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Herbal drug‑based nanotherapy for hepatocellular carcinoma: Quercetin‑contained nanocarrier as a multipurpose therapeutic agent against hepatocellular carcinoma (Review)

  • Authors:
    • Tserendolgor Batsukh
    • Altansukh Tsend‑Ayush
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy Administration and Technology, Mongolian University of Pharmaceutical Sciences, Ulaanbaatar 18130, Mongolia, Department of Molecular Biology and Genetics, School of Bio‑Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar 14210, Mongolia
    Copyright: © Batsukh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 29
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    Published online on: December 9, 2024
       https://doi.org/10.3892/br.2024.1907
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Abstract

Cancer remains one of the leading causes of morbidity and mortality worldwide, with hepatocellular carcinoma (HCC) accounting for ~75% of all primary liver cancers and exhibiting a high incidence rate. Unfortunately, the response rate to chemotherapeutic agents for liver cancer is relatively low, primarily due to the development of drug resistance and the lack of targeted therapeutic agents. The present study focused on the anticancer mechanisms of quercetin and the development of innovative nanocarriers designed to enhance its efficacy against HCC while mitigating drug resistance. Quercetin demonstrates a diverse array of biological activities, making it a promising candidate for therapeutic applications. Its mechanisms include inhibition of tumor cell cycle, induction of apoptosis, modulation of reactive oxygen species and inhibition of chemotherapeutic resistance. Given these properties, extensive research has been conducted in pharmaceutical engineering to develop well‑designed nanocarriers that incorporate quercetin. These nanocarriers aim to improve the bioavailability and targeting of quercetin, thereby enhancing its therapeutic efficacy against HCC and overcoming the challenges associated with anticancer drug resistance. Through this approach, quercetin could potentially play a pivotal role in the future of HCC treatment, providing a synergistic effect when combined with traditional chemotherapy leading to improved patient outcomes.
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1 

Morgan E, Soerjomataram I, Rumgay H, Coleman HG, Thrift AP, Vignat J, Laversanne M, Ferlay J and Arnold M: The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality in 2020 and projections to 2040: New estimates from GLOBOCAN 2020. Gastroenterology. 163:649–658.e2. 2022.PubMed/NCBI View Article : Google Scholar

2 

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 74:229–263. 2024.PubMed/NCBI View Article : Google Scholar

3 

Mattiuzzi C and Lippi G: Current cancer epidemiology. J Epidemiol Glob Health. 9:217–222. 2019.PubMed/NCBI View Article : Google Scholar

4 

Sayiner M, Golabi P and Younossi ZM: Disease burden of hepatocellular carcinoma: A global Dig Dis. Sci. 64:910–917. 2019.PubMed/NCBI View Article : Google Scholar

5 

Joyce H, McCann A, Clynes M and Larkin A: Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism. Expert Opin Drug Metab Toxicol. 11:795–809. 2015.PubMed/NCBI View Article : Google Scholar

6 

Lundqvist EÅ, Fujiwara K and Seoud M: Principles of chemotherapy. Int J Gynaecol Obstet. 131 (Suppl 2):S146–S149. 2015.PubMed/NCBI View Article : Google Scholar

7 

Wu H, Wei M, Xu Y, Li Y, Zhai X, Su P, Ma Q and Zhang H: PDA-based drug delivery nanosystems: A potential approach for glioma treatment. Int J Nanomedicine. 17:3751–3775. 2022.PubMed/NCBI View Article : Google Scholar

8 

Ding Y, Li W, Zhang F, Liu Z, Zanjanizadeh Ezazi N, Liu D and Santos HA: Electrospun fibrous architectures for drug delivery, tissue engineering and cancer therapy. Adv Funct Mater. 29(1802852)2019.

