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Article Open Access

Redox biomarker levels in patients with myelodysplastic syndrome

  • Authors:
    • Eleni Tsiara
    • Sotiria Makri
    • Zoi Skaperda
    • Nikolaos Giannakoulas
    • George Vasilopoulos
    • Demetrios Kouretas
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Viopolis, Mezourlo, Larissa 41110, Greece, Department of Biochemistry and Biotechnology, University of Thessaly, Viopolis, Mezourlo, Larissa 41500, Greece
    Copyright: © Tsiara et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 45
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    Published online on: January 14, 2025
       https://doi.org/10.3892/br.2025.1923
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Abstract

Myelodysplastic syndrome (MDS) is a heterogeneous clonal disorder characterized by insufficient hematopoiesis, peripheral blood cytopenia and an increased risk for malignant transformation to acute myeloid leukemia. Several factors, such as age, sex and lifestyle, promote the development of MDS syndrome. Oxidative stress, along with its detrimental effects, cause hematological disorders; however, its role in the pathogenesis of MDS is unknown. The present study enrolled 50 patients with MDS and 50 additional healthy individuals to assess the endogenous antioxidant defense system by measuring specific redox biomarkers at the time of diagnosis. Glutathione (GSH) levels, catalase (CAT) activity and total antioxidant capacity (TAC) were measured in red blood cells, whereas levels of thiobarbituric acid reactive substances (TBARS) and protein carbonyls were measured in the plasma. A decrease in GSH levels, increased TBARS levels and TAC levels were observed in patients with MDS compared with healthy volunteers, supporting the hypothesis that oxidative stress disturbance could promote MDS.
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Copy and paste a formatted citation
Spandidos Publications style
Tsiara E, Makri S, Skaperda Z, Giannakoulas N, Vasilopoulos G and Kouretas D: Redox biomarker levels in patients with myelodysplastic syndrome. Biomed Rep 22: 45, 2025.
APA
Tsiara, E., Makri, S., Skaperda, Z., Giannakoulas, N., Vasilopoulos, G., & Kouretas, D. (2025). Redox biomarker levels in patients with myelodysplastic syndrome. Biomedical Reports, 22, 45. https://doi.org/10.3892/br.2025.1923
MLA
Tsiara, E., Makri, S., Skaperda, Z., Giannakoulas, N., Vasilopoulos, G., Kouretas, D."Redox biomarker levels in patients with myelodysplastic syndrome". Biomedical Reports 22.3 (2025): 45.
Chicago
Tsiara, E., Makri, S., Skaperda, Z., Giannakoulas, N., Vasilopoulos, G., Kouretas, D."Redox biomarker levels in patients with myelodysplastic syndrome". Biomedical Reports 22, no. 3 (2025): 45. https://doi.org/10.3892/br.2025.1923
Copy and paste a formatted citation
x
Spandidos Publications style
Tsiara E, Makri S, Skaperda Z, Giannakoulas N, Vasilopoulos G and Kouretas D: Redox biomarker levels in patients with myelodysplastic syndrome. Biomed Rep 22: 45, 2025.
APA
Tsiara, E., Makri, S., Skaperda, Z., Giannakoulas, N., Vasilopoulos, G., & Kouretas, D. (2025). Redox biomarker levels in patients with myelodysplastic syndrome. Biomedical Reports, 22, 45. https://doi.org/10.3892/br.2025.1923
MLA
Tsiara, E., Makri, S., Skaperda, Z., Giannakoulas, N., Vasilopoulos, G., Kouretas, D."Redox biomarker levels in patients with myelodysplastic syndrome". Biomedical Reports 22.3 (2025): 45.
Chicago
Tsiara, E., Makri, S., Skaperda, Z., Giannakoulas, N., Vasilopoulos, G., Kouretas, D."Redox biomarker levels in patients with myelodysplastic syndrome". Biomedical Reports 22, no. 3 (2025): 45. https://doi.org/10.3892/br.2025.1923
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