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Article Special Issue

Treatment advances of sepsis‑induced myopathy (Review)

This article is part of the special Issue: FUNDAMENTAL AND MODERN RESEARCHES IN SEPSIS BASED ON INTERDISCIPLINARY APPROACHES
  • Authors:
    • Qiuli Xue
    • Deyou Zhang
    • Jiarui Zou
    • Haitao Wang
    • Ruiyuan Shi
    • Lihua Dong
  • View Affiliations / Copyright

    Affiliations: Department of Intensive Care Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
  • Article Number: 19
    |
    Published online on: November 25, 2024
       https://doi.org/10.3892/br.2024.1897
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Abstract

Sepsis‑induced myopathy (SIM) is a muscle disease caused by multiple pathological and physiological mechanisms associated with sepsis. The pathogenesis of SIM is extremely complex and still unclear, making treatment challenging. At present, clinical treatment includes early functional exercise, respiratory muscle strength training, regulation of nutritional structure and functional electrical stimulation. Drugs targeting the regulation of the ubiquitin‑proteasome system, autophagy‑lysosome system, calpain and caspase activation pathways, have provided potential therapeutic targets for the treatment of muscle atrophy. Stem cell transplantation therapy brings new hope for the treatment of SIM.
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1 

Callahan LA and Supinski GS: Sepsis-induced myopathy. Crit Care Med. 37 (10 Suppl):S354–S367. 2009.PubMed/NCBI View Article : Google Scholar

2 

Borges RC, Carvalho CRF, Colombo AS, da Silva Borges MP and Soriano FG: Physical activity, muscle strength, and exercise capacity 3 months after severe sepsis and septic shock. Intensive Care Med. 41:1433–1444. 2015.PubMed/NCBI View Article : Google Scholar

3 

Fan E, Cheek F, Chlan L, Gosselink R, Hart N, Herridge MS, Hopkins RO, Hough CL, Kress JP, Latronico N, et al: An official American thoracic society clinical practice guideline: The diagnosis of intensive care unit-acquired weakness in adults. Am J Respir Crit Care Med. 190:1437–1446. 2014.PubMed/NCBI View Article : Google Scholar

4 

Zhang L, Hu W, Cai Z, Liu J, Wu J, Deng Y, Yu K, Chen X, Zhu L, Ma J and Qin Y: Early mobilization of critically ill patients in the intensive care unit: A systematic review and meta-analysis. PLOS One. 14(e0223185)2019.PubMed/NCBI View Article : Google Scholar

5 

Zang K, Chen B, Wang M, Chen D, Hui L, Guo S, Ji T and Shang F: The effect of early mobilization in critically ill patients: A meta-analysis. Nurs Crit Care. 25:360–367. 2020.PubMed/NCBI View Article : Google Scholar

6 

Wang J, Ren D, Liu Y, Wang Y, Zhang B and Xiao Q: Effects of early mobilization on the prognosis of critically ill patients: A systematic review and meta-analysis. Int J Nurs Stud. 110(103708)2020.PubMed/NCBI View Article : Google Scholar

7 

Elkins M and Dentice R: Inspiratory muscle training facilitates weaning from mechanical ventilation among patients in the intensive care unit: A systematic review. J Physiother. 61:125–134. 2015.PubMed/NCBI View Article : Google Scholar

8 

Yang T, Li Z, Jiang L, Wang Y and Xi X: Risk factors for intensive care unit-acquired weakness: A systematic review and meta-analysis. Acta Neurol Scand. 138:104–114. 2018.PubMed/NCBI View Article : Google Scholar

9 

Watanabe S, Morita Y, Suzuki S, Kochi K, Ohno M, Liu K and Iida Y: Effects of the intensity and activity time of early rehabilitation on activities of daily living dependence in mechanically ventilated patients. Prog Rehabil Med. 6(20210054)2021.PubMed/NCBI View Article : Google Scholar

10 

Mignemi NA, McClatchey PM, Kilchrist KV, Williams IM, Millis BA, Syring KE, Duvall CL, Wasserman DH and McGuinness OP: Rapid changes in the microvascular circulation of skeletal muscle impair insulin delivery during sepsis. Am J Physiol Endocrinol Metab. 316:E1012–E1023. 2019.PubMed/NCBI View Article : Google Scholar

