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Oxidative stress and acute pancreatitis (Review)

  • Authors:
    • Yongxia Cai
    • Feng Yang
    • Xizhu Huang
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, P.R. China, Department of Emergency Medicine, The First People's Hospital of Wuyi County, Jinhua, Zhejiang 321200, P.R. China
    Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 124
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    Published online on: June 27, 2024
       https://doi.org/10.3892/br.2024.1812
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Abstract

Acute pancreatitis (AP) is a common inflammatory disorder of the exocrine pancreas that causes severe morbidity and mortality. Although the pathophysiology of AP is poorly understood, a substantial body of evidence suggests some critical events for this disease, such as dysregulation of digestive enzyme production, cytoplasmic vacuolization, acinar cell death, edema formation, and inflammatory cell infiltration into the pancreas. Oxidative stress plays a role in the acute inflammatory response. The present review clarified the role of oxidative stress in the occurrence and development of AP by introducing oxidative stress to disrupt cellular Ca2+ balance and stimulating transcription factor activation and excessive release of inflammatory mediators for the application of antioxidant adjuvant therapy in the treatment of AP.
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1 

Mayerle J, Sendler M, Hegyi E, Beyer G, Lerch MM and Sahin-Toth M: Genetics, cell biology, and pathophysiology of pancreatitis. Gastroenterology. 156:1951–1968 e1. 2019.PubMed/NCBI View Article : Google Scholar

2 

Patel HR, Diaz Almanzar VM, LaComb JF, Ju J and Bialkowska AB: The role of MicroRNAs in pancreatitis development and progression. Int J Mol Sci. 24(1057)2023.PubMed/NCBI View Article : Google Scholar

3 

Fu X, Xiu Z and Xu H: Interleukin-22 and acute pancreatitis: A review. Medicine (Baltimore). 102(e35695)2023.PubMed/NCBI View Article : Google Scholar

4 

Cai Y, Shen Y, Gao L, Chen M, Xiao M, Huang Z and Zhang D: Karyopherin Alpha 2 Promotes the Inflammatory Response in Rat Pancreatic Acinar Cells Via Facilitating NF-ĸB Activation. Dig Dis Sci. 61:747–757. 2016.PubMed/NCBI View Article : Google Scholar

5 

Qiu M, Zhou X, Zippi M, Goyal H, Basharat Z, Jagielski M and Hong W: Comprehensive review on the pathogenesis of hypertriglyceridaemia-associated acute pancreatitis. Ann Med. 55(2265939)2023.PubMed/NCBI View Article : Google Scholar

6 

Zerem E, Kurtcehajic A, Kunosic S, Zerem Malkocevic D and Zerem O: Current trends in acute pancreatitis: Diagnostic and therapeutic challenges. World J Gastroenterol. 29:2747–2763. 2023.PubMed/NCBI View Article : Google Scholar

7 

Hong W, Pan J, Goyal H and Zippi M: Editorial: Acute pancreatitis infection: Epidemiology, prevention, clinical characteristics, treatment, and prediction. Front Cell Infect Microbiol. 13(1175195)2023.PubMed/NCBI View Article : Google Scholar

8 

Saluja A, Dudeja V, Dawra R and Sah RP: Early intra-acinar events in pathogenesis of pancreatitis. Gastroenterology. 156:1979–1993. 2019.PubMed/NCBI View Article : Google Scholar

9 

Qu C, Wei M and Li WQ: Extrapancreatic and pancreatic infection in acute pancreatitis. Eur J Gastroenterol Hepatol. 33:598–599. 2021.PubMed/NCBI View Article : Google Scholar

10 

Hu Z, Wang D, Gong J, Li Y, Ma Z, Luo T, Jia X, Shi Y and Song Z: MSCs Deliver hypoxia-treated mitochondria reprogramming acinar metabolism to alleviate severe acute pancreatitis injury. Adv Sci (Weinh). 10(e2207691)2023.PubMed/NCBI View Article : Google Scholar

11 

Wiley MB, Mehrotra K, Bauer J, Yazici C, Bialkowska AB and Jung B: Acute Pancreatitis: Current clinical approaches, molecular pathophysiology, and potential therapeutics. Pancreas. 52:e335–e343. 2023.PubMed/NCBI View Article : Google Scholar

