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Diagnosis and latest treatment strategies of ANCA‑associated glomerulonephritis (Review)

  • Authors:
    • Yi Ren
    • Yinghua Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, People's Hospital of Longhua, Shenzhen, Guangdong 518109, P.R. China, Department of Rheumatology and Immunology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102200, P.R. China
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 78
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    Published online on: February 28, 2025
       https://doi.org/10.3892/br.2025.1956
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Abstract

Antineutrophil cytoplasmic antibody (ANCA)‑associated vasculitis (AAV) is a spectrum of conditions characterized by inflammation of the small‑ and medium‑sized vasculature. Glomerulonephritis associated with AAV (AAV‑GN) exerts a profound effect on patient survival and long‑term prognosis, with renal impairment resulting in end‑stage renal disease in ~20% of cases within a 5‑year period. Therefore, the early detection of renal involvement is of pivotal significance. The present review aimed to summarize the diagnostic utility of serological and urinary assays, coupled with renal biopsy, in the context of AAV‑GN, thus promoting the early diagnosis of the disease. Furthermore, standardized protocols for glucocorticoid and immunosuppressive therapy have been established in the last decade, with the development of subsequent targeted treatment regimens. The current review also summarized the current research developments associated with AAV‑GN, thus providing more references for clinical practice and benefiting a greater number of patients.
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Copy and paste a formatted citation
Spandidos Publications style
Ren Y and Zhao Y: Diagnosis and latest treatment strategies of ANCA‑associated glomerulonephritis (Review). Biomed Rep 22: 78, 2025.
APA
Ren, Y., & Zhao, Y. (2025). Diagnosis and latest treatment strategies of ANCA‑associated glomerulonephritis (Review). Biomedical Reports, 22, 78. https://doi.org/10.3892/br.2025.1956
MLA
Ren, Y., Zhao, Y."Diagnosis and latest treatment strategies of ANCA‑associated glomerulonephritis (Review)". Biomedical Reports 22.5 (2025): 78.
Chicago
Ren, Y., Zhao, Y."Diagnosis and latest treatment strategies of ANCA‑associated glomerulonephritis (Review)". Biomedical Reports 22, no. 5 (2025): 78. https://doi.org/10.3892/br.2025.1956
Copy and paste a formatted citation
x
Spandidos Publications style
Ren Y and Zhao Y: Diagnosis and latest treatment strategies of ANCA‑associated glomerulonephritis (Review). Biomed Rep 22: 78, 2025.
APA
Ren, Y., & Zhao, Y. (2025). Diagnosis and latest treatment strategies of ANCA‑associated glomerulonephritis (Review). Biomedical Reports, 22, 78. https://doi.org/10.3892/br.2025.1956
MLA
Ren, Y., Zhao, Y."Diagnosis and latest treatment strategies of ANCA‑associated glomerulonephritis (Review)". Biomedical Reports 22.5 (2025): 78.
Chicago
Ren, Y., Zhao, Y."Diagnosis and latest treatment strategies of ANCA‑associated glomerulonephritis (Review)". Biomedical Reports 22, no. 5 (2025): 78. https://doi.org/10.3892/br.2025.1956
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