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Evaluation of hepatoprotective and nephroprotective activities of Castanopsis costata extract in rats

  • Authors:
    • Maulana Yusuf Alkandahri
    • Asman Sadino
    • Ermi Abriyani
    • Faizal Hermanto
    • Zulpakor Oktoba
    • Muhammad Fitra Wardhana Sayoeti
    • Putu Ristyaning Ayu Sangging
    • Diah Wardani
    • Nahrul Hasan
    • Suci Wulan Sari
    • Nurul Aeni Safitri
    • Windi Ikhtianingsih
    • Safitri Safitri
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, West Java 41361, Indonesia, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Garut, Garut, West Java 44151, Indonesia, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, West Java 41361, Indonesia, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Jenderal Achmad Yani, Cimahi, West Java 40525, Indonesia, Department of Pharmacy, Faculty of Medicine, Universitas Lampung, Bandar Lampung 35141, Indonesia, Department of Clinical Pathology, Faculty of Medicine, Universitas Lampung, Bandar Lampung 35141, Indonesia, Diploma Program of Pharmacy, Karsa Husada Garut College of Health Sciences, Garut, West Java 44151, Indonesia, Department of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman, Purwokerto, Central Java 53122, Indonesia, Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, West Java 41361, Indonesia
    Copyright: © Alkandahri et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 24
    |
    Published online on: December 4, 2024
       https://doi.org/10.3892/br.2024.1902
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Abstract

The liver and kidneys are important organs for body homeostasis but susceptible to damage or injury caused by different factors. A number of medicinal plants, such as Castanopsis costata have been proven effective in protecting the liver and kidneys from damage. Therefore, the present study aimed to examine the effect of C. costata extract (CcE) on paracetamol‑induced hepatotoxicity and gentamicin‑induced nephrotoxicity in rat model. Each treatment group was given CcE at doses of 100, 200 and 400 mg/kg for 21 and 8 days for hepatoprotective tests and nephroprotective tests, respectively. To induce liver and kidney damage, rats were given paracetamol 1,000 mg/kg orally for 7 (15‑21) and gentamicin 80 mg/kg intraperitoneally for 5 (4‑8) days. To assess liver function, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin (TB), total cholesterol (TC), total albumin (TA) and total protein (TP) were measured, as well as liver antioxidant enzymes. Meanwhile, to assess kidney function, the levels of serum creatinine (SCr), serum urea (SU) and uric acid (UA) were measured. TNF‑α and IFN‑γ were also measured with histopathology testing to assess the effects of liver and kidney organ damage in each experiment. The results showed that CcE reduced the levels of AST, ALT, ALP, TB and TC, increased TA, TP and liver antioxidant enzymes, as well as reducing SCr, SU and UA when compared with the pathological group. Additionally, CcE reduced the levels of TNF‑α and IFN‑γ, as well as improving the structure of liver and kidney tissue as confirmed by histopathology. CcE had hepatoprotective and nephroprotective effects on paracetamol‑induced and gentamicin‑induced rats, respectively.
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1 

Narayanan M, Gopi A, Natarajan D, Kandasamy S, Saravanan M, El Askary A, Elfasakhany A and Pugazhendhi A: Hepato and nephroprotective activity of methanol extract of Hygrophila spinosa and its antibacterial potential against multidrug resistant Pandoraea sputorum. Environ Res. 201(111594)2021.PubMed/NCBI View Article : Google Scholar

2 

Parasuraman S, Qi YZ and Jie LW: Hepato- and nephroprotective effects of ethanolic extract of seeds of Macrotyloma uniflorum on paracetamol-induced hepato- and nephrotoxicity in rats. Indian J Pharm Educ Res. 56:772–779. 2022.

