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Mortality rate analysis of patients on invasive mechanical ventilation in the intensive care unit on day 28

  • Authors:
    • Song Zhong
    • Haohao Yang
    • Zheren Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Intensive Care Unit, Renhe Hospital, Shanghai 200431, P.R. China
    Copyright: © Zhong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 140
    |
    Published online on: August 1, 2024
       https://doi.org/10.3892/br.2024.1828
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Abstract

Outcomes in patients receiving invasive mechanical ventilation (IMV) are currently unclear. The present study aimed to explore the prognostic factors of the mortality rate on day 28 in patients treated in the intensive care unit (ICU) and undergoing IMV. The IMV Mortality Prediction Score (IMPRES) of 129 patients in the ICU receiving IMV after emergency (or selective) endotracheal intubation from March 2018 to August 2020 was calculated. The patients were divided into survival (n=73) and death groups (n=56) on day 28. The predictive factors of independent and combined mortality rates were determined using a receiver operating characteristic (ROC) curve and the area under the ROC curve (AUC). The AUC of the IMPRES for predicting patient death on day 28 was 0.785 (95% confidence interval (CI): 0.704‑0.864, P<0.01). When the IMPRES cut‑off was 4.50, the Youden index was at its maximum (0.487) with a sensitivity of 85.7% and a specificity of 63.0%. The AUC of the ventilator use time (days) at 12.5 days cut‑off was 0.653 (95% CI: 0.56‑0.746, P<0.01), the Youden index was 0.235 with a sensitivity of 52.1% and a specificity of 71.4%. The AUC of the IMPRES combined with the duration of ventilator use was 0.856 (95% CI: 0.789‑0.922, P<0.001), the Youden index was 0.635 with a sensitivity of 84.9% and a specificity of 78.6%. The IMPRES was observed to be the main factor influencing the mortality rate of patients receiving IMV at the ICU on day 28, and the IMPRES combined with the duration of ventilator use had a significant predictive value for the 28‑day mortality rates of these patients.
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Copy and paste a formatted citation
Spandidos Publications style
Zhong S, Yang H and Zhao Z: Mortality rate analysis of patients on invasive mechanical ventilation in the intensive care unit on day 28. Biomed Rep 21: 140, 2024.
APA
Zhong, S., Yang, H., & Zhao, Z. (2024). Mortality rate analysis of patients on invasive mechanical ventilation in the intensive care unit on day 28. Biomedical Reports, 21, 140. https://doi.org/10.3892/br.2024.1828
MLA
Zhong, S., Yang, H., Zhao, Z."Mortality rate analysis of patients on invasive mechanical ventilation in the intensive care unit on day 28". Biomedical Reports 21.4 (2024): 140.
Chicago
Zhong, S., Yang, H., Zhao, Z."Mortality rate analysis of patients on invasive mechanical ventilation in the intensive care unit on day 28". Biomedical Reports 21, no. 4 (2024): 140. https://doi.org/10.3892/br.2024.1828
Copy and paste a formatted citation
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Spandidos Publications style
Zhong S, Yang H and Zhao Z: Mortality rate analysis of patients on invasive mechanical ventilation in the intensive care unit on day 28. Biomed Rep 21: 140, 2024.
APA
Zhong, S., Yang, H., & Zhao, Z. (2024). Mortality rate analysis of patients on invasive mechanical ventilation in the intensive care unit on day 28. Biomedical Reports, 21, 140. https://doi.org/10.3892/br.2024.1828
MLA
Zhong, S., Yang, H., Zhao, Z."Mortality rate analysis of patients on invasive mechanical ventilation in the intensive care unit on day 28". Biomedical Reports 21.4 (2024): 140.
Chicago
Zhong, S., Yang, H., Zhao, Z."Mortality rate analysis of patients on invasive mechanical ventilation in the intensive care unit on day 28". Biomedical Reports 21, no. 4 (2024): 140. https://doi.org/10.3892/br.2024.1828
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