Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
March-2025 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2025 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Age‑related changes in endoplasmic reticulum stress response‑associated protein expression in rat tibial nerves

  • Authors:
    • Masahiro Sakita
    • Wataru Isobe
    • Koji Nonaka
    • Shinichiro Murakami
    • Ryo Miyachi
    • Kento Sakane
    • Saki Sugimoto
    • Airi Yamaguchi
    • Koki Yamamoto
  • View Affiliations / Copyright

    Affiliations: Department of Physical Therapy, Faculty of Health Sciences, Kyoto Tachibana University, Kyoto 607‑8175, Japan, Department of Rehabilitation, Faculty of Health Care Sciences, Naragakuen University, Nara 631‑0003, Japan, Department of Physical Therapy, Faculty of Health Care Sciences, Himeji‑Dokkyo University, Himeji, Hyogo 670‑0896, Japan, Department of Physical Therapy, Faculty of Health Care Sciences, Hokuriku University, Kanazawa, Ishikawa 920‑1154, Japan
    Copyright: © Sakita et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 50
    |
    Published online on: January 21, 2025
       https://doi.org/10.3892/br.2025.1928
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In age‑related peripheral neurodegeneration, changes in the promotion or inhibition of endoplasmic reticulum (ER) stress response related to the ubiquitin‑proteasome degradation system (UPS), autophagy and apoptosis signaling factors during aging remain unclear. In the present study, the expression of ER stress response signaling‑related protein factors was examined in tibial nerves during aging in rats. Tibial nerves were extracted from continuously housed rats at 20, 50, 70, 90 and 105 weeks of age. Expression of factors associated with ER stress‑related degradation, including X‑box binding protein 1 (XBP1s), eukaryotic translation initiation factor 2 subunit 1 (eIF2α), Beclin‑1 (Becn1), and Caspase‑3 (Casp3); ER stress‑related repair, including binding immunoglobulin protein [also known as 78 kDa glucose‑regulated protein (BiP/GRP78)], protein disulfide isomerase (PDI), brain‑derived neurotrophic factor (BDNF) and the inflammatory cytokine IL6, was assessed by western blotting of tibial nerves from rats in each age group. Expression of XBP1s and Becn1, which promote UPS and autophagy, decreased significantly after 50 weeks of age. However, expression of eIF2α and Casp3, which inhibit new protein biosynthesis and promote apoptosis, increased significantly after 50 weeks. Expression of BiP/GRP78 and PDI, which are refolding factors for denatured proteins, showed a significant decrease after 50 (or 70) weeks of age. The expression of BDNF, a ligand protein for the repair cascade, showed a significant increase after 70 weeks of age, while that of IL6 increased significantly after 50 weeks of age. These results indicate that ER stress‑related degradation (UPS and autophagy) and refolding repair functions are reduced in rat tibial nerves after 50 weeks, followed by enhanced apoptosis and inflammation. These findings shed light on the progression of age‑related peripheral neurodegeneration in rats.
View Figures

Figure 1

Figure 2

View References

1 

Beaudart C, Zaaria M, Pasleau F, Reginster JY and Bruyère O: Health outcomes of sarcopenia: A systematic review and meta-analysis. PLoS One. 12(e0169548)2017.PubMed/NCBI View Article : Google Scholar

2 

Kelley GA and Kelley KS: Is sarcopenia associated with an increased risk of all-cause mortality and functional disability? Exp Gerontol. 96:100–103. 2017.PubMed/NCBI View Article : Google Scholar

3 

Chen X, Cao M, Liu M, Liu S, Zhao Z and Chen H: Association between sarcopenia and cognitive impairment in the older people: A Meta-analysis. Eur Geriatr Med. 13:771–787. 2022.PubMed/NCBI View Article : Google Scholar

4 

Zhang X, Huang P, Dou Q, Wang C, Zhang W, Yang Y, Wang J, Xie X, Zhou J and Zeng Y: Falls among older adults with sarcopenia dwelling in nursing home or community: A meta-analysis. Clin Nutr. 39:33–39. 2020.PubMed/NCBI View Article : Google Scholar

5 

Landi F, Liperoti R, Russo A, Giovannini S, Tosato M, Capoluongo E, Bernabei R and Onder G: Sarcopenia as a risk factor for falls in elderly individuals: Results from the ilSIRENTE study. Clin Nutr. 31:652–658. 2012.PubMed/NCBI View Article : Google Scholar