3 

Li M, Xie F, Wang L, Zhu G, Qi LW and Jiang S: Celastrol: An update on its hepatoprotective properties and the linked molecular mechanisms. Front Pharmacol. 13(857956)2022.PubMed/NCBI View Article : Google Scholar

4 

Alkandahri MY, Pamungkas BT, Oktoba Z, Shafirany MZ, Sulastri L, Arfania M, Anggraeny EN, Pratiwi A, Astuti FD, Indriyani  , et al: Hepatoprotective effect of kaempferol: A review of the dietary sources, bioavailability, mechanisms of action, and safety. Adv Pharmacol Pharm Sci. 2023(1387665)2023.PubMed/NCBI View Article : Google Scholar

5 

Iranshahy M, Iranshahi M, Abtahi SR and Karimi G: The role of nuclear factor erythroid 2-related factor 2 in hepatoprotective activity of natural products: A review. Food Chem Toxicol. 120:261–276. 2018.PubMed/NCBI View Article : Google Scholar

6 

Okokon JE, Udobang JA, Bassey AI, Edem UA and Agu EC: Hepatoprotective and nephroprotective activities of husk extract of Zea mays against paracetamol-induced liver and kidney injuries in rats. Trop J Nat Prod Res. 4:67–76. 2020.

7 

Abdel-Hady H, El-Sayed M, Abdel-hady AA, Hashash MM, Abdel-Hady AM, Aboushousha T, Abdel-Hameed ES, Abdel-Lateef EE and Morsi EA: Nephroprotective activity of methanolic extract of Lantana camara and squash (Cucurbita pepo) on cisplatin-induced nephrotoxicity in rats and identification of certain chemical constituents of Lantana camara by HPLC-ESI-MS. Pharmacogn J. 10:136–147. 2018.

8 

Al-Snafi AE and Talab TA: A review of medicinal plants with nephroprotective effects. GSC Biol Pharm Sci. 8:114–122. 2019.

9 

Sujana D, Saptarini NM, Sumiwi SA and Levita J: Nephroprotective activity of medicinal plants: A review on in-silico, in-vitro, and in-vivo based studies. J Appl Pharm Sci. 11:113–127. 2021.

10 

Wannes WA and Tounsi MS: Tunisian nephroprotective plants: A review. J Explor Res Pharmacol. 8:74–91. 2023.

11 

Devarbhavi H, Asrani SK, Arab JP, Nartey YA, Pose E and Kamath PS: Global burden of liver disease: 2023 update. J Hepatol. 79:516–537. 2023.PubMed/NCBI View Article : Google Scholar

12 

Bello AK, Okpechi IG, Levin A, Ye F, Damster S, Arruebo S, Donner JA, Caskey FJ, Cho Y, Davids MR, et al: An update on the global disparities in kidney disease burden and care across world countries and regions. Lancet Glob Health. 12:e382–e395. 2024.PubMed/NCBI View Article : Google Scholar

13 

El-Rabey HA, Rezk SM, Sakran MI, Mohammed GM, Bahattab O, Balgoon MJ, Elbakry MA and Bakry N: Green coffee methanolic extract and silymarin protect against CCl4-induced hepatotoxicity in albino male rats. BMC Complement Med Ther. 21(19)2021.PubMed/NCBI View Article : Google Scholar

14 

Tienda-Vázquez MA, Morreeuw ZP, Sosa-Hernández JE, Cardador-Martínez A, Sabath E, Melchor-Martínez EM, Iqbal HMN and Parra-Saldívar R: Nephroprotective plants: A review on the use in pre-renal and post-renal diseases. Plants (Basel). 11(818)2022.PubMed/NCBI View Article : Google Scholar

15 

Lawson SK, Satyal P and Setzer WN: The volatile phytochemistry of seven native american aromatic medicinal plants. Plants (Basel). 10(1061)2021.PubMed/NCBI View Article : Google Scholar

16 

Alkandahri MY, Maulana YE, Subarnas A, Kwarteng A and Berbudi A: Antimalarial activity of extract and fractions of Cayratia trifolia (L.) domin. Int J Pharm Res. 12:1435–1441. 2020.

17 

Elfahmi  , Woerdenbag HJ and Kayser O: Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use. J Herb Med. 4:51–73. 2014.

18 

Farhamzah Kusumawati AH, Alkandahri MY, Hidayah H, Sujana D, Gunarti NS, Yuniarsih N, Apriana SD and Agustina LS: Sun protection factor activity of black glutinous rice emulgel extract (Oryza sativa var glutinosa). Indian J Pharm Educ Res. 56:302–310. 2022.

19 

Salim E, Fatimah C and Fanny DY: Analgetic activity of Cep-cepan (Saurauia cauliflora Dc.) leaves extract. J Nat. 17:31–38. 2017.

