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Traumatic brain injury: Advances in coagulopathy (Review)

  • Authors:
    • Hongqiao Hou
    • Zhe Qu
    • Ruping Liu
    • Bowen Jiang
    • Lanlan Wang
    • Aiqun Li
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Yantai Affiliated Hospital of Binzhou Medical College, Yantai, Shandong 264100, P.R. China
    Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 156
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    Published online on: August 27, 2024
       https://doi.org/10.3892/br.2024.1844
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Abstract

Trauma is a prevalent cause of coagulopathy, with traumatic brain injury (TBI) accompanied by coagulation disorders particularly linked to adverse outcomes. TBI is distinguished by minimal bleeding volume and unique injury sites, which precipitate complex coagulation disturbances. Historically, research into trauma‑induced coagulopathy has primarily concentrated on the molecular biology and pathophysiology of endogenous anticoagulation and inflammation. Nonetheless, recognizing that cells are the fundamental units of structure and function in all living organisms, the present review aimed to distill our understanding of coagulopathy post‑TBI by elucidating the intricate cellular mechanisms involving endothelial cells, neutrophils and platelets. Additionally, this study evaluates the strengths and weaknesses of various diagnostic tools and discusses the characteristics of pharmacological treatments and potential therapies for patients with TBI and coagulation disorders. The aim of this review is to amalgamate recent updates in mechanistic research and innovative diagnostic and therapeutic methodologies, thereby fostering the progression of precision medicine within this specialized domain.
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Hou H, Qu Z, Liu R, Jiang B, Wang L and Li A: Traumatic brain injury: Advances in coagulopathy (Review). Biomed Rep 21: 156, 2024.
APA
Hou, H., Qu, Z., Liu, R., Jiang, B., Wang, L., & Li, A. (2024). Traumatic brain injury: Advances in coagulopathy (Review). Biomedical Reports, 21, 156. https://doi.org/10.3892/br.2024.1844
MLA
Hou, H., Qu, Z., Liu, R., Jiang, B., Wang, L., Li, A."Traumatic brain injury: Advances in coagulopathy (Review)". Biomedical Reports 21.5 (2024): 156.
Chicago
Hou, H., Qu, Z., Liu, R., Jiang, B., Wang, L., Li, A."Traumatic brain injury: Advances in coagulopathy (Review)". Biomedical Reports 21, no. 5 (2024): 156. https://doi.org/10.3892/br.2024.1844
Copy and paste a formatted citation
x
Spandidos Publications style
Hou H, Qu Z, Liu R, Jiang B, Wang L and Li A: Traumatic brain injury: Advances in coagulopathy (Review). Biomed Rep 21: 156, 2024.
APA
Hou, H., Qu, Z., Liu, R., Jiang, B., Wang, L., & Li, A. (2024). Traumatic brain injury: Advances in coagulopathy (Review). Biomedical Reports, 21, 156. https://doi.org/10.3892/br.2024.1844
MLA
Hou, H., Qu, Z., Liu, R., Jiang, B., Wang, L., Li, A."Traumatic brain injury: Advances in coagulopathy (Review)". Biomedical Reports 21.5 (2024): 156.
Chicago
Hou, H., Qu, Z., Liu, R., Jiang, B., Wang, L., Li, A."Traumatic brain injury: Advances in coagulopathy (Review)". Biomedical Reports 21, no. 5 (2024): 156. https://doi.org/10.3892/br.2024.1844
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