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Case Report Open Access

Trichomonas tenax detected in pleural effusion fluid: A case report

  • Authors:
    • Jinxia Wang
    • Qianqian Zhao
    • Dongxu Li
    • Yongzhong Ning
    • Lizhong Duan
    • Junge Zhang
    • Yuting Yang
    • Aifang Ji
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China, Department of Clinical Laboratory Medicine, Xijing Hospital, Fourth Military Medical University (Air Force Medical University), Xi'an, Shanxi 710032, P.R. China, Department of Laboratory Medicine, Beijing Chuiyangliu Hospital, Beijing 100020, P.R. China, Department of Clinical Laboratory, Affiliated Hospital of Anhui College of Traditional Chinese Medicine, Wuhu Hospital of Traditional Chinese Medicine, Wuhu, Anhui 241000, P.R. China, Department of Clinical Laboratory, Xiangshan Red Cross Taiwan Compatriot Hospital, Xiangshan, Zhejiang 315700, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 31
    |
    Published online on: December 10, 2024
       https://doi.org/10.3892/br.2024.1909
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Abstract

Trichomonas tenax is predominant in dental caries and is commonly observed in patients with oral diseases; however, its presence in patients with pleural effusion remains rare. Pleural effusion can arise from various causes, including malignant tumors, tuberculosis and bacterial infections. Concurrent infections involving bacteria, fungi and Trichomonas are infrequent. This scenario is particularly rare in patients with tumor‑associated Trichomonas tenax infection. The current study presents a case of Trichomonas tenax infection in a patient with a lung tumor. The patient, a 71‑year‑old male, experienced symptoms of chest tightness, shortness of breath, coughing and expectoration following surgery for a right lung tumor. The expectorated sputum was white and sticky, making coughing difficult. The patient had a history of a prior right lung tumor resection and was subsequently admitted to Heping Hospital Affiliated to Changzhi Medical College (Changzhi, China). Routine examination of the pleural effusion fluid revealed the presence of Trichomonas tenax under a wet‑film microscope. Molecular sequencing confirmed that the isolate was Trichomonas tenax. This case highlights Trichomonas tenax as a potential opportunistic pathogen in patients with lung cancer, underscoring the need for heightened clinical awareness. This study offers valuable insights for the diagnosis and prevention of infectious diseases among patients with cancer in the future.
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1 

Theel ES and Pritt BS: Parasites. Microbiol Spectr 4: DMIH2-0013-2015, 2016.

2 

Hsu SL and Fan CK: Emerging and reemerging parasitic diseases in Taiwan: A retrospective study of clinical case reports in 2001~2018. Pathogens. 13(383)2024.PubMed/NCBI View Article : Google Scholar

3 

Kooshki F, Khalaf AK, Mahmoudvand H, Baharvand P, Gandomi Rouzbahani F and Selahbarzin B: Molecular epidemiology and associated risk factors of parasites in oral cavity of children with malignancies in western Iran. Iran J Parasitol. 18:324–330. 2023.PubMed/NCBI View Article : Google Scholar

4 

Maritz JM, Land KM, Carlton JM and Hirt RP: What is the importance of zoonotic trichomonads for human health? Trends Parasitol. 30:333–341. 2014.PubMed/NCBI View Article : Google Scholar

5 

Kochanowsky JA, Mira PM, Elikaee S, Muratore K, Rai AK, Riestra AM and Johnson PJ: : Trichomonas vaginalis extracellular vesicles up-regulate and directly transfer adherence factors promoting host cell colonization. Proc Natl Acad Sci USA. 121(e2401159121)2024.PubMed/NCBI View Article : Google Scholar

6 

Xiao HD, Zhang S, Lv YH, Zhang ZD, Su N, Li LL, Zhu XQ, Xie SC and Gao WW: First molecular detection and genetic characterization of Tetratrichomonas buttreyi and Pentatrichomonas hominis in Donkeys in Shanxi Province, China. Animals (Basel). 14(2651)2024.PubMed/NCBI View Article : Google Scholar

7 

Wang SE, Brooks AES, Poole AM and Simoes-Barbosa A: Determinants of translation efficiency in the evolutionarily-divergent protist Trichomonas vaginalis. BMC Mol Cell Biol. 21(54)2020.PubMed/NCBI View Article : Google Scholar

