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Case Report Open Access

Telitacicept for systemic lupus erythematosus with post‑surgical papillary thyroid carcinoma: A case report

  • Authors:
    • Jinhui Tan
    • Hai Huang
    • Linghua Tan
    • Bo Li
  • View Affiliations / Copyright

    Affiliations: Department of Rheumatology and Immunology, People's Hospital of Longhua, Shenzhen, Guangdong 518109, P.R. China, Department of Health Management, People's Hospital of Longhua, Shenzhen, Guangdong 518109, P.R. China, Department of Health Management, Jiangmen Wuyi Hospital of Chinese Medicine, Jiangmen, Guangdong 529099, P.R. China
    Copyright: © Tan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 48
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    Published online on: January 19, 2025
       https://doi.org/10.3892/br.2025.1926
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Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex etiology primarily linked to abnormalities in B lymphocytes within the human body, resulting in the production of numerous pathogenic autoantibodies. Telitacicept is a relatively novel humanized, recombinant transmembrane activator, calcium modulator and cyclophilin ligand interactor fused with the Fc portion (TACI‑Fc). It works by competitively inhibiting the TACI site, neutralizing the activity of B‑cell lymphocyte stimulator and A proliferation‑inducing ligand. This, in turn, inhibits the development and survival of plasma cells and mature B cells. A 28‑year‑old female was admitted to the Department of Rheumatology and Immunology (People's Hospital of Longhua; Shenzhen, China) in June 2021 due to systemic edema for more than a month and hair loss lasting for a week. After comprehensive examination, the patient was diagnosed with SLE with hematological system involvement, serositis, lupus nephritis and secondary antiphospholipid syndrome. After receiving medications including glucocorticoids, mycophenolate mofetil and cyclosporine, the patient's white blood cells, platelets, hemoglobin, urinary protein and multiple serositis returned to normal. However, the levels of complement 3(C3) and C4 did not significantly improve. Subsequently, the patient underwent thyroid ultrasound examination, which suggested thyroid nodules. After thyroid puncture biopsy, the patient was diagnosed with papillary thyroid carcinoma (PTC). After surgical resection, the patient was confirmed to have PTC by pathological biopsy, with no lymph node metastasis. At two months after surgery, the patient was treated with telitacicept, and the complement levels not only returned to normal but also remained stable for a long time. The present case was the first to report the use of telitacicept for the successful treatment of a patient with SLE with post‑surgical PTC, providing a potential therapeutic option for SLE with a prior history of carcinoma. The role of telitacept in this field requires further research and attention.
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Copy and paste a formatted citation
Spandidos Publications style
Tan J, Huang H, Tan L and Li B: Telitacicept for systemic lupus erythematosus with post‑surgical papillary thyroid carcinoma: A case report. Biomed Rep 22: 48, 2025.
APA
Tan, J., Huang, H., Tan, L., & Li, B. (2025). Telitacicept for systemic lupus erythematosus with post‑surgical papillary thyroid carcinoma: A case report. Biomedical Reports, 22, 48. https://doi.org/10.3892/br.2025.1926
MLA
Tan, J., Huang, H., Tan, L., Li, B."Telitacicept for systemic lupus erythematosus with post‑surgical papillary thyroid carcinoma: A case report". Biomedical Reports 22.3 (2025): 48.
Chicago
Tan, J., Huang, H., Tan, L., Li, B."Telitacicept for systemic lupus erythematosus with post‑surgical papillary thyroid carcinoma: A case report". Biomedical Reports 22, no. 3 (2025): 48. https://doi.org/10.3892/br.2025.1926
Copy and paste a formatted citation
x
Spandidos Publications style
Tan J, Huang H, Tan L and Li B: Telitacicept for systemic lupus erythematosus with post‑surgical papillary thyroid carcinoma: A case report. Biomed Rep 22: 48, 2025.
APA
Tan, J., Huang, H., Tan, L., & Li, B. (2025). Telitacicept for systemic lupus erythematosus with post‑surgical papillary thyroid carcinoma: A case report. Biomedical Reports, 22, 48. https://doi.org/10.3892/br.2025.1926
MLA
Tan, J., Huang, H., Tan, L., Li, B."Telitacicept for systemic lupus erythematosus with post‑surgical papillary thyroid carcinoma: A case report". Biomedical Reports 22.3 (2025): 48.
Chicago
Tan, J., Huang, H., Tan, L., Li, B."Telitacicept for systemic lupus erythematosus with post‑surgical papillary thyroid carcinoma: A case report". Biomedical Reports 22, no. 3 (2025): 48. https://doi.org/10.3892/br.2025.1926
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