6 

Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, et al: Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 39:412–423. 2010.PubMed/NCBI View Article : Google Scholar

7 

Su YC, Chang SF and Tsai HC: The relationship between sarcopenia and injury events: A systematic review and Meta-analysis of 98,754 Older Adults. J Clin Med. 11(6474)2022.PubMed/NCBI View Article : Google Scholar

8 

Yeung SSY, Reijnierse EM, Pham VK, Trappenburg MC, Lim WK, Meskers CGM and Maier AB: Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 10:485–500. 2019.PubMed/NCBI View Article : Google Scholar

9 

Verdú E, Ceballos D, Vilches JJ and Navarro X: Influence of aging on peripheral nerve function and regeneration. J Peripher Nerv Syst. 5:191–208. 2000.PubMed/NCBI View Article : Google Scholar

10 

Coletti C, Acosta GF, Keslacy S and Coletti D: Exercise-mediated reinnervation of skeletal muscle in elderly people: An update. Eur J Transl Myol. 32:1–11. 2022.PubMed/NCBI View Article : Google Scholar

11 

Liu J, Zhang B, Lei H, Feng Z, Liu J, Hsu AL and Xu XZ: Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans. Cell Metab. 18:392–402. 2013.PubMed/NCBI View Article : Google Scholar

12 

Nagashima K and Oota K: A histopathological study of the human spinal ganglia. 1. Normal variations in aging. Acta Pathol Jpn. 24:333–344. 1974.PubMed/NCBI View Article : Google Scholar

13 

O'Sullivan DJ and Swallow M: The fibre size and content of the radial and sural nerves. J Neurol Neurosurg Psychiatry. 31:464–470. 1968.PubMed/NCBI View Article : Google Scholar

14 

Bergman E and Ulfhake B: Loss of primary sensory neurons in the very old rat: Neuron number estimates using the disector method and confocal optical sectioning. J Comp Neurol. 396:211–222. 1998.PubMed/NCBI

15 

Sakita M, Murakami S, Nonaka K, Sakamoto R, Saito T, Isobe W and Kumagai S: Different patterns in age-related morphometric alteration of myelinated fibers and capillaries of the tibial nerve: A longitudinal study in normal rats. J Anat. 236:1101–1111. 2020.PubMed/NCBI View Article : Google Scholar

16 

Ceballos D, Cuadras J, Verdu E and Navarro X: Morphometric and ultrastructural changes with ageing in mouse peripheral nerve. J Anat. 195:563–576. 1999.PubMed/NCBI View Article : Google Scholar

17 

Bouche P, Cattelin F, Saint-Jean O, Léger JM, Queslati S, Guez D, Moulonguet A, Brault Y, Aquino JP and Simunek P: Clinical and electrophysiological study of the peripheral nervous system in the elderly. J Neurol. 240:263–268. 1993.PubMed/NCBI View Article : Google Scholar

18 

Verdú E, Butí M and Navarro X: Functional changes of the peripheral nervous system with aging in the mouse. Neurobiol Aging. 17:73–77. 1996.PubMed/NCBI View Article : Google Scholar

19 

Ciechanover A: Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Cell Death Differ. 12:1178–1190. 2005.PubMed/NCBI View Article : Google Scholar

20 

Aman Y, Schmauck-Medina T, Hansen M, Morimoto RI, Simon AK, Bjedov I, Palikaras K, Simonsen A, Johansen T and Tavernarakis N: Autophagy in healthy aging and disease. Nat Aging. 1:634–650. 2021.PubMed/NCBI View Article : Google Scholar

21 

Rajawat YS, Hilioti Z and Bossis I: Aging: Central role for autophagy and the lysosomal degradative system. Ageing Res Rev. 8:199–213. 2009.PubMed/NCBI View Article : Google Scholar

22 

Amm I, Sommer T and Wolf DH: Protein quality control and elimination of protein waste: The role of the ubiquitin-proteasome system. Biochim Biophys Acta. 1843:182–196. 2014.PubMed/NCBI View Article : Google Scholar

23 

Guo J, Huang X, Dou L, Yan M, Shen T, Tang W and Li J: Aging and aging-related diseases: From molecular mechanisms to interventions and treatments. Signal Transduct Target Ther. 7(391)2022.PubMed/NCBI View Article : Google Scholar

