|
1
|
Diaz-Garcia CM, Mongeon R, Lahmann C,
Koveal D, Zucker H and Yellen G: Neuronal stimulation triggers
neuronal glycolysis and not lactate uptake. Cell Metab.
26:361–374.e4. 2017.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Roy CS and Sherrington CS: On the
regulation of the blood-supply of the brain. J Physiol.
11:85–158.117. 1890.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Xue Q, Liu Y, Qi H, Ma Q, Xu L, Chen W,
Chen G and Xu X: A novel brain neurovascular unit model with
neurons, astrocytes and microvascular endothelial cells of rat. Int
J Biol Sci. 9:174–189. 2013.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Harder DR, Zhang C and Gebremedhin D:
Astrocytes function in matching blood flow to metabolic activity.
News Physiol Sci. 17:27–31. 2002.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Simard M, Arcuino G, Takano T, Liu QS and
Nedergaard M: Signaling at the gliovascular interface. J Neurosci.
23:9254–9262. 2003.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Reese TS and Karnovsky MJ: Fine structural
localization of a blood-brain barrier to exogenous peroxidase. J
Cell Biol. 34:207–217. 1967.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Yamamizu K, Iwasaki M, Takakubo H,
Sakamoto T, Ikuno T, Miyoshi M, Kondo T, Nakao Y, Nakagawa M, Inoue
H and Yamashita JK: In vitro modeling of blood-brain barrier with
human iPSC-derived endothelial cells, pericytes, neurons, and
astrocytes via notch signaling. Stem Cell Reports. 8:634–647.
2017.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Ehrlich P: Das sauerstoff-bedürfnis des
organismus: Eine farbenanalytische studie. August Hirschwald,
1885.
|
|
9
|
Saunders NR, Dreifuss JJ, Dziegielewska
KM, Johansson PA, Habgood MD, Møllgård K and Bauer HC: The rights
and wrongs of blood-brain barrier permeability studies: A walk
through 100 years of history. Front Neurosci. 8(404)2014.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Patel R, Page S and Al-Ahmad AJ: Isogenic
blood-brain barrier models based on patient-derived stem cells
display inter-individual differences in cell maturation and
functionality. J Neurochem. 142:74–88. 2017.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Salmina AB, Kharitonova EV, Gorina YV,
Teplyashina EA, Malinovskaya NA, Khilazheva ED, Mosyagina AI,
Morgun AV, Shuvaev AN, Salmin VV, et al: Blood-brain barrier and
neurovascular unit in vitro models for studying mitochondria-driven
molecular mechanisms of neurodegeneration. Int J Mol Sci.
22(4661)2021.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Salmina AB, Kuvacheva NV, Morgun AV,
Komleva YK, Pozhilenkova EA, Lopatina OL, Gorina YV, Taranushenko
TE and Petrova LL: Glycolysis-mediated control of blood-brain
barrier development and function. Int J Biochem Cell Biol.
64:174–184. 2015.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Lv J, Hu W, Yang Z, Li T, Jiang S, Ma Z,
Chen F and Yang Y: Focusing on claudin-5: A promising candidate in
the regulation of BBB to treat ischemic stroke. Prog Neurobiol.
161:79–96. 2018.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Zhu J, Lin X, Chen C, Tan H, Gao Y, Li D
and Chen G: WNK3 promotes neuronal survival after traumatic brain
injury in rats. Neuroscience. 477:76–88. 2021.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Huang W, Li J, Geng X, Li S, Zou Y, Li Y,
Jing C and Yu H: The reactive astrocytes after surgical brain
injury potentiates the migration, invasion, and angiogenesis of C6
glioma. World Neurosurg. 168:e595–e606. 2022.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Wu D, Lai N, Deng R, Liang T, Pan P, Yuan
G, Li X, Li H, Shen H, Wang Z and Chen G: Activated WNK3 induced by
intracerebral hemorrhage deteriorates brain injury maybe via
WNK3/SPAK/NKCC1 pathway. Exp Neurol. 332(113386)2020.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Drouin-Ouellet J, Sawiak SJ, Cisbani G,
Lagacé M, Kuan WL, Saint-Pierre M, Dury RJ, Alata W, St-Amour I,
Mason SL, et al: Cerebrovascular and blood-brain barrier
impairments in Huntington's disease: Potential implications for its
pathophysiology. Ann Neurol. 78:160–177. 2015.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Mohi-Ud-Din R, Mir RH, Mir PA, Banday N,
Shah AJ, Sawhney G, Bhat MM, Batiha GE and Pottoo FH: Dysfunction
of ABC transporters at the surface of BBB: Potential implications
in intractable epilepsy and applications of nanotechnology enabled
drug delivery. Curr Drug Metab. 23:735–756. 2022.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Ferraro S, Klugah-Brown B, Tench CR,
Bazinet V, Bore MC, Nigri A, Demichelis G, Bruzzone MG, Palermo S,
Zhao W, et al: The central autonomic system revisited-convergent
evidence for a regulatory role of the insular and midcingulate
cortex from neuroimaging meta-analyses. Neurosci Biobehav Rev.
