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Therapeutic potential of garlic, aged garlic extract and garlic‑derived compounds on pancreatic cancer (Review)

  • Authors:
    • Hiromichi Kawasaki
    • Gabriel Nussbaum
  • View Affiliations / Copyright

    Affiliations: Institute of Biomedical and Oral Research, Hebrew University of Jerusalem, Jerusalem 9112102, Israel
    Copyright: © Kawasaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 54
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    Published online on: January 27, 2025
       https://doi.org/10.3892/br.2025.1932
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Abstract

Garlic is a popular ingredient used in cuisines and traditional medicines worldwide. It contains numerous bioactive organosulfur‑containing compounds, such as allicin, with reported potential for anticancer and antimicrobial therapy. The biological activity and potential use of garlic and its products have been extensively investigated. Aged garlic extract (AGE) is a product manufactured by aging garlic, and has been shown to have numerous health benefits. It has been previously revealed that several garlic‑derived compounds, including AGE, have tumor‑suppressive effects in various cancer models. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, and carries a dismal prognosis. Recently, numerous tumors, including PDAC, were shown to harbor intracellular bacteria, some of which are oral pathogens. Tumor‑associated bacteria have been linked to cancer progression. Garlic may inhibit tumor development, in part, by targeting these bacteria. Although it requires further investigation, pharmacological and antibacterial effects of garlic and its products could offer significant therapeutic benefits for the prevention and treatment of PDAC. In the present review, the therapeutic potential of garlic on PDAC is summarized and discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Kawasaki H and Nussbaum G: Therapeutic potential of garlic, aged garlic extract and garlic‑derived compounds on pancreatic cancer (Review). Biomed Rep 22: 54, 2025.
APA
Kawasaki, H., & Nussbaum, G. (2025). Therapeutic potential of garlic, aged garlic extract and garlic‑derived compounds on pancreatic cancer (Review). Biomedical Reports, 22, 54. https://doi.org/10.3892/br.2025.1932
MLA
Kawasaki, H., Nussbaum, G."Therapeutic potential of garlic, aged garlic extract and garlic‑derived compounds on pancreatic cancer (Review)". Biomedical Reports 22.3 (2025): 54.
Chicago
Kawasaki, H., Nussbaum, G."Therapeutic potential of garlic, aged garlic extract and garlic‑derived compounds on pancreatic cancer (Review)". Biomedical Reports 22, no. 3 (2025): 54. https://doi.org/10.3892/br.2025.1932
Copy and paste a formatted citation
x
Spandidos Publications style
Kawasaki H and Nussbaum G: Therapeutic potential of garlic, aged garlic extract and garlic‑derived compounds on pancreatic cancer (Review). Biomed Rep 22: 54, 2025.
APA
Kawasaki, H., & Nussbaum, G. (2025). Therapeutic potential of garlic, aged garlic extract and garlic‑derived compounds on pancreatic cancer (Review). Biomedical Reports, 22, 54. https://doi.org/10.3892/br.2025.1932
MLA
Kawasaki, H., Nussbaum, G."Therapeutic potential of garlic, aged garlic extract and garlic‑derived compounds on pancreatic cancer (Review)". Biomedical Reports 22.3 (2025): 54.
Chicago
Kawasaki, H., Nussbaum, G."Therapeutic potential of garlic, aged garlic extract and garlic‑derived compounds on pancreatic cancer (Review)". Biomedical Reports 22, no. 3 (2025): 54. https://doi.org/10.3892/br.2025.1932
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