Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
May-2025 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2025 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Heat shock protein family D member 1 mediates lung cancer cell‑induced angiogenesis of endothelial cells

  • Authors:
    • Keerakarn Somsuan
    • Artitaya Rongjumnong
    • Atthapan Morchang
    • Phateep Hankittichai
    • Jatuporn Ngoenkam
    • Anupong Makeudom
    • Kriengsak Lirdprapamongkol
    • Suttichai Krisanaprakornkit
    • Sutatip Pongcharoen
    • Jisnuson Svasti
    • Siripat Aluksanasuwan
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Mae Fah Luang University, Chiang Rai 57100, Thailand, Cancer and Immunology Research Unit, Mae Fah Luang University, Chiang Rai 57100, Thailand, Department of Microbiology and Parasitology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand, School of Dentistry, Mae Fah Luang University, Chiang Rai 57100, Thailand, Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok 10210, Thailand, Department of Medicine, Faculty of Medicine, Naresuan University, Phitsanulok 65000, Thailand
    Copyright: © Somsuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 77
    |
    Published online on: February 27, 2025
       https://doi.org/10.3892/br.2025.1955
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Angiogenesis is a crucial process in lung cancer growth and progression. Heat shock protein family D member 1 (HSPD1 or HSP60) plays a significant role in promoting lung cancer development, but its role in angiogenesis remains largely unexplored. The present study aimed to investigate the involvement of HSPD1 in lung cancer cell‑induced angiogenesis using indirect co‑culture experiments. Secretomes were collected from stable HSPD1‑knockdown A549 lung cancer cells [short hairpin (sh)HSPD1‑A549 cells] and scramble control cells (shControl‑A549 cells) and used to treat human endothelial EA.hy926 cells. Effects of the secretomes on key steps of angiogenesis, including endothelial cell proliferation, migration, invasion, aggregation and tube formation, were assessed using BrdU incorporation, wound healing, Transwell invasion, hanging‑drop and Matrigel tube formation assays, respectively. The amount of vascular endothelial growth factor (VEGF) secreted by EA.hy926 cells was determined using ELISA. The correlation of VEGFA expression with HSPD1 expression and overall survival in patients with lung adenocarcinoma was evaluated using bioinformatics analysis. The results revealed that the shControl‑A549 secretome markedly stimulated endothelial cell proliferation, migration, invasion, aggregation, tube formation and VEGF secretion, whereas the shHSPD1‑A549 secretome had no significant effects on these processes. VEGFA expression was markedly associated with HSPD1 expression and overall survival in patients with lung adenocarcinoma. In conclusion, the findings highlighted the role of HSPD1 in promoting angiogenesis capability of endothelial cells, potentially through VEGF‑mediated pathways. Targeting HSPD1 may represent a promising therapeutic strategy to inhibit angiogenesis and improve clinical outcomes in lung cancer patients.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Folkman J: Role of angiogenesis in tumor growth and metastasis. Semin Oncol. 29 (6 Suppl 16):S15–S18. 2002.PubMed/NCBI View Article : Google Scholar

2 

Li Y, Lin M, Wang S, Cao B, Li C and Li G: Novel angiogenic regulators and anti-angiogenesis drugs targeting angiogenesis signaling pathways: Perspectives for targeting angiogenesis in lung cancer. Front Oncol. 12(842960)2022.PubMed/NCBI View Article : Google Scholar

3 

Altorki NK, Markowitz GJ, Gao D, Port JL, Saxena A, Stiles B, McGraw T and Mittal V: The lung microenvironment: an important regulator of tumour growth and metastasis. Nat Rev Cancer. 19:9–31. 2019.PubMed/NCBI View Article : Google Scholar

4 

Hwang I, Kim JW, Ylaya K, Chung EJ, Kitano H, Perry C, Hanaoka J, Fukuoka J, Chung JY and Hewitt SM: Tumor-associated macrophage, angiogenesis and lymphangiogenesis markers predict prognosis of non-small cell lung cancer patients. J Transl Med. 18(443)2020.PubMed/NCBI View Article : Google Scholar

5 

Bremnes RM, Camps C and Sirera R: Angiogenesis in non-small cell lung cancer: The prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood. Lung Cancer. 51:143–158. 2006.PubMed/NCBI View Article : Google Scholar

6 

Gu X, Chu L and Kang Y: Angiogenic factor-based signature predicts prognosis and immunotherapy response in non-small-cell lung cancer. Front Genet. 13(894024)2022.PubMed/NCBI View Article : Google Scholar

