Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
November-2024 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2024 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Massive chylous pleural effusion and protein‑losing enteropathy caused by mesenteric panniculitis: A case report

  • Authors:
    • Yasutaka Nakazawa
    • Mitsuaki Ishida
    • Kazuomi Sekine
    • Fumio Shimada
    • Tomio Suzuki
    • Yoshinobu Hirose
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569‑8686, Japan, Department of General Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569‑8686, Japan
    Copyright: © Nakazawa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 148
    |
    Published online on: August 19, 2024
       https://doi.org/10.3892/br.2024.1836
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Mesenteric panniculitis (MP), also known as sclerosing mesenteritis, is a rare idiopathic condition characterised by chronic inflammation and fibrosis in the mesentery. While small amounts of chylous ascites due to lymph drainage obstruction are not rare in patients with MP, massive ascites is a rare complication. Moreover, protein‑losing enteropathy (PLE), a rare intestinal condition of uncompensated plasma protein loss, can occur in patients with MP. To the best of our knowledge, the present study is the first to report MP with massive chylous pleural effusion and PLE in a 56‑year‑old male presenting with dyspnoea at Osaka Medical and Pharmaceutical University Hospital (Osaka, Japan) in March 2023. Approximately 5 years prior, the patient noticed systemic oedema, transient abdominal pain and fever and weight loss, and was diagnosed with chylous ascites and PLE by abdominal paracentesis and endoscopic examination of the small intestine. Although initial prednisolone (20 mg/day) administration improved the oedema gradual and uncontrolled fluid buildup was observed. Computed tomography revealed pneumothorax, bilateral massive pleural effusion, and pneumonia. Despite extensive antibiotic therapy [voriconazole (300 mg, twice/day), Ampicillin/Sulbactam (3 g x 4/day), and Vancomycin (1,000 mg x 2/day)], the patient succumbed to respiratory failure 1 month later. Autopsy revealed massive chylous ascites, pleural effusion and the presence of thickened and calcified nodules in the mesentery. Histopathological examination showed diffuse fat necrosis with fibrosclerosis, calcification and lymphocytic infiltration within the mesentery. Therefore, a definitive diagnosis of MP was made. The present case highlighted the importance of considering MP as a differential diagnosis in cases of concurrent chylous ascites, pleural effusion and PLE in patients with abdominal pain, fever and weight loss.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Sharma P, Yadav S, Needham CM and Feuerstadt P: Sclerosing mesenteritis: A systematic review of 192 cases. Clin J Gastroenterol. 10:103–111. 2017.PubMed/NCBI View Article : Google Scholar

2 

Emory TS, Monihan JM, Carr NJ and Sobin LH: Sclerosing mesenteritis, mesenteric panniculitis and mesenteric lipodystrophy: A single entity? Am J Surg Pathol. 21:392–398. 1997.PubMed/NCBI View Article : Google Scholar

3 

Ogden WW II, Bradburn DM and Rives JD: Mesenteric panniculitis: Review of 27 cases. Ann Surg. 161:864–875. 1965.PubMed/NCBI View Article : Google Scholar

4 

Akram S, Pardi DS, Schaffner JA and Smyrk TC: Sclerosing mesenteritis: Clinical features, treatment, and outcome in ninety-two patients. Clin Gastroenterol Hepatol. 5:589–596. 2007.PubMed/NCBI View Article : Google Scholar

5 

Arora M and Dubin E: A clinical case study: Sclerosing mesenteritis presenting as chylous ascites. Medscape J Med. 10(30)2008.PubMed/NCBI

6 

Ehrenpreis ED, Boiskin I and Schaefer K: Chylous ascites in a patient with mesenteric panniculits. J Clin Gastroenterol. 42:327–328. 2008.PubMed/NCBI View Article : Google Scholar

7 

Lim HW and Sultan KS: Sclerosing mesenteritis causing chylous ascites and small bowel perforation. Am J Case Rep. 18:696–699. 2017.PubMed/NCBI View Article : Google Scholar

8 

Rice BL, Stoller JK and Heresi GA: Transudative chylothorax associated with sclerosing mesenteritis. Respir Care. 55:475–477. 2010.PubMed/NCBI

9 

Kobayashi H, Notohara K, Otsuka T, Kobayashi Y, Ujita M, Yoshioka Y, Suzuki N, Aoyagi R, Ohashi R and Suzuki T: An autopsy case of mesenteric panniculitis with massive pleural effusions. Am J Case Rep. 19:13–20. 2018.PubMed/NCBI View Article : Google Scholar

10 

Ozen A and Lenardo MJ: Protein-losing enteropathy. N Engl J Med. 389:733–748. 2023.PubMed/NCBI View Article : Google Scholar

11 

Strober and Fuss IJ: Protein-losing enteropathies. In: Mestecky J, Strober W, Russell MW, eds. Mucosal Immunology. 4th ed. Academic Press, Boston, 1667-1694, 2015.

