Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
November-2024 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2024 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Advances in ferroptosis in head and neck cancer (Review)

  • Authors:
    • Xinyi Wang
    • Kunpeng Li
    • Teng Song
    • Suliang Xing
    • Wei Wang
    • Yuhui Fang
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Fuyang People's Hospital Affiliated to Bengbu Medical University, Fuyang, Anhui 236000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 151
    |
    Published online on: August 20, 2024
       https://doi.org/10.3892/br.2024.1839
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Ferroptosis is an iron‑dependent form of cell death that was discovered in 2012. It encompasses the coordinated orchestration of three fundamental biological pathways: Iron homeostasis, glutathione regulation and lipid metabolism. Head and neck cancer (HNC) is a heterogeneous group of cancers occurring on the mucosal surfaces of the upper respiratory and digestive tracts. Head and neck squamous cell carcinoma is the most common type of HNC, accounting for >90% of HNC cases, and has high morbidity and mortality rates. Despite improvements in diagnosis and treatment, the 5‑year survival rate hovers at a dismal 50‑60%, with recurrence afflicting nearly 30% of patients, highlighting the inadequacies of currently available treatments. Of note, research exploring the nexus between ferroptosis and HNC remains scarce; however, the present review endeavors to synthesize current knowledge surrounding ferroptosis. The present review elaborated on the normal physiological role of ferroptosis and discussed its potential involvement in HNC pathogenesis. Therapeutic strategies and prognostic paradigms for HNC that target ferroptosis were also reviewed. This review aims to provide direction to catalyze future investigations into ferroptosis in HNC.
View Figures

Figure 1

View References

1 

Bertheloot D, Latz E and Franklin BS: Necroptosis, pyroptosis and apoptosis: An intricate game of cell death. Cell Mol Immunol. 18:1106–1121. 2021.PubMed/NCBI View Article : Google Scholar

2 

Tang D, Kang R, Berghe TV, Vandenabeele P and Kroemer G: The molecular machinery of regulated cell death. Cell Res. 29:347–364. 2019.PubMed/NCBI View Article : Google Scholar

3 

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, et al: Molecular mechanisms of cell death: Recommendations of the nomenclature committee on cell death 2018. Cell Death Differ. 25:486–541. 2018.PubMed/NCBI View Article : Google Scholar

4 

Conradt B: Genetic control of programmed cell death during animal development. Annu Rev Genet. 43:493–523. 2009.PubMed/NCBI View Article : Google Scholar

5 

Zhang X, Huang Z, Xie Z, Chen Y, Zheng Z, Wei X, Huang B, Shan Z, Liu J, Fan S, et al: Homocysteine induces oxidative stress and ferroptosis of nucleus pulposus via enhancing methylation of GPX4. Free Radic Biol Med. 160:552–565. 2020.PubMed/NCBI View Article : Google Scholar

6 

Torti SV and Torti FM: Iron and cancer: More ore to be mined. Nat Rev Cancer. 13:342–355. 2013.PubMed/NCBI View Article : Google Scholar

7 

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, et al: Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 171:273–285. 2017.PubMed/NCBI View Article : Google Scholar

8 

Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R and Tang D: Ferroptosis: Process and function. Cell Death Differ. 23:369–379. 2016.PubMed/NCBI View Article : Google Scholar

9 

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al: Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell. 149:1060–1072. 2012.PubMed/NCBI View Article : Google Scholar

10 

Chen X, Kang R, Kroemer G and Tang D: Broadening horizons: The role of ferroptosis in cancer. Nat Rev Clin Oncol. 18:280–296. 2021.PubMed/NCBI View Article : Google Scholar

11 

Mahoney-Sánchez L, Bouchaoui H, Ayton S, Devos D, Duce JA and Devedjian JC: Ferroptosis and its potential role in the physiopathology of Parkinson's disease. Prog Neurobiol. 196(101890)2021.PubMed/NCBI View Article : Google Scholar

12 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021.PubMed/NCBI View Article : Google Scholar

13 

Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE and Grandis JR: Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 6(92)2020.PubMed/NCBI View Article : Google Scholar