12 

Ge P, Luo Y, Okoye CS and Chen H, Liu J, Zhang G, Xu C and Chen H: Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: A troublesome trio for acute pancreatitis. Biomed Pharmacother. 132(110770)2020.PubMed/NCBI View Article : Google Scholar

13 

Scurt FG, Bose K, Canbay A, Mertens PR and Chatzikyrkou C: Acute kidney injury following acute pancreatitis (AP-AKI): Definition, Pathophysiology, Diagnosis and Therapy. Z Gastroenterol. 58:1241–1266. 2020.PubMed/NCBI View Article : Google Scholar : (In German).

14 

Rodriguez-Nicolas A, Jimenez P, Carmona FD, Martín J, Matas Cobos AM, Ruiz-Cabello F and Redondo-Cerezo E: Association between Genetic polymorphisms of inflammatory response genes and acute pancreatitis. Immunol Invest. 48:585–596. 2019.PubMed/NCBI View Article : Google Scholar

15 

Komara NL, Paragomi P, Greer PJ, Wilson AS, Breze C, Papachristou GI and Whitcomb DC: Severe acute pancreatitis: Capillary permeability model linking systemic inflammation to multiorgan failure. Am J Physiol Gastrointest Liver Physiol. 319:G573–G583. 2020.PubMed/NCBI View Article : Google Scholar

16 

Lee PJ and Papachristou GI: New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol. 16:479–496. 2019.PubMed/NCBI View Article : Google Scholar

17 

Han X, Li B, Bao J, Wu Z, Chen C, Ni J, Shen J, Song P, Peng Q, Wan R, et al: Endoplasmic reticulum stress promoted acinar cell necroptosis in acute pancreatitis through cathepsinB-mediated AP-1 activation. Front Immunol. 13(968639)2022.PubMed/NCBI View Article : Google Scholar

18 

Kong L, Deng J, Zhou X, Cai B, Zhang B, Chen X, Chen Z and Wang W: Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury. Cell Death Dis. 12(928)2021.PubMed/NCBI View Article : Google Scholar

19 

Zhang T, Gan Y and Zhu S: Association between autophagy and acute pancreatitis. Front Genet. 14(998035)2023.PubMed/NCBI View Article : Google Scholar

20 

Padureanu V, Florescu DN, Padureanu R, Ghenea AE, Gheonea DI and Oancea CN: Role of antioxidants and oxidative stress in the evolution of acute pancreatitis (Review). Exp Ther Med. 23(197)2022.PubMed/NCBI View Article : Google Scholar

21 

Yang J, Sha X, Wu D, Wu B, Pan X, Pan LL, Gu Y and Dong X: Formononetin alleviates acute pancreatitis by reducing oxidative stress and modulating intestinal barrier. Chin Med. 18(78)2023.PubMed/NCBI View Article : Google Scholar

22 

Burzynski J, Fichna J and Tarasiuk A: Putative molecular targets for vitamin A in neutralizing oxidative stress in acute and chronic pancreatitis-a systematic review. Naunyn Schmiedebergs Arch Pharmacol. 396:1361–1370. 2023.PubMed/NCBI View Article : Google Scholar

23 

He J, Ma M, Li D, Wang K, Wang Q, Li Q, He H, Zhou Y, Li Q, Hou X and Yang L: Sulfiredoxin-1 attenuates injury and inflammation in acute pancreatitis through the ROS/ER stress/Cathepsin B axis. Cell Death Dis. 12(626)2021.PubMed/NCBI View Article : Google Scholar

24 

Zhang D, Li L, Li J, Wei Y, Tang J, Man X and Liu F: Colchicine improves severe acute pancreatitis-induced acute lung injury by suppressing inflammation, apoptosis and oxidative stress in rats. Biomed Pharmacother. 153(113461)2022.PubMed/NCBI View Article : Google Scholar

25 

Yuan J, Wei Z, Xin G, Liu X, Zhou Z, Zhang Y, Yu X, Wan C, Chen Q, Zhao W, et al: Vitamin B(12) attenuates acute pancreatitis by suppressing oxidative stress and improving mitochondria dysfunction via CBS/SIRT1 pathway. Oxid Med Cell Longev. 2021(7936316)2021.PubMed/NCBI View Article : Google Scholar