9 

Ali I, Nadeem Lone M, Suhail M, Danish Mukhtar S and Asnin L: Advances in nanocarriers for anticancer drugs delivery. Curr Med Chem. 23:2159–2187. 2016.PubMed/NCBI View Article : Google Scholar

10 

Sun Y, Su J, Liu G, Chen J, Zhang X, Zhang R, Jiang M and Qiu M: Advances of blood cell-based drug delivery systems. Eur J Pharm Sci. 96:115–128. 2017.PubMed/NCBI View Article : Google Scholar

11 

Upadhyay RK: Therapeutic and pharmaceutical potential of Cinnamomum tamala. Res Rev Pharm Pharm Sci. 6:18–28. 2017.

12 

Sultana S, Munir N, Mahmood Z, Riaz M, Akram M, Rebezov M, Kuderinova N, Moldabayeva Z, Shariati MA, Rauf A and Rengasamy KRR: Molecular targets for the management of cancer using Curcuma longa Linn. phytoconstituents: A review. Biomed Pharmacother. 135(111078)2021.PubMed/NCBI View Article : Google Scholar

13 

Taleghani A, Emami SA and Tayarani-Najaran Z: Artemisia: A promising plant for the treatment of cancer. Bioorg Med Chem. 28(115180)2020.PubMed/NCBI View Article : Google Scholar

14 

Ji S, Li Z, Song W, Wang Y, Liang W, Li K, Tang S, Wang Q, Qiao X, Zhou D, et al: Bioactive constituents of Glycyrrhiza uralensis (Licorice): Discovery of the effective components of a traditional herbal medicine. J Nat Prod. 79:281–292. 2016.PubMed/NCBI View Article : Google Scholar

15 

Makia R, Al-Sammarrae K, Al-Halbosiy M and Al-Mashhadani M: In vitro cytotoxic activity of total flavonoid from Equisetum arvense extract. Rep Biochem Mol Biol. 11:487–492. 2022.PubMed/NCBI View Article : Google Scholar

16 

Lee D, Park S, Choi S, Kim SH and Kang KS: In vitro estrogenic and breast cancer inhibitory activities of chemical constituents isolated from Rheum undulatum L. Molecules. 23(1215)2018.PubMed/NCBI View Article : Google Scholar

17 

Cheng CS, Chen J, Tan HY, Wang N, Chen Z and Feng Y: Scutellaria baicalensis and cancer treatment: Recent progress and perspectives in biomedical and clinical studies. Am J Chin Med. 46:25–54. 2018.PubMed/NCBI View Article : Google Scholar

18 

Men K, Duan X, Wei XW, Gou ML, Huang MJ, Chen LJ, Qian ZY and Wei YQ: Nanoparticle-delivered quercetin for cancer therapy. Anticancer Agents Med Chem. 14:826–832. 2014.PubMed/NCBI View Article : Google Scholar

19 

An T, Yin H, Lu Y and Liu F: The emerging potential of parthenolide nanoformulations in tumor therapy. Drug Des Devel Ther. 16:1255–1272. 2022.PubMed/NCBI View Article : Google Scholar

20 

Dang X, Cho S, Wang H, Seok WJ, Ha JH and Kim IH: Quercetin extracted from Sophora japonica flower improves growth performance, nutrient digestibility, cecal microbiota, organ indexes, and breast quality in broiler chicks. Anim Biosci. 35:577–586. 2022.PubMed/NCBI View Article : Google Scholar

21 

Lekar AV, Borisenko SN, Vetrova EV, Sushkova SN and Borisenko NI: Extraction of quercetin from Polygonum hydropiper L. by subcritical water. Am J Agric Biol Sci. 9:1–5. 2014.

