ‑308 G/A genetic polymorphism in patients with chronic obstructive pulmonary disease presenting with hyperactive airways. Biomed Rep 21: 113, 2024.
APA
Hipolito, P.D., Quilala, P.F., Dimamay, M.S., Liles, V.R., Yungca, M.X., & Baclig, M.O. (2024). Tumor necrosis factor‑α ‑308 G/A genetic polymorphism in patients with chronic obstructive pulmonary disease presenting with hyperactive airways. Biomedical Reports, 21, 113. https://doi.org/10.3892/br.2024.1802
MLA
Hipolito, P. D., Quilala, P. F., Dimamay, M. S., Liles, V. R., Yungca, M. X., Baclig, M. O."Tumor necrosis factor‑α ‑308 G/A genetic polymorphism in patients with chronic obstructive pulmonary disease presenting with hyperactive airways". Biomedical Reports 21.2 (2024): 113.
Chicago
Hipolito, P. D., Quilala, P. F., Dimamay, M. S., Liles, V. R., Yungca, M. X., Baclig, M. O."Tumor necrosis factor‑α ‑308 G/A genetic polymorphism in patients with chronic obstructive pulmonary disease presenting with hyperactive airways". Biomedical Reports 21, no. 2 (2024): 113. https://doi.org/10.3892/br.2024.1802
Copy and paste a formatted citation
x
Spandidos Publications style
Hipolito PD, Quilala PF, Dimamay MS, Liles VR, Yungca MX and Baclig MO: Tumor necrosis factor‑α ‑308 G/A genetic polymorphism in patients with chronic obstructive pulmonary disease presenting with hyperactive airways. Biomed Rep 21: 113, 2024.
APA
Hipolito, P.D., Quilala, P.F., Dimamay, M.S., Liles, V.R., Yungca, M.X., & Baclig, M.O. (2024). Tumor necrosis factor‑α ‑308 G/A genetic polymorphism in patients with chronic obstructive pulmonary disease presenting with hyperactive airways. Biomedical Reports, 21, 113. https://doi.org/10.3892/br.2024.1802
MLA
Hipolito, P. D., Quilala, P. F., Dimamay, M. S., Liles, V. R., Yungca, M. X., Baclig, M. O."Tumor necrosis factor‑α ‑308 G/A genetic polymorphism in patients with chronic obstructive pulmonary disease presenting with hyperactive airways". Biomedical Reports 21.2 (2024): 113.
Chicago
Hipolito, P. D., Quilala, P. F., Dimamay, M. S., Liles, V. R., Yungca, M. X., Baclig, M. O."Tumor necrosis factor‑α ‑308 G/A genetic polymorphism in patients with chronic obstructive pulmonary disease presenting with hyperactive airways". Biomedical Reports 21, no. 2 (2024): 113. https://doi.org/10.3892/br.2024.1802
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