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Effects of selective serotonin reuptake inhibitors on endocrine system (Review)

  • Authors:
    • Carolina Ruiz-Santiago
    • Carla Valeria Rodríguez-Pinacho
    • Gilberto Pérez-Sánchez
    • Erika Acosta-Cruz
  • View Affiliations / Copyright

    Affiliations: Department of Biotechnology, Faculty of Chemistry, Universidad Autónoma de Coahuila, Saltillo Coahuila 25280, México, Laboratory of Psychoimmunology, National Institute of Psychiatry Ramón de la Fuente Muñíz, México City 14370, México
    Copyright: © Ruiz-Santiago et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 128
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    Published online on: July 5, 2024
       https://doi.org/10.3892/br.2024.1816
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Abstract

Selective serotonin reuptake inhibitors (SSRIs) are typically prescribed for treating major depressive disorder (MDD) due to their high efficacy. These drugs function by inhibiting the reuptake of serotonin [also termed 5‑hydroxytryptamine (5‑HT)], which raises the levels of 5‑HT in the synaptic cleft, leading to prolonged activation of postsynaptic 5‑HT receptors. Despite the therapeutic benefits of SSRIs, this mechanism of action also disturbs the neuroendocrine response. Hypothalamic‑pituitary‑adrenal (HPA) axis activity is strongly linked to both MDD and the response to antidepressants, owing to the intricate interplay within the serotonergic system, which regulates feeding, water intake, sexual drive, reproduction and circadian rhythms. The aim of the present review was to provide up‑to‑date evidence for the proposed effects of SSRIs, such as fluoxetine, citalopram, escitalopram, paroxetine, sertraline and fluvoxamine, on the endocrine system. For this purpose, the literature related to the effects of SSRIs on the endocrine system was searched using the PubMed database. According to the available literature, SSRIs may have an adverse effect on glucose metabolism, sexual function and fertility by dysregulating the function of the HPA axis, pancreas and gonads. Therefore, considering that SSRIs are often prescribed for extended periods, it is crucial to monitor the patient closely with particular attention to the function of the endocrine system.
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1 

Alboni S, Van DIjk RM, Poggini S, Milior G, Perrotta M, Drenth T, Brunello N, Wolfer DP, Limatola C, Amrein I, et al: Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment. Mol Psychiatry. 22:552–561. 2017.PubMed/NCBI View Article : Google Scholar

2 

World Health Organization: Mental Disorders, 2022.

3 

Isaac R, Boura-Halfon S, Gurevitch D, Shainskaya A, Levkovitz Y and Zick Y: Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells. J Biol Chem. 288:5682–5693. 2013.

4 

Berardelli R, Margarito E, Ghiggia F, Picu A, Balbo M, Bonelli L, Giordano R, Karamouzis I, Bo M, Ghigo E and Arvat E: Neuroendocrine effects of citalopram, a selective serotonin re-uptake inhibitor, during lifespan in humans. J Endocrinol Invest. 33:657–662. 2010.PubMed/NCBI View Article : Google Scholar

5 

Ruhé HG, Khoenkhoen SJ, Ottenhof KW, Koeter MW, Mocking RJT and Schene AH: Longitudinal effects of the SSRI paroxetine on salivary cortisol in major depressive disorder. Psychoneuroendocrinology. 52:261–271. 2015.PubMed/NCBI View Article : Google Scholar

6 

Dubovicky M, Belovicova K, Csatlosova K and Bogi E: Risks of using SSRI/SNRI antidepressants during pregnancy and lactation. Interdiscip Toxicol. 10:30–34. 2017.PubMed/NCBI View Article : Google Scholar

7 

Avitsur R: Prenatal fluoxetine modifies the behavioral and hormonal responses to stress in male mice: Role for glucocorticoid insensitivity. Behav Pharmacol. 28:345–355. 2017.PubMed/NCBI View Article : Google Scholar

8 

Edinoff AN, Akuly HA, Hanna TA, Ochoa CO, Patti SJ, Ghaffar YA, Kaye AD, Viswanath O, Urits I, Boyer AG, et al: Selective serotonin reuptake inhibitors and adverse effects: A narrative review. Neurol Int. 13:387–401. 2021.PubMed/NCBI View Article : Google Scholar

9 

Malagié I, Trillat AC, Jacquot C and Gardier AM: Effects of acute fluoxetine on extracellular serotonin levels in the raphe: An in vivo microdialysis study. Eur J Pharmacol. 286:213–217. 1995.PubMed/NCBI View Article : Google Scholar