26 

Jin H, Zhao K, Li J, Xu Z, Liao S and Sun S: Matrine alleviates oxidative stress and ferroptosis in severe acute pancreatitis-induced acute lung injury by activating the UCP2/SIRT3/PGC1α pathway. Int Immunopharmacol. 117(109981)2023.PubMed/NCBI View Article : Google Scholar

27 

Bansod S, Chilvery S, Saifi MA, Das TJ, Tag H and Godugu C: Borneol protects against cerulein-induced oxidative stress and inflammation in acute pancreatitis mice model. Environ Toxicol. 36:530–539. 2021.PubMed/NCBI View Article : Google Scholar

28 

Neri M, Fineschi V, Di Paolo M, Pomara C, Riezzo I, Turillazzi E and Cerretani D: Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction. Curr Vasc Pharmacol. 13:26–36. 2015.PubMed/NCBI View Article : Google Scholar

29 

Pu X, Li F, Lin X, Wang R and Chen Z: Oxidative stress and expression of inflammatory factors in lung tissue of acute mountain sickness rats. Mol Med Rep. 25(49)2022.PubMed/NCBI View Article : Google Scholar

30 

El Morsy EM and Ahmed MAE: Carvedilol attenuates l-arginine induced acute pancreatitis in rats through modulation of oxidative stress and inflammatory mediators. Chem Biol Interact. 327(109181)2020.PubMed/NCBI View Article : Google Scholar

31 

Kojayan GG, Alizadeh RF, Li S and Ichii H: Reducing pancreatic fibrosis using antioxidant therapy targeting Nrf2 Antioxidant Pathway: A possible treatment for chronic pancreatitis. Pancreas. 48:1259–1262. 2019.PubMed/NCBI View Article : Google Scholar

32 

Choi J, Oh TG, Jung HW, Park KY, Shin H, Jo T, Kang DS, Chanda D, Hong S, Kim J, et al: Estrogen-Related Receptor ү maintains pancreatic acinar cell function and identity by regulating cellular metabolism. Gastroenterology. 163:239–256. 2022.PubMed/NCBI View Article : Google Scholar

33 

Ma D, Jiang P, Jiang Y, Li H and Zhang D: Effects of Lipid Peroxidation-mediated ferroptosis on severe acute pancreatitis-induced intestinal barrier injury and bacterial translocation. Oxid Med Cell Longev. 2021(6644576)2021.PubMed/NCBI View Article : Google Scholar

34 

Liu K, Liu J, Zou B, Li C, Zeh HJ, Kang R, Kroemer G, Huang J and Tang D: Trypsin-Mediated sensitization to ferroptosis increases the severity of pancreatitis in mice. Cell Mol Gastroenterol Hepatol. 13:483–500. 2022.PubMed/NCBI View Article : Google Scholar

35 

Abdelzaher WY, Ahmed SM, Welson NN, Marraiki N, Batiha GE and Kamel MY: Vinpocetine ameliorates L-arginine induced acute pancreatitis via Sirt1/Nrf2/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis. Biomed Pharmacother 2021: 133: 110976.

36 

Liang X, Hu C, Liu C, Yu K, Zhang J and Jia Y: Dihydrokaempferol (DHK) ameliorates severe acute pancreatitis (SAP) via Keap1/Nrf2 pathway. Life Sci. 261(118340)2020.PubMed/NCBI View Article : Google Scholar

37 

Forman HJ and Zhang H: Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy. Nat Rev Drug Discov. 20:689–709. 2021.PubMed/NCBI View Article : Google Scholar

38 

Nazari A, Mohamadi A, Imani AR, Faghihi M, Tarahi MJ, Moghimian M and Cheraghi M: Effect of vasopressin on electrocardiographic changes produced by ischemia-reperfusion in rats. Pak J Pharm Sci. 34:1409–1414. 2021.PubMed/NCBI

39 

Baliou S, Adamaki M, Ioannou P, Pappa A, Panayiotidis MI, Spandidos DA, Christodoulou I, Kyriakopoulos AM and Zoumpourlis V: Protective role of taurine against oxidative stress (Review). Mol Med Rep. 24(605)2021.PubMed/NCBI View Article : Google Scholar

