Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
December-2024 Volume 21 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2024 Volume 21 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Enhanced metabolic health and immune response with bictegravir/emtricitabine/TAF: Insights from a 96‑week retrospective study

  • Authors:
    • Serena Spampinato
    • Giuseppe Nicolò Conti
    • Andrea Marino
    • Vincenzo Raimondo
    • Benedetto Maurizio Celesia
    • Giovanni Francesco Pellicanò
    • Mariangela Valentina Puci
    • Giovanni Sotgiu
    • Roberto Bruno
    • Nunziatina Villari
    • Alessia Mirabile
    • Viviana Agata Maria Coco
    • Michele Salvatore Paternò Raddusa
    • Eugenia Pistarà
    • Vincenzo Boscia
    • Viviana Fisicaro
    • Giorgia Fiorenza
    • Bruno Cacopardo
    • Emmanuele Venanzi Rullo
    • Giuseppe Nunnari
  • View Affiliations / Copyright

    Affiliations: Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, Azienda di Rilievo Nazionale ed Alta Specializzazione Garibaldi Hospital, University of Catania, Catania I-95124, Italy, Unit of Infectious Diseases, G. Martino University Hospital, University of Messina, Department of Clinical and Experimental Medicine, Messina I-98124, Italy, Clinical Epidemiology and Medical Statistics Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari I-07100, Italy, Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, Catania I-95124, Italy
  • Article Number: 179
    |
    Published online on: October 2, 2024
       https://doi.org/10.3892/br.2024.1867
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF), as a fixed dosed combination, is effective in people living with human immunodeficiency virus (PLWH) previously treated with other therapeutic regimens. The aim of the present retrospective observational real‑life study was to analyze virological suppression and immunological, metabolic and safety profile of B/F/TAF. Data were collected from 127 PLHW who switched from any regimen to B/F/TAF. Viral load and virological suppression (viral load <50 copies/ml) were assessed by using real‑time PCR methodologies; CD4 and CD8 T cell count as well as CD4/CD8 ratio were determined by cytofluorimetric analyses; other metabolic parameters such as total cholesterol, triglycerides, High‑ and Low‑Density Lipoproteins were assessed by using immunoenzymatic assay. All of the aforementioned parameters were assessed at different timepoints (Baseline, 48 and 96 weeks) for the patients switching to B/F/TAF. Of 127 PLHW [96 (75.6%) male and 31 (24.4%) female, with a mean age of 46.8±10.7 years], 107 PLHW were included in the analysis. The percentage of virologically suppressed PLWH increased from 66.4 to 74.8% at 96 weeks. A statistically significant increase in absolute CD4 (P<0.0001) and CD8 T cell count (P=0.002) was observed. Of importance, there was a significant increase in CD4/CD8 ratio from 0.95 (0.52‑1.31) to 1.16 (0.75‑1.39) (P=0.003) after 96 weeks. There was a significant decrease in the median values ​​of triglycerides (P<0.0001) and total cholesterol (P<0.0001). Serum creatinine showed a significant increase (P=0.0001). In real life, switching to B/F/T was safe and highly effective both virologically and immunologically. Decrease in cholesterol and triglyceride levels suggested a favorable metabolic profile, which may decrease inflammation, leading to a healthier state and less organ damage.
View Figures

Figure 1

View References

1 

Trickey A, Sabin CA, Burkholder G, Crane H, d'Arminio Monforte A, Egger M, Gill MJ, Grabar S, Guest JL, Jarrin I, et al: Life expectancy after 2015 of adults with HIV on long-term antiretroviral therapy in Europe and North America: A collaborative analysis of cohort studies. Lancet HIV. 10:e295–e307. 2023.PubMed/NCBI View Article : Google Scholar

2 

Marino A, Zafarana G, Ceccarelli M, Cosentino F, Moscatt V, Bruno G, Bruno R, Benanti F, Cacopardo B and Celesia BM: Immunological and clinical impact of DAA-Mediated HCV Eradication in a Cohort of HIV/HCV Coinfected Patients: Monocentric Italian Experience. Diagnostics (Basel). 11(2336)2021.PubMed/NCBI View Article : Google Scholar

3 

D'Andrea F, Venanzi Rullo E, Marino A, Moscatt V, Celesia BM, Cacopardo B, Condorelli F, La Rocca G, Di Rosa M, Pellicanò GF, et al: Hepatitis B virus infection and hepatocellular carcinoma in PLWH: Epidemiology, pathogenesis and treatment. World Cancer Res J. 7(e1537)2020.

