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High serum levels of soluble PD‑1 and PD‑L1 are associated with advanced clinical stages in patients with cervical cancer

  • Authors:
    • Silvia Elizabeth Pérez‑Picazo
    • Patricia Martínez‑Morales
    • Ileana Conde‑Rodríguez
    • Julio Reyes‑Leyva
    • Verónica Vallejo‑Ruiz
  • View Affiliations / Copyright

    Affiliations: Eastern Biomedical Research Center, Mexican Institute of Social Security, Atlixco, Puebla 72760, Mexico, CONAHCYT‑Faculty of Biological Sciences, Autonomous University of Puebla, Puebla 72570, Mexico, Faculty of Chemical Sciences, Autonomous University of Puebla, Puebla 72570, Mexico
    Copyright: © Pérez‑Picazo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 70
    |
    Published online on: February 19, 2025
       https://doi.org/10.3892/br.2025.1948
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Abstract

The binding of programmed cell death receptor‑ligand 1 (PD‑L1) to programmed cell death protein 1 (PD‑1) inhibits T‑cell activation, playing a negative role in the anticancer immune response. The soluble forms of these proteins, found in blood circulation, have recently received increasing attention and their function in the cancer immune response remains unclear. The present study evaluated the serum levels of soluble (s)PD‑1 and sPD‑L1 in patients with cervical cancer and healthy controls, and their associations with clinicopathological characteristics and clinical outcomes. The serum concentrations of both soluble proteins were determined via ELISA. The concentrations of sPD‑1 and sPD‑L1 were higher in patients with cervical cancer and advanced clinical stages. The evaluation of sPD‑1 and clinical outcome revealed higher levels in deceased patients than in total remission patients. sPD‑1 and sPD‑L1 concentrations were moderately positively correlated; however, in patients with clinical stage IV disease, a very strong correlation was observed. sPD‑1 and sPD‑L1 could be used as potential diagnostic biomarkers for patients with cervical cancer. Considering the higher levels in advanced clinical stages, their role in cervical cancer progression or treatment response must be explored.
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Copy and paste a formatted citation
Spandidos Publications style
Pérez‑Picazo S, Martínez‑Morales P, Conde‑Rodríguez I, Reyes‑Leyva J and Vallejo‑Ruiz V: High serum levels of soluble PD‑1 and PD‑L1 are associated with advanced clinical stages in patients with cervical cancer. Biomed Rep 22: 70, 2025.
APA
Pérez‑Picazo, S., Martínez‑Morales, P., Conde‑Rodríguez, I., Reyes‑Leyva, J., & Vallejo‑Ruiz, V. (2025). High serum levels of soluble PD‑1 and PD‑L1 are associated with advanced clinical stages in patients with cervical cancer. Biomedical Reports, 22, 70. https://doi.org/10.3892/br.2025.1948
MLA
Pérez‑Picazo, S., Martínez‑Morales, P., Conde‑Rodríguez, I., Reyes‑Leyva, J., Vallejo‑Ruiz, V."High serum levels of soluble PD‑1 and PD‑L1 are associated with advanced clinical stages in patients with cervical cancer". Biomedical Reports 22.4 (2025): 70.
Chicago
Pérez‑Picazo, S., Martínez‑Morales, P., Conde‑Rodríguez, I., Reyes‑Leyva, J., Vallejo‑Ruiz, V."High serum levels of soluble PD‑1 and PD‑L1 are associated with advanced clinical stages in patients with cervical cancer". Biomedical Reports 22, no. 4 (2025): 70. https://doi.org/10.3892/br.2025.1948
Copy and paste a formatted citation
x
Spandidos Publications style
Pérez‑Picazo S, Martínez‑Morales P, Conde‑Rodríguez I, Reyes‑Leyva J and Vallejo‑Ruiz V: High serum levels of soluble PD‑1 and PD‑L1 are associated with advanced clinical stages in patients with cervical cancer. Biomed Rep 22: 70, 2025.
APA
Pérez‑Picazo, S., Martínez‑Morales, P., Conde‑Rodríguez, I., Reyes‑Leyva, J., & Vallejo‑Ruiz, V. (2025). High serum levels of soluble PD‑1 and PD‑L1 are associated with advanced clinical stages in patients with cervical cancer. Biomedical Reports, 22, 70. https://doi.org/10.3892/br.2025.1948
MLA
Pérez‑Picazo, S., Martínez‑Morales, P., Conde‑Rodríguez, I., Reyes‑Leyva, J., Vallejo‑Ruiz, V."High serum levels of soluble PD‑1 and PD‑L1 are associated with advanced clinical stages in patients with cervical cancer". Biomedical Reports 22.4 (2025): 70.
Chicago
Pérez‑Picazo, S., Martínez‑Morales, P., Conde‑Rodríguez, I., Reyes‑Leyva, J., Vallejo‑Ruiz, V."High serum levels of soluble PD‑1 and PD‑L1 are associated with advanced clinical stages in patients with cervical cancer". Biomedical Reports 22, no. 4 (2025): 70. https://doi.org/10.3892/br.2025.1948
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