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Association of HHV‑6 reactivation and SLC6A3 (C>T, rs40184), BDNF (C>T, rs6265), and JARID2 (G>A, rs9383046) single nucleotide polymorphisms in depression

  • Authors:
    • Sureewan Bumrungthai
    • Surachat Buddhisa
    • Sureewan Duangjit
    • Supaporn Passorn
    • Sasiwimon Sumala
    • Nattaphol Prakobkaew
  • View Affiliations / Copyright

    Affiliations: Division of Biopharmacy, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand, Department of Medical Technology, Faculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand, Division of Biotechnology, School of Agriculture and Natural resources, University of Phayao, Phayao 56000, Thailand
    Copyright: © Bumrungthai et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 181
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    Published online on: October 3, 2024
       https://doi.org/10.3892/br.2024.1869
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Abstract

Major depressive disorder (MDD) is a global health concern with a complex etiology involving genetic, environmental and infectious factors. The exact cause of MDD remains unknown. The present study explored the association between genetic factors, human herpesvirus 6 (HHV‑6) and MDD. The present study analyzed single nucleotide polymorphisms (SNPs) and HHV‑6 viral load in oral buccal samples from patients with MDD (with and without blood relatives with MDD) and healthy controls. The study used high‑resolution melt analysis to examine rs40184 (C>T) in the solute carrier family 6 member 3 (SLC6A31) gene, rs6265 (C>T) in the brain‑derived neurotrophic factor (BDNF) gene and rs9383046 (G>A) in the jumonji and AT‑rich interaction domain‑containing 2 (JARID2) gene. HHV‑6 infection and viral load was assessed using the quantitative PCR. Whole‑exome sequencing was used to examine SNPs. The variant alleles of SNPs rs40184 [18/40 (45.00) vs. 29/238 (12.55%)] and rs6265 [30/54 (55.46) vs. 117/292 (40.06%)] were significantly more common in patients with MDD than in healthy controls, indicating they may be probable hereditary risk factors for MDD. HHV‑6 positivity was significantly more common in carriers of the G/A genotype (12/15, 80%) than carriers of the G/G genotype (75/363, 20.7%) for rs9383046, implying that genetic variations may affect HHV‑6 risk and MDD onset. Similarly, HHV‑6 viral loads were significantly higher in carriers of the G/A genotype (99,990.85±118,392.64 copies/ng DNA) than carriers of the G/G genotype (48,249.30±101,216.28 copies/ng DNA) for rs9383046. Whole‑exome sequencing identified two SNPs in JARID2 (rs11757092 and rs9383050) associated with MDD, highlighting its genetic complexity. The present study helps explain the complex interactions between HHV‑6 infection, genetics and MDD onset, improving understanding of how SNPs in JARID2 contribute to HHV‑6 infection and MDD onset; these findings may impact future approaches to diagnosing and treating MDD.
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Copy and paste a formatted citation
Spandidos Publications style
Bumrungthai S, Buddhisa S, Duangjit S, Passorn S, Sumala S and Prakobkaew N: Association of HHV‑6 reactivation and SLC6A3 (C>T, rs40184), BDNF (C>T, rs6265), and JARID2 (G>A, rs9383046) single nucleotide polymorphisms in depression. Biomed Rep 21: 181, 2024.
APA
Bumrungthai, S., Buddhisa, S., Duangjit, S., Passorn, S., Sumala, S., & Prakobkaew, N. (2024). Association of HHV‑6 reactivation and SLC6A3 (C>T, rs40184), BDNF (C>T, rs6265), and JARID2 (G>A, rs9383046) single nucleotide polymorphisms in depression. Biomedical Reports, 21, 181. https://doi.org/10.3892/br.2024.1869
MLA
Bumrungthai, S., Buddhisa, S., Duangjit, S., Passorn, S., Sumala, S., Prakobkaew, N."Association of HHV‑6 reactivation and SLC6A3 (C>T, rs40184), BDNF (C>T, rs6265), and JARID2 (G>A, rs9383046) single nucleotide polymorphisms in depression". Biomedical Reports 21.6 (2024): 181.
Chicago
Bumrungthai, S., Buddhisa, S., Duangjit, S., Passorn, S., Sumala, S., Prakobkaew, N."Association of HHV‑6 reactivation and SLC6A3 (C>T, rs40184), BDNF (C>T, rs6265), and JARID2 (G>A, rs9383046) single nucleotide polymorphisms in depression". Biomedical Reports 21, no. 6 (2024): 181. https://doi.org/10.3892/br.2024.1869
Copy and paste a formatted citation
x
Spandidos Publications style
Bumrungthai S, Buddhisa S, Duangjit S, Passorn S, Sumala S and Prakobkaew N: Association of HHV‑6 reactivation and SLC6A3 (C>T, rs40184), BDNF (C>T, rs6265), and JARID2 (G>A, rs9383046) single nucleotide polymorphisms in depression. Biomed Rep 21: 181, 2024.
APA
Bumrungthai, S., Buddhisa, S., Duangjit, S., Passorn, S., Sumala, S., & Prakobkaew, N. (2024). Association of HHV‑6 reactivation and SLC6A3 (C>T, rs40184), BDNF (C>T, rs6265), and JARID2 (G>A, rs9383046) single nucleotide polymorphisms in depression. Biomedical Reports, 21, 181. https://doi.org/10.3892/br.2024.1869
MLA
Bumrungthai, S., Buddhisa, S., Duangjit, S., Passorn, S., Sumala, S., Prakobkaew, N."Association of HHV‑6 reactivation and SLC6A3 (C>T, rs40184), BDNF (C>T, rs6265), and JARID2 (G>A, rs9383046) single nucleotide polymorphisms in depression". Biomedical Reports 21.6 (2024): 181.
Chicago
Bumrungthai, S., Buddhisa, S., Duangjit, S., Passorn, S., Sumala, S., Prakobkaew, N."Association of HHV‑6 reactivation and SLC6A3 (C>T, rs40184), BDNF (C>T, rs6265), and JARID2 (G>A, rs9383046) single nucleotide polymorphisms in depression". Biomedical Reports 21, no. 6 (2024): 181. https://doi.org/10.3892/br.2024.1869
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