|
1
|
Wynn TA, Chawla A and Pollard JW: Macrophage biology in development, homeostasis and disease. Nature. 496:445–455. 2013.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Lazarov T, Juarez-Carreño S, Cox N and Geissmann F: Physiology and diseases of tissue-resident macrophages. Nature. 618:698–707. 2023.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Park MD, Silvin A, Ginhoux F and Merad M: Macrophages in health and disease. Cell. 185:4259–4279. 2022.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Kodera Y, Kurita M, Nakamoto M and Matsutomo T: Chemistry of aged garlic: Diversity of constituents in aged garlic extract and their production mechanisms via the combination of chemical and enzymatic reactions. Exp Ther Med. 19:1574–1584. 2020.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Amagase H, Petesch BL, Matsuura H, Kasuga S and Itakura Y: Intake of garlic and its bioactive components. J Nutr. 131:955S–962S. 2001.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Nantz MP, Rowe CA, Muller CE, Creasy RA, Stanilka JM and Percival SS: Supplementation with aged garlic extract improves both NK and γδ-T cell function and reduces the severity of cold and flu symptoms: A randomized, double-blind, placebo-controlled nutrition intervention. Clin Nutr. 31:337–344. 2012.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Wlosinska M, Nilsson AC, Hlebowicz J, Hauggaard A, Kjellin M, Fakhro M and Lindstedt S: The effect of aged garlic extract on the atherosclerotic process-a randomized double-blind placebo-controlled trial. BMC Complement Med Ther. 20(132)2020.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Ishikawa H, Saeki T, Otani T, Suzuki T, Shimozuma K, Nishino H, Fukuda S and Morimoto K: Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer. J Nutr. 136:816S–820S. 2006.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Ried K, Frank OR and Stocks NP: Aged garlic extract reduces blood pressure in hypertensives: A dose-response trial. Eur J Clin Nutr. 67:64–70. 2013.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Xu C, Mathews AE, Rodrigues C, Eudy BJ, Rowe CA, O'Donoughue A and Percival SS: Aged garlic extract supplementation modifies inflammation and immunity of adults with obesity: A randomized, double-blind, placebo-controlled clinical trial. Clin Nutr ESPEN. 24:148–155. 2018.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Lindstedt S, Wlosinska M, Nilsson AC, Hlebowicz J, Fakhro M and Sheikh R: Successful improved peripheral tissue perfusion was seen in patients with atherosclerosis after 12 months of treatment with aged garlic extract. Int Wound J. 18:681–691. 2021.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Leitão R, de Oliveira GV, Rezende C, Volino-Souza M, Mesquita J, de Carvalho LL and Alvares TS: Improved microvascular reactivity after aged garlic extract intake is not mediated by hydrogen sulfide in older adults at risk for cardiovascular disease: A randomized clinical trial. Eur J Nutr. 61:3357–3366. 2022.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Tedeschi P, Nigro M, Travagli A, Catani M, Cavazzini A, Merighi S and Gessi S: Therapeutic potential of allicin and aged garlic extract in Alzheimer's disease. Int J Mol Sci. 23(6950)2022.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Lim JJ, Grinstein S and Roth Z: Diversity and versatility of phagocytosis: Roles in innate immunity, tissue remodeling, and homeostasis. Front Cell Infect Microbiol. 7(191)2017.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Chen S, Saeed A, Liu Q, Jiang Q, Xu H, Xiao GG, Rao L and Duo Y: Macrophages in immunoregulation and therapeutics. Signal Transduct Target Ther. 8(207)2023.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Kyo E, Uda N, Suzuki A, Kakimoto M, Ushijima M, Kasuga S and Itakura Y: Immunomodulation and antitumor activities of aged garlic extract. Phytomedicine. 5:259–267. 1998.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Chandrashekar PM, Prashanth KV and Venkatesh YP: Isolation, structural elucidation and immunomodulatory activity of fructans from aged garlic extract. Phytochemistry. 72:255–264. 2011.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Dupré-Crochet S, Erard M and Nüβe O: ROS production in phagocytes: Why, when, and where? J Leukoc Biol. 94:657–670. 2013.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Lau BH, Yamasaki T and Gridley DS: Garlic compounds modulate macrophage and T-lymphocyte functions. Mol Biother. 3:103–107. 1991.PubMed/NCBI
