Efficacy of aged garlic extract on periodontal pockets:&nbsp; An 18‑month dose response study

Zini,Avraham; Zecharyahu,Lital; Gonen,Hila; Vered,Yuval

doi:10.3892/br.2025.1954

April-2025 Volume 22 Issue 4

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April-2025 Volume 22 Issue 4

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Efficacy of aged garlic extract on periodontal pockets: An 18‑month dose response study

Authors:
- Avraham Zini
- Lital Zecharyahu
- Hila Gonen
- Yuval Vered
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Affiliations: Institute of Biomedical and Oral Research, Faculty of Dental Medicine, Hebrew University of Jerusalem, 91120 Jerusalem, Israel, Department of Community Dentistry, Hadassah Medical Center, Faculty of Dental Medicine, Hebrew University of Jerusalem, 91120 Jerusalem, Israel

Copyright: © Zini et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 76
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Published online on: February 27, 2025

https://doi.org/10.3892/br.2025.1954
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Abstract

The present 18‑month study assessed the long‑term effects of aged garlic extract (AGE) on deep periodontal pockets in generally healthy adults with moderate‑to‑severe periodontal pockets. The present study was a randomized, controlled, examiner‑blind trial, involving four parallel treatment groups, including three AGE dosage groups and a placebo (control) group, with 300 participants in total. Study participants were instructed to use the AGE products at home throughout the study, following both written and verbal guidelines provided at the start. Periodontal assessments, including periodontal measurements, were performed at baseline and at 6, 12 and 18 months. After 18 months, a significant reduction in pocket depth was observed in the AGE groups compared with that of the placebo group, indicating a dose‑response trend. In a multiple linear regression analysis, the baseline pocket depth, smoking status and the amount of AGE consumed on a daily basis were all demonstrated to be predictors of pocket depth. The results of the present study indicate that AGE is effective in improving oral health and further emphasize the potential role of AGE in promoting overall health due to the link between periodontitis and systemic diseases such as diabetes, hypertension and atherosclerosis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Efficacy of aged garlic extract on periodontal pockets: An 18‑month dose response study

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