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Efficacy and safety of loxoprofen sodium cataplasms in the treatment of osteoarthritis: A randomized, multicenter study

  • Authors:
    • Yutian Lei
    • Zeyu Liu
    • Xin Jin
    • Guicheng Gao
    • Sen Luo
    • Xu Gao
    • Qirang Liu
    • Pei Yang
    • Run Tian
  • View Affiliations / Copyright

    Affiliations: Department of Bone and Joint Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China, Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, P.R. China, Department of Bone and Joint Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China, Department of Orthopedics, Xi'an Honghui Hospital, Xi'an, Shaanxi 710054, P.R. China
    Copyright: © Lei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 57
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    Published online on: February 4, 2025
       https://doi.org/10.3892/br.2025.1935
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Abstract

The present study aimed to compare the efficacy and safety of loxoprofen sodium cataplasm (LSC) with those of flurbiprofen cataplasm (FPC) in osteoarthritis (OA) treatment. In this multicenter, randomized controlled trial, subjects meeting the inclusion and exclusion criteria were randomly assigned to the two treatment groups. According to the manufacturer's instructions, the first group received LSC once daily, with the application of one patch per area for 2 weeks, whereas the second group received FPC twice daily, with the application of one patch per area for 2 weeks. The treatment response was evaluated based on the Visual Analog Scale (VAS) score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) global score, Lysholm score and adverse events for 296 patients enrolled across three subcenters, with 192 patients in the LSC group and 104 patients in the FPC group. The treatment effectiveness rates, based on the VAS, WOMAC global and Lysholm scores, were 74.46, 61.41 and 85.25%, respectively, for the LSC group and 43.14, 31.37 and 66.67%, respectively, for the FPC group. Regardless of the effectiveness criterion used, the LSC group exhibited a superior treatment effectiveness rate compared with the FPC group. After 2 weeks of treatment, OA symptoms improved in both groups, with the LSC group exhibiting lower VAS (P<0.05) and WOMAC global scores (comprising pain, stiffness and physical function scores) compared with the FPC group (P<0.05), while the Lysholm score was higher in the LSC group compared with the FPC group (P<0.05). The FPC group experienced more general adverse events (P>0.05) and dressing shedding (P<0.05) compared with the LSC group, whereas the LSC group had more specific adverse events (such as skin itching, fever and allergy) compared with the FPC group (P>0.05). The results suggested that compared with FPC, LSC exhibited higher short‑term efficacy and a consistent safety profile. The present study was registered at Chinese Clinical Trial Register (chictr.org.cn; ChiCTR2300072504; date of registration, June 15, 2023).
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Copy and paste a formatted citation
Spandidos Publications style
Lei Y, Liu Z, Jin X, Gao G, Luo S, Gao X, Liu Q, Yang P and Tian R: Efficacy and safety of loxoprofen sodium cataplasms in the treatment of osteoarthritis: A randomized, multicenter study. Biomed Rep 22: 57, 2025.
APA
Lei, Y., Liu, Z., Jin, X., Gao, G., Luo, S., Gao, X. ... Tian, R. (2025). Efficacy and safety of loxoprofen sodium cataplasms in the treatment of osteoarthritis: A randomized, multicenter study. Biomedical Reports, 22, 57. https://doi.org/10.3892/br.2025.1935
MLA
Lei, Y., Liu, Z., Jin, X., Gao, G., Luo, S., Gao, X., Liu, Q., Yang, P., Tian, R."Efficacy and safety of loxoprofen sodium cataplasms in the treatment of osteoarthritis: A randomized, multicenter study". Biomedical Reports 22.4 (2025): 57.
Chicago
Lei, Y., Liu, Z., Jin, X., Gao, G., Luo, S., Gao, X., Liu, Q., Yang, P., Tian, R."Efficacy and safety of loxoprofen sodium cataplasms in the treatment of osteoarthritis: A randomized, multicenter study". Biomedical Reports 22, no. 4 (2025): 57. https://doi.org/10.3892/br.2025.1935
Copy and paste a formatted citation
x
Spandidos Publications style
Lei Y, Liu Z, Jin X, Gao G, Luo S, Gao X, Liu Q, Yang P and Tian R: Efficacy and safety of loxoprofen sodium cataplasms in the treatment of osteoarthritis: A randomized, multicenter study. Biomed Rep 22: 57, 2025.
APA
Lei, Y., Liu, Z., Jin, X., Gao, G., Luo, S., Gao, X. ... Tian, R. (2025). Efficacy and safety of loxoprofen sodium cataplasms in the treatment of osteoarthritis: A randomized, multicenter study. Biomedical Reports, 22, 57. https://doi.org/10.3892/br.2025.1935
MLA
Lei, Y., Liu, Z., Jin, X., Gao, G., Luo, S., Gao, X., Liu, Q., Yang, P., Tian, R."Efficacy and safety of loxoprofen sodium cataplasms in the treatment of osteoarthritis: A randomized, multicenter study". Biomedical Reports 22.4 (2025): 57.
Chicago
Lei, Y., Liu, Z., Jin, X., Gao, G., Luo, S., Gao, X., Liu, Q., Yang, P., Tian, R."Efficacy and safety of loxoprofen sodium cataplasms in the treatment of osteoarthritis: A randomized, multicenter study". Biomedical Reports 22, no. 4 (2025): 57. https://doi.org/10.3892/br.2025.1935
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