40 

Amini L, Chekini R, Nateghi MR, Haghani H, Jamialahmadi T, Sathyapalan T and Sahebkar A: The effect of combined vitamin C and vitamin E supplementation on oxidative stress markers in women with endometriosis: A Randomized, triple-blind placebo-controlled clinical trial. Pain Res Manag. 2021(5529741)2021.PubMed/NCBI View Article : Google Scholar

41 

Li W, Wang K, Liu Y, Wu H, He Y, Li C, Wang Q, Su X, Yan S, Su W, et al: A novel drug combination of mangiferin and cinnamic acid alleviates rheumatoid arthritis by inhibiting TLR4/NFĸB/NLRP3 activation-induced pyroptosis. Front Immunol. 13(912933)2022.PubMed/NCBI View Article : Google Scholar

42 

Feng M, Wei S, Zhang S and Yang Y: Anti-Inflammation and anti-pyroptosis activities of mangiferin via suppressing NF-ĸB/NLRP3/GSDMD signaling cascades. Int J Mol Sci. 23(10124)2022.PubMed/NCBI View Article : Google Scholar

43 

Khan J, Deb PK, Priya S, Medina KD, Devi R, Walode SG and Rudrapal M: Dietary Flavonoids: Cardioprotective potential with antioxidant effects and their pharmacokinetic, toxicological and therapeutic concerns. Molecules. 26(4021)2021.PubMed/NCBI View Article : Google Scholar

44 

Xu BL, Zhang GJ and Ji YB: Active components alignment of Gegenqinlian decoction protects ulcerative colitis by attenuating inflammatory and oxidative stress. J Ethnopharmacol. 162:253–260. 2015.PubMed/NCBI View Article : Google Scholar

45 

Maleth J and Hegyi P: Ca2+ toxicity and mitochondrial damage in acute pancreatitis: Translational overview. Philos Trans R Soc Lond B Biol Sci. 371(20150425)2016.PubMed/NCBI View Article : Google Scholar

46 

Du W, Liu G, Shi N, Tang D, Ferdek PE, Jakubowska MA, Liu S, Zhu X, Zhang J, Yao L, et al: A microRNA checkpoint for Ca(2+) signaling and overload in acute pancreatitis. Mol Ther. 30:1754–1774. 2022.PubMed/NCBI View Article : Google Scholar

47 

Gerasimenko JV, Gerasimenko OV and Petersen OH: The role of Ca2+ in the pathophysiology of pancreatitis. J Physiol. 592:269–280. 2014.PubMed/NCBI View Article : Google Scholar

48 

Nakamura Y, Do JH, Yuan J, Odinokova IV, Mareninova O, Gukovskaya AS and Pandol SJ: Inflammatory cells regulate p53 and caspases in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 298:G92–G100. 2010.PubMed/NCBI View Article : Google Scholar

49 

Cao MH, Xu J, Cai HD, Lv ZW, Feng YJ, Li K, Chen CQ and Li YY: p38 MAPK inhibition alleviates experimental acute pancreatitis in mice. Hepatobiliary Pancreat Dis Int. 14:101–106. 2015.PubMed/NCBI View Article : Google Scholar

50 

Pardalis V, Palli E, Lambropoulou M, Tsigalou C, Anagnostoulis S, Garoufalis G, Bolanaki H, Simopoulos C and Karayiannakis AJ: Expression of Fas (CD95/APO-1) and Fas ligand (FasL) in experimentally-induced acute pancreatitis. J Invest Surg. 27:65–72. 2014.PubMed/NCBI View Article : Google Scholar

51 

Milnerowicz H, Bukowski R, Jablonowska M, Sciskalska M and Milnerowicz U: The antioxidant profiles, lysosomal and membrane enzymes activity in patients with acute pancreatitis. Mediators Inflamm. 2014(376518)2014.PubMed/NCBI View Article : Google Scholar

52 

Gao L, Chong E, Pendharkar S, Phillips A, Ke L, Li W and Windsor JA: The Challenges and effects of ascorbic acid treatment of acute pancreatitis: A systematic review and meta-analysis of preclinical and clinical studies. Front Nutr. 8(734558)2021.PubMed/NCBI View Article : Google Scholar

