Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
January-2025 Volume 22 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2025 Volume 22 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Network pharmacology analysis and clinical verification of Panax notoginseng saponins in deep venous thrombosis prevention

  • Authors:
    • Bin Yan
    • Yachan Ning
    • Julong Guo
    • Limin Liu
    • Chunmei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Intensive Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China, Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China, Department of Orthopaedics, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 8
    |
    Published online on: November 1, 2024
       https://doi.org/10.3892/br.2024.1886
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In the present study, the mechanism of Panax notoginseng saponins (PNS), the extract of Panax notoginseng, against deep vein thrombosis (DVT) was explored by networks pharmacology and its effect was demonstrated through clinical data. PNS includes 5 main active components, which have 101 targets. A total of 1,342 DVT‑related targets were obtained, 55 of which were the common targets of PNS and DVT. AKT1, TNF, IL1B, EGFR, VEGFA and MAPK3 were selected as hub genes from the protein‑protein interaction network. The potential anti‑DVT mechanism of PNS may involve the AGE‑RAGE signaling pathway and the PI3K‑Akt signaling pathway. Molecular docking presented a total of 10 binding interactions, with all molecules showing good binding ability with PNS‑DVT common hub target genes (all binding energy <‑6 kcal/mol). Analysis of clinical data showed that the combined use of PNS significantly reduced the incidence of postoperative DVT in patients undergoing orthopedic surgery compared with the use of low‑molecular‑weight heparin alone, which is the most commonly used clinical anticoagulant.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Giustozzi M, Franco L, Vedovati MC, Becattini C and Agnelli G: Safety of direct oral anticoagulants versus traditional anticoagulants in venous thromboembolism. J Thromb Thrombolysis. 48:439–453. 2019.PubMed/NCBI View Article : Google Scholar

2 

Shargall Y and Litle VR: European perspectives in Thoracic Surgery, the ESTS venous thromboembolism (VTE) working group. J Thorac Dis. 10 (Suppl 8):S963–S968. 2018.PubMed/NCBI View Article : Google Scholar

3 

Fritz MK, Kincaid SE, Sargent CG, Green AH and Davis GA: Venous thromboembolism (VTE) risk stratification in general medical patients at an academic medical center. J Thromb Thrombolysis. 51:67–73. 2021.PubMed/NCBI View Article : Google Scholar

4 

Saleh J, El-Othmani MM and Saleh KJ: Deep vein thrombosis and pulmonary embolism considerations in orthopedic surgery. Orthop Clin North Am. 48:127–135. 2017.PubMed/NCBI View Article : Google Scholar

5 

Anderson DR, Morgano GP, Bennett C, Dentali F, Francis CW, Garcia DA, Kahn SR, Rahman M, Rajasekhar A, Rogers FB, et al: American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients. Blood Adv. 3:3898–3944. 2019.PubMed/NCBI View Article : Google Scholar

6 

Louis SG, Van PY, Riha GM, Barton JS, Kunio NR, Underwood SJ, Differding JA, Rick E, Ginzburg E and Schreiber MA: Thromboelastogram-guided enoxaparin dosing does not confer protection from deep venous thrombosis: A randomized controlled pilot trial. J Trauma Acute Care Surg. 76:937–42; discussion 942-3. 2014.PubMed/NCBI View Article : Google Scholar

7 

Wang CM, Guo XF, Liu LM, Huang Y, Meng L, Song LP, Wu YF, Ning YC, Reilly KH and Wang HB: Prevention of deep vein thrombosis by panax notoginseng saponins combined with low-molecular-weight heparin in surgical patients. Chin J Integr Med. 28:771–778. 2022.PubMed/NCBI View Article : Google Scholar

8 

van Rein N, Biedermann JS, van der Meer FJM, Cannegieter SC, Wiersma N, Vermaas HW, Reitsma PH, Kruip MJHA and Lijfering WH: Major bleeding risks of different low-molecular-weight heparin agents: A cohort study in 12 934 patients treated for acute venous thrombosis. J Thromb Haemost. 15:1386–1391. 2017.PubMed/NCBI View Article : Google Scholar