10 

Perez-Caballero L, Torres-Sanchez S, Bravo L, Mico JA and Berrocoso E: Fluoxetine: A case history of its discovery and preclinical development. Expert Opin Drug Discov. 9:567–578. 2014.PubMed/NCBI View Article : Google Scholar

11 

Wille SMR, Cooreman SG, Neels HM and Lambert WEE: Relevant issues in the monitoring and the toxicology of antidepressants. Crit Rev Clin Lab Sci. 45:25–89. 2008.PubMed/NCBI View Article : Google Scholar

12 

Catterson ML and Preskorn SH: Pharmacokinetics of selective serotonin reuptake inhibitors: Clinical relevance. Pharmacol Toxicol. 78:203–208. 1996.PubMed/NCBI View Article : Google Scholar

13 

Benfield P, Heel RC and Lewis SP: Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs. 32:481–508. 1986.PubMed/NCBI View Article : Google Scholar

14 

Reis M, Aamo T, Spigset O and Ahlner J: Serum concentrations of antidepressant drugs in a naturalistic setting: Compilation based on a large therapeutic drug monitoring database. Ther Drug Monit. 31:42–56. 2009.PubMed/NCBI View Article : Google Scholar

15 

Gomez F and García-García L: Anxiogenic-like effects of fluoxetine render adult male rats vulnerable to the effects of a novel stress. Pharmacol Biochem Behav. 153:32–44. 2017.PubMed/NCBI View Article : Google Scholar

16 

Alboni S, Benatti C, Montanari C, Tascedda F and Brunello N: Chronic antidepressant treatments resulted in altered expression of genes involved in inflammation in the rat hypothalamus. Eur J Pharmacol. 721:158–167. 2013.PubMed/NCBI View Article : Google Scholar

17 

Pawluski JL, Rayen I, Niessen NA, Kristensen S, van Donkelaar EL, Balthazart J, Steinbusch HW and Charlier TD: Developmental fluoxetine exposure differentially alters central and peripheral measures of the HPA system in adolescent male and female offspring. Neuroscience. 220:131–141. 2012.PubMed/NCBI View Article : Google Scholar

18 

Knaepen L, Rayen I, Charlier TD, Fillet M, Houbart V, van Kleef M, Steinbusch HW, Patijn J, Tibboel D, Joosten EA and Pawluski JL: Developmental fluoxetine exposure normalizes the long-term effects of maternal stress on post-operative pain in Sprague-Dawley rat offspring. PLoS One. 8(e57608)2013.PubMed/NCBI View Article : Google Scholar

19 

Gemmel M, Hazlett M, Bögi E, De Lacalle S, Hill LA, Kokras N, Hammond GL, Dalla C, Charlier TD and Pawluski JL: Perinatal fluoxetine effects on social play, the HPA system, and hippocampal plasticity in pre-adolescent male and female rats: Interactions with pre-gestational maternal stress. Psychoneuroendocrinology. 84:159–171. 2017.PubMed/NCBI View Article : Google Scholar

20 

Avitsur R, Grinshpahet R, Goren N, Weinstein I, Kirshenboim O and Chlebowski N: Prenatal SSRI alters the hormonal and behavioral responses to stress in female mice: Possible role for glucocorticoid resistance. Horm Behav. 84:41–49. 2016.PubMed/NCBI View Article : Google Scholar

21 

Ghaeli P, Shahsavand E, Mesbahi M, Kamkar MZ, Sadeghi M and Dashti-Khavidaki S: Comparing the effects of 8-week treatment with fluoxetine and imipramine on fasting blood glucose of patients with major depressive disorder. J Clin Psychopharmacol. 24:386–388. 2004.PubMed/NCBI View Article : Google Scholar

22 

Pan SJ, Tan YL, Yao SW, Xin Y, Yang X, Liu J and Xiong J: Fluoxetine induces lipid metabolism abnormalities by acting on the liver in patients and mice with depression. Acta Pharmacol Sin. 39:1463. 2018.PubMed/NCBI View Article : Google Scholar

23 

Masand PS and Gupta S: Long-term side effects of newer-generation antidepressants: SSRIS, venlafaxine, nefazodone, bupropion, and mirtazapine. Ann Clin Psychiatry. 14:175–182. 2002.PubMed/NCBI View Article : Google Scholar