53 

Zhao Q, Tang X, Huang J, Li J, Chen Q, Sun Y and Wu J: Melatonin attenuates endoplasmic reticulum stress in acute pancreatitis. Pancreas. 47:884–891. 2018.PubMed/NCBI View Article : Google Scholar

54 

Cao WL, Xiang XH, Chen K, Xu W and Xia SH: Potential role of NADPH oxidase in pathogenesis of pancreatitis. World J Gastrointest Pathophysiol. 5:169–177. 2014.PubMed/NCBI View Article : Google Scholar

55 

Shin JY, Choi JW, Kim DG, Zhou ZQ, Shin YK, Seo JH, Song HJ, Choi BM, Bae GS and Park SJ: Protective effects of Coenzyme Q10 against acute pancreatitis. Int Immunopharmacol. 88(106900)2020.PubMed/NCBI View Article : Google Scholar

56 

Gukovsky I, Pandol SJ and Gukovskaya AS: Organellar dysfunction in the pathogenesis of pancreatitis. Antioxid Redox Signal. 15:2699–2710. 2011.PubMed/NCBI View Article : Google Scholar

57 

Ward JB, Petersen OH, Jenkins SA and Sutton R: Is an elevated concentration of acinar cytosolic free ionised calcium the trigger for acute pancreatitis? Lancet. 346:1016–1019. 1995.PubMed/NCBI View Article : Google Scholar

58 

Mukherjee R, Mareninova OA, Odinokova IV, Huang W, Murphy J, Chvanov M, Javed MA, Wen L, Booth DM, Cane MC, et al: Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP. Gut. 65:1333–1346. 2016.PubMed/NCBI View Article : Google Scholar

59 

Armstrong JA, Cash NJ, Morton JC, Tepikin AV, Sutton R and Criddle DN: Mitochondrial targeting of antioxidants alters pancreatic acinar cell bioenergetics and determines cell fate. Int J Mol Sci. 20(1700)2019.PubMed/NCBI View Article : Google Scholar

60 

Vela S, Guerra A, Farrell G, Trivedi S, Chaffin H, Rood C, Singh R, Kostenko S, Chang YH, Snozek C, et al: Pathophysiology and biomarker potential of fatty acid ethyl ester elevation during alcoholic pancreatitis. Gastroenterology. 161:1513–1525. 2021.PubMed/NCBI View Article : Google Scholar

61 

Lee J, Lim JW and Kim H: Lycopene inhibits oxidative stress-mediated inflammatory responses in ethanol/palmitoleic acid-stimulated pancreatic acinar AR42J cells. Int J Mol Sci. 22(2101)2021.PubMed/NCBI View Article : Google Scholar

62 

Armstrong JA, Cash NJ, Ouyang Y, Morton JC, Chvanov M, Latawiec D, Awais M, Tepikin AV, Sutton R and Criddle DN: Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift. J Biol Chem. 293:8032–8047. 2018.PubMed/NCBI View Article : Google Scholar

63 

Booth DM, Murphy JA, Mukherjee R, Awais M, Neoptolemos JP, Gerasimenko OV, Tepikin AV, Petersen OH, Sutton R and Criddle DN: Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells. Gastroenterology. 140:2116–2125. 2011.PubMed/NCBI View Article : Google Scholar

64 

Minati MA, Libert M, Dahou H, Jacquemin P and Assi M: N-Acetylcysteine reduces the pro-oxidant and inflammatory responses during pancreatitis and pancreas tumorigenesis. Antioxidants (Basel). 10(1107)2021.PubMed/NCBI View Article : Google Scholar

65 

Xie C, Wang P, Gu Z and Yang R: Spermidine alleviates oxidative damage and enhances phenolic compounds accumulation in barley seedlings under UV-B stress. J Sci Food Agric. 103:648–656. 2023.PubMed/NCBI View Article : Google Scholar

66 

Ali MY, Sina AA, Khandker SS, Neesa L, Tanvir EM, Kabir A, Khalil MI and Gan SH: Nutritional composition and bioactive compounds in tomatoes and their impact on human health and disease: A review. Foods. 10(45)2020.PubMed/NCBI View Article : Google Scholar