7 

Majidpoor J and Mortezaee K: Angiogenesis as a hallmark of solid tumors-clinical perspectives. Cell Oncol (Dordr). 44:715–737. 2021.PubMed/NCBI View Article : Google Scholar

8 

Ghalehbandi S, Yuzugulen J, Pranjol MZI and Pourgholami MH: The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF. Eur J Pharmacol. 949(175586)2023.PubMed/NCBI View Article : Google Scholar

9 

Lee S, Chen TT, Barber CL, Jordan MC, Murdock J, Desai S, Ferrara N, Nagy A, Roos KP and Iruela-Arispe ML: Autocrine VEGF signaling is required for vascular homeostasis. Cell. 130:691–703. 2007.PubMed/NCBI View Article : Google Scholar

10 

Liu Y, Cox SR, Morita T and Kourembanas S: Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer. Circ Res. 77:638–643. 1995.PubMed/NCBI View Article : Google Scholar

11 

Du H, Shi H, Chen D, Zhou Y and Che G: Cross-talk between endothelial and tumor cells via basic fibroblast growth factor and vascular endothelial growth factor signaling promotes lung cancer growth and angiogenesis. Oncol Lett. 9:1089–1094. 2015.PubMed/NCBI View Article : Google Scholar

12 

Zhao Y, Guo S, Deng J, Shen J, Du F, Wu X, Chen Y, Li M, Chen M, Li X, et al: VEGF/VEGFR-targeted therapy and immunotherapy in non-small cell lung cancer: Targeting the tumor microenvironment. Int J Biol Sci. 18:3845–3858. 2022.PubMed/NCBI View Article : Google Scholar

13 

Vakhrushev IV, Nezhurina EK, Karalkin PA, Tsvetkova AV, Sergeeva NS, Majouga AG and Yarygin KN: Heterotypic multicellular spheroids as experimental and preclinical models of sprouting angiogenesis. Biology (Basel). 11(18)2021.PubMed/NCBI View Article : Google Scholar

14 

Yun CW, Kim HJ, Lim JH and Lee SH: Heat shock proteins: Agents of cancer development and therapeutic targets in anti-cancer therapy. Cells. 9(60)2019.PubMed/NCBI View Article : Google Scholar

15 

Quintana FJ and Cohen IR: The HSP60 immune system network. Trends Immunol. 32:89–95. 2011.PubMed/NCBI View Article : Google Scholar

16 

Tang Y, Yang Y, Luo J, Liu S, Zhan Y, Zang H, Zheng H, Zhang Y, Feng J, Fan S and Wen Q: Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients. Cancer Biomark. 30:85–94. 2021.PubMed/NCBI View Article : Google Scholar

17 

Parma B, Ramesh V, Gollavilli PN, Siddiqui A, Pinna L, Schwab A, Marschall S, Zhang S, Pilarsky C, Napoli F, et al: Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting. J Exp Clin Cancer Res. 40(248)2021.PubMed/NCBI View Article : Google Scholar

18 

Aluksanasuwan S, Somsuan K, Ngoenkam J, Chutipongtanate S and Pongcharoen S: Potential association of HSPD1 with dysregulations in ribosome biogenesis and immune cell infiltration in lung adenocarcinoma: An integrated bioinformatic approach. Cancer Biomark. 39:155–170. 2024.PubMed/NCBI View Article : Google Scholar

19 

Aluksanasuwan S, Somsuan K, Ngoenkam J, Chiangjong W, Rongjumnong A, Morchang A, Chutipongtanate S and Pongcharoen S: Knockdown of heat shock protein family D member 1 (HSPD1) in lung cancer cell altered secretome profile and cancer-associated fibroblast induction. Biochim Biophys Acta Mol Cell Res. 187(119736)2024.PubMed/NCBI View Article : Google Scholar

20 

Duan Y, Tang H, Mitchell-Silbaugh K, Fang X, Han Z and Ouyang K: Heat shock protein 60 in cardiovascular physiology and diseases. Front Mol Biosci. 7(73)2020.PubMed/NCBI View Article : Google Scholar

21 

Qiu J, Gao HQ, Liang Y, Yu H and Zhou RH: Comparative proteomics analysis reveals role of heat shock protein 60 in digoxin-induced toxicity in human endothelial cells. Biochim Biophys Acta. 1784:1857–1864. 2008.PubMed/NCBI View Article : Google Scholar

22 

Billack B, Heck DE, Mariano TM, Gardner CR, Sur R, Laskin DL and Laskin JD: Induction of cyclooxygenase-2 by heat shock protein 60 in macrophages and endothelial cells. Am J Physiol Cell Physiol. 283:C1267–C1277. 2002.PubMed/NCBI View Article : Google Scholar