24 

Shahsavand Ananloo E, Ghaeli P, Kamkar MZ and Sadeghi M: Comparing the effects of fluoxetine and imipramine on total cholesterol, triglyceride, and weight in patients with major depression. Daru. 21(4)2013.PubMed/NCBI View Article : Google Scholar

25 

Biagetti B and Corcoy R: Hypoglycemia associated with fluoxetine treatment in a patient with type 1 diabetes. World J Clin Cases. 1:169–171. 2013.PubMed/NCBI View Article : Google Scholar

26 

Giri D, Price V, Yung Z, Didi M and Senniappan S: Fluoxetine-induced hypoglycaemia in a patient with congenital hyperinsulinism on lanreotide therapy. J Clin Res Pediatr Endocrinol. 8:347–350. 2016.PubMed/NCBI View Article : Google Scholar

27 

Andersohn F, Schade R, Suissa S and Garbe E: Long-term use of antidepressants for depressive disorders and the risk of diabetes mellitus. Am J Psychiatry. 166:591–598. 2009.PubMed/NCBI View Article : Google Scholar

28 

Sawka AM, Burgart V and Zimmerman D: Loss of hypoglycemia awareness in an adolescent with type 1 diabetes mellitus during treatment with fluoxetine hydrochloride. J Pediatr. 136:394–396. 2000.PubMed/NCBI View Article : Google Scholar

29 

Deeg MA and Lipkin EW: Hypoglycemia associated with the use of fluoxetine. West J Med. 164:262–263. 1996.PubMed/NCBI

30 

Preeti S, Jayaram SD and Chittaranjan A: Sexual dysfunction in patients with antidepressant-treated anxiety or depressive disorders: A pragmatic multivariable longitudinal study. East Asian Arch Psychiatry. 28:9–16. 2018.PubMed/NCBI

31 

AlBreiki M, Al Maqbali M, AlRisi K, AlSinawi H, AlBalushi M and Al Zakwani W: Prevalence of antidepressant-induced sexual dysfunction among psychiatric outpatients attending a tertiary care hospital. Neurosciences (Riyadh). 25:55–60. 2020.PubMed/NCBI View Article : Google Scholar

32 

Rowland D, McMahon CG, Abdo C, Chen J, Jannini E, Waldinger MD and Ahn TY: Disorders of orgasm and ejaculation in men. J Sex Med. 7:1668–1686. 2010.PubMed/NCBI View Article : Google Scholar

33 

Solomon R, Shvartsur R and Azab AN: The association between psychotropic drug use and fertility problems among male subjects. J Psychiatr Pract. 25:22–33. 2019.PubMed/NCBI View Article : Google Scholar

34 

Trenque T, Maura G, Herlem E, Vallet C, Sole E, Auriche P and Drame M: Reports of sexual disorders related to serotonin reuptake inhibitors in the French pharmacovigilance database: An example of underreporting. Drug Saf. 36:515–519. 2013.PubMed/NCBI View Article : Google Scholar

35 

Relwani R, Berger D, Santoro N, Hickmon C, Nihsen M, Zapantis A, Werner M, Polotsky AJ and Jindal S: Semen parameters are unrelated to BMI but vary with SSRI use and prior urological surgery. Reprod Sci. 18:391–397. 2011.PubMed/NCBI View Article : Google Scholar

36 

Safarinejad MR: Sperm DNA damage and semen quality impairment after treatment with selective serotonin reuptake inhibitors detected using semen analysis and sperm chromatin structure assay. J Urol. 180:2124–2128. 2008.PubMed/NCBI View Article : Google Scholar

37 

Moore CJ, DeLong NE, Chan KA, Holloway AC, Petrik JJ and Sloboda DM: Perinatal administration of a selective serotonin reuptake inhibitor induces impairments in reproductive function and follicular dynamics in female rat offspring. Reprod Sci. 22:1297–1311. 2015.PubMed/NCBI View Article : Google Scholar

38 

Ayala ME, Gonzáles A, Olivarez RM and Aragón-Martínez A: Fluoxetine treatment of prepubertal male rats uniformly diminishes sex hormone levels and, in a subpopulation of animals, negatively affects sperm quality. Reprod Fertil Dev. 30:1329–1341. 2018.PubMed/NCBI View Article : Google Scholar

39 

de Oliveira WM, de Sá IR, de Torres SM, de Morais RN, Andrade AM, Maia FC, Tenorio BM and da Silva Junior VA: Perinatal exposure to fluoxetine via placenta and lactation inhibits the testicular development in male rat offspring. Syst Biol Reprod Med. 59:244–250. 2013.PubMed/NCBI View Article : Google Scholar