24 

Perner C and Krüger E: Endoplasmic reticulum stress and its role in homeostasis and immunity of central and peripheral neurons. Front Immunol. 13(859703)2022.PubMed/NCBI View Article : Google Scholar

25 

Shinno K, Miura Y, Iijima KM, Suzuki E and Ando K: Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β. bioRxiv. 2024(576435)2024.PubMed/NCBI View Article : Google Scholar

26 

Cuervo AM and Dice JF: How do intracellular proteolytic systems change with age? Front Biosci. 3:d25–d43. 1998.PubMed/NCBI View Article : Google Scholar

27 

Hughes AL and Gottschling DE: An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature. 492:261–265. 2012.PubMed/NCBI View Article : Google Scholar

28 

Leidal AM, Levine B and Debnath J: Autophagy and the cell biology of age-related disease. Nat Cell Biol. 20:1338–1348. 2018.PubMed/NCBI View Article : Google Scholar

29 

Thrasivoulou C, Soubeyre V, Ridha H, Giuliani D, Giaroni C, Michael GJ, Saffrey MJ and Cowen T: Reactive oxygen species, dietary restriction and neurotrophic factors in age-related loss of myenteric neurons. Aging Cell. 5:247–257. 2006.PubMed/NCBI View Article : Google Scholar

30 

Keller JN, Huang FF and Markesbery WR: Decreased levels of proteasome activity and proteasome expression in aging spinal cord. Neuroscience. 98:149–156. 2000.PubMed/NCBI View Article : Google Scholar

31 

Sims-Robinson C, Hur J, Hayes JM, Dauch JR, Keller PJ, Brooks SV and Feldman EL: The role of oxidative stress in nervous system aging. PLoS One. 8(e68011)2013.PubMed/NCBI View Article : Google Scholar

32 

Eaton SL, Roche SL, Llavero Hurtado M, Oldknow KJ, Farquharson C, Gillingwater TH and Wishart TM: Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting. PLoS One. 8(e72457)2013.PubMed/NCBI View Article : Google Scholar

33 

Moritz CP: Tubulin or not tubulin: Heading toward total protein staining as loading control in western blots. Proteomics: 17, 2017 doi: 10.1002/pmic.201600189.

34 

Nistiar F, Racz O, Lukacinova A, Hubkova B, Novakova J, Lovasova E and Sedlakova E: Age dependency on some physiological and biochemical parameters of male Wistar rats in controlled environment. J Environ Sci Health A Tox Hazard Subst Environ Eng. 47:1224–1233. 2012.PubMed/NCBI View Article : Google Scholar

35 

Tamaki T, Hirata M and Uchiyama Y: Qualitative alteration of peripheral motor system begins prior to appearance of typical sarcopenia syndrome in middle-aged rats. Front Aging Neurosci. 6(296)2014.PubMed/NCBI View Article : Google Scholar

36 

Gao Q, Hu K, Yan C, Zhao B, Mei F, Chen F, Zhao L, Shang Y, Ma Y and Ma B: Associated factors of sarcopenia in community-Dwelling older adults: A systematic review and Meta-analysis. Nutrients. 13(4291)2021.PubMed/NCBI View Article : Google Scholar

37 

Cruz-Jentoft AJ and Sayer AA: Sarcopenia. Lancet. 393:2636–2646. 2019.PubMed/NCBI View Article : Google Scholar

38 

Hollien J and Weissman JS: Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science. 313:104–107. 2006.PubMed/NCBI View Article : Google Scholar

39 

Hollien J, Lin JH, Li H, Stevens N, Walter P and Weissman JS: Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol. 186:323–331. 2009.PubMed/NCBI View Article : Google Scholar

40 

Park SM, Kang TI and So JS: Roles of XBP1s in transcriptional regulation of target genes. Biomedicines. 9(791)2021.PubMed/NCBI View Article : Google Scholar

41 

Oñate M, Catenaccio A, Martínez G, Armentano D, Parsons G, Kerr B, Hetz C and Court FA: Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury. Sci Rep. 6(21709)2016.PubMed/NCBI View Article : Google Scholar

42 

Cabral-Miranda F, Tamburini G, Martinez G, Ardiles AO, Medinas DB, Gerakis Y, Hung MD, Vidal R, Fuentealba M, Miedema T, et al: Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging. EMBO J. 41(e111952)2022.PubMed/NCBI View Article : Google Scholar