14 

Hammond EC and Horn D: Smoking and death rates: Report on forty-four months of follow-up of 187,783 men. 2. Death rates by cause. J Am Med Assoc. 166:1294–1308. 1958.PubMed/NCBI View Article : Google Scholar

15 

Hashibe M, Brennan P, Benhamou S, Castellsague X, Chen C, Curado MP, Dal Maso L, Daudt AW, Fabianova E, Fernandez L, et al: Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: Pooled analysis in the international head and neck cancer epidemiology consortium. J Natl Cancer Inst. 99:777–789. 2007.PubMed/NCBI View Article : Google Scholar

16 

Mehanna H, Beech T, Nicholson T, El-Hariry I, McConkey C, Paleri V and Roberts S: Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer-systematic review and meta-analysis of trends by time and region. Head Neck. 35:747–755. 2013.PubMed/NCBI View Article : Google Scholar

17 

Canning M, Guo G, Yu M, Myint C, Groves MW, Byrd JK and Cui Y: Heterogeneity of the head and neck squamous cell carcinoma immune landscape and its impact on immunotherapy. Front Cell Dev Biol. 7(52)2019.PubMed/NCBI View Article : Google Scholar

18 

Sturgis EM and Cinciripini PM: Trends in head and neck cancer incidence in relation to smoking prevalence: An emerging epidemic of human papillomavirus-associated cancers? Cancer. 110:1429–1435. 2007.PubMed/NCBI View Article : Google Scholar

19 

Dai E, Han L, Liu J, Xie Y, Kroemer G, Klionsky DJ, Zeh HJ, Kang R, Wang J and Tang D: Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein. Autophagy. 16:2069–2083. 2020.PubMed/NCBI View Article : Google Scholar

20 

Hassannia B, Vandenabeele P and Vanden Berghe T: Targeting ferroptosis to iron out cancer. Cancer Cell. 35:830–849. 2019.PubMed/NCBI View Article : Google Scholar

21 

Mou Y, Wang J, Wu J, He D, Zhang C, Duan C and Li B: Ferroptosis, a new form of cell death: Opportunities and challenges in cancer. J Hematol Oncol. 12(34)2019.PubMed/NCBI View Article : Google Scholar

22 

Raudenská M, Balvan J and Masařík M: Cell death in head and neck cancer pathogenesis and treatment. Cell Death Dis. 12(192)2021.PubMed/NCBI View Article : Google Scholar

23 

Rochette L, Dogon G, Rigal E, Zeller M, Cottin Y and Vergely C: Lipid peroxidation and iron metabolism: Two corner stones in the homeostasis control of ferroptosis. Int J Mol Sci. 24(449)2022.PubMed/NCBI View Article : Google Scholar

24 

Gao G, Li J, Zhang Y and Chang YZ: Cellular iron metabolism and regulation. In: Chang YZ (ed). Brain Iron Metabolism and CNS Diseases. Advances in Experimental Medicine and Biology. Vol 1173. Springer Singapore, Singapore, pp21-32, 2019.

25 

Rochette L, Gudjoncik A, Guenancia C, Zeller M, Cottin Y and Vergely C: The iron-regulatory hormone hepcidin: A possible therapeutic target? Pharmacol Ther. 146:35–52. 2015.PubMed/NCBI View Article : Google Scholar

26 

Fujimaki M, Furuya N, Saiki S, Amo T, Imamichi Y and Hattori N: Iron supply via NCOA4-mediated ferritin degradation maintains mitochondrial functions. Mol Cell Biol. 39:e00010–19. 2019.PubMed/NCBI View Article : Google Scholar

27 

Do MT, Kim HG, Choi JH and Jeong HG: Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents. Free Radic Biol Med. 74:21–34. 2014.PubMed/NCBI View Article : Google Scholar

28 

Wei R, Zhao Y, Wang J, Yang X, Li S, Wang Y, Yang X, Fei J, Hao X, Zhao Y, et al: Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells. Int J Biol Sci. 17:2703–2717. 2021.PubMed/NCBI View Article : Google Scholar

29 

Dalton TP, Chen Y, Schneider SN, Nebert DW and Shertzer HG: Genetically altered mice to evaluate glutathione homeostasis in health and disease. Free Radic Biol Med. 37:1511–1526. 2004.PubMed/NCBI View Article : Google Scholar