22 

Yang HH, Hwangbo K, Zheng MS, Cho JH, Son JK, Kim HY, Baek SH, Choi HC, Park SY and Kim JR: Quercetin-3-O-β-D-glucuronide isolated from Polygonum aviculare inhibits cellular senescence in human primary cells. Arch Pharm Res. 37:1219–1233. 2014.PubMed/NCBI View Article : Google Scholar

23 

Anand David AV, Arulmoli R and Parasuraman S: Overviews of Biological importance of quercetin: A bioactive flavonoid. Pharmacogn Rev. 10:84–89. 2016.PubMed/NCBI View Article : Google Scholar

24 

Michala AS and Pritsa A: Quercetin: A molecule of great biochemical and clinical value and its beneficial effect on diabetes and cancer. Diseases. 10(37)2022.PubMed/NCBI View Article : Google Scholar

25 

Wang SY, Duan KM, Li Y, Mei Y, Sheng H, Liu H, Mei X, Ouyang W, Zhou HH and Liu ZQ: Effect of quercetin on P-glycoprotein transport ability in Chinese healthy subjects. Eur J Clin Nutr. 67:390–394. 2013.PubMed/NCBI View Article : Google Scholar

26 

Davoodvandi A, Shabani Varkani M, Clark CCT and Jafarnejad S: Quercetin as an anticancer agent: Focus on esophageal cancer. J Food Biochem. 44(e13374)2020.PubMed/NCBI View Article : Google Scholar

27 

Vafadar A, Shabaninejad Z, Movahedpour A, Fallahi F, Taghavipour M, Ghasemi Y, Akbari M, Shafiee A, Hajighadimi S, Moradizarmehri S, et al: Quercetin and cancer: New insights into its therapeutic effects on ovarian cancer cells. Cell Biosci. 10(31)2020.PubMed/NCBI View Article : Google Scholar

28 

Jeong JH, An JY, Kwon YT, Rhee JG and Lee YJ: Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression. J Cell Biochem. 106:73–82. 2009.PubMed/NCBI View Article : Google Scholar

29 

Ganthala PD, Alavala S, Chella N, andugulapati SB, Bathini NB and Sistla R: Co-encapsulated nanoparticles of erlotinib and quercetin for targeting lung cancer through nuclear EGFR and PI3K/AKT inhibition. Colloids Surf B Biointerfaces. 211(112305)2022.PubMed/NCBI View Article : Google Scholar

30 

Safi A, Heidarian E and Ahmadi R: Quercetin synergistically enhances the anticancer efficacy of docetaxel through induction of apoptosis and modulation of PI3K/AKT, MAPK/ERK and JAK/STAT3 signaling pathways in MDA-MB-231 breast cancer cell line. Int J Mol Cell Med. 10:11–22. 2021.PubMed/NCBI View Article : Google Scholar

31 

Guo T, Wu C, Zhang J, Yu J, Li G, Jiang H, Zhang X, Yu R and Liu X: Dual blockade of EGFR and PI3K signaling pathways offers a therapeutic strategy for glioblastoma. Cell Commun Signal. 21(363)2023.PubMed/NCBI View Article : Google Scholar

32 

Li Y, Han N, Hou P, Zhao FQ and Liu H: Roles of MAPK and Nrf2 signaling pathways in quercetin alleviating redox imbalance induced by hydrogen peroxide in mammary epithelial cells. Anim Nutr. 1(e1)2024.

33 

Liu W, Chen D, Su J, Zheng R, Kong R, Zhu B, Dong H and Li Y: Quercetin induced HepG2 cells apoptosis through ATM/JNK/STAT3 signaling pathways. Biocell. 47:187–194. 2023.

34 

Wang ZX, Ma J, Li XY, Wu Y, Shi H, Chen Y, Lu G, Shen HM, Lu GD and Zhou J: Quercetin induces p53-independent cancer cell death through lysosome activation by the transcription factor EB and reactive oxygen species-dependent ferroptosis. Br J Pharmacol. 178:1133–1148. 2021.PubMed/NCBI View Article : Google Scholar

35 

Chan ST, Yang NC, Huang CS, Liao JW and Yeh SL: Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. PLoS One. 8(e54255)2013.PubMed/NCBI View Article : Google Scholar

36 

Granado-Serrano AB, Martín MA, Bravo L, Goya L and Ramos S: Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2). J Nutr. 136:2715–2721. 2006.PubMed/NCBI View Article : Google Scholar

