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Article

Study of the association between thyroid dysfunction and serum lipid abnormalities

  • Authors:
    • Ibrahim Al‑Odat
    • Saad Al‑Fawaeir
    • Malik H. Al‑Mahmoud
  • View Affiliations / Copyright

    Affiliations: Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, Jadara University, Irbid 21110, Jordan, Department of Endocrinology, Saudi German Hospital Dubai, Dubai 391093, UAE
  • Article Number: 138
    |
    Published online on: July 31, 2024
       https://doi.org/10.3892/br.2024.1826
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Abstract

The prevalence of thyroid dysfunction is increasing, often leading to unfavorable alterations in lipid profiles. Dyslipidemia is a risk factor for cardiovascular disease. The present study aimed to assess the prevalence of thyroid dysfunction and examine its effects on serum lipid profiles among Jordanians. A total of 228 subjects were recruited and divided into two groups: patients with thyroid dysfunction (n=178, mean age=52.6±9.8 years) and a control group (n=50, mean age=51.7±9.2 years). Serum thyroid‑stimulating hormone, free thyroxine 4, free triiodothyronine 3, total cholesterol (TC), low‑density lipoprotein (LDL), high‑density lipoprotein and triglycerides (TG) were measured. Results showed that thyroid dysfunction was diagnosed in 75% of participants, with an increased frequency among females. The prevalence of overt hypothyroidism was 17.4%, subclinical hypothyroidism was 43.8%, overt hyperthyroidism was 18.4% and subclinical hyperthyroidism was 20.4%. There was a significant association between hypothyroidism and elevated TC (>200 mg/dl), LDL (>130 mg/dl) and TG (>200 mg/dl; P<0.05). Among the hypothyroid patients, 48.4% had hypercholesterolemia and 32.3% had hypertriglyceridemia. In conclusion, public screening and education are necessary to combat thyroid dysfunction. There is a notable link between thyroid dysfunction and lipid abnormalities, necessitating regular monitoring for dyslipidemia and cardiovascular disease in affected patients.
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Copy and paste a formatted citation
Spandidos Publications style
Al‑Odat I, Al‑Fawaeir S and Al‑Mahmoud MH: Study of the association between thyroid dysfunction and serum lipid abnormalities. Biomed Rep 21: 138, 2024.
APA
Al‑Odat, I., Al‑Fawaeir, S., & Al‑Mahmoud, M.H. (2024). Study of the association between thyroid dysfunction and serum lipid abnormalities. Biomedical Reports, 21, 138. https://doi.org/10.3892/br.2024.1826
MLA
Al‑Odat, I., Al‑Fawaeir, S., Al‑Mahmoud, M. H."Study of the association between thyroid dysfunction and serum lipid abnormalities". Biomedical Reports 21.4 (2024): 138.
Chicago
Al‑Odat, I., Al‑Fawaeir, S., Al‑Mahmoud, M. H."Study of the association between thyroid dysfunction and serum lipid abnormalities". Biomedical Reports 21, no. 4 (2024): 138. https://doi.org/10.3892/br.2024.1826
Copy and paste a formatted citation
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Spandidos Publications style
Al‑Odat I, Al‑Fawaeir S and Al‑Mahmoud MH: Study of the association between thyroid dysfunction and serum lipid abnormalities. Biomed Rep 21: 138, 2024.
APA
Al‑Odat, I., Al‑Fawaeir, S., & Al‑Mahmoud, M.H. (2024). Study of the association between thyroid dysfunction and serum lipid abnormalities. Biomedical Reports, 21, 138. https://doi.org/10.3892/br.2024.1826
MLA
Al‑Odat, I., Al‑Fawaeir, S., Al‑Mahmoud, M. H."Study of the association between thyroid dysfunction and serum lipid abnormalities". Biomedical Reports 21.4 (2024): 138.
Chicago
Al‑Odat, I., Al‑Fawaeir, S., Al‑Mahmoud, M. H."Study of the association between thyroid dysfunction and serum lipid abnormalities". Biomedical Reports 21, no. 4 (2024): 138. https://doi.org/10.3892/br.2024.1826
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