4 

Peters E and Iwuji AC: Efficacy, safety and tolerability of Biktarvy in HIV-1 infection: A scoping review. Antivir Ther. 28(13596535231159030)2023.PubMed/NCBI View Article : Google Scholar

5 

Celesia BM, Marino A, del Vecchio RF, Bruno R, Palermo F, Gussio M, Nunnari G and Cacopardo B: Is it Safe and Cost Saving to Defer the CD4+ cell count monitoring in stable patients on art with more than 350 or 500 cells/µl? Mediterr J Hematol Infect Dis. 11(e2019063)2019.PubMed/NCBI View Article : Google Scholar

6 

Celesia BM, Marino A, Borracino S, Arcadipane AF, Pantò G, Gussio M, Coniglio S, Pennisi A, Cacopardo B and Panarello G: Successful extracorporeal membrane oxygenation treatment in an acquired immune deficiency syndrome (AIDS) patient with acute respiratory distress syndrome (ARDS) Complicating Pneumocystis jirovecii Pneumonia: A Challenging Case. Am J Case Rep. 21(e919570)2020.PubMed/NCBI View Article : Google Scholar

7 

Micali C, Russotto Y, Facciolà A, Marino A, Celesia BM, Pistarà E, Caci G, Nunnari G, Pellicanò GF and Venanzi Rullo E: Pulmonary kaposi sarcoma without respiratory symptoms and skin lesions in an HIV-Naïve Patient: A case report and literature review. Infect Dis Rep. 14:228–242. 2022.PubMed/NCBI View Article : Google Scholar

8 

Ambrosioni J, Levi L, Alagaratnam J, Van Bremen K, Mastrangelo A, Waalewijn H, Molina JM, Guaraldi G, Winston A, Boesecke C, et al: Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023. HIV Med. 24:1126–1136. 2023.PubMed/NCBI View Article : Google Scholar

9 

Marino A, Cosentino F, Ceccarelli M, Moscatt V, Pampaloni A, Scuderi D, D'Andrea F, Rullo EV, Nunnari G, Benanti F, et al: Entecavir resistance in a patient with treatment-naïve HBV: A case report. Mol Clin Oncol. 14(113)2021.PubMed/NCBI View Article : Google Scholar

10 

Marino A, Pavone G, Martorana F, Fisicaro V, Motta L, Spampinato S, Celesia BM, Cacopardo B, Vigneri P and Nunnari G: Navigating the Nexus: HIV and Breast Cancer-A Critical Review. Int J Mol Sci. 25(3222)2024.PubMed/NCBI View Article : Google Scholar

11 

Ron R, Martínez-Sanz J, Herrera S, Ramos-Ruperto L, Díez A, Sainz T, Álvarez-Díaz N, Correa-Pérez A, Muriel A, López-Alcalde J, et al: CD4/CD8 ratio and CD8+ T-cell count as prognostic markers for non-AIDS mortality in people living with HIV. A systematic review and meta-analysis. Front Immunol. 15(1343124)2024.PubMed/NCBI View Article : Google Scholar

12 

Serrano-Villar S, Wu K, Hunt PW, Lok JJ, Ron R, Sainz T, Moreno S, Deeks SG and Bosch RJ: Predictive value of CD8+ T cell and CD4/CD8 ratio at two years of successful ART in the risk of AIDS and non-AIDS events. EBioMedicine. 80(104072)2022.PubMed/NCBI View Article : Google Scholar

13 

World Health Organization (WHO): Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: Recommendations for a public health approach. WHO, Geneva, 2021.

14 

Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, Wangisi J, Tappero JW, Bukusi EA, Cohen CR, Katabira E, et al: Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med. 367:399–410. 2012.PubMed/NCBI View Article : Google Scholar

15 

Baeten JM, Kahle E, Lingappa JR, Coombs RW, Delany-Moretlwe S, Nakku-Joloba E, Mugo NR, Wald A, Corey L, Donnell D, et al: Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission. Sci Transl Med. 3(77ra29)2011.PubMed/NCBI View Article : Google Scholar

16 

Acosta RK, Willkom M, Andreatta K, Liu H, Martin R, Parvangada A, Martin H, Collins S and White KL: Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) From Dolutegravir (DTG)+F/TAF or DTG+F/Tenofovir Disoproxil Fumarate (TDF) in the Presence of Pre-existing NRTI Resistance. J Acquir Immune Defic Syndr. 85:363–371. 2020.PubMed/NCBI View Article : Google Scholar

