|
1
|
UNAIDS: Global HIV & AIDS
statistics-Fact sheet. 2023.
|
|
2
|
Deeks SG, Lewin SR and Havlir DV: The end
of AIDS: HIV infection as a chronic disease. Lancet. 382:1525–1533.
2013.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Zicari S, Sessa L, Cotugno N, Ruggiero A,
Morrocchi E, Concato C, Rocca S, Zangari P, Manno EC and Palma P:
Immune Activation, Inflammation, and Non-AIDS Co-Morbidities in
HIV-Infected Patients under Long-Term ART. Viruses.
11(200)2019.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Sherman KE and Thomas DL: HIV and liver
disease: A comprehensive update. Top Antivir Med. 30:547–558.
2022.PubMed/NCBI
|
|
5
|
Han WM, Ueaphongsukkit T, Chattranukulchai
P, Siwamogsatham S, Chaiteerakij R, Sophonphan J, Gatechompol S,
Ubolyam S, Phonphithak S, Ruxrungtham K, et al: Incident liver
cirrhosis, associated factors, and cardiovascular disease risks
among people living with HIV: A longitudinal study. J Acquir Immune
Defic Syndr. 86:463–472. 2021.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Sun J, Althoff KN, Jing Y, Horberg MA,
Buchacz K, Gill MJ, Justice AC, Rabkin CS, Goedert JJ, Sigel K, et
al: Trends in Hepatocellular Carcinoma Incidence and Risk Among
Persons With HIV in the US and Canada, 1996-2015. JAMA Netw Open.
4(e2037512)2021.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Torgersen J, Kallan MJ, Carbonari DM, Park
LS, Mehta RL, D'Addeo K, Tate JP, Lim JK, Goetz MB,
Rodriguez-Barradas MC, et al: HIV RNA, CD4+ Percentage, and Risk of
Hepatocellular Carcinoma by Cirrhosis Status. J Natl Cancer Inst.
112:747–755. 2020.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Chamroonkul N and Bansal MB: HIV and the
liver. Nat Rev Gastroenterol Hepatol. 16:1–2. 2019.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Ganesan M, Poluektova LY, Kharbanda KK and
Osna NA: Human immunodeficiency virus and hepatotropic viruses
co-morbidities as the inducers of liver injury progression. World J
Gastroenterol. 25:398–410. 2019.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Sherman KE, Peters MG and Thomas D: Human
immunodeficiency virus and liver disease: A comprehensive update.
Hepatol Commun. 1:987–1001. 2017.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Mohr R, Schierwagen R, Schwarze-Zander C,
Boesecke C, Wasmuth JC, Trebicka J and Rockstroh JK: Liver Fibrosis
in HIV Patients Receiving a Modern cART: Which Factors Play a Role?
Medicine (Baltimore). 94(e2127)2015.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Rivero-Juarez A, Camacho A, Merchante N,
Pérez-Camacho I, Macias J, Ortiz-Garcia C, Cifuentes C,
Torre-Cisneros J, Peña J, Pineda JA, et al: Incidence of liver
damage of uncertain origin in HIV patients not co-infected with
HCV/HBV. PLoS One. 8(e68953)2013.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Sulyok M, Ferenci T, Makara M, Horváth G,
Szlávik J, Rupnik Z, Kormos L, Gerlei Z, Sulyok Z and Vályi-Nagy I:
Hepatic fibrosis and factors associated with liver stiffness in HIV
mono-infected individuals. PeerJ. 5(e2867)2017.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Medrano LM, Garcia-Broncano P, Berenguer
J, González-García J, Jiménez-Sousa MÁ, Guardiola JM, Crespo M,
Quereda C, Sanz J, Canorea I, et al: Elevated liver stiffness is
linked to increased biomarkers of inflammation and immune
activation in HIV/hepatitis C virus-coinfected patients. AIDS.
32:1095–1105. 2018.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Portocarrero Nunez JA, Gonzalez-Garcia J,
Berenguer J, Gallego MJV, Loyarte JAI, Metola L, Bernal E, Navarro
G, Del Amo J and Jarrín I: and the Cohort of the Spanish HIV
Research Network (CoRIS). Impact of co-infection by hepatitis C
virus on immunological and virological response to antiretroviral
therapy in HIV-positive patients. Medicine (Baltimore).
97(e12238)2018.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Kim HN, Newcomb CW, Carbonari DM, Roy JA,
Torgersen J, Althoff KN, Kitahata MM, Reddy KR, Lim JK, Silverberg
MJ, et al: Risk of HCC With Hepatitis B Viremia Among
HIV/HBV-Coinfected Persons in North America. Hepatology.