20 

Alkandahri MY, Berbudi A, Utami NV and Subarnas A: Antimalarial activity of extract and fractions of Castanopsis costata (Blume) A.DC. Avicenna J Phytomed. 9:474–481. 2019.PubMed/NCBI

21 

Alkandahri MY, Sujana D, Hasyim DM, Shafirany MZ, Sulastri L, Arfania M, Frianto D, Farhamzah Kusumawati AH and Yuniarsih N: Antidiabetic activity of extract and fractions of Castanopsis costata leaves on alloxan-induced diabetic mice. Pharmacogn J. 13:1589–1593. 2021.

22 

Alkandahri MY, Arfania M, Abriyani E, Ridwanuloh D, Farhamzah F, Fikayuniar L, Hasyim DM and Nurul and Wardani D: Evaluation of antioxidant and antipyretic effects of ethanolic extract of cep-cepan leaves (Castanopsis costata (Blume) A.DC). J Adv Pharm Educ Res. 12:107–112. 2022.

23 

Alkandahri MY, Kusumiyati K, Renggana H, Arfania M, Frianto D, Wahyuningsih ES and Maulana YE: Antihyperlipidemic activity of extract and fractions of Castanopsis costata leaves on rats fed with high cholesterol diet. RASĀYAN J Chem. 15:2350–2358. 2022.

24 

Alkandahri MY, Sholih MG, Fadilah NN, Arfania M, Amal S, Frianto D, Mardiana LA, Astuti D and Hasyim DM: Evaluation of antidiarrheal, antispasmodic, and antisecretory activities of extract and fractions of Castanopsis costata leaves in animal models. Pharmacogn J. 15:31–37. 2023.

25 

Alkandahri MY, Sadino A, Pamungkas BT, Oktoba Z, Arfania M, Yuniarsih N, Wahyuningsih ES and Putri DE: Pharmacological evaluation of anti-inflammatory, antipyretic, analgesic, and antioxidant activities of Castanopsis costata leaf fractions (water, ethyl acetate, and n-hexane fractions): The potential medicinal plants from North Sumatra, Indonesia. Res Pharm Sci. 19:251–266. 2024.PubMed/NCBI View Article : Google Scholar

26 

Ielciu I, Sevastre B, Olah NK, Turdean A, Chișe E, Marica R, Oniga I, Uifălean A, Sevastre-Berghian AC, Niculae M, et al: Evaluation of hepatoprotective activity and oxidative stress reduction of Rosmarinus officinalis L. shoots tincture in rats with experimentally induced hepatotoxicity. Molecules. 26(1737)2021.PubMed/NCBI View Article : Google Scholar

27 

Song X, Liu Z, Zhang J, Yang Q, Ren Z, Zhang C, Liu M, Gao Z, Zhao H and Jia L: Anti-inflammatory and hepatoprotective effects of exopolysaccharides isolated from Pleurotus geesteranus on alcohol-induced liver injury. Sci Rep. 8(10493)2018.PubMed/NCBI View Article : Google Scholar

28 

Wang W, Liu H, Zhang Y, Feng Y, Yuan F, Song X, Gao Z, Zhang J, Song Z and Jia L: Antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable polysaccharides by Dictyophora indusiata. Sci Rep. 9(14266)2019.PubMed/NCBI View Article : Google Scholar

29 

Wardani G, Nugraha J, Mustafa MR and Sudjarwo SA: Antioxidative stress and anti-inflammatory activity of fucoidan nanoparticles against nephropathy of streptozotocin-induced diabetes in rats. Evid Based Complement Alternat Med. 2022(3405871)2022.PubMed/NCBI View Article : Google Scholar

30 

Perez-Meseguer J, Torres-González L, Gutiérrez-González JA, Alarcón-Galván G, Zapata-Chavira H, Torres NW, Moreno-Peña DP, Muñoz-Espinosa LE and Cordero-Pérez P: Anti-inflammatory and nephroprotective activity of Juglans mollis against renal ischemia-reperfusion damage in a wistar rat model. BMC Complement Altern Med. 19(186)2019.PubMed/NCBI View Article : Google Scholar

31 

Al-Harbi LN, Alshammari GM, Shamlan G, Binobead MA, AlSedairy SA, Al-Nouri DM, Arzoo S and Yahya MA: Nephroprotective and anti-diabetic potential of Beta vulgaris L. Root (Beetroot) methanolic extract in a rat model of type 2 diabetes mellitus. Medicina (Kaunas). 60(394)2024.PubMed/NCBI View Article : Google Scholar

32 

Hidayah H, Amal S, Yuniarsih N, Farhamzah F, Kusumawati AH, Gunarti NS, Abriyani E, Mursal ILP, Sundara AK and Alkandahri MY: Sun protection factor activity of Jamblang leaves serum extract (Syzygium cumini). Pharmacogn J. 15:134–140. 2023.