12 

Höring E, Hingerl T, Hens K, von Gaisberg U and Kieninger G: Protein-losing enteropathy: First manifestation of sclerosing mesenteritis. Eur J Gastroenterol Hepatol. 7:481–483. 1995.PubMed/NCBI

13 

Rajendran B and Duerksen DR: Retractile mesenteritis presenting as protein-losing gastroenteropathy. Can J Gastroenterol. 20:787–789. 2006.PubMed/NCBI View Article : Google Scholar

14 

Kida T, Suzuki K, Matsuyama T, Okita M, Isozaki Y, Matsumoto N, Miki S, Nagao Y, Kawabata K, Kohno M and Oyamada H: Sclerosing mesenteritis presenting as protein-losing enteropathy: A fatal case. Intern Med. 50:2845–2849. 2011.PubMed/NCBI View Article : Google Scholar

15 

Endo K, Moroi R, Sugimura M, Fujishima F, Naitoh T, Tanaka N, Shiga H, Kakuta Y, Takahashi S, Kinouchi Y and Shimosegawa T: Refractory sclerosing mesenteritis involving the small intestinal mesentery: A case report and literature review. Intern Med. 53:1419–1427. 2014.PubMed/NCBI View Article : Google Scholar

16 

Rispo A, Sica M, Bucci L, Musto D, Camera L, Ciancia G, Luglio G and Caporaso N: Protein-losing enteropathy in sclerosing mesenteritis. Eur Rev Med Pharmacol Sci. 19:477–480. 2015.PubMed/NCBI

17 

Saito Y, Hiramatsu K, Nosaka T, Ozaki Y, Takahashi K, Naito T, Ofuji K, Matsuda H, Ohtani M, Nemoto T, et al: A case of protein-losing enteropathy caused by sclerosing mesenteritis diagnosed with capsule endoscopy and double-balloon endoscopy. Clin J Gastroenterol. 10:351–356. 2017.PubMed/NCBI View Article : Google Scholar

18 

Ordóñez NG: Podoplanin: A novel diagnostic immunohistochemical marker. Adv Anat Pathol. 13:83–88. 2006.PubMed/NCBI View Article : Google Scholar

19 

Liu Z, Jiao Y, He L, Wang H and Wang D: A rare case report of immunoglobulin G4-related sclerosing mesenteritis and review of the literature. Medicine (Baltimore). 99(e22579)2020.PubMed/NCBI View Article : Google Scholar

20 

Avincsal MO, Otani K, Kanzawa M, Fujikura K, Jimbo N, Morinaga Y, Hirose T, Itoh T and Zen Y: Sclerosing mesenteritis: A real manifestation or histological mimic of IgG4-related disease? Pathol Int. 66:158–163. 2016.PubMed/NCBI View Article : Google Scholar

21 

Wang H, Zhao Z, Cao Q and Ning J: A review of 17 cases of mesenteric panniculitis in Zhengzhou ninth people's hospital in China. BMC Gastroenterol. 24(48)2024.PubMed/NCBI View Article : Google Scholar

22 

Cardenas A, Kelleher T and Chopra S: Review article: Hepatic hydrothorax. Aliment Pharmacol Ther. 20:271–279. 2004.PubMed/NCBI View Article : Google Scholar

23 

Roussos A, Philippou N, Mantzaris GJ and Gourgouliannis KI: Hepatic hydrothorax: Pathophysiology diagnosis and management. J Gastroenterol Hepatol. 22:1388–1393. 2007.PubMed/NCBI View Article : Google Scholar

24 

Huggins JT, Sahn SA, Heidecker J, Ravenel JG and Doelken P: Characteristics of trapped lung: Pleural fluid analysis, manometry, and air-contrast chest CT. Chest. 131:206–213. 2007.PubMed/NCBI View Article : Google Scholar

25 

Owen SC, Bersabe DR, Skabelund AJ, McCann ET and Morris MJ: Transudative chylothorax from cirrhosis complicated by lung entrapment. Respir Med Case Rep. 28(100243)2016.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nakazawa Y, Ishida M, Sekine K, Shimada F, Suzuki T and Hirose Y: Massive chylous pleural effusion and protein‑losing enteropathy caused by mesenteric panniculitis: A case report. Biomed Rep 21: 148, 2024.
APA
Nakazawa, Y., Ishida, M., Sekine, K., Shimada, F., Suzuki, T., & Hirose, Y. (2024). Massive chylous pleural effusion and protein‑losing enteropathy caused by mesenteric panniculitis: A case report. Biomedical Reports, 21, 148. https://doi.org/10.3892/br.2024.1836
MLA
Nakazawa, Y., Ishida, M., Sekine, K., Shimada, F., Suzuki, T., Hirose, Y."Massive chylous pleural effusion and protein‑losing enteropathy caused by mesenteric panniculitis: A case report". Biomedical Reports 21.5 (2024): 148.
Chicago
Nakazawa, Y., Ishida, M., Sekine, K., Shimada, F., Suzuki, T., Hirose, Y."Massive chylous pleural effusion and protein‑losing enteropathy caused by mesenteric panniculitis: A case report". Biomedical Reports 21, no. 5 (2024): 148. https://doi.org/10.3892/br.2024.1836
Copy and paste a formatted citation
x
Spandidos Publications style
Nakazawa Y, Ishida M, Sekine K, Shimada F, Suzuki T and Hirose Y: Massive chylous pleural effusion and protein‑losing enteropathy caused by mesenteric panniculitis: A case report. Biomed Rep 21: 148, 2024.
APA
Nakazawa, Y., Ishida, M., Sekine, K., Shimada, F., Suzuki, T., & Hirose, Y. (2024). Massive chylous pleural effusion and protein‑losing enteropathy caused by mesenteric panniculitis: A case report. Biomedical Reports, 21, 148. https://doi.org/10.3892/br.2024.1836
MLA
Nakazawa, Y., Ishida, M., Sekine, K., Shimada, F., Suzuki, T., Hirose, Y."Massive chylous pleural effusion and protein‑losing enteropathy caused by mesenteric panniculitis: A case report". Biomedical Reports 21.5 (2024): 148.
Chicago
Nakazawa, Y., Ishida, M., Sekine, K., Shimada, F., Suzuki, T., Hirose, Y."Massive chylous pleural effusion and protein‑losing enteropathy caused by mesenteric panniculitis: A case report". Biomedical Reports 21, no. 5 (2024): 148. https://doi.org/10.3892/br.2024.1836
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team