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Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome

  • Authors:
    • Alexander Lopez‑Roblero
    • Eleazar Serrano‑Guzmán
    • Rocío Stephania Guerrero‑Báez
    • Iván Delgado‑Enciso
    • Saúl Gómez‑Manzo
    • Javier Aguilar‑Fuentes
    • Vivían Ovando‑Garay
    • Beatriz Hernández‑Ochoa
    • Iliana Concepción Quezada‑Cruz
    • Noe Lopez‑Lopez
    • Luis Miguel Canseco‑Ávila
  • View Affiliations / Copyright

    Affiliations: Diagnostic and Molecular Biomedicine Laboratory, Faculty of Chemistry Sciences, Campus IV, Autonomous University of Chiapas, Tapachula, Chiapas 30700, México, Cancerology State Institute, Colima State Health Services, Colima 28085, México, Genetic Biochemistry Laboratory, National Institute of Pediatrics, Ministry of Health, México City 04530, México, Faculty of Agricultural Sciences, Autonomous University of Chiapas, Huehuetán, Chiapas 30660, México, Faculty of Medicine, Campus IV, Autonomous University of Chiapas, Tapachula, Chiapas 30700, México, Immunochemistry Laboratory, Children's Hospital of México Federico Gómez, Ministry of Health, México City 06720, México, Faculty of Chemistry Sciences, Campus IV, Autonomous University of Chiapas, Tapachula, Chiapas 30700, México
    Copyright: © Lopez‑Roblero et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 150
    |
    Published online on: August 20, 2024
       https://doi.org/10.3892/br.2024.1838
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Abstract

Acute coronary syndrome (ACS) is a leading cause of mortality worldwide. Several studies have shown that certain single nucleotide polymorphisms (SNPs) are linked to the development of ACS. In particular, C‑reactive protein (CRP) has emerged as an important predictive biomarker for cardiovascular disease. The current study aimed to investigate four polymorphisms of the CRP gene as possible biomarkers for ACS in a sample of 252 individuals (114 patients with ACS and 138 healthy controls) from Southeastern Mexico. Multivariate analysis adjusted for clinical variables showed that the polymorphism 3872CT for the genotype CC/CT [adjusted Odds Ratio (AdOR)=3.78; 95% Confidence Interval (CI): 1.11‑12.92; P=0.034] and the genotype GG/GC of the polymorphisms 2667CG (AdOR=4.82; 95% CI: 1.69‑13.72; P=0.02) were associated with ACS. However, the polymorphisms 3006AC genotype AA/AC and 5237GA genotype GG/GC were not found to be associated in the multivariate analysis with ACS (P>0.05). These results suggested that 3872CC/CT and 2667CC/CG polymorphism of the CRP gene plays a significant role in the development of ACS.
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Copy and paste a formatted citation
Spandidos Publications style
Lopez‑Roblero A, Serrano‑Guzmán E, Guerrero‑Báez R, Delgado‑Enciso I, Gómez‑Manzo S, Aguilar‑Fuentes J, Ovando‑Garay V, Hernández‑Ochoa B, Quezada‑Cruz I, Lopez‑Lopez N, Lopez‑Lopez N, et al: Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome. Biomed Rep 21: 150, 2024.
APA
Lopez‑Roblero, A., Serrano‑Guzmán, E., Guerrero‑Báez, R., Delgado‑Enciso, I., Gómez‑Manzo, S., Aguilar‑Fuentes, J. ... Canseco‑Ávila, L. (2024). Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome. Biomedical Reports, 21, 150. https://doi.org/10.3892/br.2024.1838
MLA
Lopez‑Roblero, A., Serrano‑Guzmán, E., Guerrero‑Báez, R., Delgado‑Enciso, I., Gómez‑Manzo, S., Aguilar‑Fuentes, J., Ovando‑Garay, V., Hernández‑Ochoa, B., Quezada‑Cruz, I., Lopez‑Lopez, N., Canseco‑Ávila, L."Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome". Biomedical Reports 21.5 (2024): 150.
Chicago
Lopez‑Roblero, A., Serrano‑Guzmán, E., Guerrero‑Báez, R., Delgado‑Enciso, I., Gómez‑Manzo, S., Aguilar‑Fuentes, J., Ovando‑Garay, V., Hernández‑Ochoa, B., Quezada‑Cruz, I., Lopez‑Lopez, N., Canseco‑Ávila, L."Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome". Biomedical Reports 21, no. 5 (2024): 150. https://doi.org/10.3892/br.2024.1838
Copy and paste a formatted citation
x
Spandidos Publications style
Lopez‑Roblero A, Serrano‑Guzmán E, Guerrero‑Báez R, Delgado‑Enciso I, Gómez‑Manzo S, Aguilar‑Fuentes J, Ovando‑Garay V, Hernández‑Ochoa B, Quezada‑Cruz I, Lopez‑Lopez N, Lopez‑Lopez N, et al: Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome. Biomed Rep 21: 150, 2024.
APA
Lopez‑Roblero, A., Serrano‑Guzmán, E., Guerrero‑Báez, R., Delgado‑Enciso, I., Gómez‑Manzo, S., Aguilar‑Fuentes, J. ... Canseco‑Ávila, L. (2024). Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome. Biomedical Reports, 21, 150. https://doi.org/10.3892/br.2024.1838
MLA
Lopez‑Roblero, A., Serrano‑Guzmán, E., Guerrero‑Báez, R., Delgado‑Enciso, I., Gómez‑Manzo, S., Aguilar‑Fuentes, J., Ovando‑Garay, V., Hernández‑Ochoa, B., Quezada‑Cruz, I., Lopez‑Lopez, N., Canseco‑Ávila, L."Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome". Biomedical Reports 21.5 (2024): 150.
Chicago
Lopez‑Roblero, A., Serrano‑Guzmán, E., Guerrero‑Báez, R., Delgado‑Enciso, I., Gómez‑Manzo, S., Aguilar‑Fuentes, J., Ovando‑Garay, V., Hernández‑Ochoa, B., Quezada‑Cruz, I., Lopez‑Lopez, N., Canseco‑Ávila, L."Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome". Biomedical Reports 21, no. 5 (2024): 150. https://doi.org/10.3892/br.2024.1838
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