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Chronic moderate‑intensity exercise can induce physiological hypertrophy in aged cardiomyocytes through autophagy, with minimal Yap/Taz involvement

  • Authors:
    • Yenni Limyati
    • Teresa Lucretia
    • Julia Windi Gunadi
    • Vitriana Vitriana
    • Diana Krisanti Jasaputra
    • Kevin De Mello Wahyudi
    • Ronny Lesmana
  • View Affiliations / Copyright

    Affiliations: Pasca Sarjana Faculty of Medicine Universitas Padjadjaran, Bandung, West Java 40164, Indonesia, Department of Histology, Faculty of Medicine, Maranatha Christian University, Bandung, West Java 40164, Indonesia, Department of Physiology, Faculty of Medicine, Maranatha Christian University, Bandung, West Java 40164, Indonesia, Department of Physical Medicine and Rehabilitation, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung, West Java 40164, Indonesia, Department of Pharmacology, Faculty of Medicine, Maranatha Christian University, Bandung, West Java 40164, Indonesia, Undergraduate Program in Medicine, Faculty of Medicine, Maranatha Christian University, Bandung, West Java 40164, Indonesia, Physiology Molecular, Biological Activity Division, Central Laboratory, Sumedang, West Java 45363, Indonesia
    Copyright: © Limyati et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 44
    |
    Published online on: January 9, 2025
       https://doi.org/10.3892/br.2025.1922
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Abstract

Aging is known to cause increased comorbidities associated with cardiovascular decline. Physical exercises were known to be an effective intervention for the age‑associated decline in cardiac function. Exercise caused physiological hypertrophy influenced by Yap/Taz, autophagy and myosin heavy chain (MHC) dynamics. However, whether exercise‑induced changes are associated with aging has yet to be determined. The present study explored the effects of moderate‑intensity exercises on autophagy, MHC dynamics, and Yap/Taz activity to understand their complex interactions at the molecular effects on the cardiac function of aging cardiac tissue. The present study used male Wistar (Rattus norvegicus) rats (80 weeks‑old) randomly divided into two groups (n=12): control and intervention. The intervention group was given an intervention using an animal treadmill. After 8 weeks, the animal was sacrificed, and data were collected. Statistical analysis was conducted using an independent t‑test or Mann‑Whitney U test when appropriate. Exercise in aged rats can induce physiological hypertrophy, as shown by gross measurement and histological features. Yap/Taz did not mediate the effects of exercise on hypertrophy. Autophagy function was shown to increase, which may cause the low expression of Yap/Taz. In conclusion, exercise is a viable intervention in increasing heart mass and potentially delaying the decline in function associated with aging.
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Copy and paste a formatted citation
Spandidos Publications style
Limyati Y, Lucretia T, Gunadi JW, Vitriana V, Jasaputra DK, Wahyudi KD and Lesmana R: Chronic moderate‑intensity exercise can induce physiological hypertrophy in aged cardiomyocytes through autophagy, with minimal Yap/Taz involvement. Biomed Rep 22: 44, 2025.
APA
Limyati, Y., Lucretia, T., Gunadi, J.W., Vitriana, V., Jasaputra, D.K., Wahyudi, K.D., & Lesmana, R. (2025). Chronic moderate‑intensity exercise can induce physiological hypertrophy in aged cardiomyocytes through autophagy, with minimal Yap/Taz involvement. Biomedical Reports, 22, 44. https://doi.org/10.3892/br.2025.1922
MLA
Limyati, Y., Lucretia, T., Gunadi, J. W., Vitriana, V., Jasaputra, D. K., Wahyudi, K. D., Lesmana, R."Chronic moderate‑intensity exercise can induce physiological hypertrophy in aged cardiomyocytes through autophagy, with minimal Yap/Taz involvement". Biomedical Reports 22.3 (2025): 44.
Chicago
Limyati, Y., Lucretia, T., Gunadi, J. W., Vitriana, V., Jasaputra, D. K., Wahyudi, K. D., Lesmana, R."Chronic moderate‑intensity exercise can induce physiological hypertrophy in aged cardiomyocytes through autophagy, with minimal Yap/Taz involvement". Biomedical Reports 22, no. 3 (2025): 44. https://doi.org/10.3892/br.2025.1922
Copy and paste a formatted citation
x
Spandidos Publications style
Limyati Y, Lucretia T, Gunadi JW, Vitriana V, Jasaputra DK, Wahyudi KD and Lesmana R: Chronic moderate‑intensity exercise can induce physiological hypertrophy in aged cardiomyocytes through autophagy, with minimal Yap/Taz involvement. Biomed Rep 22: 44, 2025.
APA
Limyati, Y., Lucretia, T., Gunadi, J.W., Vitriana, V., Jasaputra, D.K., Wahyudi, K.D., & Lesmana, R. (2025). Chronic moderate‑intensity exercise can induce physiological hypertrophy in aged cardiomyocytes through autophagy, with minimal Yap/Taz involvement. Biomedical Reports, 22, 44. https://doi.org/10.3892/br.2025.1922
MLA
Limyati, Y., Lucretia, T., Gunadi, J. W., Vitriana, V., Jasaputra, D. K., Wahyudi, K. D., Lesmana, R."Chronic moderate‑intensity exercise can induce physiological hypertrophy in aged cardiomyocytes through autophagy, with minimal Yap/Taz involvement". Biomedical Reports 22.3 (2025): 44.
Chicago
Limyati, Y., Lucretia, T., Gunadi, J. W., Vitriana, V., Jasaputra, D. K., Wahyudi, K. D., Lesmana, R."Chronic moderate‑intensity exercise can induce physiological hypertrophy in aged cardiomyocytes through autophagy, with minimal Yap/Taz involvement". Biomedical Reports 22, no. 3 (2025): 44. https://doi.org/10.3892/br.2025.1922
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