43 

Costa-Mattioli M and Walter P: The integrated stress response: From mechanism to disease. Science. 368:2020.PubMed/NCBI View Article : Google Scholar

44 

Kashiwagi K, Yokoyama T, Nishimoto M, Takahashi M, Sakamoto A, Yonemochi M, Shirouzu M and Ito T: Structural basis for eIF2B inhibition in integrated stress response. Science. 364:495–499. 2019.PubMed/NCBI View Article : Google Scholar

45 

Rashid HO, Yadav RK, Kim HR and Chae HJ: ER stress: Autophagy induction, inhibition and selection. Autophagy. 11:1956–1977. 2015.PubMed/NCBI View Article : Google Scholar

46 

Li J, Ni M, Lee B, Barron E, Hinton DR and Lee AS: The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. Cell Death Differ. 15:1460–1471. 2008.PubMed/NCBI View Article : Google Scholar

47 

Smith MI and Deshmukh M: Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons. Cell Death Differ. 14:1011–1019. 2007.PubMed/NCBI View Article : Google Scholar

48 

Kaufman RJ: Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls. Genes Dev. 13:1211–1233. 1999.PubMed/NCBI View Article : Google Scholar

49 

Morishima N, Nakanishi K, Takenouchi H, Shibata T and Yasuhiko Y: An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem. 277:34287–34294. 2002.PubMed/NCBI View Article : Google Scholar

50 

Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A and Nagata S: A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature. 391:43–50. 1998.PubMed/NCBI View Article : Google Scholar

51 

Rasheva VI and Domingos PM: Cellular responses to endoplasmic reticulum stress and apoptosis. Apoptosis. 14:996–1007. 2009.PubMed/NCBI View Article : Google Scholar

52 

Chaudhari N, Talwar P, Parimisetty A, Lefebvre d'Hellencourt C and Ravanan P: A molecular web: Endoplasmic reticulum stress, inflammation, and oxidative stress. Front Cell Neurosci. 8(213)2014.PubMed/NCBI View Article : Google Scholar

53 

Sanchez CL, Sims SG, Nowery JD and Meares GP: Endoplasmic reticulum stress differentially modulates the IL-6 family of cytokines in murine astrocytes and macrophages. Sci Rep. 9(14931)2019.PubMed/NCBI View Article : Google Scholar

54 

Brocchieri L, Conway de Macario E and Macario AJ: hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions. BMC Evol Biol. 8(19)2008.PubMed/NCBI View Article : Google Scholar

55 

Ibrahim IM, Abdelmalek DH and Elfiky AA: GRP78: A cell's response to stress. Life Sci. 226:156–163. 2019.PubMed/NCBI View Article : Google Scholar

56 

Ellgaard L and Ruddock LW: The human protein disulphide isomerase family: Substrate interactions and functional properties. EMBO Rep. 6:28–32. 2005.PubMed/NCBI View Article : Google Scholar

57 

Mayer M, Kies U, Kammermeier R and Buchner J: BiP and PDI cooperate in the oxidative folding of antibodies in vitro. J Biol Chem. 275:29421–29425. 2000.PubMed/NCBI View Article : Google Scholar

58 

Grek C and Townsend DM: Protein disulfide isomerase superfamily in disease and the regulation of apoptosis. Endoplasmic Reticulum Stress Dis. 1:4–17. 2014.PubMed/NCBI View Article : Google Scholar

59 

Helan M, Aravamudan B, Hartman WR, Thompson MA, Johnson BD, Pabelick CM and Prakash YS: BDNF secretion by human pulmonary artery endothelial cells in response to hypoxia. J Mol Cell Cardiol. 68:89–97. 2014.PubMed/NCBI View Article : Google Scholar

60 

Wilhelm JC, Xu M, Cucoranu D, Chmielewski S, Holmes T, Lau KS, Bassell GJ and English AW: Cooperative roles of BDNF expression in neurons and Schwann cells are modulated by exercise to facilitate nerve regeneration. J Neurosci. 32:5002–5009. 2012.PubMed/NCBI View Article : Google Scholar

61 

Shimoke K, Utsumi T, Kishi S, Nishimura M, Sasaya H, Kudo M and Ikeuchi T: Prevention of endoplasmic reticulum stress-induced cell death by brain-derived neurotrophic factor in cultured cerebral cortical neurons. Brain Res. 1028:105–111. 2004.PubMed/NCBI View Article : Google Scholar