142(104915)2022.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Bittern J, Pogodalla N, Ohm H, Brüser L,
Kottmeier R, Schirmeier S and Klämbt C: Neuron-glia interaction in
the Drosophila nervous system. Dev Neurobiol. 81:438–452.
2021.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Rolls MM and Jegla TJ: Neuronal polarity:
An evolutionary perspective. J Exp Biol. 218:572–580.
2015.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Muzio MR and Cascella M: Marco Cascella
declares no relevant financial relationships with ineligible
companies. In: Histology, Axon. StatPearls, Treasure Island, FL,
2024.
|
|
23
|
Zhang D, Ruan J, Peng S, Li J, Hu X, Zhang
Y, Zhang T, Ge Y, Zhu Z, Xiao X, et al: Synaptic-like transmission
between neural axons and arteriolar smooth muscle cells drives
cerebral neurovascular coupling. Nat Neurosci. 27:232–248.
2024.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Qin D and Wang J, Le A, Wang TJ, Chen X
and Wang J: Traumatic brain injury: Ultrastructural features in
neuronal ferroptosis, glial cell activation and polarization, and
blood-brain barrier breakdown. Cells. 10(1009)2021.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Schirmeier S and Klämbt C: The Drosophila
blood-brain barrier as interface between neurons and hemolymph.
Mech Dev. 138:50–55. 2015.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Miller F, Afonso PV, Gessain A and
Ceccaldi PE: Blood-brain barrier and retroviral infections.
Virulence. 3:222–229. 2012.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Cataldi M: The changing landscape of
voltage-gated calcium channels in neurovascular disorders and in
neurodegenerative diseases. Curr Neuropharmacol. 11:276–297.
2013.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Lauritzen M, Mathiesen C, Schaefer K and
Thomsen KJ: Neuronal inhibition and excitation, and the dichotomic
control of brain hemodynamic and oxygen responses. Neuroimage.
62:1040–1050. 2012.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Cheng YT, Luna-Figueroa E, Woo J, Chen HC,
Lee ZF, Harmanci AS and Deneen B: Inhibitory input directs
astrocyte morphogenesis through glial GABA(B)R. Nature.
617:369–376. 2023.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Ancatén-González C, Segura I,
Alvarado-Sánchez R, Chávez AE and Latorre R: Ca2+- and
voltage-activated K+ (BK) channels in the nervous
system: One gene, a myriad of physiological functions. Int J Mol
Sci. 24(3407)2023.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Cohen S and Greenberg ME: Communication
between the synapse and the nucleus in neuronal development,
plasticity, and disease. Annu Rev Cell Dev Biol. 24:183–209.
2008.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Sun J, Zheng Y, Chen Z and Wang Y: The
role of Na+ -K+ -ATPase in the epileptic
brain. CNS Neurosci Ther. 28:1294–1302. 2022.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Jiang S, Fan F, Yang L, Chen K, Sun Z,
Zhang Y, Cairang N, Wang X and Meng X: Salidroside attenuates high
altitude hypobaric hypoxia-induced brain injury in mice via
inhibiting NF-κB/NLRP3 pathway. Eur J Pharmacol.