30 

Oestreicher J and Morgan B: Glutathione: Subcellular distribution and membrane transport 1. Biochem Cell Biol. 97:270–289. 2019.PubMed/NCBI View Article : Google Scholar

31 

Rochette L and Vergely C: Coronary artery disease: Can aminothiols be distinguished from reactive oxygen species? Nat Rev Cardiol. 13:128–130. 2016.PubMed/NCBI View Article : Google Scholar

32 

Belalcázar AD, Ball JG, Frost LM, Valentovic MA and Wilkinson J IV: Transsulfuration is a significant source of sulfur for glutathione production in human mammary epithelial cells. ISRN Biochem. 2013(637897)2014.PubMed/NCBI View Article : Google Scholar

33 

Wu X, Liu C, Li Z, Gai C, Ding D, Chen W, Hao F and Li W: Regulation of GSK3β/Nrf2 signaling pathway modulated erastin-induced ferroptosis in breast cancer. Mol Cell Biochem. 473:217–228. 2020.PubMed/NCBI View Article : Google Scholar

34 

Yang WS, Kim KJ, Gaschler MM, Patel M, Shchepinov MS and Stockwell BR: Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc Natl Acad Sci USA. 113:E4966–E4975. 2016.PubMed/NCBI View Article : Google Scholar

35 

Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, et al: Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 13:81–90. 2017.PubMed/NCBI View Article : Google Scholar

36 

Tang D, Chen X, Kang R and Kroemer G: Ferroptosis: Molecular mechanisms and health implications. Cell Res. 31:107–125. 2021.PubMed/NCBI View Article : Google Scholar

37 

Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, et al: ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 13:91–98. 2017.PubMed/NCBI View Article : Google Scholar

38 

Mayr L, Grabherr F, Schwärzler J, Reitmeier I, Sommer F, Gehmacher T, Niederreiter L, He GW, Ruder B, Kunz KTR, et al: Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease. Nat Commun. 11(1775)2020.PubMed/NCBI View Article : Google Scholar

39 

Delesderrier E, Monteiro JDC, Freitas S, Pinheiro IC, Batista MS and Citelli M: Can iron and polyunsaturated fatty acid supplementation induce ferroptosis? Cell Physiol Biochem. 57:24–41. 2023.PubMed/NCBI View Article : Google Scholar

40 

Bai Y, Meng L, Han L, Jia Y, Zhao Y, Gao H, Kang R, Wang X, Tang D and Dai E: Lipid storage and lipophagy regulates ferroptosis. Biochem Biophys Res Commun. 508:997–1003. 2019.PubMed/NCBI View Article : Google Scholar

41 

Sun X, Yang S, Feng X, Zheng Y, Zhou J, Wang H, Zhang Y, Sun H and He C: The modification of ferroptosis and abnormal lipometabolism through overexpression and knockdown of potential prognostic biomarker perilipin2 in gastric carcinoma. Gastric Cancer. 23:241–259. 2020.PubMed/NCBI View Article : Google Scholar

42 

Magtanong L, Ko PJ, To M, Cao JY, Forcina GC, Tarangelo A, Ward CC, Cho K, Patti GJ, Nomura DK, et al: Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state. Cell Chem Biol. 26:420–432.e9. 2019.PubMed/NCBI View Article : Google Scholar

43 

Liu Y, Lu S, Wu LL, Yang L, Yang L and Wang J: The diversified role of mitochondria in ferroptosis in cancer. Cell Death Dis. 14(519)2023.PubMed/NCBI View Article : Google Scholar

44 

Li Y, Wu T, Jiao Z and Yang A: BASP1 is up-regulated in tongue squamous cell carcinoma and associated with a poor prognosis. Asian J Surg. 45:1101–1106. 2022.PubMed/NCBI View Article : Google Scholar

45 

Pan X, Xu X, Wang L, Zhang S, Chen Y, Yang R, Chen X, Cheng B, Xia J and Ren X: BASP1 is a prognostic biomarker associated with immunotherapeutic response in head and neck squamous cell carcinoma. Front Oncol. 13(1021262)2023.PubMed/NCBI View Article : Google Scholar

