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Effects of fructose consumption during pregnancy in murine models (Review)

  • Authors:
    • Ana Luisa Urrego Arredondo
    • Cristian David Moreno Urrutia
    • Juan David Gonzalez Calderon
    • Johanna Andrea Gutiérrez Vargas
  • View Affiliations / Copyright

    Affiliations: University Institution Colegio Mayor de Antioquia, Medellín, Antioquia 65‑46, Colombia, Uniremington Biomedical Research Group, Faculty of Health Sciences, Remington University Corporation, Medellín, Antioquia 51‑27, Colombia, Neuroscience and Aging Group (GISAM), Faculty of Health Sciences, Remington University Corporation, Medellín, Antioquia 51‑27, Colombia
    Copyright: © Urrego Arredondo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 87
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    Published online on: March 18, 2025
       https://doi.org/10.3892/br.2025.1965
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Abstract

After standardizing methods for industrial fructose production, this sugar has been intensively used as a food additive. The growing use of this sugar in food has coincided with increased metabolic disorders in recent decades, and it remains a widely used sweetener. The high ingestion of fructose has contributed to the increasing prevalence of numerous chronic health conditions. Fructose intake and its impact during pregnancy and lactation have drawn the attention of researchers. In the present review, the latest information on the effects of maternal diets rich in fructose on rat or mouse offspring was compiled. The findings suggest a generalized negative response to excess fructose, such as alterations in mitochondrial function, neuroinflammation, oxidative stress, reproductive health, placental and intrauterine effects, epigenetics, transcriptomics modifications and cognitive function impairment. This demonstrates that chronic maternal fructose consumption could deteriorate the offspring's health.
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Copy and paste a formatted citation
Spandidos Publications style
Urrego Arredondo AL, Moreno Urrutia CD, Gonzalez Calderon JD and Gutiérrez Vargas JA: Effects of fructose consumption during pregnancy in murine models (Review). Biomed Rep 22: 87, 2025.
APA
Urrego Arredondo, A.L., Moreno Urrutia, C.D., Gonzalez Calderon, J.D., & Gutiérrez Vargas, J.A. (2025). Effects of fructose consumption during pregnancy in murine models (Review). Biomedical Reports, 22, 87. https://doi.org/10.3892/br.2025.1965
MLA
Urrego Arredondo, A. L., Moreno Urrutia, C. D., Gonzalez Calderon, J. D., Gutiérrez Vargas, J. A."Effects of fructose consumption during pregnancy in murine models (Review)". Biomedical Reports 22.5 (2025): 87.
Chicago
Urrego Arredondo, A. L., Moreno Urrutia, C. D., Gonzalez Calderon, J. D., Gutiérrez Vargas, J. A."Effects of fructose consumption during pregnancy in murine models (Review)". Biomedical Reports 22, no. 5 (2025): 87. https://doi.org/10.3892/br.2025.1965
Copy and paste a formatted citation
x
Spandidos Publications style
Urrego Arredondo AL, Moreno Urrutia CD, Gonzalez Calderon JD and Gutiérrez Vargas JA: Effects of fructose consumption during pregnancy in murine models (Review). Biomed Rep 22: 87, 2025.
APA
Urrego Arredondo, A.L., Moreno Urrutia, C.D., Gonzalez Calderon, J.D., & Gutiérrez Vargas, J.A. (2025). Effects of fructose consumption during pregnancy in murine models (Review). Biomedical Reports, 22, 87. https://doi.org/10.3892/br.2025.1965
MLA
Urrego Arredondo, A. L., Moreno Urrutia, C. D., Gonzalez Calderon, J. D., Gutiérrez Vargas, J. A."Effects of fructose consumption during pregnancy in murine models (Review)". Biomedical Reports 22.5 (2025): 87.
Chicago
Urrego Arredondo, A. L., Moreno Urrutia, C. D., Gonzalez Calderon, J. D., Gutiérrez Vargas, J. A."Effects of fructose consumption during pregnancy in murine models (Review)". Biomedical Reports 22, no. 5 (2025): 87. https://doi.org/10.3892/br.2025.1965
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