37 

Lee DH, Szczepanski M and Lee YJ: Role of Bax in quercetin-induced apoptosis in human prostate cancer cells. Biochem Pharmacol. 75:2345–2355. 2008.PubMed/NCBI View Article : Google Scholar

38 

Huang CF, Liu SH, Ho TJ, Lee KI, Fang KM, Lo WC, Liu JM, Wu CC and Su CC: Quercetin induces tongue squamous cell carcinoma cell apoptosis via the JNK activation-regulated ERK/GSK-3α/β-mediated mitochondria-dependent apoptotic signaling pathway. Oncol Lett. 23(78)2022.PubMed/NCBI View Article : Google Scholar

39 

Xu D, Hu MJ, Wang YQ and Cui YL: Antioxidant activities of quercetin and its complexes for medicinal application. Molecules. 24(1123)2019.PubMed/NCBI View Article : Google Scholar

40 

Lee YJ, Lee DM and Lee SH: Nrf2 expression and apoptosis in quercetin-treated malignant mesothelioma cells. Mol Cells. 38:416–425. 2015.PubMed/NCBI View Article : Google Scholar

41 

Rashidi Z, Aleyasin A, Eslami M, Nekoonam S, Zendedel A, Bahramrezaie M and Amidi F: Quercetin protects human granulosa cells against oxidative stress via thioredoxin system. Reprod Biol. 19:245–254. 2019.PubMed/NCBI View Article : Google Scholar

42 

Baba RA, Mir HA, Mokhdomi TA, Bhat HF, Ahmad A and Khanday FA: Quercetin suppresses ROS production and migration by specifically targeting Rac1 activation in gliomas. Front Pharmacol. 15(1318797)2024.PubMed/NCBI View Article : Google Scholar

43 

Biswas P, Dey D, Biswas PK, Rahaman TI, Saha S, Parvez A, Khan DA, Lily NJ, Saha K, Sohel M, et al: A comprehensive analysis and anti-cancer activities of quercetin in ROS-mediated cancer and cancer stem cells. Int J Mol Sci. 23(11746)2022.PubMed/NCBI View Article : Google Scholar

44 

Zhang Q, Cheng G, Qiu H, Zhu L, Ren Z, Zhao W, Zhang T and Liu L: The p53-inducible gene 3 involved in flavonoid-induced cytotoxicity through the reactive oxygen species-mediated mitochondrial apoptotic pathway in human hepatoma cells. Food Funct. 6:1518–1525. 2015.PubMed/NCBI View Article : Google Scholar

45 

Pratheeshkumar P, Budhraja A, Son YO, Wang X, Zhang Z, Ding S, Wang L, Hitron A, Lee JC, Xu M, et al: Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR-2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One. 7(e47516)2012.PubMed/NCBI View Article : Google Scholar

46 

Igura K, Ohta T, Kuroda Y and Kaji K: Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett. 171:11–16. 2001.PubMed/NCBI View Article : Google Scholar

47 

Okumo T, Furuta A, Kimura T, Yusa K, Asano K and Sunagawa M: Inhibition of angiogenic factor productions by quercetin in vitro and in vivo. Medicines (Basel). 8(22)2021.PubMed/NCBI View Article : Google Scholar

48 

Ren KW, Li YH, Wu G, Ren JZ, Lu HB, Li ZM and Han XW: Quercetin nanoparticles display antitumor activity via proliferation inhibition and apoptosis induction in liver cancer cells. Int J Oncol. 50:1299–1311. 2017.PubMed/NCBI View Article : Google Scholar

49 

Guan X, Gao M, Xu H, Zhang C, Liu H, Lv L, Deng S, Gao D and Tian Y: Quercetin-loaded poly (lactic-co-glycolic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for the targeted treatment of liver cancer. Drug Deliv. 23:3307–3318. 2016.PubMed/NCBI View Article : Google Scholar