9 

Hogan M and Berger JS: Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management. Vasc Med. 25:160–173. 2020.PubMed/NCBI View Article : Google Scholar

10 

Zhang X, Wang M, Qiao Y, Shan Z, Yang M, Li G, Xiao Y, Wei L, Bi H and Gao T: Exploring the mechanisms of action of Cordyceps sinensis for the treatment of depression using network pharmacology and molecular docking. Ann Transl Med. 10(282)2022.PubMed/NCBI View Article : Google Scholar

11 

Dong Y, Duan L, Chen HW, Liu YM, Zhang Y and Wang J: Network pharmacology-based prediction and verification of the targets and mechanism for panax notoginseng saponins against coronary heart disease. Evid Based Complement Alternat Med. 2019(6503752)2019.PubMed/NCBI View Article : Google Scholar

12 

Wang C, Chen H, Ma ST, Mao BB, Chen Y, Xu HN and Yu H: A Network Pharmacology Approach for Exploring the Mechanisms of Panax notoginseng Saponins in Ischaemic Stroke. Evid Based Complement Alternat Med. 2021(5582782)2021.PubMed/NCBI View Article : Google Scholar

13 

Zhu B, Zhang W, Lu Y, Hu S, Gao R, Sun Z, Chen X, Ma J, Guo S, Du S and Li P: Network pharmacology-based identification of protective mechanism of Panax Notoginseng Saponins on aspirin induced gastrointestinal injury. Biomed Pharmacother. 105:159–166. 2018.PubMed/NCBI View Article : Google Scholar

14 

Jiang Y, Li S, Xie X, Li H, Huang P, Li B, Huo L, Zhong J, Li Y and Xia X: Exploring the Mechanism of Panax notoginseng Saponins against Alzheimer's Disease by Network Pharmacology and Experimental Validation. Evid Based Complement Alternat Med. 2021(5730812)2021.PubMed/NCBI View Article : Google Scholar

15 

Yu G and Wang J: Exploring mechanisms of Panax notoginseng saponins in treating coronary heart disease by integrating gene interaction network and functional enrichment analysis. Chin J Integr Med. 22:589–596. 2016.PubMed/NCBI View Article : Google Scholar

16 

Han S, Chen Y, Wang J, Zhang Q, Han B, Ge Y, Xiang Y, Liang R, Zhu X and Liao F: Anti-thrombosis Effects and Mechanisms by Xueshuantong Capsule Under Different Flow Conditions. Front Pharmacol. 10(35)2019.PubMed/NCBI View Article : Google Scholar

17 

Ru J, Li P, Wang J, Zhou W, Li B, Huang C, Li P, Guo Z, Tao W, Yang Y, et al: TCMSP: A database of systems pharmacology for drug discovery from herbal medicines. J Cheminform. 6(13)2014.PubMed/NCBI View Article : Google Scholar

18 

Wu Y, Zhang F, Yang K, Fang S, Bu D, Li H, Sun L, Hu H, Gao K, Wang W, et al: SymMap: An integrative database of traditional Chinese medicine enhanced by symptom mapping. Nucleic Acids Res. 47:D1110–D1117. 2019.PubMed/NCBI View Article : Google Scholar

19 

Boyadjiev SA and Jabs EW: Online Mendelian Inheritance in Man (OMIM) as a knowledgebase for human developmental disorders. Clin Genet. 57:253–266. 2000.PubMed/NCBI View Article : Google Scholar

20 

Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, et al: DrugBank 5.0: A major update to the DrugBank database for 2018. Nucleic Acids Res. 46:D1074–D1082. 2018.PubMed/NCBI View Article : Google Scholar