40 

Elsedawi BF, Hussein Y, Sabry MA and Aziz JA: Effect of fluoxetine on the testes of adult albino rats and the possible protective role of curcumin. Anat Sci Int. 96:187–196. 2021.PubMed/NCBI View Article : Google Scholar

41 

Erdemir F, Atilgan D, Firat F, Markoc F, Parlaktas BS and Sogut E: The effect of sertraline, paroxetine, fluoxetine and escitalopram on testicular tissue and oxidative stress parameters in rats. Int Braz J Urol. 40:100–108. 2014.PubMed/NCBI View Article : Google Scholar

42 

Sakr HF, Abbas AM, Elsamanoudy AZ and Ghoneim FM: Effect of fluoxetine and resveratrol on testicular functions and oxidative stress in a rat model of chronic mild stress-induced depression. J Physiol Pharmacol. 66:515–527. 2015.PubMed/NCBI

43 

Câmara ML, Almeida TB, de Santi F, Rodrigues BM, Cerri PS, Beltrame FL and Sasso-Cerri E: Fluoxetine-induced androgenic failure impairs the seminiferous tubules integrity and increases ubiquitin carboxyl-terminal hydrolase L1 (UCHL1): Possible androgenic control of UCHL1 in germ cell death? Biomed Pharmacother. 109:1126–1139. 2019.PubMed/NCBI View Article : Google Scholar

44 

Monteiro Filho WO, de Torres SM, Amorim MJ, Andrade AJ, de Morais RN, Tenorio BM and da Silva Junior VA: Fluoxetine induces changes in the testicle and testosterone in adult male rats exposed via placenta and lactation. Syst Biol Reprod Med. 60:274–281. 2014.PubMed/NCBI View Article : Google Scholar

45 

dos Santos AH, Vieira ML, de Azevedo Camin N, Anselmo-Franci JA, Ceravolo GS, Pelosi GG, Moreira EG, Kiss AC, Mesquita Sde F and Gerardin DC: In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring. Reprod Toxicol. 62:1–8. 2016.PubMed/NCBI View Article : Google Scholar

46 

Romero-Reyes J, Cárdenas M, Damián-Matsumura P, Domínguez R and Ayala ME: Inhibition of serotonin reuptake in the prepubertal rat ovary by fluoxetine and effects on ovarian functions. Reprod Toxicol. 59:80–88. 2016.PubMed/NCBI View Article : Google Scholar

47 

De Long NE, Hyslop JR, Raha S, Hardy DB and Holloway AC: Fluoxetine-induced pancreatic beta cell dysfunction: New insight into the benefits of folic acid in the treatment of depression. J Affect Disord. 166:6–13. 2014.PubMed/NCBI View Article : Google Scholar

48 

Cataldo LR, Cortés VA, Mizgier ML, Aranda E, Mezzano D, Olmos P, Galgani JE, Suazo J and Santos JL: Fluoxetine impairs insulin secretion without modifying extracellular serotonin levels in MIN6 β-cells. Exp Clin Endocrinol Diabetes. 123:473–478. 2015.PubMed/NCBI View Article : Google Scholar

49 

Grankvist K, Marklund SL and Täljedal IB: CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochem J. 199:393–398. 1981.PubMed/NCBI View Article : Google Scholar

50 

Lenzen S, Drinkgern J and Tiedge M: Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med. 20:463–466. 1996.PubMed/NCBI View Article : Google Scholar

51 

Elmorsy E, Al-Ghafari A, Helaly ANM, Hisab AS, Oehrle B and Smith PA: Editor's highlight: Therapeutic concentrations of antidepressants inhibit pancreatic beta-cell function via mitochondrial complex inhibition. Toxicol Sci. 158:286–301. 2017.PubMed/NCBI View Article : Google Scholar

52 

Dissanayake WC, Sorrenson B and Shepherd PR: The role of adherens junction proteins in the regulation of insulin secretion. Biosci Rep. 38(BSR20170989)2018.PubMed/NCBI View Article : Google Scholar

53 

Chang HY, Chen SL, Shen MR, Kung ML, Chuang LM and Chen YW: Selective serotonin reuptake inhibitor, fluoxetine, impairs E-cadherin-mediated cell adhesion and alters calcium homeostasis in pancreatic beta cells. Sci Rep. 7(3515)2017.PubMed/NCBI View Article : Google Scholar