17 

Chang HM, Chou PY, Chou CH and Tsai HC: Outcomes After Switching to BIC/FTC/TAF in patients with virological failure to protease inhibitors or non-nucleoside reverse transcriptase inhibitors: A real-world cohort study. Infect Drug Resist. 14:4877–4886. 2021.PubMed/NCBI View Article : Google Scholar

18 

Chen LY, Sun HY, Chuang YC, Huang YS, Liu WD, Lin KY, Chang HY, Luo YZ, Wu PY, Su YC, et al: Patient-reported outcomes among virally suppressed people living with HIV after switching to Co-formulated bictegravir, emtricitabine and tenofovir alafenamide. J Microbiol Immunol Infect. 56:575–585. 2023.PubMed/NCBI View Article : Google Scholar

19 

Daar ES, DeJesus E, Ruane P, Crofoot G, Oguchi G, Creticos C, Rockstroh JK, Molina JM, Koenig E, Liu YP, et al: Efficacy and safety of switching to fixed-dose bictegravir, emtricitabine, and tenofovir alafenamide from boosted protease inhibitor-based regimens in virologically suppressed adults with HIV-1: 48 week results of a randomised, open-label, multicentre, phase 3, non-inferiority trial. Lancet HIV. 5:e347–e356. 2018.PubMed/NCBI View Article : Google Scholar

20 

De Socio GV, Tordi S, Altobelli D, Gidari A, Zoffoli A and Francisci D: Dolutegravir/Lamivudine versus Tenofovir Alafenamide/Emtricitabine/Bictegravir as a Switch Strategy in a Real-Life Cohort of Virogically Suppressed People Living with HIV. J Clin Med. 12(7759)2023.PubMed/NCBI View Article : Google Scholar

21 

Hagins D, Kumar P, Saag M, Wurapa AK, Brar I, Berger D, Osiyemi O, Hileman CO, Ramgopal MN, McDonald C, et al: Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide in Black Americans With HIV-1: A Randomized Phase 3b, Multicenter, Open-Label Study. J Acquir Immune Defic Syndr. 88:86–95. 2021.PubMed/NCBI View Article : Google Scholar

22 

Kityo C, Hagins D, Koenig E, Avihingsanon A, Chetchotisakd P, Supparatpinyo K, Gankina N, Pokrovsky V, Voronin E, Stephens JL, et al: Switching to Fixed-Dose Bictegravir, Emtricitabine, and Tenofovir Alafenamide (B/F/TAF) in Virologically Suppressed HIV-1 Infected Women: A Randomized, Open-Label, Multicenter, Active-Controlled, Phase 3, Noninferiority Trial. J Acquir Immune Defic Syndr. 82:321–328. 2019.PubMed/NCBI View Article : Google Scholar

23 

Knobel H, Cañas-Ruano E, Guelar A, Knobel P, Villar-García J, González-Mena A, Canepa C, Arrieta-Aldea I, Marcos A, Abalat-Torrres A and Güerri-Fernández R: Switching to Dolutegravir/lamivudine or Bictegravir/Emtricitabine/Tenofovir alafenamide. A comparative real-world study. HIV Res Clin Pract. 24(2239564)2023.PubMed/NCBI

24 

Lake JE, Hyatt AN, Feng H, Debroy P, Kettelhut A, Miao H, Peng L, Bhasin S, Bell S, Rianon N, et al: A randomized clinical trial of transgender women switching to B/F/TAF: The (mo)BETTA Trial. Open Forum Infect Dis. 10(ofad178)2023.PubMed/NCBI View Article : Google Scholar

25 

Lazzaro A, Cacciola EG, Borrazzo C, Innocenti GP, Cavallari EN, Mezzaroma I, Falciano M, Fimiani C, Mastroianni CM, Ceccarelli G and d'Ettorre G: Switching to a Bictegravir Single Tablet Regimen in Elderly People Living with HIV-1: Data Analysis from the BICTEL Cohort. Diagnostics (Basel). 12(76)2021.PubMed/NCBI View Article : Google Scholar