50 

Srisa-Nga K, Mankhetkorn S, Okonogi S and Khonkarn R: Delivery of superparamagnetic polymeric micelles loaded with quercetin to hepatocellular carcinoma cells. J Pharm Sci. 108:996–1006. 2019.PubMed/NCBI View Article : Google Scholar

51 

Wang C, Su L, Wu C, Wu J, Zhu C and Yuan G: RGD peptide targeted lipid-coated nanoparticles for combinatorial delivery of sorafenib and quercetin against hepatocellular carcinoma. Drug Dev Ind Pharm. 42:1938–1944. 2016.PubMed/NCBI View Article : Google Scholar

52 

Deng Q, Huang Y, Zeng J, Li X, Zheng X, Guo L, Shi J and Bai L: Recent advancements in the small-molecule drugs for hepatocellular carcinoma (HCC): Structure-activity relationships, pharmacological activities, and the clinical trials. Biomed Pharmacother. 179(117343)2024.PubMed/NCBI View Article : Google Scholar

53 

Tang W, Chen Z, Zhang W, Cheng Y, Zhang B, Wu F, Wang Q, Wang S, Rong D, Reiter FP, et al: The mechanisms of sorafenib resistance in hepatocellular carcinoma: Theoretical basis and therapeutic aspects. Signal Transduct Target Ther. 5(87)2020.PubMed/NCBI View Article : Google Scholar

54 

Pradhan A, Kumari A, Srivastava R and Panda D: Quercetin encapsulated biodegradable plasmonic nanoparticles for photothermal therapy of hepatocellular carcinoma cells. ACS Appl Bio Mater. 2:5727–5738. 2019.PubMed/NCBI View Article : Google Scholar

55 

Varshosaz J, Jafarian A, Salehi G and Zolfaghari B: Comparing different sterol containing solid lipid nanoparticles for targeted delivery of quercetin in hepatocellular carcinoma. J Liposome Res. 24:191–203. 2014.PubMed/NCBI View Article : Google Scholar

56 

Koulouris A, Tsagkaris C, Spyrou V, Pappa E, Troullinou A and Nikolaou M: Hepatocellular carcinoma: An overview of the changing landscape of treatment options. J Hepatocell Carcinoma. 8:387–401. 2021.PubMed/NCBI View Article : Google Scholar

57 

Bukowski K, Kciuk M and Kontek R: Mechanisms of multidrug resistance in cancer chemotherapy. Int J Mol Sci. 21(3233)2020.PubMed/NCBI View Article : Google Scholar

58 

Talib WH, Alsayed AR, Barakat M, Abu-Taha MI and Mahmod AI: Targeting drug chemo-resistance in cancer using natural products. Biomedicines. 9(1353)2021.PubMed/NCBI View Article : Google Scholar

59 

Al Saihati HA and Rabaan AA: Cellular resistance mechanisms in cancer and the new approaches to overcome resistance mechanisms chemotherapy. Saudi Med J. 44:329–344. 2023.PubMed/NCBI View Article : Google Scholar

60 

Halder J, Pradhan D, Kar B, Ghosh G and Rath G: Nanotherapeutics approaches to overcome P-glycoprotein-mediated multi-drug resistance in cancer. Nanomedicine. 40(102494)2022.PubMed/NCBI View Article : Google Scholar

61 

Waghray D and Zhang Q: Inhibit or evade multidrug resistance P-glycoprotein in cancer treatment: Miniperspective. J Med Chem. 61:5108–5121. 2017.PubMed/NCBI View Article : Google Scholar

62 

Li S, Zhao Q, Wang B, Yuan S, Wang X and Li K: Quercetin reversed MDR in breast cancer cells through down-regulating P-gp expression and eliminating cancer stem cells mediated by YB-1 nuclear translocation. Phytother Res. 32:1530–1536. 2018.PubMed/NCBI View Article : Google Scholar