54 

Tharmaraja T, Stahl D, Hopkins CWP, Persaud SJ, Jones PM, Ismail K and Moulton CD: The association between selective serotonin reuptake inhibitors and glycemia: A systematic review and meta-analysis of randomized controlled trials. Psychosom Med. 81:570–583. 2019.PubMed/NCBI View Article : Google Scholar

55 

Ye Z, Chen L, Yang Z, Li Q, Huang Y, He M, Zhang S, Zhang Z, Wang X, Zhao W, et al: Metabolic effects of fluoxetine in adults with type 2 diabetes mellitus: A meta-analysis of randomized placebo-controlled trials. PLoS One. 6(e21551)2011.PubMed/NCBI View Article : Google Scholar

56 

Liu B, Ruz-Maldonado I, Toczyska K, Olaniru OE, Zariwala MG, Hopkins D, Zhao M and Persaud SJ: The selective serotonin reuptake inhibitor fluoxetine has direct effects on beta cells, promoting insulin secretion and increasing beta-cell mass. Diabetes Obes Metab. 24:2038–2050. 2022.PubMed/NCBI View Article : Google Scholar

57 

Flandreau EI, Bourke CH, Ressler KJ, Vale WW, Nemeroff CB and Owens MJ: Escitalopram alters gene expression and HPA axis reactivity in rats following chronic overexpression of corticotropin-releasing factor from the central amygdala. Psychoneuroendocrinology. 38:1349–1361. 2013.PubMed/NCBI View Article : Google Scholar

58 

Hansen CH, Larsen LW, Sørensen AM, Halling-Sørensen B and Styrishave B: The six most widely used selective serotonin reuptake inhibitors decrease androgens and increase estrogens in the H295R cell line. Toxicol In Vitro. 41:1–11. 2017.PubMed/NCBI View Article : Google Scholar

59 

Nikisch G, Mathé AA, Czernik A, Thiele J, Bohner J, Eap CB, Agren H and Baumann P: Long-term citalopram administration reduces responsiveness of HPA axis in patients with major depression: Relationship with S-citalopram concentrations in plasma and cerebrospinal fluid (CSF) and clinical response. Psychopharmacology (Berl). 181:751–760. 2005.PubMed/NCBI View Article : Google Scholar

60 

Jørgensen H, Knigge U, Kjær A, Møller M and Warberg J: Serotonergic stimulation of corticotropin-releasing hormone and pro-opiomelanocortin gene expression. J Neuroendocrinol. 14:788–795. 2002.PubMed/NCBI View Article : Google Scholar

61 

Durell N, Franks R, Coon S, Cowart K and Carris NW: Effect of antidepressants on glucagon-like peptide-1 receptor agonist-related weight loss. J Pharm Technol. 38:283–288. 2022.PubMed/NCBI View Article : Google Scholar

62 

Ilgin S, Kilic G, Baysal M, Kilic V, Korkut B, Ucarcan S and Atli O: Citalopram induces reproductive toxicity in male rats. Birth Defects Res. 109:475–485. 2017.PubMed/NCBI View Article : Google Scholar

63 

Prasad P, Ogawa S and Parhar IS: Serotonin reuptake inhibitor citalopram inhibits GnRH synthesis and spermatogenesis in the male zebrafish. Biol Reprod. 93(102)2015.PubMed/NCBI View Article : Google Scholar

64 

Koyuncu H, Serefoglu EC, Yencilek E, Atalay H, Akbas NB and Sarıca K: Escitalopram treatment for premature ejaculation has a negative effect on semen parameters. Int J Impot Res. 23:257–261. 2011.PubMed/NCBI View Article : Google Scholar

65 

Sanchez C, Reines EH and Montgomery SA: A comparative review of escitalopram, paroxetine, and sertraline: Are they all alike? Int Clin Psychopharmacol. 29:185–196. 2014.PubMed/NCBI View Article : Google Scholar

66 

Pastoor D and Gobburu J: Clinical pharmacology review of escitalopram for the treatment of depression. Expert Opin Drug Metab Toxicol. 10:121–128. 2014.PubMed/NCBI View Article : Google Scholar

67 

Wu C, Gong WG, Wang YJ, Sun JJ, Zhou H, Zhang ZJ and Ren QG: Escitalopram alleviates stress-induced Alzheimer's disease-like tau pathologies and cognitive deficits by reducing hypothalamic-pituitary-adrenal axis reactivity and insulin/GSK-3β signal pathway activity. Neurobiol Aging. 67:137–147. 2018.PubMed/NCBI View Article : Google Scholar