|
|
20
|
Andrabi SM, Sharma NS, Karan A, Shahriar SMS, Cordon B, Ma B and Xie J: Nitric oxide: Physiological functions, delivery, and biomedical applications. Adv Sci (Weinh). 10(e2303259)2023.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Chakravortty D and Hensel M: Inducible nitric oxide synthase and control of intracellular bacterial pathogens. Microbes Infect. 5:621–627. 2003.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Nathan CF and Hibbs JB Jr: Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol. 3:65–70. 1991.PubMed/NCBI View Article : Google Scholar
|
|
23
|
MacMicking J, Xie QW and Nathan C: Nitric oxide and macrophage function. Annu Rev Immunol. 15:323–350. 1997.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Xue Q, Yan Y, Zhang R and Xiong H: Regulation of iNOS on immune cells and its role in diseases. Int J Mol Sci. 19(3805)2018.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Laskin DL, Sunil VR, Gardner CR and Laskin JD: Macrophages and tissue injury: Agents of defense or destruction? Annu Rev Pharmacol Toxicol. 51:267–288. 2011.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Pannu R and Singh I: Pharmacological strategies for the regulation of inducible nitric oxide synthase: Neurodegenerative versus neuroprotective mechanisms. Neurochem Int. 49:170–182. 2006.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, et al: Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease. PLoS One. 7(e44156)2012.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Hobbs AJ, Higgs A and Moncada S: Inhibition of nitric oxide synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol. 39:191–220. 1999.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Ide N and Lau BH: Aged garlic extract attenuates intracellular oxidative stress. Phytomedicine. 6:125–131. 1999.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Kim KM, Chun SB, Koo MS, Choi WJ, Kim TW, Kwon YG, Chung HT, Billiar TR and Kim YM: Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine. Free Radic Biol Med. 30:747–756. 2001.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Arnal JF, Dinh-Xuan AT, Pueyo M, Darblade B and Rami J: Endothelium-derived nitric oxide and vascular physiology and pathology. Cell Mol Life Sci. 55:1078–1087. 1999.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Colín-González AL, Santana RA, Silva-Islas CA, Chánez-Cárdenas ME, Santamaría A and Maldonado PD: The antioxidant mechanisms underlying the aged garlic extract- and S-allylcysteine-induced protection. Oxid Med Cell Longev. 2012(907162)2012.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Nathan C and Cunningham-Bussel A: Beyond oxidative stress: An immunologist's guide to reactive oxygen species. Nat Rev Immunol. 13:349–361. 2013.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Canton M, Sánchez-Rodríguez R, Spera I, Venegas FC, Favia M, Viola A and Castegna A: Reactive oxygen species in macrophages: Sources and targets. Front Immunol. 12(734229)2021.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Nowak WN, Deng J, Ruan XZ and Xu Q: Reactive oxygen species generation and atherosclerosis. Arterioscler Thromb Vasc Biol. 37:e41–e52. 2017.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Liao Y, Zhu E and Zhou W: Ox-LDL aggravates the oxidative stress and inflammatory responses of THP-1 macrophages by reducing the inhibition effect of miR-491-5p on MMP-9. Front Cardiovasc Med. 8(697236)2021.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Poznyak AV, Nikiforov NG, Markin AM, Kashirskikh DA, Myasoedova VA, Gerasimova EV and Orekhov AN: Overview of OxLDL and its impact on cardiovascular health: Focus on atherosclerosis. Front Pharmacol. 11(613780)2020.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Lara-Guzmán OJ, Gil-Izquierdo Á, Medina S, Osorio E, Álvarez-Quintero R, Zuluaga N, Oger C, Galano JM, Durand T and Muñoz-Durango K: Oxidized LDL triggers changes in oxidative stress and inflammatory biomarkers in human macrophages. Redox Biol. 15:1–11. 2018.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Ide N, Lau BH, Ryu K, Matsuura H and Itakura Y: Antioxidant effects of fructosyl arginine, a Maillard reaction product in aged garlic extract. J Nutr Biochem. 