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Performance and value of 18F‑FDG PET/CT in patients with fever of unknown origin

  • Authors:
    • Ahmed Fathala
    • Rawan Benkuddah
    • Ahmad Almuhaideb
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    Affiliations: Department of Radiology, Nuclear Medicine and Cardiovascular Imaging, King Faisal Specialist Hospital & Research Centre, Riyadh 11211, Saudi Arabia, Department of Radiology, National Guard Hospital, Jeddah 11426, Saudi Arabia
    Copyright: © Fathala et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 169
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    Published online on: September 12, 2024
       https://doi.org/10.3892/br.2024.1857
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Abstract

Fever of unknown origin (FUO) is a common clinical and diagnostic challenge. The main aim of the present study was to evaluate the diagnostic accuracy of 18F‑fluorodeoxyglucose (18FDG) positron emission tomography (PET)/CT in patients who present with FUO. Overall, 105 consecutive patients (61 men and 44 women) with a mean age of 51±35 years with FUO underwent 18FDG PET/CT scans. The performance of 18FDG PET/CT in determining the etiology of FUO was assessed. According to the PET/CT results, patients were classified into four groups: Group 1, patients with true‑positive results (n=51; 49%), in whom abnormal 18FDG uptake identified the final diagnosis; group 2, patients with false‑positive results (n=24; 23%), in whom 18FDG uptake was not consistent with the final diagnosis; group 3, patients with true‑negative results (n=10; 9.5%), in whom the 18FDG uptake was normal and no final disease was established; and group 4, patients with false‑negative results (n=20; 19%), in whom 18FDG uptake was normal and disease was finally established. Of the 51 patients with true‑positive PET/CT results, 51% had infections, 35% had malignancies and 14% had inflammatory processes. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 72, 29, 68, 33 and 58%, respectively. In conclusion, the present results demonstrated that 18FDG PET/CT established the final diagnosis of FUO in the majority of patients (72%). These results support the use of 18FDG PET/CT in the initial evaluation and management of patients with FUO.
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Copy and paste a formatted citation
Spandidos Publications style
Fathala A, Benkuddah R and Almuhaideb A: Performance and value of <sup>18</sup>F‑FDG PET/CT in patients with fever of unknown origin. Biomed Rep 21: 169, 2024.
APA
Fathala, A., Benkuddah, R., & Almuhaideb, A. (2024). Performance and value of <sup>18</sup>F‑FDG PET/CT in patients with fever of unknown origin. Biomedical Reports, 21, 169. https://doi.org/10.3892/br.2024.1857
MLA
Fathala, A., Benkuddah, R., Almuhaideb, A."Performance and value of <sup>18</sup>F‑FDG PET/CT in patients with fever of unknown origin". Biomedical Reports 21.5 (2024): 169.
Chicago
Fathala, A., Benkuddah, R., Almuhaideb, A."Performance and value of <sup>18</sup>F‑FDG PET/CT in patients with fever of unknown origin". Biomedical Reports 21, no. 5 (2024): 169. https://doi.org/10.3892/br.2024.1857
Copy and paste a formatted citation
x
Spandidos Publications style
Fathala A, Benkuddah R and Almuhaideb A: Performance and value of <sup>18</sup>F‑FDG PET/CT in patients with fever of unknown origin. Biomed Rep 21: 169, 2024.
APA
Fathala, A., Benkuddah, R., & Almuhaideb, A. (2024). Performance and value of <sup>18</sup>F‑FDG PET/CT in patients with fever of unknown origin. Biomedical Reports, 21, 169. https://doi.org/10.3892/br.2024.1857
MLA
Fathala, A., Benkuddah, R., Almuhaideb, A."Performance and value of <sup>18</sup>F‑FDG PET/CT in patients with fever of unknown origin". Biomedical Reports 21.5 (2024): 169.
Chicago
Fathala, A., Benkuddah, R., Almuhaideb, A."Performance and value of <sup>18</sup>F‑FDG PET/CT in patients with fever of unknown origin". Biomedical Reports 21, no. 5 (2024): 169. https://doi.org/10.3892/br.2024.1857
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