21 

Safran M, Chalifa-Caspi V, Shmueli O, Olender T, Lapidot M, Rosen N, Shmoish M, Peter Y, Glusman G, Feldmesser E, et al: Human Gene-Centric Databases at the Weizmann Institute of Science: GeneCards, UDB, CroW 21 and HORDE. Nucleic Acids Res. 31:142–146. 2003.PubMed/NCBI View Article : Google Scholar

22 

Piñero J, Queralt-Rosinach N, Bravo A, Deu-Pons J, Bauer-Mehren A, Baron M, Sanz F and Furlong LI: DisGeNET: A discovery platform for the dynamical exploration of human diseases and their genes. Database (Oxford). 2015(bav028)2015.PubMed/NCBI View Article : Google Scholar

23 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003.PubMed/NCBI View Article : Google Scholar

24 

Chin CH, Chen SH, Wu HH, Ho CW, Ko MT and Lin CY: CytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 8 (Suppl 4)(S11)2014.PubMed/NCBI View Article : Google Scholar

25 

Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, et al: STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47:D607–D613. 2019.PubMed/NCBI View Article : Google Scholar

26 

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C and Chanda SK: Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 10(1523)2019.PubMed/NCBI View Article : Google Scholar

27 

Burley SK, Berman HM, Kleywegt GJ, Markley JL, Nakamura H and Velankar S: Protein Data Bank (PDB): The single global macromolecular structure archive. Methods Mol Biol. 1607:627–641. 2017.PubMed/NCBI View Article : Google Scholar

28 

Forli S, Huey R, Pique ME, Sanner MF, Goodsell DS and Olson AJ: Computational protein-ligand docking and virtual drug screening with the AutoDock suite. Nat Protoc. 11:905–919. 2016.PubMed/NCBI View Article : Google Scholar

29 

Seeliger D and de Groot BL: Ligand docking and binding site analysis with PyMOL and Autodock/Vina. J Comput Aided Mol Des. 24:417–422. 2010.PubMed/NCBI View Article : Google Scholar

30 

Yang X, Wang L, Zeng J, Wu A, Qin M, Wen M, Zhang T, Chen W, Mei Q, Qin D, et al: Caulis Polygoni Multiflori Accelerates Megakaryopoiesis and Thrombopoiesis via Activating PI3K/Akt and MEK/ERK Signaling Pathways. Pharmaceuticals (Basel). 15(1204)2022.PubMed/NCBI View Article : Google Scholar

31 

Fritz DI, Ding Y, Merrill-Skoloff G, Flaumenhaft R, Hanada T and Chishti AH: Dematin regulates calcium mobilization, thrombosis, and early akt activation in platelets. Mol Cell Biol. 43:283–299. 2023.PubMed/NCBI View Article : Google Scholar

32 

Woulfe DS: Akt signaling in platelets and thrombosis. Expert Rev Hematol. 3:81–91. 2010.PubMed/NCBI View Article : Google Scholar

33 

Yin H, Stojanovic A, Hay N and Du X: The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation. Blood. 111:658–665. 2008.PubMed/NCBI View Article : Google Scholar

34 

Chen S, Tian CB, Bai LY, He XC, Lu QY, Zhao YL and Luo XD: Thrombosis inhibited by Corydalis decumbens through regulating PI3K-Akt pathway. J Ethnopharmacol. 329(118177)2024.PubMed/NCBI View Article : Google Scholar

35 

Zhang T, Li Q, Wang L and Li G: Expression variations and clinical significance of MMP-1, MMP-2 and inflammatory factors in serum of patients with deep venous thrombosis of lower extremity. Exp Ther Med. 17:181–186. 2019.PubMed/NCBI View Article : Google Scholar

36 

Saha P and Smith A: TNF-α (Tumor Necrosis Factor-α). Arterioscler Thromb Vasc Biol. 38:2542–2543. 2018.PubMed/NCBI View Article : Google Scholar

37 

Lopes-Bezerra LM and Filler SG: Endothelial cells, tissue factor and infectious diseases. Braz J Med Biol Res. 36:987–991. 2003.PubMed/NCBI View Article : Google Scholar