23 

Lin CS, He PJ, Hsu WT, Wu MS, Wu CJ, Shen HW, Hwang CH, Lai YK, Tsai NM and Liao KW: Helicobacter pylori-derived heat shock protein 60 enhances angiogenesis via a CXCR2-mediated signaling pathway. Biochem Biophys Res Commun. 397:283–289. 2010.PubMed/NCBI View Article : Google Scholar

24 

Zheng D, Zhang X, Xu J, Chen S, Wang B and Yuan X: LncRNA LINC01503 promotes angiogenesis in colorectal cancer by regulating VEGFA expression via miR-342-3p and HSP60 binding. J Biomed Res: Oct 25, 2024 (Epub ahead of print).

25 

Suarez-Arnedo A, Torres Figueroa F, Clavijo C, Arbeláez P, Cruz JC and Muñoz-Camargo C: An image J plugin for the high throughput image analysis of in vitro scratch wound healing assays. PLoS One. 15(e0232565)2020.PubMed/NCBI View Article : Google Scholar

26 

Somsuan K, Peerapen P, Boonmark W, Plumworasawat S, Samol R, Sakulsak N and Thongboonkerd V: ARID1A knockdown triggers epithelial-mesenchymal transition and carcinogenesis features of renal cells: Role in renal cell carcinoma. FASEB J. 33:12226–12239. 2019.PubMed/NCBI View Article : Google Scholar

27 

Schneider CA, Rasband WS and Eliceiri KW: NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 9:671–675. 2012.PubMed/NCBI View Article : Google Scholar

28 

Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS, Li B and Liu XS: TIMER: A web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 77:e108–e110. 2017.PubMed/NCBI View Article : Google Scholar

29 

Li B, Severson E, Pignon JC, Zhao H, Li T, Novak J, Jiang P, Shen H, Aster JC, Rodig S, et al: Comprehensive analyses of tumor immunity: Implications for cancer immunotherapy. Genome Biol. 17(174)2016.PubMed/NCBI View Article : Google Scholar

30 

Győrffy B: Transcriptome-level discovery of survival-associated biomarkers and therapy targets in non-small-cell lung cancer. Br J Pharmacol. 181:362–374. 2024.PubMed/NCBI View Article : Google Scholar

31 

Makridakis M and Vlahou A: Secretome proteomics for discovery of cancer biomarkers. J Proteomics. 73:2291–2305. 2010.PubMed/NCBI View Article : Google Scholar

32 

da Cunha BR, Domingos C, Stefanini ACB, Henrique T, Polachini GM, Castelo-Branco P and Tajara EH: Cellular interactions in the tumor microenvironment: The role of secretome. J Cancer. 10:4574–4587. 2019.PubMed/NCBI View Article : Google Scholar

33 

Cheng HW, Chen YF, Wong JM, Weng CW, Chen HY, Yu SL, Chen HW, Yuan A and Chen JJ: Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathway. J Exp Clin Cancer Res. 36(27)2017.PubMed/NCBI View Article : Google Scholar

34 

Zhong L, Roybal J, Chaerkady R, Zhang W, Choi K, Alvarez CA, Tran H, Creighton CJ, Yan S, Strieter RM, et al: Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment. Cancer Res. 68:7237–7245. 2008.PubMed/NCBI View Article : Google Scholar

35 

Kramer N, Walzl A, Unger C, Rosner M, Krupitza G, Hengstschläger M and Dolznig H: In vitro cell migration and invasion assays. Mutat Res. 752:10–24. 2013.PubMed/NCBI View Article : Google Scholar

36 

Tian J, Guo X, Liu XM, Liu L, Weng QF, Dong SJ, Knowlton AA, Yuan WJ and Lin L: Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes. Cardiovasc Res. 98:391–401. 2013.PubMed/NCBI View Article : Google Scholar

37 

Vabulas RM, Ahmad-Nejad P, da Costa C, Miethke T, Kirschning CJ, Häcker H and Wagner H: Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem. 276:31332–31339. 2001.PubMed/NCBI View Article : Google Scholar

38 

Stierschneider A and Wiesner C: Shedding light on the molecular and regulatory mechanisms of TLR4 signaling in endothelial cells under physiological and inflamed conditions. Front Immunol. 14(1264889)2023.PubMed/NCBI View Article : Google Scholar

39 

Pei Z, Lin D, Song X, Li H and Yao H: TLR4 signaling promotes the expression of VEGF and TGFbeta1 in human prostate epithelial PC3 cells induced by lipopolysaccharide. Cell Immunol. 254:20–27. 2008.PubMed/NCBI View Article : Google Scholar