46 

Xu Y, Hong M, Kong D, Deng J, Zhong Z and Liang J: Ferroptosis-associated DNA methylation signature predicts overall survival in patients with head and neck squamous cell carcinoma. BMC Genomics. 23(63)2022.PubMed/NCBI View Article : Google Scholar

47 

Wu C, Liu F, Chen H, Liu Q, Song C, Cheng K, Gao Z and Fan C: Identification of ferroptosis-related lncRNA pairs for predicting the prognosis of head and neck squamous cell carcinoma. J Oncol. 2022(7602482)2022.PubMed/NCBI View Article : Google Scholar

48 

Shi M, Du J, Shi J, Huang Y, Zhao Y and Ma L: Ferroptosis-related gene ATG5 is a novel prognostic biomarker in nasopharyngeal carcinoma and head and neck squamous cell carcinoma. Front Bioeng Biotechnol. 10(1006535)2022.PubMed/NCBI View Article : Google Scholar

49 

Feng Y, Li X, Yang B, Li M, Du Y, Wang J, Liu S, Gong L, Li L and Gao L: The role of ferroptosis in radiotherapy and combination therapy for head and neck squamous cell carcinoma (review). Oncol Rep. 51(79)2024.PubMed/NCBI View Article : Google Scholar

50 

Ma P, Xiao H, Yu C, Liu J, Cheng Z, Song H, Zhang X, Li C, Wang J, Gu Z and Lin J: Enhanced cisplatin chemotherapy by iron oxide nanocarrier-mediated generation of highly toxic reactive oxygen species. Nano Lett. 17:928–937. 2017.PubMed/NCBI View Article : Google Scholar

51 

Feng L, Zhao K, Sun L, Yin X, Zhang J, Liu C and Li B: SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis. J Transl Med. 19(367)2021.PubMed/NCBI View Article : Google Scholar

52 

Xie J, Lan T, Zheng DL, Ding LC and Lu YG: CDH4 inhibits ferroptosis in oral squamous cell carcinoma cells. BMC Oral Health. 23(329)2023.PubMed/NCBI View Article : Google Scholar

53 

Liu F, Tang L, Li Q, Chen L, Pan Y, Yin Z, He J and Tian J: Single-cell transcriptomics uncover the key ferroptosis regulators contribute to cancer progression in head and neck squamous cell carcinoma. Front Mol Biosci. 9(962742)2022.PubMed/NCBI View Article : Google Scholar

54 

Codenotti S, Poli M, Asperti M, Zizioli D, Marampon F and Fanzani A: Cell growth potential drives ferroptosis susceptibility in rhabdomyosarcoma and myoblast cell lines. J Cancer Res Clin Oncol. 144:1717–1730. 2018.PubMed/NCBI View Article : Google Scholar

55 

Sui X, Zhang R, Liu S, Duan T, Zhai L, Zhang M, Han X, Xiang Y, Huang X, Lin H and Xie T: RSL3 drives ferroptosis through GPX4 inactivation and ROS production in colorectal cancer. Front Pharmacol. 9(1371)2018.PubMed/NCBI View Article : Google Scholar

56 

Shin D, Kim EH, Lee J and Roh JL: Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 129:454–462. 2018.PubMed/NCBI View Article : Google Scholar

57 

Li S, Liu Y, Li J, Zhao X and Yu D: Mechanisms of ferroptosis and application to head and neck squamous cell carcinoma treatments. DNA Cell Biol. 40:720–732. 2021.PubMed/NCBI View Article : Google Scholar

58 

Lin R, Zhang Z, Chen L, Zhou Y, Zou P, Feng C, Wang L and Liang G: Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells. Cancer Lett. 381:165–175. 2016.PubMed/NCBI View Article : Google Scholar

59 

Zhu T, Shi L, Yu C, Dong Y, Qiu F, Shen L, Qian Q, Zhou G and Zhu X: Ferroptosis promotes photodynamic therapy: Supramolecular photosensitizer-inducer nanodrug for enhanced cancer treatment. Theranostics. 9:3293–3307. 2019.PubMed/NCBI View Article : Google Scholar