63 

Ganesan M, Kanimozhi G, Pradhapsingh B, Khan HA, Alhomida AS, Ekhzaimy A, Brindha GR and Prasad NR: Phytochemicals reverse P-glycoprotein mediated multidrug resistance via signal transduction pathways. Biomed Pharmacother. 139(111632)2021.PubMed/NCBI View Article : Google Scholar

64 

Suroowan S, Abdallah HH and Mahomoodally MF: Herb-drug interactions and toxicity: Underscoring potential mechanisms and forecasting clinically relevant interactions induced by common phytoconstituents via data mining and computational approaches. Food Chem Toxicol. 156(112432)2021.PubMed/NCBI View Article : Google Scholar

65 

Palmeira A, Sousa E, Vasconcelos MH and Pinto MM: Three decades of P-gp inhibitors: Skimming through several generations and scaffolds. Curr Med Chem. 19:1946–2025. 2012.PubMed/NCBI View Article : Google Scholar

66 

Gurunath S, Nanjwade BK and Patil PA: Oral bioavailability and intestinal absorption of candesartan cilexetil: Role of naringin as P-glycoprotein inhibitor. Drug Dev Ind Pharm. 41:170–176. 2015.PubMed/NCBI View Article : Google Scholar

67 

Di Sotto A, Irannejad H, Eufemi M, Mancinelli R, Abete L, Mammola CL, Altieri F, Mazzanti G and Di Giacomo S: Potentiation of low-dose doxorubicin cytotoxicity by affecting P-glycoprotein through caryophyllane sesquiterpenes in hepG2 cells: An in vitro and in silico study. Int J Mol Sci. 21(633)2020.PubMed/NCBI View Article : Google Scholar

68 

Dewanjee S, Dua TK, Bhattacharjee N, Das A, Gangopadhyay M, Khanra R, Joardar S, Riaz M, Feo V and Zia-Ul-Haq M: Natural products as alternative choices for P-glycoprotein (P-gp) inhibition. Molecules. 22(871)2017.PubMed/NCBI View Article : Google Scholar

69 

Mohos V, Fliszár-Nyúl E, Ungvári O, Kuffa K, Needs PW, Kroon PA, Telbisz Á, Özvegy-Laczka C and Poór M: Inhibitory effects of quercetin and its main methyl, sulfate, and glucuronic acid conjugates on cytochrome p450 enzymes, and on OATP, BCRP and MRP2 transporters. Nutrients. 12(2306)2020.PubMed/NCBI View Article : Google Scholar

70 

Arinç E, Yilmaz D and Bozcaarmutlu A: Mechanism of inhibition of CYP1A1 and glutathione S-transferase activities in fish liver by quercetin, resveratrol, naringenin, hesperidin, and rutin. Nutr Cancer. 67:137–144. 2015.PubMed/NCBI View Article : Google Scholar

71 

van Zanden JJ, Ben Hamman O, van Iersel ML, Boeren S, Cnubben NH, Lo Bello M, Vervoort J, van Bladeren PJ and Rietjens IM: Inhibition of human glutathione S-transferase P1-1 by the flavonoid quercetin. Chem Biol Interact. 145:139–148. 2003.PubMed/NCBI View Article : Google Scholar

72 

Choi JS, Piao YJ and Kang KW: Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin. Arch Pharm Res. 34:607–613. 2011.PubMed/NCBI View Article : Google Scholar

73 

Borska S, Sopel M, Chmielewska M, Zabel M and Dziegiel P: Quercetin as a potential modulator of P-glycoprotein expression and function in cells of human pancreatic carcinoma line resistant to daunorubicin. Molecules. 15:857–870. 2010.PubMed/NCBI View Article : Google Scholar

74 

Singh A, Patel SK, Kumar P, Das KC, Verma D, Sharma R, Tripathi T, Giri R, Martins N and Garg N: Quercetin acts as a P-gp modulator via impeding signal transduction from nucleotide-binding domain to transmembrane domain. J Biomol Struct Dyn. 40:4507–4515. 2020.PubMed/NCBI View Article : Google Scholar