10:372–376. 1999.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Ide N and Lau BH: Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factor-kappa b activation. J Nutr. 131:1020S–1026S. 2001.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Sun Y, Li J, Xie X, Gu F, Sui Z, Zhang K and Yu T: Macrophage-osteoclast associations: Origin, polarization, and subgroups. Front Immunol. 12(778078)2021.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N and Lee SY: A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood. 106:852–859. 2005.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Chen Y, Sun J, Dou C, Li N, Kang F, Wang Y, Cao Z, Yang X and Dong S: Alliin attenuated RANKL-induced osteoclastogenesis by scavenging reactive oxygen species through inhibiting Nox1. Int J Mol Sci. 17(1516)2016.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Mosser DM, Hamidzadeh K and Goncalves R: Macrophages and the maintenance of homeostasis. Cell Mol Immunol. 18:579–587. 2021.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Duque GA and Descoteaux A: Macrophage cytokines: Involvement in immunity and infectious diseases. Front Immunol. 5(491)2014.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Lissner D, Schumann M, Batra A, Kredel LI, Kühl AA, Erben U, May C, Schulzke JD and Siegmund B: Monocyte and M1 macrophage-induced barrier defect contributes to chronic intestinal inflammation in IBD. Inflamm Bowel Dis. 21:1297–1305. 2015.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Chen R, Zhang H, Tang B, Luo Y, Yang Y, Zhong X, Chen S, Xu X, Huang S and Liu C: Macrophages in cardiovascular diseases: Molecular mechanisms and therapeutic targets. Signal Transduct Target Ther. 9(130)2024.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Belchamber KBR and Donnelly LE: Macrophage dysfunction in respiratory disease. Results Probl Cell Differ. 62:299–313. 2017.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Ombrello MJ and Schulert GS: COVID-19 and cytokine storm syndrome: Are there lessons from macrophage activation syndrome? Transl Res. 232:1–12. 2021.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Miki S, Suzuki JI, Takashima M, Ishida M, Kokubo H and Yoshizumi M: S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling. Sci Rep. 11(22469)2021.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Kaur B, Kumar N, Kumari L, Gupta AP, Sharma R, Chopra K and Saxena S: In vitro antioxidant and anti-inflammatory potential along with p.o. pharmacokinetic profile of key bioactive phytocompounds of snow mountain garlic: A comparative analysis vis-à-vis normal garlic. Inflammopharmacology. 32:1871–1886. 2024.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, Mehler MF, Conway SJ, Ng LG, Stanley ER, et al: Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. 330:841–845. 2010.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Song H, Lu Y, Qu Z, Mossine VV, Martin MB, Hou J, Cui J, Peculis BA, Mawhinney TP, Cheng J, et al: Effects of aged garlic extract and FruArg on gene expression and signaling pathways in lipopolysaccharide-activated microglial cells. Sci Rep. 6(35323)2016.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Yunna C, Mengru H, Lei W and Weidong C: Macrophage M1/M2 polarization. Eur J Pharmacol. 877(173090)2020.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Orecchioni M, Ghosheh Y, Pramod AB and Ley K: Macrophage polarization: Different gene signatures in M1(LPS+) vs. classically and M2(LPS-) vs. Alternatively activated macrophages. Front Immunol. 10(1084)2019.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Abe K, Hori Y and Myoda T: Volatile compounds of fresh and processed garlic. Exp Ther Med. 19:1585–1593. 2020.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Zhang XN, Zhao N, Guo FF, Wang YR, Liu SX and Zeng T: Diallyl disulfide suppresses the lipopolysaccharide-driven inflammatory response of macrophages by activating the Nrf2 pathway. Food Chem Toxicol. 159(112760)2022.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Wu J, He S, Song Z, Chen S, Lin X, Sun H, Zhou P, Peng Q, Du S, Zheng S and Liu X: Macrophage polarization states in atherosclerosis. Front Immunol. 14(1185587)2023.PubMed/NCBI View Article : Google Scholar
|