40 

Riddell JR, Maier P, Sass SN, Moser MT, Foster BA and Gollnick SO: Peroxiredoxin 1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1α. PLoS One. 7(e50394)2012.PubMed/NCBI View Article : Google Scholar

41 

Voron T, Colussi O, Marcheteau E, Pernot S, Nizard M, Pointet AL, Latreche S, Bergaya S, Benhamouda N, Tanchot C, et al: VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors. J Exp Med. 212:139–148. 2015.PubMed/NCBI View Article : Google Scholar

42 

Gabrilovich D, Ishida T, Oyama T, Ran S, Kravtsov V, Nadaf S and Carbone DP: Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood. 92:4150–4166. 1998.PubMed/NCBI

43 

Song X and Luo Y: The regulatory mechanism of Hsp90alpha secretion from endothelial cells and its role in angiogenesis during wound healing. Biochem Biophys Res Commun. 398:111–117. 2010.PubMed/NCBI View Article : Google Scholar

44 

Schleicher M, Shepherd BR, Suarez Y, Fernandez-Hernando C, Yu J, Pan Y, Acevedo LM, Shadel GS and Sessa WC: Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. J Cell Biol. 180:101–112. 2008.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Somsuan K, Rongjumnong A, Morchang A, Hankittichai P, Ngoenkam J, Makeudom A, Lirdprapamongkol K, Krisanaprakornkit S, Pongcharoen S, Svasti J, Svasti J, et al: Heat shock protein family D member 1 mediates lung cancer cell‑induced angiogenesis of endothelial cells. Biomed Rep 22: 77, 2025.
APA
Somsuan, K., Rongjumnong, A., Morchang, A., Hankittichai, P., Ngoenkam, J., Makeudom, A. ... Aluksanasuwan, S. (2025). Heat shock protein family D member 1 mediates lung cancer cell‑induced angiogenesis of endothelial cells. Biomedical Reports, 22, 77. https://doi.org/10.3892/br.2025.1955
MLA
Somsuan, K., Rongjumnong, A., Morchang, A., Hankittichai, P., Ngoenkam, J., Makeudom, A., Lirdprapamongkol, K., Krisanaprakornkit, S., Pongcharoen, S., Svasti, J., Aluksanasuwan, S."Heat shock protein family D member 1 mediates lung cancer cell‑induced angiogenesis of endothelial cells". Biomedical Reports 22.5 (2025): 77.
Chicago
Somsuan, K., Rongjumnong, A., Morchang, A., Hankittichai, P., Ngoenkam, J., Makeudom, A., Lirdprapamongkol, K., Krisanaprakornkit, S., Pongcharoen, S., Svasti, J., Aluksanasuwan, S."Heat shock protein family D member 1 mediates lung cancer cell‑induced angiogenesis of endothelial cells". Biomedical Reports 22, no. 5 (2025): 77. https://doi.org/10.3892/br.2025.1955
Copy and paste a formatted citation
x
Spandidos Publications style
Somsuan K, Rongjumnong A, Morchang A, Hankittichai P, Ngoenkam J, Makeudom A, Lirdprapamongkol K, Krisanaprakornkit S, Pongcharoen S, Svasti J, Svasti J, et al: Heat shock protein family D member 1 mediates lung cancer cell‑induced angiogenesis of endothelial cells. Biomed Rep 22: 77, 2025.
APA
Somsuan, K., Rongjumnong, A., Morchang, A., Hankittichai, P., Ngoenkam, J., Makeudom, A. ... Aluksanasuwan, S. (2025). Heat shock protein family D member 1 mediates lung cancer cell‑induced angiogenesis of endothelial cells. Biomedical Reports, 22, 77. https://doi.org/10.3892/br.2025.1955
MLA
Somsuan, K., Rongjumnong, A., Morchang, A., Hankittichai, P., Ngoenkam, J., Makeudom, A., Lirdprapamongkol, K., Krisanaprakornkit, S., Pongcharoen, S., Svasti, J., Aluksanasuwan, S."Heat shock protein family D member 1 mediates lung cancer cell‑induced angiogenesis of endothelial cells". Biomedical Reports 22.5 (2025): 77.
Chicago
Somsuan, K., Rongjumnong, A., Morchang, A., Hankittichai, P., Ngoenkam, J., Makeudom, A., Lirdprapamongkol, K., Krisanaprakornkit, S., Pongcharoen, S., Svasti, J., Aluksanasuwan, S."Heat shock protein family D member 1 mediates lung cancer cell‑induced angiogenesis of endothelial cells". Biomedical Reports 22, no. 5 (2025): 77. https://doi.org/10.3892/br.2025.1955
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team