38 

Nagareddy P and Smyth SS: Inflammation and thrombosis in cardiovascular disease. Curr Opin Hematol. 20:457–463. 2013.PubMed/NCBI View Article : Google Scholar

39 

Christiansen SC, Naess IA, Cannegieter SC, Hammerstrøm J, Rosendaal FR and Reitsma PH: Inflammatory cytokines as risk factors for a first venous thrombosis: A prospective population-based study. PLoS Med. 3(e334)2006.PubMed/NCBI View Article : Google Scholar

40 

Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Taruya A, Furuta M, Mukaida N and Kondo T: Contribution of the TNF-α (Tumor Necrosis Factor-α)-TNF-Rp55 (Tumor Necrosis Factor Receptor p55) Axis in the Resolution of Venous Thrombus. Arterioscler Thromb Vasc Biol. 38:2638–2650. 2018.PubMed/NCBI View Article : Google Scholar

41 

Pai RZ, Fang Q, Tian G, Zhu B and Ge X: Expression and role of interleukin-1β and associated biomarkers in deep vein thrombosis. Exp Ther Med. 22(1366)2021.PubMed/NCBI View Article : Google Scholar

42 

Fan LM, Douglas G, Bendall JK, McNeill E, Crabtree MJ, Hale AB, Mai A, Li JM, McAteer MA, Schneider JE, et al: Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection. Circulation. 129:2661–2672. 2014.PubMed/NCBI View Article : Google Scholar

43 

Kanaji N, Sato T, Nelson A, Wang X, Li Y, Kim M, Nakanishi M, Basma H, Michalski J, Farid M, et al: Inflammatory cytokines regulate endothelial cell survival and tissue repair functions via NF-κB signaling. J Inflamm Res. 4:127–138. 2011.PubMed/NCBI View Article : Google Scholar

44 

Zepeda-Orozco D, Wen HM, Hamilton BA, Raikwar NS and Thomas CP: . EGF regulation of proximal tubule cell proliferation and VEGF-A secretion. Physiol Rep. 5(e13453)2017.PubMed/NCBI View Article : Google Scholar

45 

Kaye B, Ali A, Correa Bastianon Santiago RA, Ibrahim B, Isidor J, Awad H, Sabahi M, Obrzut M, Adada B, Ranjan S and Borghei-Razavi H: The Role of EGFR amplification in deep venous thrombosis occurrence in IDH Wild-Type Glioblastoma. Curr Oncol. 30:4946–4956. 2023.PubMed/NCBI View Article : Google Scholar

46 

Roopkumar J, Poudel SK, Gervaso L, Reddy CA, Velcheti V, Pennell NA, McCrae KR and Khorana AA: Risk of thromboembolism in patients with ALK- and EGFR-mutant lung cancer: A cohort study. J Thromb Haemost. 19:822–829. 2021.PubMed/NCBI View Article : Google Scholar

47 

Li Q, Chen Y, Zhao D, Yang S, Zhang S, Wei Z, Wang Y, Qian K, Zhao B, Zhu Y, et al: LongShengZhi Capsule reduces carrageenan-induced thrombosis by reducing activation of platelets and endothelial cells. Pharmacol Res. 144:167–180. 2019.PubMed/NCBI View Article : Google Scholar

48 

Zhang Y, Liu J, Jia W, Tian X, Jiang P, Cheng Z and Li J: AGEs/RAGE blockade downregulates Endothenin-1 (ET-1), mitigating Human Umbilical Vein Endothelial Cells (HUVEC) injury in deep vein thrombosis (DVT). Bioengineered. 12:1360–1368. 2021.PubMed/NCBI View Article : Google Scholar

49 

Yamagishi SI: Role of advanced glycation end products (AGEs) and receptor for AGEs (RAGE) in vascular damage in diabetes. Exp Gerontol. 46:217–224. 2011.PubMed/NCBI View Article : Google Scholar