26 

Lazzaro A, Bianchini D, Gentilini Cacciola E, Mezzaroma I, Falciano M, Andreoni C, Fimiani C, Santinelli L, Maddaloni L, Bugani G, et al: Immune Reconstitution and Safe Metabolic Profile after the Switch to Bictegravir/Emtricitabine/Tenofovir Alafenamide Fumarate among Virologically Controlled PLWH: A 96 Week Update from the BICTEL Cohort. Viruses. 15(1222)2023.PubMed/NCBI View Article : Google Scholar

27 

Maggiolo F, Rizzardini G, Molina JM, Pulido F, De Wit S, Vandekerckhove L, Berenguer J, D'Antoni ML, Blair C, Chuck SK, et al: Bictegravir/Emtricitabine/Tenofovir Alafenamide in Virologically Suppressed People with HIV Aged ≥ 65 Years: Week 48 Results of a Phase 3b, Open-Label Trial. Infect Dis Ther. 10:775–788. 2021.PubMed/NCBI View Article : Google Scholar

28 

Molina JM, Ward D, Brar I, Mills A, Stellbrink HJ, López-Cortés L, Ruane P, Podzamczer D, Brinson C, Custodio J, et al: Switching to fixed-dose bictegravir, emtricitabine, and tenofovir alafenamide from dolutegravir plus abacavir and lamivudine in virologically suppressed adults with HIV-1: 48 week results of a randomised, double-blind, multicentre, active-controlled, phase 3, non-inferiority trial. Lancet HIV. 5:e357–e365. 2018.PubMed/NCBI View Article : Google Scholar

29 

Tsai MS, Sun HY, Chen CP, Lee CH, Lee CY, Liu CE, Tang HJ, Hung TC, Li CW, Lee YT, et al: Switching to coformulated bictegravir, emtricitabine, and tenofovir alafenamide maintained viral suppression in adults with historical virological failures and K65N/R mutation. Int J Infect Dis. 126:39–47. 2023.PubMed/NCBI View Article : Google Scholar

30 

Rolle CP, Nguyen V, Patel K, Cruz D, DeJesus E and Hinestrosa F: Real-world efficacy and safety of switching to bictegravir/emtricitabine/tenofovir alafenamide in older people living with HIV. Medicine (Baltimore). 100(e27330)2021.PubMed/NCBI View Article : Google Scholar

31 

Sax PE, Rockstroh JK, Luetkemeyer AF, Yazdanpanah Y, Ward D, Trottier B, Rieger A, Liu H, Acosta R, Collins SE, et al: Switching to bictegravir, emtricitabine, and tenofovir alafenamide in virologically suppressed adults with human immunodeficiency virus. Clin Infect Dis. 73:e485–e493. 2021.PubMed/NCBI View Article : Google Scholar

32 

Klatzmann D, Barré-Sinoussi F, Nugeyre MT, Danquet C, Vilmer E, Griscelli C, Brun-Veziret F, Rouzioux C, Gluckman JC, Chermann JC, et al: Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes. Science. 225:59–63. 1984.PubMed/NCBI View Article : Google Scholar

33 

Doitsh G and Greene WC: Dissecting How CD4 T Cells Are Lost During HIV Infection. Cell Host Microbe. 19:280–291. 2016.PubMed/NCBI View Article : Google Scholar

34 

Bishop JD, DeShields S, Cunningham T and Troy SB: CD4 count recovery after initiation of antiretroviral therapy in patients infected with human immunodeficiency virus. Am J Med Sci. 352:239–244. 2016.PubMed/NCBI View Article : Google Scholar

35 

Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM and Markowitz M: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature. 373:123–126. 1995.PubMed/NCBI View Article : Google Scholar

36 

Roederer M, Dubs JG, Anderson MT, Raju PA and Herzenberg LA and Herzenberg LA: CD8 naive T cell counts decrease progressively in HIV-infected adults. J Clin Invest. 95:2061–2066. 1995.PubMed/NCBI View Article : Google Scholar

37 

Favre D, Stoddart CA, Emu B, Hoh R, Martin JN, Hecht FM, Deeks SG and McCune JM: HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cells. Blood. 117:2189–2199. 2011.PubMed/NCBI View Article : Google Scholar

38 

Oxenius A, Price DA, Easterbrook PJ, O'Callaghan CA, Kelleher AD, Whelan JA, Sontag G, Sewell AK and Phillips RE: Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc Natl Acad Sci USA. 97:3382–3387. 2000.PubMed/NCBI View Article : Google Scholar

