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Dapagliflozin treatment alleviates fatty liver in patients with type 2 diabetes

  • Authors:
    • Xiuying Gao
    • Chuanming Zhu
    • Wei Zhu
    • Lin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Beijing Aerospace General Hospital, Beijing 100076, P.R. China, Department of Radiology, Beijing Aerospace General Hospital, Beijing 100076, P.R. China, Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 26
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    Published online on: December 5, 2024
       https://doi.org/10.3892/br.2024.1904
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Abstract

Non‑alcoholic fatty liver disease (NAFLD) is common in patients with type 2 diabetes mellitus (T2DM). The present study evaluated the effect of dapagliflozin on the liver fat content in patients with T2DM and NAFLD. The changes in biochemical data and metabolic parameters were analyzed. Clinical data of patients with T2DM and NAFLD treated by dapagliflozin were retrospectively collected between June 2022 and December 2022. A total of 35 patients, with a mean age of 45.8±2.2 years, consisting of 60.0% male patients, were included in the final analysis. After 20 weeks of dapagliflozin treatment, the parameters of diabetes improved. Plasma glucose and hemoglobin A1C levels significantly decreased (P<0.01), and insulin resistance improved. The change in liver fat content was evaluated by quantitative computed tomography, which revealed a decrease from 16.1±2.2 to 11.2±1.3% after treatment (P<0.01). Liver function (alanine aminotransferase, aspartate aminotransferase and γ‑glutamyltransferase levels) also improved. Visceral and subcutaneous fat areas showed a significant decrease after treatment, and there was a more significant reduction in visceral fat area. The factors associated with liver fat content were determined by Pearson's correlation and regression analyses. Pearson's correlation analysis indicated that the post‑treatment decrease in liver fat content was positively correlated with the change in body weight (r=0.642, P=0.033), index of homeostasis model assessment‑insulin resistance (r=0.670, P=0.048), triglycerides (r=0.627, P=0.039), high sensitivity C‑reactive protein (r=0.608, P=0.047) and interleukin (IL)‑6 (r=0.604, P=0.049). Linear regression analysis revealed that body weight (β=0.416, P=0.001), IL‑6 (β=0.284, P=0.009), triglycerides (β=0.262, P=0.011) and total cholesterol (β=0.388, P=0.001) were independent factors related to liver fat content. In conclusion, dapagliflozin can reduce liver fat in patients with T2DM and NAFLD. The reduction in liver fat is associated with improvement of metabolic parameters and inflammatory cytokines.
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Copy and paste a formatted citation
Spandidos Publications style
Gao X, Zhu C, Zhu W and Wang L: Dapagliflozin treatment alleviates fatty liver in patients with type 2 diabetes. Biomed Rep 22: 26, 2025.
APA
Gao, X., Zhu, C., Zhu, W., & Wang, L. (2025). Dapagliflozin treatment alleviates fatty liver in patients with type 2 diabetes. Biomedical Reports, 22, 26. https://doi.org/10.3892/br.2024.1904
MLA
Gao, X., Zhu, C., Zhu, W., Wang, L."Dapagliflozin treatment alleviates fatty liver in patients with type 2 diabetes". Biomedical Reports 22.2 (2025): 26.
Chicago
Gao, X., Zhu, C., Zhu, W., Wang, L."Dapagliflozin treatment alleviates fatty liver in patients with type 2 diabetes". Biomedical Reports 22, no. 2 (2025): 26. https://doi.org/10.3892/br.2024.1904
Copy and paste a formatted citation
x
Spandidos Publications style
Gao X, Zhu C, Zhu W and Wang L: Dapagliflozin treatment alleviates fatty liver in patients with type 2 diabetes. Biomed Rep 22: 26, 2025.
APA
Gao, X., Zhu, C., Zhu, W., & Wang, L. (2025). Dapagliflozin treatment alleviates fatty liver in patients with type 2 diabetes. Biomedical Reports, 22, 26. https://doi.org/10.3892/br.2024.1904
MLA
Gao, X., Zhu, C., Zhu, W., Wang, L."Dapagliflozin treatment alleviates fatty liver in patients with type 2 diabetes". Biomedical Reports 22.2 (2025): 26.
Chicago
Gao, X., Zhu, C., Zhu, W., Wang, L."Dapagliflozin treatment alleviates fatty liver in patients with type 2 diabetes". Biomedical Reports 22, no. 2 (2025): 26. https://doi.org/10.3892/br.2024.1904
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