74:1190–1202. 2021.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Shmagel KV, Saidakova EV, Shmagel NG,
Korolevskaya LB, Chereshnev VA, Robinson J, Grivel JC, Douek DC,
Margolis L, Anthony DD and Lederman MM: Systemic inflammation and
liver damage in HIV/hepatitis C virus coinfection. HIV Med.
17:581–589. 2016.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Shata MTM, Abdel-Hameed EA, Rouster SD, Yu
L, Liang M, Song E, Esser MT, Shire N and Sherman KE: HBV and
HIV/HBV infected patients have distinct immune exhaustion and
apoptotic serum biomarker profiles. Pathog Immun. 4:39–65.
2019.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Lin W, Tsai WL, Shao RX, Wu G, Peng LF,
Barlow LL, Chung WJ, Zhang L, Zhao H, Jang JY and Chung RT:
Hepatitis C virus regulates transforming growth factor beta1
production through the generation of reactive oxygen species in a
nuclear factor kappaB-dependent manner. Gastroenterology.
138:2509–2518, 2518 e1. 2010.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Salloum S, Holmes JA, Jindal R, Bale SS,
Brisac C, Alatrakchi N, Lidofsky A, Kruger AJ, Fusco DN, Luther J,
et al: Exposure to human immunodeficiency virus/hepatitis C virus
in hepatic and stellate cell lines reveals cooperative profibrotic
transcriptional activation between viruses and cell types.
Hepatology. 64:1951–1968. 2016.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Ming D, Yu X, Guo R, Deng Y, Li J, Lin C,
Su M, Lin Z and Su Z: Elevated TGF-β1/IL-31 pathway is associated
with the disease severity of hepatitis B virus-related liver
cirrhosis. Viral Immunol. 28:209–216. 2015.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Akekawatchai C, Sretapunya W,
Pipatsatitpong D and Chuenchit T: Hepatitis B or C virus
coinfection in and risks for transaminitis in human
immunodeficiency virus-infected Thais on combined antiretroviral
therapy. Asian Biomedicine. 9:353–361. 2015.
|
|
23
|
Chiraunyanann T, Changsri K, Sretapunya W,
Yuenyongchaiwat K and Akekawatchai C: CXCL12 G801A polymorphism is
associated with significant liver fibrosis in HIV-infected Thais: A
cross-sectional study. Asian Pac J Allergy Immunol. 37:162–170.
2019.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Foca E, Fabbiani M, Prosperi M, Quiros
Roldan E, Castelli F, Maggiolo F, Di Filippo E, Di Giambenedetto S,
Gagliardini R, Saracino A, et al: Liver fibrosis progression and
clinical outcomes are intertwined: Role of CD4+ T-cell count and
NRTI exposure from a large cohort of HIV/HCV-coinfected patients
with detectable HCV-RNA: A MASTER cohort study. Medicine
(Baltimore). 95(e4091)2016.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Sterling RK, Lissen E, Clumeck N, Sola R,
Correa MC, Montaner J, S Sulkowski M, Torriani FJ, Dieterich DT,
Thomas DL, et al: Development of a simple noninvasive index to
predict significant fibrosis in patients with HIV/HCV coinfection.
Hepatology. 43:1317–1325. 2006.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Wai CT, Greenson JK, Fontana RJ,
Kalbfleisch JD, Marrero JA, Conjeevaram HS and Lok AS: A simple
noninvasive index can predict both significant fibrosis and
cirrhosis in patients with chronic hepatitis C. Hepatology.
38:518–526. 2003.PubMed/NCBI View Article : Google Scholar
|
|
27
|
World Health Organization: Guidelines for
the Care and Treatment of Persons Diagnosed with Chronic Hepatitis
C Virus Infection. 2018.
|
|
28
|
Lowry OH, Rosebrough NJ, Farr AL and
Randall RJ: Protein measurement with the Folin phenol reagent. J
Biol Chem. 193:265–275. 1951.PubMed/NCBI
|
|
29
|
Tyanova S, Temu T and Cox J: The MaxQuant
computational platform for mass spectrometry-based shotgun
proteomics. Nat Protoc. 11:2301–2319. 2016.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Howe EA, Sinha R, Schlauch D and
Quackenbush J: RNA-Seq analysis in MeV. Bioinformatics.
27:3209–3210. 2011.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Pang Z, Zhou G, Ewald J, Chang L, Hacariz
O, Basu N and Xia J: Using MetaboAnalyst 5.0 for LC-HRMS spectra
processing, multi-omics integration and covariate adjustment of
global metabolomics data. Nat Protoc. 17:1735–1761. 2022.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Starruss J, de Back W, Brusch L and
Deutsch A: Morpheus: A user-friendly modeling environment for
multiscale and multicellular systems biology. Bioinformatics.
