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Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review)

  • Authors:
    • Shijie Zheng
    • Linlin Yang
    • Qiuting Dai
    • Xiangyan Li
    • Takayoshi  Masuoka
    • Jianfeng Lv
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Affiliated Renhe Hospital of China Three Gorges University, Yichang, Hubei 443001, P.R. China, Department of Orthopedics, Affiliated Renhe Hospital of China Three Gorges University, Yichang, Hubei 443001, P.R. China, Department of Pharmacology, School of Medicine, Kanazawa Medical University, Uchinada, Ishikawa 920‑0293, Japan
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 46
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    Published online on: January 14, 2025
       https://doi.org/10.3892/br.2025.1924
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Abstract

Depression and coronary heart disease (CHD) are two interconnected diseases that profoundly impact global health. Depression is both a complex psychiatric disorder and an established risk factor for CHD. Sirtuin 1 (SIRT1) is an enzyme that requires the cofactor nicotinamide adenine dinucleotide (NAD+) to perform its deacetylation function, and its involvement is crucial in reducing cardiovascular risks that are associated with depression. SIRT1 exerts its cardioprotective effects via modulating oxidative stress, inflammation and metabolic processes, all of which are central to the pathogenesis of CHD in individuals with depression. Through influencing these pathways, SIRT1 helps to reduce endothelial dysfunction, prevent the formation of atherosclerotic plaques and stabilize existing plaques, thereby decreasing the overall risk of CHD. The present review underscores the important role of SIRT1 in serving as a therapeutic intervention molecule for tackling cardiovascular complications stemming from depression. Furthermore, it highlights the need for further studies to clarify how SIRT1 influences both depression and CHD at the molecular level. The ultimate goal of this research will be to translate these findings into practical clinical intervention strategies.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng S, Yang L, Dai Q, Li X, Masuoka T and Lv J: Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review). Biomed Rep 22: 46, 2025.
APA
Zheng, S., Yang, L., Dai, Q., Li, X., Masuoka, T., & Lv, J. (2025). Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review). Biomedical Reports, 22, 46. https://doi.org/10.3892/br.2025.1924
MLA
Zheng, S., Yang, L., Dai, Q., Li, X., Masuoka, T., Lv, J."Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review)". Biomedical Reports 22.3 (2025): 46.
Chicago
Zheng, S., Yang, L., Dai, Q., Li, X., Masuoka, T., Lv, J."Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review)". Biomedical Reports 22, no. 3 (2025): 46. https://doi.org/10.3892/br.2025.1924
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng S, Yang L, Dai Q, Li X, Masuoka T and Lv J: Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review). Biomed Rep 22: 46, 2025.
APA
Zheng, S., Yang, L., Dai, Q., Li, X., Masuoka, T., & Lv, J. (2025). Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review). Biomedical Reports, 22, 46. https://doi.org/10.3892/br.2025.1924
MLA
Zheng, S., Yang, L., Dai, Q., Li, X., Masuoka, T., Lv, J."Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review)". Biomedical Reports 22.3 (2025): 46.
Chicago
Zheng, S., Yang, L., Dai, Q., Li, X., Masuoka, T., Lv, J."Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review)". Biomedical Reports 22, no. 3 (2025): 46. https://doi.org/10.3892/br.2025.1924
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