925(175015)2022.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Li B, Li N, Chen L, Ren S, Gao D, Geng H,
Fu J, Zhou M and Xing C: Alleviating neuroinflammation through
photothermal conjugated polymer nanoparticles by regulating
reactive oxygen species and Ca2+ signaling. ACS Appl
Mater Interfaces. 14:48416–48425. 2022.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Reddiar SB, de Veer M, Paterson BM,
Sepehrizadeh T, Wai DCC, Csoti A, Panyi G, Nicolazzo JA and Norton
RS: A biodistribution study of the radiolabeled Kv1.3-blocking
peptide DOTA-HsTX1[R14A] demonstrates brain uptake in a mouse model
of neuroinflammation. Mol Pharm. 20:255–266. 2023.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Carbajal-Contreras H, Murillo-de-Ozores
AR, Magaña-Avila G, Marquez-Salinas A, Bourqui L, Tellez-Sutterlin
M, Bahena-Lopez JP, Cortes-Arroyo E, Behn-Eschenburg SG,
Lopez-Saavedra A, et al: Arginine vasopressin regulates the renal
Na+-Cl- and
Na+-K+-Cl- cotransporters through
with-no-lysine kinase 4 and inhibitor 1 phosphorylation. Am J
Physiol Renal Physiol. 326:F285–F299. 2024.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Engelhardt B and Sorokin L: The
blood-brain and the blood-cerebrospinal fluid barriers: Function
and dysfunction. Semin Immunopathol. 31:497–511. 2009.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Stokum JA, Gerzanich V and Simard JM:
Molecular pathophysiology of cerebral edema. J Cereb Blood Flow
Metab. 36:513–538. 2016.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Wiley CA, Bissel SJ, Lesniak A, Dixon CE,
Franks J, Beer Stolz D, Sun M, Wang G, Switzer R, Kochanek PM and
Murdoch G: Ultrastructure of diaschisis lesions after traumatic
brain injury. J Neurotrauma. 33:1866–1882. 2016.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Hosokawa M and Ueno M: Aging of
blood-brain barrier and neuronal cells of eye and ear in SAM mice.
Neurobiol Aging. 20:117–123. 1999.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Gong Y, Wu M, Gao F, Shi M, Gu H, Gao R,
Dang BQ and Chen G: Inhibition of the p-SPAK/p-NKCC1 signaling
pathway protects the blood-brain barrier and reduces neuronal
apoptosis in a rat model of surgical brain injury. Mol Med Rep.
24(717)2021.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Gong Y, Wu M, Shen J, Tang J, Li J, Xu J,
Dang B and Chen G: Inhibition of the NKCC1/NF-κB signaling pathway
decreases inflammation and improves brain edema and nerve cell
apoptosis in an SBI rat model. Front Mol Neurosci.
14(641993)2021.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Wu MY, Gao F, Tang JF, Shen JC, Gao R,
Dang BQ and Chen G: Possible mechanisms of the PERK pathway on
neuronal apoptosis in a rat model of surgical brain injury. Am J
Transl Res. 13:732–742. 2021.PubMed/NCBI
|
|
44
|
Shen J, Qian M, Wu M, Tang J, Gong Y, Li
J, Ji J and Dang B: Rosiglitazone inhibits acyl-CoA synthetase
long-chain family number 4 and improves secondary brain injury in a
rat model of surgical brain injury. Clin Exp Pharmacol Physiol.
50:927–935. 2023.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Wu M, Gao R, Dang B and Chen G: The blood
component iron causes neuronal apoptosis following intracerebral
hemorrhage via the PERK pathway. Front Neurol.
11(588548)2020.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Wu M, Wang C, Gong Y, Huang Y, Jiang L,
Zhang M, Gao R and Dang B: Potential mechanism of TMEM2/CD44 in
endoplasmic reticulum stress-induced neuronal apoptosis in a rat
model of traumatic brain injury. Int J Mol Med.
52(119)2023.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Li J, Wu M, Gong Y, Tang J, Shen J, Xu L,
Dang B and Chen G: Inhibition of LRRK2-Rab10 pathway improves
secondary brain injury after surgical brain injury in rats. Front
Surg. 8(749310)2022.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Anthony IC, Ramage SN, Carnie FW, Simmonds
P and Bell JE: Does drug abuse alter microglial phenotype and cell
turnover in the context of advancing HIV infection? Neuropathol
Appl Neurobiol. 31:325–338. 2005.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Haruwaka K, Ikegami A, Tachibana Y, Ohno
N, Konishi H, Hashimoto A, Matsumoto M, Kato D, Ono R, Kiyama H, et
al: Dual microglia effects on blood brain barrier permeability
induced by systemic inflammation. Nat Commun.