68 

Benatti C, Alboni S, Blom JMC, Mendlewicz J, Tascedda F and Brunello N: Molecular changes associated with escitalopram response in a stress-based model of depression. Psychoneuroendocrinology. 87:74–82. 2018.PubMed/NCBI View Article : Google Scholar

69 

Ronaldson A, Carvalho LA, Kostich K, Lazzarino AI, Urbanova L and Steptoe A: The effects of six-day SSRI administration on diurnal cortisol secretion in healthy volunteers. Psychopharmacology (Berl). 235:3415–3422. 2018.PubMed/NCBI View Article : Google Scholar

70 

Tafet GE and Nemeroff CB: Pharmacological treatment of anxiety disorders: The role of the HPA axis. Front Psychiatry. 11(443)2020.PubMed/NCBI View Article : Google Scholar

71 

Knorr U, Vinberg M, Gether U, Winkel P, Gluud C, Wetterslev J and Kessing LV: The effect of escitalopram versus placebo on perceived stress and salivary cortisol in healthy first-degree relatives of patients with depression-A randomised trial. Psychiatry Res. 200:354–360. 2012.PubMed/NCBI View Article : Google Scholar

72 

Bourke CH, Stowe ZN, Neigh GN, Olson DE and Owens MJ: Prenatal exposure to escitalopram and/or stress in rats produces limited effects on endocrine, behavioral, or gene expression measures in adult male rats. Neurotoxicol Teratol. 39:100–109. 2013.PubMed/NCBI View Article : Google Scholar

73 

Schroeder JW, Smith AK, Brennan PA, Conneely KN, Kilaru V, Knight BT, Newport DJ, Cubells JF and Stowe ZN: DNA methylation in neonates born to women receiving psychiatric care. Epigenetics. 7:409–414. 2012.PubMed/NCBI View Article : Google Scholar

74 

Nevels RM, Gontkovsky ST and Williams BE: Paroxetine-the antidepressant from hell? Probably not, but caution required. Psychopharmacol Bull. 46:77–104. 2016.PubMed/NCBI

75 

Bourin M, Chue P and Guillon Y: Paroxetine: A review. CNS Drug Rev. 7:25–47. 2001.PubMed/NCBI View Article : Google Scholar

76 

Jacobsen NW, Hansen CH, Nellemann C, Styrishave B and Halling-Sørensen B: Effects of selective serotonin reuptake inhibitors on three sex steroids in two versions of the aromatase enzyme inhibition assay and in the H295R cell assay. Toxicol In Vitro. 29:1729–1735. 2015.PubMed/NCBI View Article : Google Scholar

77 

Jing E and Straw-Wilson K: Sexual dysfunction in selective serotonin reuptake inhibitors (SSRIs) and potential solutions: A narrative literature review. Ment Health Clin. 6:191–196. 2016.PubMed/NCBI View Article : Google Scholar

78 

Ulker N, Yardimci A, Kaya Tektemur N, Colakoglu N, Ozcan M, Canpolat S and Kelestimur H: Chronic exposure to paroxetine or bupropion modulates the pubertal maturation and the reproductive system in female rats. Reprod Biol. 20:154–163. 2020.PubMed/NCBI View Article : Google Scholar

79 

Singh HK and Saadabadi A: Sertraline. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2023.

80 

Fuller RW, Hemrick-Luecke SK, Littlefield ES and Audia JE: Comparison of desmethylsertraline with sertraline as a monoamine uptake inhibitor in vivo. Prog Neuropsychopharmacol Biol Psychiatry. 19:135–149. 1995.PubMed/NCBI View Article : Google Scholar

81 

López-Muñoz F and Alamo C: Active metabolites as antidepressant drugs: The role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders. Front Psychiatry. 4(102)2013.PubMed/NCBI View Article : Google Scholar

82 

Rothmore J: Antidepressant-induced sexual dysfunction. Med J Aust. 212:329–334. 2020.PubMed/NCBI View Article : Google Scholar

83 

Lyons DJ, Ammari R, Hellysaz A and Broberger C: Serotonin and antidepressant SSRIs inhibit rat neuroendocrine dopamine neurons: Parallel actions in the lactotrophic axis. J Neurosci. 36:7392–7406. 2016.PubMed/NCBI View Article : Google Scholar

84 

Munkboel CH, Larsen LW, Weisser JJ, Møbjerg Kristensen D and Styrishave B: Sertraline suppresses testis and adrenal steroid production and steroidogenic gene expression while increasing LH in plasma of male rats resulting in compensatory hypogonadism. Toxicol Sci. 163:609–619. 2018.PubMed/NCBI View Article : Google Scholar