8 

Rashidi Maybodi F, Haerian Ardakani A, Fattahi Bafghi A, Haerian Ardakani A and Zafarbakhsh A: The effect of nonsurgical periodontal therapy on Trichomonas tenax and Entamoeba gingivalis in patients with chronic periodontitis. J Dent (Shiraz). 17:171–176. 2016.PubMed/NCBI

9 

Chen CP: Fetal therapy and cytogenetic testing: Prenatal detection of chromosome aberration during thoracocentesis for congenital chylothorax by karyotyping from pleural effusion fluid and review of the literature. Genet Couns. 16:301–305. 2005.PubMed/NCBI

10 

Kikuta N, Yamamoto A, Fukura K and Goto N: Specific and sensitive detection of Trichomonas tenax by the polymerase chain reaction. Lett Appl Microbiol. 24:193–197. 1997.PubMed/NCBI View Article : Google Scholar

11 

Wu Y, Ye Y, Yang Y, Yang W, Lin J and Cao K: Pyopneumothorax from coinfection by Trichomonas tenax and Geotrichum capitatum in a child from China: A case report. BMC Infect Dis. 21(842)2021.PubMed/NCBI View Article : Google Scholar

12 

Mehr AK, Zarandi A and Anush K: Prevalence of oral Trichomonas tenax in periodontal lesions of down syndrome in Tabriz, Iran. J Clin Diagn Res. 9:Zc88–Zc90. 2015.PubMed/NCBI View Article : Google Scholar

13 

Leterrier M, Morio F, Renard BT, Poirier AS, Miegeville M and Chambreuil G: Trichomonads in pleural effusion: Case report, literature review and utility of PCR for species identification. New Microbiol. 35:83–87. 2012.PubMed/NCBI

14 

Yaseen A, Mahafzah A, Dababseh D, Taim D, Hamdan AA, Al-Fraihat E, Hassona Y, Şahin GÖ, Santi-Rocca J and Sallam M: Oral colonization by Entamoeba gingivalis and Trichomonas tenax: A PCR-based study in health, gingivitis, and periodontitis. Front Cell Infect Microbiol. 11(782805)2021.PubMed/NCBI View Article : Google Scholar

15 

Memik F: Trichomonads in pleural effusion. JAMA. 204:1145–1146. 1968.PubMed/NCBI

16 

Ohkura T, Suzuki N and Hashiguchi Y: Invasion of the human respiratory tracts by trichomonads. Am J Trop Med Hyg. 34(823)1985.PubMed/NCBI

17 

Shiota T, Arizono N, Morimoto T, Shimatsu A and Nakao K: : Trichomonas tenax empyema in an immunocompromised patient with advanced cancer. Parasite. 5:375–377. 1998.PubMed/NCBI View Article : Google Scholar

18 

Porcheret H, Maisonneuve L, Estève V, Jagot JL and Le Pennec MP: Pleural trichomoniasis due to Trichomonas tenax. Rev Mal Respir. 19:97–99. 2002.PubMed/NCBI(In French).

19 

Mallat H, Podglajen I, Lavarde V, Mainardi JL, Frappier J and Cornet M: Molecular characterization of Trichomonas tenax causing pulmonary infection. J Clin Microbiol. 42:3886–3887. 2004.PubMed/NCBI View Article : Google Scholar

20 

Bellanger AP, Cabaret O, Costa JM, Foulet F, Bretagne S and Botterel F: Two unusual occurrences of trichomoniasis: Rapid species identification by PCR. J Clin Microbiol. 46:3159–3161. 2008.PubMed/NCBI View Article : Google Scholar

21 

Cai DH and Fang XL: Pyopneumothorax caused by Trichomonas tenax and Porphyromonas endodontalis coinfection in a patient with previous cerebral infarction: A case report and literature review. Infect Drug Resist. 15:6101–6108. 2022.PubMed/NCBI View Article : Google Scholar

22 

Hinderfeld AS and Simoes-Barbosa A: Vaginal dysbiotic bacteria act as pathobionts of the protozoal pathogen Trichomonas vaginalis. Microb Pathog. 138(103820)2020.PubMed/NCBI View Article : Google Scholar