11 

Hermans G, De Jonghe B, Bruyninckx F and Van den Berghe G: Interventions for preventing critical illness polyneuropathy and critical illness myopathy. Cochrane Database Syst Rev. 2014(CD006832)2014.PubMed/NCBI View Article : Google Scholar

12 

Lad H, Saumur TM, Herridge MS, Dos Santos CC, Mathur S, Batt J and Gilbert PM: Intensive care unit-acquired weakness: Not just another muscle atrophying condition. Int J Mol Sci. 21(7840)2020.PubMed/NCBI View Article : Google Scholar

13 

Stana F, Vujovic M, Mayaki D, Leduc-Gaudet JP, Leblanc P, Huck L and Hussain SNA: Differential regulation of the autophagy and proteasome pathways in skeletal muscles in sepsis. Crit Care Med. 45:e971–e979. 2017.PubMed/NCBI View Article : Google Scholar

14 

Holeček M: The role of skeletal muscle in the pathogenesis of altered concentrations of branched-chain amino acids (valine, leucine, and isoleucine) in liver cirrhosis, diabetes, and other diseases. Physiol Res. 70:293–305. 2021.PubMed/NCBI View Article : Google Scholar

15 

Hernandez-García A, Manjarín R, Suryawan A, Nguyen HV, Davis TA and Orellana RA: Amino acids, independent of insulin, attenuate skeletal muscle autophagy in neonatal pigs during endotoxemia. Pediatr Res. 80:448–451. 2016.PubMed/NCBI View Article : Google Scholar

16 

Wang W, Xu C, Ma X, Zhang X and Xie P: Intensive Care unit-acquired weakness: A review of recent progress with a look toward the future. Front Med (Lausanne). 7(559789)2020.PubMed/NCBI View Article : Google Scholar

17 

Baldelli S, Ciccarone F, Limongi D, Checconi P, Palamara AT and Ciriolo MR: Glutathione and nitric oxide: Key team players in use and disuse of skeletal muscle. Nutrients. 11(2318)2019.PubMed/NCBI View Article : Google Scholar

18 

Ortolani O, Conti A, De Gaudio AR, Moraldi E, Cantini Q and Novelli G: The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock. Am J Respir Crit Care Med. 161:1907–1911. 2000.PubMed/NCBI View Article : Google Scholar

19 

Heyland DK, Wibbenmeyer L, Pollack JA, Friedman B, Turgeon AF, Eshraghi N, Jeschke MG, Bélisle S, Grau D, Mandell S, et al: A randomized trial of enteral glutamine for treatment of burn injuries. N Engl J Med. 387:1001–1010. 2022.PubMed/NCBI View Article : Google Scholar

20 

Gerovasili V, Stefanidis K, Vitzilaios K, Karatzanos E, Politis P, Koroneos A, Chatzimichail A, Routsi C, Roussos C and Nanas S: Electrical muscle stimulation preserves the muscle mass of critically ill patients: A randomized study. Crit Care. 13(R161)2009.PubMed/NCBI View Article : Google Scholar

21 

Chen S, Jiang Y, Yu B, Dai Y, Mi Y, Tan Y, Yao J and Tian Y: Effect of transcutaneous neuromuscular electrical stimulation on prevention of intensive care unit-acquired weakness in chronic obstructive pulmonary disease patients with mechanical ventilation. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 31:709–713. 2019.PubMed/NCBI View Article : Google Scholar : (In Chinese).

22 

Yoshihara I, Kondo Y, Okamoto K and Tanaka H: Sepsis-associated muscle wasting: A comprehensive review from bench to bedside. Int J Mol Sci. 24(5040)2023.PubMed/NCBI View Article : Google Scholar

23 

Khalil R: Ubiquitin-proteasome pathway and muscle atrophy. Adv Exp Med Biol. 1088:235–248. 2018.PubMed/NCBI View Article : Google Scholar

24 

Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, et al: Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 294:1704–1708. 2001.PubMed/NCBI View Article : Google Scholar

25 

Gehrig SM, van der Poel C, Sayer TA, Schertzer JD, Henstridge DC, Church JE, Lamon S, Russell AP, Davies KE, Febbraio MA and Lynch GS: Hsp72 preserves muscle function and slows progression of severe muscular dystrophy. Nature. 484:394–398. 2012.PubMed/NCBI View Article : Google Scholar