85 

Gregorian RS, Golden KA, Bahce A, Goodman C, Kwong WJ and Khan ZM: Antidepressant-induced sexual dysfunction. Ann Pharmacother. 36:1577–1589. 2002.PubMed/NCBI View Article : Google Scholar

86 

Hamdi H: The preventive role of wheat germ oil against sertraline-induced testicular damage in male albino rats. Andrologia. 51(e13369)2019.PubMed/NCBI View Article : Google Scholar

87 

Van der Paal J, Neyts EC, Verlackt CCW and Bogaerts A: Effect of lipid peroxidation on membrane permeability of cancer and normal cells subjected to oxidative stress. Chem Sci. 7:489–498. 2016.PubMed/NCBI View Article : Google Scholar

88 

Atli O, Baysal M, Aydogan-Kilic G, Kilic V, Ucarcan S, Karaduman B and Ilgin S: Sertraline-induced reproductive toxicity in male rats: Evaluation of possible underlying mechanisms. Asian J Androl. 19:672–679. 2017.PubMed/NCBI View Article : Google Scholar

89 

Pinney SE and Simmons RA: Epigenetic mechanisms in the development of type 2 diabetes. Trends Endocrinol Metab. 21:223–229. 2010.PubMed/NCBI View Article : Google Scholar

90 

De Long NE, Gutgesell MK, Petrik JJ and Holloway AC: Fetal exposure to sertraline hydrochloride impairs pancreatic β-cell development. Endocrinology. 156:1952–1957. 2015.PubMed/NCBI View Article : Google Scholar

91 

Benfield P and Ward A: Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs. 32:313–334. 1986.PubMed/NCBI View Article : Google Scholar

92 

Sukhatme VP, Reiersen AM, Vayttaden SJ and Sukhatme VV: Fluvoxamine: A review of its mechanism of action and its role in COVID-19. Front Pharmacol. 12(652688)2021.PubMed/NCBI View Article : Google Scholar

93 

Anderson IM, Deakin JF and Miller HE: The effect of chronic fluvoxamine on hormonal and psychological responses to buspirone in normal volunteers. Psychopharmacology (Berl). 128:74–82. 1996.PubMed/NCBI View Article : Google Scholar

94 

Rinne T, de Kloet ER, Wouters L, Goekoop JG, de Rijk RH and van den Brink W: Fluvoxamine reduces responsiveness of HPA axis in adult female BPD patients with a history of sustained childhood abuse. Neuropsychopharmacol. 28:126–132. 2003.PubMed/NCBI View Article : Google Scholar

95 

Oishi A, Mochizuki Y, Otsu R and Inaba N: Pilot study of fluvoxamine treatment for climacteric symptoms in Japanese women. Biopsychosoc Med. 1(12)2007.PubMed/NCBI View Article : Google Scholar

96 

Ishibashi Y, Izumo N, Iwata K, Morikawa T, Kameyama T, Watanabe Y, Manabe T and Matsuzaki H: Research and Report Fluvoxamine reverses estrogen-dependent decline in voluntary activities and decreased amygdala levels of serotonin in ovariectomized rats. J Brain Sci. 46:5–19. 2016.

97 

Cella S, Pen̄alva A, Locatelli V, Novelli A, Cocchi D and Müller EE: Neuroendocrine studies with fluvoxamine: Animal data. Br J Clin Pharmacol. 15 (Suppl 3):357S–364S. 1983.PubMed/NCBI View Article : Google Scholar

98 

Hosoi T, Miyahara T, Kayano T, Yokoyama S and Ozawa K: Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance. Front Endocrinol (Lausanne). 3(12)2012.PubMed/NCBI View Article : Google Scholar

99 

Obradovic M, Sudar-Milovanovic E, Soskic S, Essack M, Arya S, Stewart AJ, Gojobori T and Isenovic ER: Leptin and obesity: Role and clinical implication. Front Endocrinol (Lausanne). 12(585887)2021.PubMed/NCBI View Article : Google Scholar

100 

Kotkowska Z and Strzelecki D: Depression and autoimmune hypothyroidism-their relationship and the effects of treating psychiatric and thyroid disorders on changes in clinical and biochemical parameters including BDNF and other cytokines-A systematic review. Pharmaceuticals (Basel). 15(391)2022.PubMed/NCBI View Article : Google Scholar