23 

Milner DA Jr: Malaria pathogenesis. Cold Spring Harb Perspect Med. 8(a025569)2018.PubMed/NCBI View Article : Google Scholar

24 

Santos JO and Roldán WH: Entamoeba gingivalis and Trichomonas tenax: Protozoa parasites living in the mouth. Arch Oral Biol. 147(105631)2023.PubMed/NCBI View Article : Google Scholar

25 

Ahmed NH: Cultivation of parasites. Trop Parasitol. 4:80–89. 2014.PubMed/NCBI View Article : Google Scholar

26 

Duboucher C, Mogenet M and Perie G: Salivary trichomoniasis. A case report of infestation of a submaxillary gland by Trichomonas tenax. Arch Pathol Lab Med. 119:277–279. 1995.PubMed/NCBI

27 

Azadbakht K, Baharvand P, Al-Abodi HR, Yari Y, Hadian B, Fani M, Niazi M and Mahmoudvand H: Molecular epidemiology and associated risk factors of oral cavity parasites in hemodialysis patients in western Iran. J Parasit Dis. 47:146–151. 2023.PubMed/NCBI View Article : Google Scholar

28 

Dybicz M, Perkowski K, Sędzikowska A, Baltaza W and Chomicz L: Studies on prevalence of infection with Trichomonas tenax identified by molecular techniques-in respect to oral health of patients with various systemic disease requiring immunosuppressive therapy. Ann Parasitol. 64:193–197. 2018.PubMed/NCBI View Article : Google Scholar

29 

Jiang J, Li Y, Wang Q, Zeng H, Yang W, Wu Y, Peng W, Pan P, Hu C and Deng P: Clinical implications of trichomonads detected in bronchoalveolar fluid by metagenomic next-generation sequencing: A multicenter retrospective study. Front Cell Infect Microbiol. 14(1289231)2024.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Zhao Q, Li D, Ning Y, Duan L, Zhang J, Yang Y and Ji A: <em>Trichomonas tenax</em> detected in pleural effusion fluid: A case report. Biomed Rep 22: 31, 2025.
APA
Wang, J., Zhao, Q., Li, D., Ning, Y., Duan, L., Zhang, J. ... Ji, A. (2025). <em>Trichomonas tenax</em> detected in pleural effusion fluid: A case report. Biomedical Reports, 22, 31. https://doi.org/10.3892/br.2024.1909
MLA
Wang, J., Zhao, Q., Li, D., Ning, Y., Duan, L., Zhang, J., Yang, Y., Ji, A."<em>Trichomonas tenax</em> detected in pleural effusion fluid: A case report". Biomedical Reports 22.2 (2025): 31.
Chicago
Wang, J., Zhao, Q., Li, D., Ning, Y., Duan, L., Zhang, J., Yang, Y., Ji, A."<em>Trichomonas tenax</em> detected in pleural effusion fluid: A case report". Biomedical Reports 22, no. 2 (2025): 31. https://doi.org/10.3892/br.2024.1909
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Zhao Q, Li D, Ning Y, Duan L, Zhang J, Yang Y and Ji A: <em>Trichomonas tenax</em> detected in pleural effusion fluid: A case report. Biomed Rep 22: 31, 2025.
APA
Wang, J., Zhao, Q., Li, D., Ning, Y., Duan, L., Zhang, J. ... Ji, A. (2025). <em>Trichomonas tenax</em> detected in pleural effusion fluid: A case report. Biomedical Reports, 22, 31. https://doi.org/10.3892/br.2024.1909
MLA
Wang, J., Zhao, Q., Li, D., Ning, Y., Duan, L., Zhang, J., Yang, Y., Ji, A."<em>Trichomonas tenax</em> detected in pleural effusion fluid: A case report". Biomedical Reports 22.2 (2025): 31.
Chicago
Wang, J., Zhao, Q., Li, D., Ning, Y., Duan, L., Zhang, J., Yang, Y., Ji, A."<em>Trichomonas tenax</em> detected in pleural effusion fluid: A case report". Biomedical Reports 22, no. 2 (2025): 31. https://doi.org/10.3892/br.2024.1909
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