39 

Badejo OA, Chang CC, So-Armah KA, Tracy RP, Baker JV, Rimland D, Butt AA, Gordon AJ, Rinaldo CR Jr, Kraemer K, et al: CD8+ T-Cells Count in Acute Myocardial Infarction in HIV disease in a predominantly male cohort. Biomed Res Int. 2015(246870)2015.PubMed/NCBI View Article : Google Scholar

40 

Schneider S, Spinner CD, Cassese S, Promny D, Hapfelmeier A, Byrne RA, Baumann M, Jäger H, Steinlechner E, Laugwitz KL and Kastrati A: Association of increased CD8+ and persisting C-reactive protein levels with restenosis in HIV patients after coronary stenting. AIDS. 30:1413–1421. 2016.PubMed/NCBI View Article : Google Scholar

41 

Borges ÁH, Neuhaus J, Babiker AG, Henry K, Jain MK, Palfreeman A, Mugyenyi P, Domingo P, Hoffmann C, Read TR, et al: Immediate antiretroviral therapy reduces risk of infection-related cancer during early HIV Infection. Clin Infect Dis. 63:1668–1676. 2016.PubMed/NCBI View Article : Google Scholar

42 

Helleberg M, May MT, Ingle SM, Dabis F, Reiss P, Fätkenheuer G, Costagliola D, d'Arminio A, Cavassini M, Smith C, et al: Smoking and life expectancy among HIV-infected individuals on antiretroviral therapy in Europe and North America. AIDS. 29:221–229. 2015.PubMed/NCBI View Article : Google Scholar

43 

Castilho JL, Shepherd BE, Koethe J, Turner M, Bebawy S, Logan J, Rogers WB, Raffanti S and Sterling TR: CD4+/CD8+ ratio, age, and risk of serious non-communicable diseases in HIV-infected adults on antiretroviral therapy. AIDS. 30:899–908. 2016.PubMed/NCBI View Article : Google Scholar

44 

Dock JN and Effros RB: Role of CD8 T cell replicative senescence in human aging and in HIV-mediated Immunosenescence. Aging Dis. 2:382–397. 2011.PubMed/NCBI

45 

Avelino-Silva VI, Miyaji KT, Hunt PW, Huang Y, Simoes M, Lima SB, Freire MS, Caiaffa-Filho HH, Hong MA, Costa DA, et al: CD4/CD8 Ratio and KT Ratio Predict Yellow Fever Vaccine Immunogenicity in HIV-Infected Patients. PLoS Negl Trop Dis. 10(e0005219)2016.PubMed/NCBI View Article : Google Scholar

46 

Collin A, Le Marec F, Vandenhende MA, Lazaro E, Duffau P, Cazanave C, Gérard Y, Dabis F, Bruyand M and Bonnet F: ANRS CO3 Aquitaine Cohort Study Group. Incidence and risk factors for severe bacterial infections in people living with HIV. ANRS CO3 Aquitaine Cohort, 2000-2012. PLoS One. 11(e0152970)2016.PubMed/NCBI View Article : Google Scholar

47 

Vrinceanu D, Dumitru M, Patrascu OM, Costache A, Papacocea T and Cergan R: Current diagnosis and treatment of rhinosinusal aspergilloma (Review). Exp Ther Med. 22(1264)2021.PubMed/NCBI View Article : Google Scholar

48 

Saydam FN, Erdem H, Ankarali H, El-Arab Ramadan ME, El-Sayed NM, Civljak R, Pshenichnaya N, Moroti RV, Mahmuodabad FM, Maduka AV, et al: Vector-borne and zoonotic infections and their relationships with regional and socioeconomic statuses: An ID-IRI survey in 24 countries of Europe, Africa and Asia. Travel Med Infect Dis. 44(102174)2021.PubMed/NCBI View Article : Google Scholar

49 

Sigel K, Wisnivesky J, Crothers K, Gordon K, Brown ST, Rimland D, Rodriguez-Barradas MC, Gibert C, Goetz MB, Bedimo R, et al: Immunological and infectious risk factors for lung cancer in US veterans with HIV: A longitudinal cohort study. Lancet HIV. 4:e67–e73. 2017.PubMed/NCBI View Article : Google Scholar

50 

Mujawar Z, Rose H, Morrow MP, Pushkarsky T, Dubrovsky L, Mukhamedova N, Fu Y, Dart A, Orenstein JM, Bobryshev YV, et al: Human immunodeficiency virus impairs reverse cholesterol transport from macrophages. PLoS Biol. 4(e365)2006.PubMed/NCBI View Article : Google Scholar