33 

Kiran PM, Raju AV and Rao BG: Investigation of hepatoprotective activity of Cyathea gigantea (Wall. ex. Hook.) leaves against paracetamol-induced hepatotoxicity in rats. Asian Pac J Trop Biomed. 2:352–356. 2012.PubMed/NCBI View Article : Google Scholar

34 

Zakaria ZA, Kamisan FH, Kek TL and Salleh MZ: Hepatoprotective and antioxidant activities of Dicranopteris linearis leaf extract against paracetamol-induced liver intoxication in rats. Pharm Biol. 58:478–489. 2020.PubMed/NCBI View Article : Google Scholar

35 

Okokon JE, Simeon JO and Umoh EE: Hepatoprotective activity of the extract of Homalium letestui stem against paracetamol-induced liver injury. Avicenna J Phytomed. 7:27–36. 2017.PubMed/NCBI

36 

Dewi IP, Aldiana M, Viadina ZA, Fajrin FA, Holidah D and Christianty FM: Nephroprotective effect of sugarcane (Saccharum officinarum L.) leaves ethanol extract on gentamicin-induced nephrotoxicity in rats. J Adv Pharm Technol Res. 15:208–213. 2024.PubMed/NCBI View Article : Google Scholar

37 

Iqbal SM, Hussain L, Hussain M, Akram H, Asif M, Jamshed A, Saleem A and Siddique R: Nephroprotective potential of a standardized extract of Bambusa arundinacea: In vitro and in vivo studies. ACS Omega. 7:18159–18167. 2022.PubMed/NCBI View Article : Google Scholar

38 

Foghis M, Tit DM, Bungau SG, Ghitea TC, Pallag CR, Foghis AM, Behl T, Bustea C and Pallag A: Highlighting the use of the hepatoprotective nutritional supplements among patients with chronic diseases. Healthcare (Basel). 11(2685)2023.PubMed/NCBI View Article : Google Scholar

39 

Basist P, Parveen B, Zahiruddin S, Gautam G, Parveen R, Khan MA, Krishnan A, Shahid M and Ahmad S: Potential nephroprotective phytochemicals: Mechanism and future prospects. J Ethnopharmacol. 283(114743)2022.PubMed/NCBI View Article : Google Scholar

40 

Hosack T, Damry D and Biswas S: Drug-induced liver injury: A comprehensive review. Therap Adv Gastroenterol. 16(17562848231163410)2023.PubMed/NCBI View Article : Google Scholar

41 

Perazella MA and Rosner MH: Drug-induced acute kidney injury. Clin J Am Soc Nephrol. 17:1220–1233. 2022.PubMed/NCBI View Article : Google Scholar

42 

Kang SH, Lee HW, Yoo JJ, Cho Y, Kim SU, Lee TH, Jang BK, Kim SG, Ahn SB, Kim H, et al: KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease. Clin Mol Hepatol. 27:363–401. 2021.PubMed/NCBI View Article : Google Scholar

43 

Japanese Society of Nephrology. Essential points from evidence-based clinical practice guideline for chronic kidney disease 2023. Clin Exp Nephrol. 28:473–495. 2024.PubMed/NCBI View Article : Google Scholar

44 

Meharie BG, Amare GG and Belayneh YM: Evaluation of hepatoprotective activity of the crude extract and solvent fractions of Clutia abyssinica (Euphorbiaceae) leaf against CCl4-induced hepatotoxicity in mice. J Exp Pharmacol. 12:137–150. 2020.PubMed/NCBI View Article : Google Scholar

45 

Pandey B, Baral R, Kaundinnyayana A and Panta S: Promising hepatoprotective agents from the natural sources: A study of scientific evidence. Egypt Liver J. 13(14)2023.