75 

Mu Y, Fu Y, Li J, Yu X, Li Y, Wang Y, Wu X, Zhang K, Kong M, Feng C and Chen X: Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. Carbohydr Polym. 203:10–18. 2019.PubMed/NCBI View Article : Google Scholar

76 

Guo Y, Liu S, Luo F, Tang D, Yang T, Yang X and Xie Y: A nanosized codelivery system based on intracellular stimuli-triggered dual-drug release for multilevel chemotherapy amplification in drug-resistant breast cancer. Pharmaceutics. 14(422)2022.PubMed/NCBI View Article : Google Scholar

77 

Yu J, Chen H, Jiang L and Wang J, Dai J and Wang J: Codelivery of adriamycin and P-gp inhibitor quercetin using PEGylated liposomes to overcome cancer drug resistance. J Pharm Sci. 108:1788–1799. 2019.PubMed/NCBI View Article : Google Scholar

78 

Wang X, Chen Y, Dahmani FZ, Yin L, Zhou J and Yao J: Amphiphilic carboxymethyl chitosan-quercetin conjugate with P-gp inhibitory properties for oral delivery of paclitaxel. Biomaterials. 35:7654–7665. 2014.PubMed/NCBI View Article : Google Scholar

79 

Khonkarn R, Daowtak K and Okonogi S: Chemotherapeutic efficacy enhancement in P-gp-overexpressing cancer cells by flavonoid-loaded polymeric micelles. AAPS PharmSciTech. 21(121)2020.PubMed/NCBI View Article : Google Scholar

80 

Mu Y, Wu G, Su C, Dong Y, Zhang K, Li J, Sun X, Li Y, Chen X and Feng C: pH-sensitive amphiphilic chitosan-quercetin conjugate for intracellular delivery of doxorubicin enhancement. Carbohydr Polym. 223(115072)2019.PubMed/NCBI View Article : Google Scholar

81 

Kumar M, Sharma G, Misra C, Kumar R, Singh B, Katare OP and Raza K: N-desmethyl tamoxifen and quercetin-loaded multiwalled CNTs: A synergistic approach to overcome MDR in cancer cells. Mater Sci Eng C Mater Biol Appl. 89:274–282. 2018.PubMed/NCBI View Article : Google Scholar

82 

Qian J, Liu S, Yang T, Xiao Y, Sun J, Zhao J, Zhang Z and Xie Y: Polyethyleneimine-tocopherol hydrogen succinate/hyaluronic acid-quercetin (PEI-TOS/HA-QU) core-shell micelles delivering paclitaxel for combinatorial treatment of MDR breast cancer. J Biomed Nanotechnol. 17:382–398. 2021.PubMed/NCBI View Article : Google Scholar

83 

Dallavalle S, Dobričić V, Lazzarato L, Gazzano E, Machuqueiro M, Pajeva I, Tsakovska I, Zidar N and Fruttero R: Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors. Drug Resist Updat. 50(100682)2020.PubMed/NCBI View Article : Google Scholar

84 

Deshmukh R, Prajapati M and Harwansh RK: Management of colorectal cancer using nanocarriers-based drug delivery for herbal bioactives: Current and emerging approaches. Curr Pharm Biotechnol. 25:599–622. 2024.PubMed/NCBI View Article : Google Scholar

85 

Kenchegowda M, Rahamathulla M, Hani U, Begum MY, Guruswamy S, Osmani RAM, Gowrav MP, Alshehri S, Ghoneim MM, Alshlowi A and Gowda DV: Smart nanocarriers as an emerging platform for cancer therapy: A review. Molecules. 27(146)2021.PubMed/NCBI View Article : Google Scholar

86 

Tang L, Li J, Zhao Q, Pan T, Zhong H and Wang W: Advanced and innovative nano-systems for anticancer targeted drug delivery. Pharmaceutics. 13(1151)2021.PubMed/NCBI View Article : Google Scholar