51 

Lu L, Yang Y, Yang Z, Wu Y, Liu X, Li X, Chen L, Han Y, Song X, Kong Z, et al: Altered plasma metabolites and inflammatory networks in HIV-1 infected patients with different immunological responses after long-term antiretroviral therapy. Front Immunol. 14(1254155)2023.PubMed/NCBI View Article : Google Scholar

52 

Papantoniou E, Arvanitakis K, Markakis K, Papadakos SP, Tsachouridou O, Popovic DS, Germanidis G, Koufakis T and Kotsa K: Pathophysiology and clinical management of dyslipidemia in people living with HIV: Sailing through Rough Seas. Life (Basel). 14(449)2024.PubMed/NCBI View Article : Google Scholar

53 

Stanley TL and Grinspoon SK: Body composition and metabolic changes in HIV-Infected Patients. J Infect Dis. 205 (Suppl 3):S383–S390. 2012.PubMed/NCBI View Article : Google Scholar

54 

Avihingsanon A, Chetchotisakd P, Kiertiburanakul S, Ratanasuwan W, Siripassorn K, Supparatpinyo K, Martin H, Wang H, Wong T and Wang HY: Efficacy and safety of switching to bictegravir, emtricitabine, and tenofovir alafenamide in virologically suppressed Asian adults living with HIV: A pooled analysis from three international phase III randomized trials. HIV Med. 24:290–300. 2023.PubMed/NCBI View Article : Google Scholar

55 

Maggiolo F, Rizzardini G, Molina JM, Pulido F, De Wit S, Vandekerckhove L, Berenguer J, D'Antoni ML, Blair C, Chuck SK, et al: Bictegravir/emtricitabine/tenofovir alafenamide in older individuals with HIV: Results of a 96-week, phase 3b, open-label, switch trial in virologically suppressed people ≥65 years of age. HIV Med. 24:27–36. 2023.PubMed/NCBI View Article : Google Scholar

56 

Squillace N, Ricci E, Maggi P, Taramasso L, Menzaghi B, De Socio GV, Piconi S, Maurizio Celesia B, Orofino G, Sarchi E, et al: Real-life safety of Emtricitabine/Tenofovir Alafenamide/Bictegravir. PLoS One. 18(e0289132)2023.PubMed/NCBI View Article : Google Scholar

57 

Perrone RD, Madias NE and Levey AS: Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem. 38:1933–1953. 1992.PubMed/NCBI

58 

Kashani K, Rosner MH and Ostermann M: Creatinine: From physiology to clinical application. Eur J Intern Med. 72:9–14. 2020.PubMed/NCBI View Article : Google Scholar

59 

Ando M and Yanagisawa N: Epidemiology, clinical characteristics, and management of chronic kidney disease in human immunodeficiency virus-infected patients. World J Nephrol. 4:388–395. 2015.PubMed/NCBI View Article : Google Scholar

60 

Ryom L, Mocroft A, Kirk O, Worm SW, Kamara DA, Reiss P, Ross M, Fux CA, Morlat P, Moranne O, et al: Association between antiretroviral exposure and renal impairment among HIV-positive persons with normal baseline renal function: The D:A:D study. J Infect Dis. 207:1359–1369. 2013.PubMed/NCBI View Article : Google Scholar

61 

Pottel H, Vrydags N, Mahieu B, Vandewynckele E, Croes K and Martens F: Establishing age/sex related serum creatinine reference intervals from hospital laboratory data based on different statistical methods. Clin Chim Acta. 396:49–55. 2008.PubMed/NCBI View Article : Google Scholar

62 

Yamada J, Tomiyama H, Yambe M, Koji Y, Motobe K, Shiina K, Yamamoto Y and Yamashina A: Elevated serum levels of alanine aminotransferase and gamma glutamyltransferase are markers of inflammation and oxidative stress independent of the metabolic syndrome. Atherosclerosis. 189:198–205. 2006.PubMed/NCBI View Article : Google Scholar

63 

Nixon DE and Landay AL: Biomarkers of immune dysfunction in HIV. Curr Opin HIV AIDS. 5:498–503. 2010.PubMed/NCBI View Article : Google Scholar

64 

Siest G, Schiele F, Galteau MM, Panek E, Steinmetz J, Fagnani F and Gueguen R: Aspartate aminotransferase and alanine aminotransferase activities in plasma: statistical distributions, individual variations, and reference values. Clin Chem. 21:1077–1087. 1975.PubMed/NCBI