101 

Caye A, Pilz LK, Maia AL, Hidalgo MP, Furukawa TA and Kieling C: The impact of selective serotonin reuptake inhibitors on the thyroid function among patients with major depressive disorder: A systematic review and meta-analysis. Eur Neuropsychopharmacol. 33:139–145. 2020.PubMed/NCBI View Article : Google Scholar

102 

Baumgartner A, Dubeyko M, Campos-Barros A, Eravci M and Meinhold H: Subchronic administration of fluoxetine to rats affects triiodothyronine production and deiodination in regions of the cortex and in the limbic forebrain. Brain Res. 635:68–74. 1994.PubMed/NCBI View Article : Google Scholar

103 

de Carvalho GA, Bahls SC, Boeving A and Graf H: Effects of selective serotonin reuptake inhibitors on thyroid function in depressed patients with primary hypothyroidism or normal thyroid function. Thyroid. 19:691–697. 2009.PubMed/NCBI View Article : Google Scholar

104 

Eker SS, Akkaya C, Ersoy C, Sarandol A and Kirli S: Reversible escitalopram-induced hypothyroidism. Gen Hosp Psychiatry. 32:559.e5–e7. 2010.PubMed/NCBI View Article : Google Scholar

105 

Takahashi M, Sawayama E, Sawayama T and Miyaoka H: Reversible paroxetine-induced symptomatic hypothyroidism. Pharmacopsychiatry. 40:201–202. 2007.PubMed/NCBI View Article : Google Scholar

106 

Cooper-Kazaz R and Lerer B: Efficacy and safety of triiodothyronine supplementation in patients with major depressive disorder treated with specific serotonin reuptake inhibitors. Int J Neuropsychopharmacol. 11:685–699. 2008.PubMed/NCBI View Article : Google Scholar

107 

Hage M and Azar ST: The link between thyroid function and depression. J Thyroid Res. 2012(590648)2012.PubMed/NCBI View Article : Google Scholar

108 

Jackson IM: Does thyroid hormone have a role as adjunctive therapy in depression? Thyroid. 6:63–7. 1996.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ruiz-Santiago C, Rodríguez-Pinacho CV, Pérez-Sánchez G and Acosta-Cruz E: Effects of selective serotonin reuptake inhibitors on endocrine system (Review). Biomed Rep 21: 128, 2024.
APA
Ruiz-Santiago, C., Rodríguez-Pinacho, C.V., Pérez-Sánchez, G., & Acosta-Cruz, E. (2024). Effects of selective serotonin reuptake inhibitors on endocrine system (Review). Biomedical Reports, 21, 128. https://doi.org/10.3892/br.2024.1816
MLA
Ruiz-Santiago, C., Rodríguez-Pinacho, C. V., Pérez-Sánchez, G., Acosta-Cruz, E."Effects of selective serotonin reuptake inhibitors on endocrine system (Review)". Biomedical Reports 21.3 (2024): 128.
Chicago
Ruiz-Santiago, C., Rodríguez-Pinacho, C. V., Pérez-Sánchez, G., Acosta-Cruz, E."Effects of selective serotonin reuptake inhibitors on endocrine system (Review)". Biomedical Reports 21, no. 3 (2024): 128. https://doi.org/10.3892/br.2024.1816
Copy and paste a formatted citation
x
Spandidos Publications style
Ruiz-Santiago C, Rodríguez-Pinacho CV, Pérez-Sánchez G and Acosta-Cruz E: Effects of selective serotonin reuptake inhibitors on endocrine system (Review). Biomed Rep 21: 128, 2024.
APA
Ruiz-Santiago, C., Rodríguez-Pinacho, C.V., Pérez-Sánchez, G., & Acosta-Cruz, E. (2024). Effects of selective serotonin reuptake inhibitors on endocrine system (Review). Biomedical Reports, 21, 128. https://doi.org/10.3892/br.2024.1816
MLA
Ruiz-Santiago, C., Rodríguez-Pinacho, C. V., Pérez-Sánchez, G., Acosta-Cruz, E."Effects of selective serotonin reuptake inhibitors on endocrine system (Review)". Biomedical Reports 21.3 (2024): 128.
Chicago
Ruiz-Santiago, C., Rodríguez-Pinacho, C. V., Pérez-Sánchez, G., Acosta-Cruz, E."Effects of selective serotonin reuptake inhibitors on endocrine system (Review)". Biomedical Reports 21, no. 3 (2024): 128. https://doi.org/10.3892/br.2024.1816
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