87 

Kumar V, Rahman M, Gahtori P, Al-Abbasi F, Anwar F and Kim HS: Current status and future directions of hepatocellular carcinoma-targeted nanoparticles and nanomedicine. Expert Opin Drug Deliv. 18:673–694. 2021.PubMed/NCBI View Article : Google Scholar

88 

Mishra AK, Pandey M, Dewangan HK, Sl N and Sahoo PK: A comprehensive review on liver targeting: Emphasis on nanotechnology-based molecular targets and receptors mediated approaches. Curr Drug Targets. 23:1381–1405. 2022.PubMed/NCBI View Article : Google Scholar

89 

Dutta R and Mahato RI: Recent advances in hepatocellular carcinoma therapy. Pharmacol Ther. 173:106–117. 2017.PubMed/NCBI View Article : Google Scholar

90 

Aghababaei F and Hadidi M: Recent advances in potential health benefits of quercetin. Pharmaceuticals (Basel). 16(1020)2023.PubMed/NCBI View Article : Google Scholar

91 

Manzoor MF, Hussain A, Sameen A, Sahar A, Khan S, Siddique R, Aadil RM and Xu B: Novel extraction, rapid assessment and bioavailability improvement of quercetin: A review. Ultrason Sonochem. 78(105686)2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Batsukh T and Tsend‑Ayush A: Herbal drug‑based nanotherapy for hepatocellular carcinoma: Quercetin‑contained nanocarrier as a multipurpose therapeutic agent against hepatocellular carcinoma (Review). Biomed Rep 22: 29, 2025.
APA
Batsukh, T., & Tsend‑Ayush, A. (2025). Herbal drug‑based nanotherapy for hepatocellular carcinoma: Quercetin‑contained nanocarrier as a multipurpose therapeutic agent against hepatocellular carcinoma (Review). Biomedical Reports, 22, 29. https://doi.org/10.3892/br.2024.1907
MLA
Batsukh, T., Tsend‑Ayush, A."Herbal drug‑based nanotherapy for hepatocellular carcinoma: Quercetin‑contained nanocarrier as a multipurpose therapeutic agent against hepatocellular carcinoma (Review)". Biomedical Reports 22.2 (2025): 29.
Chicago
Batsukh, T., Tsend‑Ayush, A."Herbal drug‑based nanotherapy for hepatocellular carcinoma: Quercetin‑contained nanocarrier as a multipurpose therapeutic agent against hepatocellular carcinoma (Review)". Biomedical Reports 22, no. 2 (2025): 29. https://doi.org/10.3892/br.2024.1907
Copy and paste a formatted citation
x
Spandidos Publications style
Batsukh T and Tsend‑Ayush A: Herbal drug‑based nanotherapy for hepatocellular carcinoma: Quercetin‑contained nanocarrier as a multipurpose therapeutic agent against hepatocellular carcinoma (Review). Biomed Rep 22: 29, 2025.
APA
Batsukh, T., & Tsend‑Ayush, A. (2025). Herbal drug‑based nanotherapy for hepatocellular carcinoma: Quercetin‑contained nanocarrier as a multipurpose therapeutic agent against hepatocellular carcinoma (Review). Biomedical Reports, 22, 29. https://doi.org/10.3892/br.2024.1907
MLA
Batsukh, T., Tsend‑Ayush, A."Herbal drug‑based nanotherapy for hepatocellular carcinoma: Quercetin‑contained nanocarrier as a multipurpose therapeutic agent against hepatocellular carcinoma (Review)". Biomedical Reports 22.2 (2025): 29.
Chicago
Batsukh, T., Tsend‑Ayush, A."Herbal drug‑based nanotherapy for hepatocellular carcinoma: Quercetin‑contained nanocarrier as a multipurpose therapeutic agent against hepatocellular carcinoma (Review)". Biomedical Reports 22, no. 2 (2025): 29. https://doi.org/10.3892/br.2024.1907
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