65 

Sookoian S and Pirola CJ: Liver enzymes, metabolomics and genome-wide association studies: From systems biology to the personalized medicine. World J Gastroenterol. 21:711–725. 2015.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Spampinato S, Conti GN, Marino A, Raimondo V, Celesia BM, Pellicanò GF, Puci MV, Sotgiu G, Bruno R, Villari N, Villari N, et al: Enhanced metabolic health and immune response with bictegravir/emtricitabine/TAF: Insights from a 96‑week retrospective study. Biomed Rep 21: 179, 2024.
APA
Spampinato, S., Conti, G.N., Marino, A., Raimondo, V., Celesia, B.M., Pellicanò, G.F. ... Nunnari, G. (2024). Enhanced metabolic health and immune response with bictegravir/emtricitabine/TAF: Insights from a 96‑week retrospective study. Biomedical Reports, 21, 179. https://doi.org/10.3892/br.2024.1867
MLA
Spampinato, S., Conti, G. N., Marino, A., Raimondo, V., Celesia, B. M., Pellicanò, G. F., Puci, M. V., Sotgiu, G., Bruno, R., Villari, N., Mirabile, A., Coco, V. A., Paternò Raddusa, M. S., Pistarà, E., Boscia, V., Fisicaro, V., Fiorenza, G., Cacopardo, B., Rullo, E. V., Nunnari, G."Enhanced metabolic health and immune response with bictegravir/emtricitabine/TAF: Insights from a 96‑week retrospective study". Biomedical Reports 21.6 (2024): 179.
Chicago
Spampinato, S., Conti, G. N., Marino, A., Raimondo, V., Celesia, B. M., Pellicanò, G. F., Puci, M. V., Sotgiu, G., Bruno, R., Villari, N., Mirabile, A., Coco, V. A., Paternò Raddusa, M. S., Pistarà, E., Boscia, V., Fisicaro, V., Fiorenza, G., Cacopardo, B., Rullo, E. V., Nunnari, G."Enhanced metabolic health and immune response with bictegravir/emtricitabine/TAF: Insights from a 96‑week retrospective study". Biomedical Reports 21, no. 6 (2024): 179. https://doi.org/10.3892/br.2024.1867
Copy and paste a formatted citation
x
Spandidos Publications style
Spampinato S, Conti GN, Marino A, Raimondo V, Celesia BM, Pellicanò GF, Puci MV, Sotgiu G, Bruno R, Villari N, Villari N, et al: Enhanced metabolic health and immune response with bictegravir/emtricitabine/TAF: Insights from a 96‑week retrospective study. Biomed Rep 21: 179, 2024.
APA
Spampinato, S., Conti, G.N., Marino, A., Raimondo, V., Celesia, B.M., Pellicanò, G.F. ... Nunnari, G. (2024). Enhanced metabolic health and immune response with bictegravir/emtricitabine/TAF: Insights from a 96‑week retrospective study. Biomedical Reports, 21, 179. https://doi.org/10.3892/br.2024.1867
MLA
Spampinato, S., Conti, G. N., Marino, A., Raimondo, V., Celesia, B. M., Pellicanò, G. F., Puci, M. V., Sotgiu, G., Bruno, R., Villari, N., Mirabile, A., Coco, V. A., Paternò Raddusa, M. S., Pistarà, E., Boscia, V., Fisicaro, V., Fiorenza, G., Cacopardo, B., Rullo, E. V., Nunnari, G."Enhanced metabolic health and immune response with bictegravir/emtricitabine/TAF: Insights from a 96‑week retrospective study". Biomedical Reports 21.6 (2024): 179.
Chicago
Spampinato, S., Conti, G. N., Marino, A., Raimondo, V., Celesia, B. M., Pellicanò, G. F., Puci, M. V., Sotgiu, G., Bruno, R., Villari, N., Mirabile, A., Coco, V. A., Paternò Raddusa, M. S., Pistarà, E., Boscia, V., Fisicaro, V., Fiorenza, G., Cacopardo, B., Rullo, E. V., Nunnari, G."Enhanced metabolic health and immune response with bictegravir/emtricitabine/TAF: Insights from a 96‑week retrospective study". Biomedical Reports 21, no. 6 (2024): 179. https://doi.org/10.3892/br.2024.1867
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team