26 

Akkad H, Cacciani N, Llano-Diez M, Corpeno Kalamgi R, Tchkonia T, Kirkland JL and Larsson L: Vamorolone treatment improves skeletal muscle outcome in a critical illness myopathy rat model. Acta Physiol (Oxf). 225(e13172)2019.PubMed/NCBI View Article : Google Scholar

27 

Kim YI, Lee H, Nirmala FS, Seo HD, Ha TY, Jung CH and Ahn J: Antioxidant activity of Valeriana fauriei protects against dexamethasone-induced muscle atrophy. Oxid Med Cell Longev. 2022(3645431)2022.PubMed/NCBI View Article : Google Scholar

28 

Crossland H, Constantin-Teodosiu D and Greenhaff PL: The regulatory roles of PPARs in skeletal muscle fuel metabolism and inflammation: Impact of PPAR agonism on muscle in chronic disease, contraction and sepsis. Int J Mol Sci. 22(9775)2021.PubMed/NCBI View Article : Google Scholar

29 

Khan B, Gand LV, Amrute-Nayak M and Nayak A: Emerging mechanisms of skeletal muscle homeostasis and cachexia: The SUMO perspective. Cells. 12(644)2023.PubMed/NCBI View Article : Google Scholar

30 

Thoma A and Lightfoot AP: nf-kb and inflammatory cytokine signalling: Role in skeletal muscle atrophy. Adv Exp Med Biol. 1088:267–279. 2018.PubMed/NCBI View Article : Google Scholar

31 

Petrocelli JJ and Drummond MJ: PGC-1α-targeted therapeutic approaches to enhance muscle recovery in aging. Int J Environ Res Public Health. 17(8650)2020.PubMed/NCBI View Article : Google Scholar

32 

Wu Y, Yao YM and Lu ZQ: Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure. J Mol Med (Berl). 97:451–462. 2019.PubMed/NCBI View Article : Google Scholar

33 

Rocheteau P, Chatre L, Briand D, Mebarki M, Jouvion G, Bardon J, Crochemore C, Serrani P, Lecci PP, Latil M, et al: Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy. Nat Commun. 6(10145)2015.PubMed/NCBI View Article : Google Scholar

34 

Deprez A, Orfi Z, Rieger L and Dumont NA: Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies. Biosci Rep. 43(BSR20220284)2023.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Xue Q, Zhang D, Zou J, Wang H, Shi R and Dong L: Treatment advances of sepsis‑induced myopathy (Review). Biomed Rep 22: 19, 2025.
APA
Xue, Q., Zhang, D., Zou, J., Wang, H., Shi, R., & Dong, L. (2025). Treatment advances of sepsis‑induced myopathy (Review). Biomedical Reports, 22, 19. https://doi.org/10.3892/br.2024.1897
MLA
Xue, Q., Zhang, D., Zou, J., Wang, H., Shi, R., Dong, L."Treatment advances of sepsis‑induced myopathy (Review)". Biomedical Reports 22.2 (2025): 19.
Chicago
Xue, Q., Zhang, D., Zou, J., Wang, H., Shi, R., Dong, L."Treatment advances of sepsis‑induced myopathy (Review)". Biomedical Reports 22, no. 2 (2025): 19. https://doi.org/10.3892/br.2024.1897
Copy and paste a formatted citation
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Spandidos Publications style
Xue Q, Zhang D, Zou J, Wang H, Shi R and Dong L: Treatment advances of sepsis‑induced myopathy (Review). Biomed Rep 22: 19, 2025.
APA
Xue, Q., Zhang, D., Zou, J., Wang, H., Shi, R., & Dong, L. (2025). Treatment advances of sepsis‑induced myopathy (Review). Biomedical Reports, 22, 19. https://doi.org/10.3892/br.2024.1897
MLA
Xue, Q., Zhang, D., Zou, J., Wang, H., Shi, R., Dong, L."Treatment advances of sepsis‑induced myopathy (Review)". Biomedical Reports 22.2 (2025): 19.
Chicago
Xue, Q., Zhang, D., Zou, J., Wang, H., Shi, R., Dong, L."Treatment advances of sepsis‑induced myopathy (Review)". Biomedical Reports 22, no. 2 (2025): 19. https://doi.org/10.3892/br.2024.1897
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