30:1331–1332. 2014.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Dong H, Xu C, Zhou W, Liao Y, Cao J, Li Z
and Hu B: The combination of 5 serum markers compared to FibroScan
to predict significant liver fibrosis in patients with chronic
hepatitis B virus. Clin Chim Acta. 483:145–150. 2018.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Dewidar B, Meyer C, Dooley S and
Meindl-Beinker AN: TGF-β in hepatic stellate cell activation and
liver fibrogenesis-updated 2019. Cells. 8(1419)2019.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Steele H, Cheng J, Willicut A, Dell G,
Breckenridge J, Culberson E, Ghastine A, Tardif V and Herro R: TNF
superfamily control of tissue remodeling and fibrosis. Front
Immunol. 14(1219907)2023.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Demirkol ME, Aktas G, Bilgin S, Kahveci G,
Kurtkulagi O, Atak BM and Duman TT: C-reactive protein to
lymphocyte count ratio is a promising novel marker in hepatitis C
infection: The clear hep-c study. Rev Assoc Med Bras (1992).
68:838–841. 2022.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Kosekli MA: Mean platelet volume and
platelet to lymphocyte count ratio are associated with hepatitis
B-related liver fibrosis. Eur J Gastroenterol Hepatol. 34:324–327.
2022.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Anamika Markin CJ, Rout MK and
Spyracopoulos L: Molecular basis for impaired DNA damage response
function associated with the RAP80 ∆E81 defect. J Biol Chem.
289:12852–12862. 2014.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Yan J, Kim YS, Yang XP, Li LP, Liao G, Xia
F and Jetten AM: The ubiquitin-interacting motif containing protein
RAP80 interacts with BRCA1 and functions in DNA damage repair
response. Cancer Res. 67:6647–6656. 2007.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Sobhian B, Shao G, Lilli DR, Culhane AC,
Moreau LA, Xia B, Livingston DM and Greenberg RA: RAP80 targets
BRCA1 to specific ubiquitin structures at DNA damage sites.
Science. 316:1198–1202. 2007.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Wang M, Gong Q, Zhang J, Chen L, Zhang Z,
Lu L, Yu D, Han Y, Zhang D, Chen P, et al: Characterization of gene
expression profiles in HBV-related liver fibrosis patients and
identification of ITGBL1 as a key regulator of fibrogenesis. Sci
Rep. 7(43446)2017.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Wu J, Liu C, Chen J and Yu X: RAP80
protein is important for genomic stability and is required for
stabilizing BRCA1-A complex at DNA damage sites in vivo. J Biol
Chem. 287:22919–22926. 2012.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Mei J, Wang R, Xia D, Yang X, Zhou W, Wang
H and Liu C: BRCA1 Is a novel prognostic indicator and associates
with immune cell infiltration in hepatocellular carcinoma. DNA Cell
Biol. 39:1838–1849. 2020.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Lin J, Shi J, Guo H, Yang X, Jiang Y, Long
J, Bai Y, Wang D, Yang X, Wan X, et al: Alterations in DNA damage
repair genes in primary liver cancer. Clin Cancer Res.
25:4701–4711. 2019.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Sturgeon C and Fasano A: Zonulin, a
regulator of epithelial and endothelial barrier functions, and its
involvement in chronic inflammatory diseases. Tissue Barriers.
4(e1251384)2016.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Fasano A: Zonulin and its regulation of
intestinal barrier function: The biological door to inflammation,
autoimmunity, and cancer. Physiol Rev. 91:151–175. 2011.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Calgin MK and Cetinkol Y: Decreased levels
of serum zonulin and copeptin in chronic Hepatitis-B patients. Pak
J Med Sci. 35:847–851. 2019.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Hunt PW, Sinclair E, Rodriguez B, Shive C,
Clagett B, Funderburg N, Robinson J, Huang Y, Epling L, Martin JN,
et al: Gut epithelial barrier dysfunction and innate immune
activation predict mortality in treated HIV infection. J Infect
Dis. 210:1228–1238. 2014.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Voulgaris TA, Karagiannakis D, Hadziyannis
E, Manolakopoulos S, Karamanolis GP, Papatheodoridis G and
Vlachogiannakos J: Serum zonulin levels in patients with liver
cirrhosis: Prognostic implications. World J Hepatol. 13:1394–1404.
2021.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Wang X, Li MM, Niu Y, Zhang X, Yin JB,
Zhao CJ and Wang RT: Serum Zonulin in HBV-Associated chronic
hepatitis, liver cirrhosis, and hepatocellular carcinoma. Dis
Markers. 2019(5945721)2019.PubMed/NCBI View Article : Google Scholar
|