62 

Bhaskar PT and Hay N: The two TORCs and Akt. Dev Cell. 12:487–502. 2007.PubMed/NCBI View Article : Google Scholar

63 

Scott TL, Rangaswamy S, Wicker CA and Izumi T: Repair of oxidative DNA damage and cancer: Recent progress in DNA base excision repair. Antioxid Redox Signal. 20:708–726. 2014.PubMed/NCBI View Article : Google Scholar

64 

Fukui K: Reactive oxygen species induce neurite degeneration before induction of cell death. J Clin Biochem Nutr. 59:155–159. 2016.PubMed/NCBI View Article : Google Scholar

65 

Ma Q: Transcriptional responses to oxidative stress: Pathological and toxicological implications. Pharmacol Ther. 125:376–393. 2010.PubMed/NCBI View Article : Google Scholar

66 

Hong Y, Boiti A, Vallone D and Foulkes NS: Reactive oxygen species signaling and oxidative stress: transcriptional regulation and evolution. Antioxidants (Basel). 13(312)2024.PubMed/NCBI View Article : Google Scholar

67 

Shokouhi G, Tubbs RS, Shoja MM, Roshangar L, Mesgari M, Ghorbanihaghjo A, Ahmadi N, Sheikhzadeh F and Rad JS: The effects of aerobic exercise training on the age-related lipid peroxidation, Schwann cell apoptosis and ultrastructural changes in the sciatic nerve of rats. Life Sci. 82:840–846. 2008.PubMed/NCBI View Article : Google Scholar

68 

Wickens AP: Ageing and the free radical theory. Respir Physiol. 128:379–391. 2001.PubMed/NCBI View Article : Google Scholar

69 

Haddad JJ, Saadé NE and Safieh-Garabedian B: Redox regulation of TNF-alpha biosynthesis: augmentation by irreversible inhibition of gamma-glutamylcysteine synthetase and the involvement of an IkappaB-alpha/NF-kappaB-independent pathway in alveolar epithelial cells. Cell Signal. 14:211–218. 2002.PubMed/NCBI View Article : Google Scholar

70 

Iwakoshi NN, Lee AH, Vallabhajosyula P, Otipoby KL, Rajewsky K and Glimcher LH: Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol. 4:321–329. 2003.PubMed/NCBI View Article : Google Scholar

71 

Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F and Glimcher LH: Plasma cell differentiation requires the transcription factor XBP-1. Nature. 412:300–307. 2001.PubMed/NCBI View Article : Google Scholar

72 

Haddad F, Zaldivar F, Cooper DM and Adams GR: IL-6-induced skeletal muscle atrophy. J Appl Physiol (1985). 98:911–917. 2005.PubMed/NCBI View Article : Google Scholar

73 

Visser M, Pahor M, Taaffe DR, Goodpaster BH, Simonsick EM, Newman AB, Nevitt M and Harris TB: Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: The Health ABC Study. J Gerontol A Biol Sci Med Sci. 57:M326–M332. 2002.PubMed/NCBI View Article : Google Scholar

74 

Lima T, Li TY, Mottis A and Auwerx J: Pleiotropic effects of mitochondria in aging. Nat Aging. 2:199–213. 2022.PubMed/NCBI View Article : Google Scholar

75 

Xu S, Ito A, Wang T, Kawai H, Aoyama T and Kuroki H: Ultrasound therapy of injury site modulates gene and protein expressions in the dorsal root ganglion in a sciatic nerve crush injury rat model. Ultrasound Med Biol. 48:2502–2511. 2022.PubMed/NCBI View Article : Google Scholar

76 

Lin G, Zhang H, Sun F, Lu Z, Reed-Maldonado A, Lee YC, Wang G, Banie L and Lue TF: Brain-derived neurotrophic factor promotes nerve regeneration by activating the JAK/STAT pathway in Schwann cells. Transl Androl Urolo. 5:167–175. 2016.PubMed/NCBI View Article : Google Scholar

77 

Xie ZM, Wang XM, Xu N, Wang J, Pan W, Tang XH, Zhou ZQ, Hashimoto K and Yang JJ: Alterations in the inflammatory cytokines and brain-derived neurotrophic factor contribute to depression-like phenotype after spared nerve injury: Improvement by ketamine. Sci Rep. 7(3124)2017.PubMed/NCBI View Article : Google Scholar