46 

Molaei E, Molaei A, Abedi F, Hayes AW and Karimi G: Nephroprotective activity of natural products against chemical toxicants: The role of Nrf2/ARE signaling pathway. Food Sci Nutr. 9:3362–3384. 2021.PubMed/NCBI View Article : Google Scholar

47 

Chidiac AS, Buckley NA, Noghrehchi F and Cairns R: Paracetamol (acetaminophen) overdose and hepatotoxicity: Mechanism, treatment, prevention measures, and estimates of burden of disease. Expert Opin Drug Metab Toxicol. 19:297–317. 2023.PubMed/NCBI View Article : Google Scholar

48 

Oh RC, Hustead TR, Ali SM and Pantsari MW: Mildly elevated liver transaminase levels: Causes and evaluation. Am Fam Physician. 96:709–715. 2017.PubMed/NCBI

49 

Giannini EG, Testa R and Savarino V: Liver enzyme alteration: A guide for clinicians. CMAJ. 172:367–379. 2005.PubMed/NCBI View Article : Google Scholar

50 

Nkosi CZ, Opoku AR and Terblanche SE: Effect of pumpkin seed (Cucurbita pepo) protein isolate on the activity levels of certain plasma enzymes in CCl4-induced liver injury in low-protein fed rats. Phytother Res. 19:341–345. 2005.PubMed/NCBI View Article : Google Scholar

51 

Ruiz ARG, Crespo J, Martínez RML, Iruzubieta P, Mercadal GC, Garcés ML, Lavin B and Ruiz MM: Measurement and clinical usefulness of bilirubin in liver disease. Adv Lab Med. 2:352–372. 2021.PubMed/NCBI View Article : Google Scholar

52 

Arguello G, Balboa E, Arrese M and Zanlungo S: Recent insights on the role of cholesterol in non-alcoholic fatty liver disease. Biochim Biophys Acta. 1852:1765–1778. 2015.PubMed/NCBI View Article : Google Scholar

53 

Maretti-Mira AC, Salomon MP, Hsu AM, Kanel GC and Golden-Mason L: Hepatic damage caused by long-term high cholesterol intake induces a dysfunctional restorative macrophage population in experimental NASH. Front Immunol. 13(968366)2022.PubMed/NCBI View Article : Google Scholar

54 

Wang X, Wu Q, Liu A, Anadón A, Rodríguez JL, Martínez-Larrañaga MR, Yuan Z and Martínez MA: Paracetamol: Overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro. Drug Metab Rev. 49:395–437. 2017.PubMed/NCBI View Article : Google Scholar

55 

Khademalhosseini M, Ranjbar E, Mohammadi R, Khalili P, Mehran M, Jalali N, Rajabi Z and Jamali Z: Dietary antioxidants and liver enzymes in Rafsanjan, a region in Southeast Iran. Sci Rep. 13(8555)2023.PubMed/NCBI View Article : Google Scholar

56 

Gillessen A and Schmidt HHJ: Silymarin as supportive treatment in liver diseases: A narrative review. Adv Ther. 37:1279–1301. 2020.PubMed/NCBI View Article : Google Scholar

57 

Karimi G, Vahabzadeh M, Lari P, Rashedinia M and Moshiri M: ‘Silymarin’, a promising pharmacological agent for treatment of diseases. Iran J Basic Med Sci. 14:308–317. 2011.PubMed/NCBI

58 

Akhtar MN, Saeed R, Saeed F, Asghar A, Ghani S, Ateeq H, Ahmed A, Rasheed A, Afzaal M, Waheed M, et al: Silymarin: A review on paving the way towards promising pharmacological agent. Int J Food Prop. 26:2256–2272. 2023.

59 

Balakumar P, Rohilla A and Thangathirupathi A: Gentamicin-induced nephrotoxicity: Do we have a promising therapeutic approach to blunt it? Pharmacol Res. 62:179–186. 2010.PubMed/NCBI View Article : Google Scholar

60 

Tesfa E, Munshea A, Nibret E, Mekonnen D, Sinishaw MA and Gizaw ST: Maternal serum uric acid, creatinine and blood urea levels in the prediction of pre-eclampsia among pregnant women attending ANC and delivery services at Bahir Dar city public hospitals, northwest Ethiopia: A case-control study. Heliyon. 8(e11098)2022.PubMed/NCBI View Article : Google Scholar

61 

Chen L, Zhu Z, Ye S and Zheng M: The serum uric acid to serum creatinine ratio is an independent risk factor for diabetic kidney disease. Diabetes Metab Syndr Obes. 15:3693–3703. 2022.PubMed/NCBI View Article : Google Scholar