67 

Shi Y, Han L, Zhang X, Xie L, Pan P and Chen F: Selenium alleviates cerebral ischemia/reperfusion injury by regulating oxidative stress, mitochondrial fusion and ferroptosis. Neurochem Res. 47:2992–3002. 2022.PubMed/NCBI View Article : Google Scholar

68 

Silvestrini A, Mordente A, Martino G, Bruno C, Vergani E, Meucci E and Mancini A: The role of selenium in oxidative stress and in nonthyroidal Illness Syndrome (NTIS): An overview. Curr Med Chem. 27:423–449. 2020.PubMed/NCBI View Article : Google Scholar

69 

Kruk J, Aboul-Enein BH and Duchnik E: Exercise-induced oxidative stress and melatonin supplementation: Current evidence. J Physiol Sci. 71(27)2021.PubMed/NCBI View Article : Google Scholar

70 

Chitimus DM, Popescu MR, Voiculescu SE, Panaitescu AM, Pavel B, Zagrean L and Zagrean AM: Melatonin's impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease. Biomolecules. 10(1211)2020.PubMed/NCBI View Article : Google Scholar

71 

Dvoretskaya Y, Glanz V, Gryaznova M, Syromyatnikov M and Popov V: Mitochondrial Antioxidant SkQ1 has a beneficial effect in experimental diabetes as based on the analysis of expression of microRNAs and mRNAs for the oxidative metabolism regulators. Antioxidants (Basel). 10(1749)2021.PubMed/NCBI View Article : Google Scholar

72 

Zhang ZW, Zhang QY, Zhou MT, Liu NX, Chen TK, Zhu YF and Wu L: Antioxidant inhibits HMGB1 expression and reduces pancreas injury in rats with severe acute pancreatitis. Dig Dis Sci. 55:2529–2536. 2010.PubMed/NCBI View Article : Google Scholar

73 

Kilic Y, Geyikoglu F, Colak S, Turkez H, Bakir M and Hsseinigouzdagani M: Carvacrol modulates oxidative stress and decreases cell injury in pancreas of rats with acute pancreatitis. Cytotechnology. 68:1243–1256. 2016.PubMed/NCBI View Article : Google Scholar

74 

Liu MW, Wei R, Su MX, Li H, Fang TW and Zhang W: Retraction Note: Effects of Panax notoginseng saponins on severe acute pancreatitis through the regulation of mTOR/Akt and caspase-3 signaling pathway by upregulating miR-181b expression in rats. BMC Complement Med Ther. 22(306)2022.PubMed/NCBI View Article : Google Scholar

75 

Du WD, Yuan ZR, Sun J, Tang JX, Cheng AQ, Shen DM, Huang CJ, Song XH, Yu XF and Zheng SB: Therapeutic efficacy of high-dose vitamin C on acute pancreatitis and its potential mechanisms. World J Gastroenterol. 9:2565–2569. 2003.PubMed/NCBI View Article : Google Scholar

76 

Weniger M, Reinelt L, Neumann J, Holdt L, Ilmer M, Renz B, Hartwig W, Werner J, Bazhin AV and D'Haese JG: The analgesic effect of the mitochondria-targeted antioxidant SkQ1 in pancreatic inflammation. Oxid Med Cell Longev. 2016(4650489)2016.PubMed/NCBI View Article : Google Scholar

77 

Riaz M, Al Kury LT, Atzaz N, Alattar A, Alshaman R, Shah FA and Li S: Carvacrol alleviates hyperuricemia-induced oxidative stress and inflammation by modulating the NLRP3/NF-ĸB pathwayt. Drug Des Devel Ther. 16:1159–1170. 2022.PubMed/NCBI View Article : Google Scholar

78 

Nakajima M, Kojiro M, Aso S, Matsui H, Fushimi K, Kaita Y, Goto H, Yamaguchi Y and Yasunaga H: Effect of high-dose vitamin C therapy on severe burn patients: A nationwide cohort study. Crit Care. 23(407)2019.PubMed/NCBI View Article : Google Scholar

79 

Xia J, Li D, Yu G, Xu B, Gao X, Wang H, Ma Y, Li X and Xiong Y: Effects of hypovitaminosis D on preoperative pain threshold and perioperative opioid use in colorectal cancer surgery: A cohort study. Pain Physician. 25:E1009–E1019. 2022.PubMed/NCBI

