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Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review)

  • Authors:
    • Jiarui Li
    • Mingxiu Sun
    • Ming Tang
    • Xin Song
    • Kaize Zheng
    • Tianwei Meng
    • Chengjia Li
    • Likun Du
  • View Affiliations / Copyright

    Affiliations: Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, Liaoning University of Traditional Chinese Medicine Xinglin College, Shenyang, Liaoning 110167, P.R. China, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 40
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    Published online on: December 27, 2024
       https://doi.org/10.3892/br.2024.1918
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Abstract

Obesity is a pervasive global health challenge that substantially reduces the quality of life of millions of individuals and impedes social and economic advancement. Obesity is an independent risk factor that contributes to a range of chronic non‑communicable metabolic diseases, significantly affecting energy metabolism, mental health, cancer susceptibility, sleep quality, and other physiological processes. The PI3K/AKT signaling pathway, a significant glucose, lipid, and protein metabolism regulator, is integral to cellular growth, survival, and apoptosis. Apoptosis is a highly regulated form of programmed cell death that is critical for immune cell maturation and tissue repair. The present review examines the association between obesity, the PI3K/AKT pathway, and mitochondrial apoptosis to elucidate the potential mechanisms by which obesity may activate apoptotic pathways. These findings provide a theoretical foundation for mitigating obesity‑related complications by targeting these critical pathways.
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Copy and paste a formatted citation
Spandidos Publications style
Li J, Sun M, Tang M, Song X, Zheng K, Meng T, Li C and Du L: Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review). Biomed Rep 22: 40, 2025.
APA
Li, J., Sun, M., Tang, M., Song, X., Zheng, K., Meng, T. ... Du, L. (2025). Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review). Biomedical Reports, 22, 40. https://doi.org/10.3892/br.2024.1918
MLA
Li, J., Sun, M., Tang, M., Song, X., Zheng, K., Meng, T., Li, C., Du, L."Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review)". Biomedical Reports 22.3 (2025): 40.
Chicago
Li, J., Sun, M., Tang, M., Song, X., Zheng, K., Meng, T., Li, C., Du, L."Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review)". Biomedical Reports 22, no. 3 (2025): 40. https://doi.org/10.3892/br.2024.1918
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Sun M, Tang M, Song X, Zheng K, Meng T, Li C and Du L: Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review). Biomed Rep 22: 40, 2025.
APA
Li, J., Sun, M., Tang, M., Song, X., Zheng, K., Meng, T. ... Du, L. (2025). Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review). Biomedical Reports, 22, 40. https://doi.org/10.3892/br.2024.1918
MLA
Li, J., Sun, M., Tang, M., Song, X., Zheng, K., Meng, T., Li, C., Du, L."Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review)". Biomedical Reports 22.3 (2025): 40.
Chicago
Li, J., Sun, M., Tang, M., Song, X., Zheng, K., Meng, T., Li, C., Du, L."Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review)". Biomedical Reports 22, no. 3 (2025): 40. https://doi.org/10.3892/br.2024.1918
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