62 

Bustos PS, Deza-Ponzio R, Páez PL, Cabrera JL, Virgolini MB and Ortega MG: Flavonoids as protective agents against oxidative stress induced by gentamicin in systemic circulation. Potent protective activity and microbial synergism of luteolin. Food Chem Toxicol. 118:294–302. 2018.PubMed/NCBI View Article : Google Scholar

63 

Karimi Z, Pakfetrat Z, Roozbeh J and Janfeshan S: Toll-like receptor-2 mediates systemic inflammation in gentamicin-induced rat nephrotoxicity. Clin Exp Pharmacol Physiol. 47:1584–1590. 2020.PubMed/NCBI View Article : Google Scholar

64 

Faul F, Erdfelder E, Lang AG and Buchner A: G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 39:175–191. 2007.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Alkandahri MY, Sadino A, Abriyani E, Hermanto F, Oktoba Z, Sayoeti MF, Sangging PR, Wardani D, Hasan N, Sari SW, Sari SW, et al: Evaluation of hepatoprotective and nephroprotective activities of <em>Castanopsis costata</em> extract in rats. Biomed Rep 22: 24, 2025.
APA
Alkandahri, M.Y., Sadino, A., Abriyani, E., Hermanto, F., Oktoba, Z., Sayoeti, M.F. ... Safitri, S. (2025). Evaluation of hepatoprotective and nephroprotective activities of <em>Castanopsis costata</em> extract in rats. Biomedical Reports, 22, 24. https://doi.org/10.3892/br.2024.1902
MLA
Alkandahri, M. Y., Sadino, A., Abriyani, E., Hermanto, F., Oktoba, Z., Sayoeti, M. F., Sangging, P. R., Wardani, D., Hasan, N., Sari, S. W., Safitri, N. A., Ikhtianingsih, W., Safitri, S."Evaluation of hepatoprotective and nephroprotective activities of <em>Castanopsis costata</em> extract in rats". Biomedical Reports 22.2 (2025): 24.
Chicago
Alkandahri, M. Y., Sadino, A., Abriyani, E., Hermanto, F., Oktoba, Z., Sayoeti, M. F., Sangging, P. R., Wardani, D., Hasan, N., Sari, S. W., Safitri, N. A., Ikhtianingsih, W., Safitri, S."Evaluation of hepatoprotective and nephroprotective activities of <em>Castanopsis costata</em> extract in rats". Biomedical Reports 22, no. 2 (2025): 24. https://doi.org/10.3892/br.2024.1902
Copy and paste a formatted citation
x
Spandidos Publications style
Alkandahri MY, Sadino A, Abriyani E, Hermanto F, Oktoba Z, Sayoeti MF, Sangging PR, Wardani D, Hasan N, Sari SW, Sari SW, et al: Evaluation of hepatoprotective and nephroprotective activities of <em>Castanopsis costata</em> extract in rats. Biomed Rep 22: 24, 2025.
APA
Alkandahri, M.Y., Sadino, A., Abriyani, E., Hermanto, F., Oktoba, Z., Sayoeti, M.F. ... Safitri, S. (2025). Evaluation of hepatoprotective and nephroprotective activities of <em>Castanopsis costata</em> extract in rats. Biomedical Reports, 22, 24. https://doi.org/10.3892/br.2024.1902
MLA
Alkandahri, M. Y., Sadino, A., Abriyani, E., Hermanto, F., Oktoba, Z., Sayoeti, M. F., Sangging, P. R., Wardani, D., Hasan, N., Sari, S. W., Safitri, N. A., Ikhtianingsih, W., Safitri, S."Evaluation of hepatoprotective and nephroprotective activities of <em>Castanopsis costata</em> extract in rats". Biomedical Reports 22.2 (2025): 24.
Chicago
Alkandahri, M. Y., Sadino, A., Abriyani, E., Hermanto, F., Oktoba, Z., Sayoeti, M. F., Sangging, P. R., Wardani, D., Hasan, N., Sari, S. W., Safitri, N. A., Ikhtianingsih, W., Safitri, S."Evaluation of hepatoprotective and nephroprotective activities of <em>Castanopsis costata</em> extract in rats". Biomedical Reports 22, no. 2 (2025): 24. https://doi.org/10.3892/br.2024.1902
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