50 

Cyr AR, Huckaby LV, Shiva SS and Zuckerbraun BS: Nitric oxide and endothelial dysfunction. Crit Care Clin. 36:307–321. 2020.PubMed/NCBI View Article : Google Scholar

51 

Yang S, Zheng Y and Hou X: Lipoxin A4 restores oxidative stress-induced vascular endothelial cell injury and thrombosis-related factor expression by its receptor-mediated activation of Nrf2-HO-1 axis. Cell Signal. 60:146–153. 2019.PubMed/NCBI View Article : Google Scholar

52 

Lyu X, Yi Z, He Y, Zhang C, Zhu P and Liu C: Astragaloside IV induces endothelial progenitor cell angiogenesis in deep venous thrombosis through inactivation of PI3K/AKT signaling. Histol Histopathol. 39:1149–1157. 2024.PubMed/NCBI View Article : Google Scholar

53 

Chang MC, Chen YJ, Liou EJ, Tseng WY, Chan CP, Lin HJ, Liao WC, Chang YC, Jeng PY and Jeng JH: 7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells. Oncotarget. 7:74473–74483. 2016.PubMed/NCBI View Article : Google Scholar

54 

Su XL, Su W, Wang Y, Wang YH, Ming X and Kong Y: The pyrrolidinoindoline alkaloid Psm2 inhibits platelet aggregation and thrombus formation by affecting PI3K/Akt signaling. Acta Pharmacol Sin. 37:1208–1217. 2016.PubMed/NCBI View Article : Google Scholar

55 

Guidetti GF, Canobbio I and Torti M: PI3K/Akt in platelet integrin signaling and implications in thrombosis. Adv Biol Regul. 59:36–52. 2015.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yan B, Ning Y, Guo J, Liu L and Wang C: Network pharmacology analysis and clinical verification of <em>Panax notoginseng</em> saponins in deep venous thrombosis prevention. Biomed Rep 22: 8, 2025.
APA
Yan, B., Ning, Y., Guo, J., Liu, L., & Wang, C. (2025). Network pharmacology analysis and clinical verification of <em>Panax notoginseng</em> saponins in deep venous thrombosis prevention. Biomedical Reports, 22, 8. https://doi.org/10.3892/br.2024.1886
MLA
Yan, B., Ning, Y., Guo, J., Liu, L., Wang, C."Network pharmacology analysis and clinical verification of <em>Panax notoginseng</em> saponins in deep venous thrombosis prevention". Biomedical Reports 22.1 (2025): 8.
Chicago
Yan, B., Ning, Y., Guo, J., Liu, L., Wang, C."Network pharmacology analysis and clinical verification of <em>Panax notoginseng</em> saponins in deep venous thrombosis prevention". Biomedical Reports 22, no. 1 (2025): 8. https://doi.org/10.3892/br.2024.1886
Copy and paste a formatted citation
x
Spandidos Publications style
Yan B, Ning Y, Guo J, Liu L and Wang C: Network pharmacology analysis and clinical verification of <em>Panax notoginseng</em> saponins in deep venous thrombosis prevention. Biomed Rep 22: 8, 2025.
APA
Yan, B., Ning, Y., Guo, J., Liu, L., & Wang, C. (2025). Network pharmacology analysis and clinical verification of <em>Panax notoginseng</em> saponins in deep venous thrombosis prevention. Biomedical Reports, 22, 8. https://doi.org/10.3892/br.2024.1886
MLA
Yan, B., Ning, Y., Guo, J., Liu, L., Wang, C."Network pharmacology analysis and clinical verification of <em>Panax notoginseng</em> saponins in deep venous thrombosis prevention". Biomedical Reports 22.1 (2025): 8.
Chicago
Yan, B., Ning, Y., Guo, J., Liu, L., Wang, C."Network pharmacology analysis and clinical verification of <em>Panax notoginseng</em> saponins in deep venous thrombosis prevention". Biomedical Reports 22, no. 1 (2025): 8. https://doi.org/10.3892/br.2024.1886
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team