78 

Malhotra JD and Kaufman RJ: Endoplasmic reticulum stress and oxidative stress: A vicious cycle or a double-edged sword? Antioxid Redox Signal. 9:2277–2293. 2007.PubMed/NCBI View Article : Google Scholar

79 

Shindo S, Chen SH, Gotoh S, Yokobori K, Hu H, Ray M, Moore R, Nagata K, Martinez J, Hong JS and Negishi M: Estrogen receptor α phosphorylated at Ser216 confers inflammatory function to mouse microglia. Cell Commun Signal. 18(117)2020.PubMed/NCBI View Article : Google Scholar

80 

Villa A, Vegeto E, Poletti A and Maggi A: Estrogens, neuroinflammation, and neurodegeneration. Endocr Rev. 37:372–402. 2016.PubMed/NCBI View Article : Google Scholar

81 

Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, et al: Regulation of endoplasmic reticulum turnover by selective autophagy. Nature. 522:354–358. 2015.PubMed/NCBI View Article : Google Scholar

82 

Cinque L, De Leonibus C, Iavazzo M, Krahmer N, Intartaglia D, Salierno FG, De Cegli R, Di Malta C, Svelto M, Lanzara C, et al: MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B. EMBO J. 39(e105696)2020.PubMed/NCBI View Article : Google Scholar

83 

Zhang K and Kaufman RJ: From endoplasmic-reticulum stress to the inflammatory response. Nature. 454:455–462. 2008.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sakita M, Isobe W, Nonaka K, Murakami S, Miyachi R, Sakane K, Sugimoto S, Yamaguchi A and Yamamoto K: Age‑related changes in endoplasmic reticulum stress response‑associated protein expression in rat tibial nerves. Biomed Rep 22: 50, 2025.
APA
Sakita, M., Isobe, W., Nonaka, K., Murakami, S., Miyachi, R., Sakane, K. ... Yamamoto, K. (2025). Age‑related changes in endoplasmic reticulum stress response‑associated protein expression in rat tibial nerves. Biomedical Reports, 22, 50. https://doi.org/10.3892/br.2025.1928
MLA
Sakita, M., Isobe, W., Nonaka, K., Murakami, S., Miyachi, R., Sakane, K., Sugimoto, S., Yamaguchi, A., Yamamoto, K."Age‑related changes in endoplasmic reticulum stress response‑associated protein expression in rat tibial nerves". Biomedical Reports 22.3 (2025): 50.
Chicago
Sakita, M., Isobe, W., Nonaka, K., Murakami, S., Miyachi, R., Sakane, K., Sugimoto, S., Yamaguchi, A., Yamamoto, K."Age‑related changes in endoplasmic reticulum stress response‑associated protein expression in rat tibial nerves". Biomedical Reports 22, no. 3 (2025): 50. https://doi.org/10.3892/br.2025.1928
Copy and paste a formatted citation
x
Spandidos Publications style
Sakita M, Isobe W, Nonaka K, Murakami S, Miyachi R, Sakane K, Sugimoto S, Yamaguchi A and Yamamoto K: Age‑related changes in endoplasmic reticulum stress response‑associated protein expression in rat tibial nerves. Biomed Rep 22: 50, 2025.
APA
Sakita, M., Isobe, W., Nonaka, K., Murakami, S., Miyachi, R., Sakane, K. ... Yamamoto, K. (2025). Age‑related changes in endoplasmic reticulum stress response‑associated protein expression in rat tibial nerves. Biomedical Reports, 22, 50. https://doi.org/10.3892/br.2025.1928
MLA
Sakita, M., Isobe, W., Nonaka, K., Murakami, S., Miyachi, R., Sakane, K., Sugimoto, S., Yamaguchi, A., Yamamoto, K."Age‑related changes in endoplasmic reticulum stress response‑associated protein expression in rat tibial nerves". Biomedical Reports 22.3 (2025): 50.
Chicago
Sakita, M., Isobe, W., Nonaka, K., Murakami, S., Miyachi, R., Sakane, K., Sugimoto, S., Yamaguchi, A., Yamamoto, K."Age‑related changes in endoplasmic reticulum stress response‑associated protein expression in rat tibial nerves". Biomedical Reports 22, no. 3 (2025): 50. https://doi.org/10.3892/br.2025.1928
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team