60 

Wang H, Cheng Y, Mao C, Liu S, Xiao D, Huang J and Tao Y: Emerging mechanisms and targeted therapy of ferroptosis in cancer. Mol Ther. 29:2185–2208. 2021.PubMed/NCBI View Article : Google Scholar

61 

Wang W, Green M, Choi JE, Gijón M, Kennedy PD, Johnson JK, Liao P, Lang X, Kryczek I, Sell A, et al: CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 569:270–274. 2019.PubMed/NCBI View Article : Google Scholar

62 

Chen X, Kang R, Kroemer G and Tang D: Ferroptosis in infection, inflammation, and immunity. J Exp Med. 218(e20210518)2021.PubMed/NCBI View Article : Google Scholar

63 

Zhou Z, Liang H, Yang R, Yang Y, Dong J, Di Y and Sun M: Glutathione depletion-induced activation of dimersomes for potentiating the ferroptosis and immunotherapy of ‘cold’ tumor. Angew Chem Int Ed Engl. 61(e202202843)2022.PubMed/NCBI View Article : Google Scholar

64 

Fan X, Fan YT, Zeng H, Dong XQ, Lu M and Zhang ZY: Role of ferroptosis in esophageal cancer and corresponding immunotherapy. World J Gastrointest Oncol. 15:1105–1118. 2023.PubMed/NCBI View Article : Google Scholar

65 

Niu X, Chen L, Li Y, Hu Z and He F: Ferroptosis, necroptosis, and pyroptosis in the tumor microenvironment: Perspectives for immunotherapy of SCLC. Semin Cancer Biol. 86:273–285. 2022.PubMed/NCBI View Article : Google Scholar

66 

Huang Y, Wang S, Ke A and Guo K: Ferroptosis and its interaction with tumor immune microenvironment in liver cancer. Biochim Biophys Acta Rev Cancer. 1878(188848)2023.PubMed/NCBI View Article : Google Scholar

67 

Huang J, Wang J, He H, Huang Z, Wu S, Chen C, Liu W, Xie L, Tao Y, Cong L and Jiang Y: Close interactions between lncRNAs, lipid metabolism and ferroptosis in cancer. Int J Biol Sci. 17:4493–4513. 2021.PubMed/NCBI View Article : Google Scholar

68 

Gao X, Hu W, Qian D, Bai X, He H, Li L and Sun S: The mechanisms of ferroptosis under hypoxia. Cell Mol Neurobiol. 43:3329–3341. 2023.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang X, Li K, Song T, Xing S, Wang W and Fang Y: Advances in ferroptosis in head and neck cancer (Review). Biomed Rep 21: 151, 2024.
APA
Wang, X., Li, K., Song, T., Xing, S., Wang, W., & Fang, Y. (2024). Advances in ferroptosis in head and neck cancer (Review). Biomedical Reports, 21, 151. https://doi.org/10.3892/br.2024.1839
MLA
Wang, X., Li, K., Song, T., Xing, S., Wang, W., Fang, Y."Advances in ferroptosis in head and neck cancer (Review)". Biomedical Reports 21.5 (2024): 151.
Chicago
Wang, X., Li, K., Song, T., Xing, S., Wang, W., Fang, Y."Advances in ferroptosis in head and neck cancer (Review)". Biomedical Reports 21, no. 5 (2024): 151. https://doi.org/10.3892/br.2024.1839
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Li K, Song T, Xing S, Wang W and Fang Y: Advances in ferroptosis in head and neck cancer (Review). Biomed Rep 21: 151, 2024.
APA
Wang, X., Li, K., Song, T., Xing, S., Wang, W., & Fang, Y. (2024). Advances in ferroptosis in head and neck cancer (Review). Biomedical Reports, 21, 151. https://doi.org/10.3892/br.2024.1839
MLA
Wang, X., Li, K., Song, T., Xing, S., Wang, W., Fang, Y."Advances in ferroptosis in head and neck cancer (Review)". Biomedical Reports 21.5 (2024): 151.
Chicago
Wang, X., Li, K., Song, T., Xing, S., Wang, W., Fang, Y."Advances in ferroptosis in head and neck cancer (Review)". Biomedical Reports 21, no. 5 (2024): 151. https://doi.org/10.3892/br.2024.1839
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team