80 

Lamontagne F, Masse MH, Menard J, Sprague S, Pinto R, Heyland DK, Cook DJ, Battista MC, Day AG, Guyatt GH, et al: Intravenous vitamin C in adults with sepsis in the intensive care unit. N Engl J Med. 386:2387–2398. 2022.PubMed/NCBI View Article : Google Scholar

81 

Ko SH, Jun JH, Oh JE, Shin E, Kwak YL and Shim JK: Effect of high-dose vitamin C on renal ischemia-reperfusion injury. Biomed Pharmacother. 173(116407)2024.PubMed/NCBI View Article : Google Scholar

82 

Yuan X, Li X, Ji Z, Xiao J, Zhang L, Zhang W, Su H, Kaliannan K, Long Y and Shao Z: Effects of vitamin C supplementation on blood pressure and hypertension control in response to ambient temperature changes in patients with essential hypertension. Clin Exp Hypertens. 41:414–421. 2019.PubMed/NCBI View Article : Google Scholar

83 

Sim M, Hong S, Jung S, Kim JS, Goo YT, Chun WY and Shin DM: Vitamin C supplementation promotes mental vitality in healthy young adults: Results from a cross-sectional analysis and a randomized, double-blind, placebo-controlled trial. Eur J Nutr. 61:447–459. 2022.PubMed/NCBI View Article : Google Scholar

84 

Xu F, Wen Y, Hu X, Wang T and Chen G: The potential use of vitamin C to prevent kidney injury in patients with COVID-19. Diseases. 9(46)2021.PubMed/NCBI View Article : Google Scholar

85 

Bonham MJ, Abu-Zidan FM, Simovic MO, Sluis KB, Wilkinson A, Winterbourn CC and Windsor JA: Early ascorbic acid depletion is related to the severity of acute pancreatitis. Br J Surg. 86:1296–1301. 1999.PubMed/NCBI View Article : Google Scholar

86 

Hardman J, Shields C, Schofield D, McMahon R, Redmond HP and Siriwardena AK: Intravenous antioxidant modulation of end-organ damage in L-arginine-induced experimental acute pancreatitis. Pancreatology. 5:380–386. 2005.PubMed/NCBI View Article : Google Scholar

87 

Siriwardena AK, Mason JM, Balachandra S, Bagul A, Galloway S, Formela L, Hardman JG and Jamdar S: Randomised, double blind, placebo controlled trial of intravenous antioxidant (n-acetylcysteine, selenium, vitamin C) therapy in severe acute pancreatitis. Gut. 56:1439–1444. 2007.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Cai Y, Yang F and Huang X: Oxidative stress and acute pancreatitis (Review). Biomed Rep 21: 124, 2024.
APA
Cai, Y., Yang, F., & Huang, X. (2024). Oxidative stress and acute pancreatitis (Review). Biomedical Reports, 21, 124. https://doi.org/10.3892/br.2024.1812
MLA
Cai, Y., Yang, F., Huang, X."Oxidative stress and acute pancreatitis (Review)". Biomedical Reports 21.2 (2024): 124.
Chicago
Cai, Y., Yang, F., Huang, X."Oxidative stress and acute pancreatitis (Review)". Biomedical Reports 21, no. 2 (2024): 124. https://doi.org/10.3892/br.2024.1812
Copy and paste a formatted citation
x
Spandidos Publications style
Cai Y, Yang F and Huang X: Oxidative stress and acute pancreatitis (Review). Biomed Rep 21: 124, 2024.
APA
Cai, Y., Yang, F., & Huang, X. (2024). Oxidative stress and acute pancreatitis (Review). Biomedical Reports, 21, 124. https://doi.org/10.3892/br.2024.1812
MLA
Cai, Y., Yang, F., Huang, X."Oxidative stress and acute pancreatitis (Review)". Biomedical Reports 21.2 (2024): 124.
Chicago
Cai, Y., Yang, F., Huang, X."Oxidative stress and acute pancreatitis (Review)". Biomedical Reports 21, no. 2 (2024): 124. https://doi.org/10.3892/br.2024.1812
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