10(5816)2019.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Merlini M, Rafalski VA, Ma K, Kim KY,
Bushong EA, Rios Coronado PE, Yan Z, Mendiola AS, Sozmen EG, Ryu
JK, et al: Microglial Gi-dependent dynamics regulate
brain network hyperexcitability. Nat Neurosci. 24:19–23.
2021.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Wang J, Zhang C, Zhu J, Ding J, Chen Y and
Han X: Blood-brain barrier disruption and inflammation reaction in
mice after chronic exposure to Microcystin-LR. Sci Total Environ.
689:662–678. 2019.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Ueno M, Fujita Y, Tanaka T, Nakamura Y,
Kikuta J, Ishii M and Yamashita T: Layer V cortical neurons require
microglial support for survival during postnatal development. Nat
Neurosci. 16:543–551. 2013.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Corps KN, Roth TL and McGavern DB:
Inflammation and neuroprotection in traumatic brain injury. JAMA
Neurol. 72:355–362. 2015.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Ikegami A and Wake H: Microglial
regulation of blood brain barrier, the neuro-immunological
interface. Brain Nerve. 73:913–919. 2021.PubMed/NCBI View Article : Google Scholar : (In Japanese).
|
|
55
|
Planas AM: Role of immune cells migrating
to the ischemic brain. Stroke. 49:2261–2267. 2018.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Park GH, Noh H, Shao Z, Ni P, Qin Y, Liu
D, Beaudreault CP, Park JS, Abani CP, Park JM, et al: Activated
microglia cause metabolic disruptions in developmental cortical
interneurons that persist in interneurons from individuals with
schizophrenia. Nat Neurosci. 23:1352–1364. 2020.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Zhang Z, Zhang Z, Lu H, Yang Q, Wu H and
Wang J: Microglial polarization and inflammatory mediators after
intracerebral hemorrhage. Mol Neurobiol. 54:1874–1886.
2017.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Roseborough AD, Zhu Y, Zhao L, Laviolette
SR, Pasternak SH and Whitehead SN: Fibrinogen primes the microglial
NLRP3 inflammasome and propagates pro-inflammatory signaling via
extracellular vesicles: Implications for blood-brain barrier
dysfunction. Neurobiol Dis. 177(106001)2023.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Kant R, Halder SK, Fernández JA, Griffin
JH and Milner R: Activated protein C attenuates experimental
autoimmune encephalomyelitis progression by enhancing vascular
integrity and suppressing microglial activation. Front Neurosci.
14(333)2020.PubMed/NCBI View Article : Google Scholar
|
|
60
|
Jolivel V, Bicker F, Binamé F, Ploen R,
Keller S, Gollan R, Jurek B, Birkenstock J, Poisa-Beiro L, Bruttger
J, et al: Perivascular microglia promote blood vessel
disintegration in the ischemic penumbra. Acta Neuropathol.
129:279–295. 2015.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Pan JJ, Qi L, Wang L, Liu C, Song Y,
Mamtilahun M, Hu X, Li Y, Chen X, Khan H, et al: M2 microglial
extracellular vesicles attenuated blood-brain barrier disruption
via MiR-23a-5p in cerebral ischemic mice. Aging Dis. 15:1344–1356.
2024.PubMed/NCBI View Article : Google Scholar
|
|
62
|
Clarner T, Diederichs F, Berger K, Denecke
B, Gan L, van der Valk P, Beyer C, Amor S and Kipp M: Myelin debris
regulates inflammatory responses in an experimental demyelination
animal model and multiple sclerosis lesions. Glia. 60:1468–1480.
2012.PubMed/NCBI View Article : Google Scholar
|
|
63
|
Schafer DP, Lehrman EK, Kautzman AG,
Koyama R, Mardinly AR, Yamasaki R, Ransohoff RM, Greenberg ME,
Barres BA and Stevens B: Microglia sculpt postnatal neural circuits
in an activity and complement-dependent manner. Neuron. 74:691–705.
2012.PubMed/NCBI View Article : Google Scholar
|
|
64
|
Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh
JM, Shadrach JL, van Wijngaarden P, Wagers AJ, Williams A, Franklin
RJM and Ffrench-Constant C: M2 microglia and macrophages drive
oligodendrocyte differentiation during CNS remyelination. Nat
Neurosci. 16:1211–1218. 2013.PubMed/NCBI View Article : Google Scholar
|
|
65
|
Wang Y, Luo J and Li SY: Nano-curcumin
simultaneously protects the blood-brain barrier and reduces M1
microglial activation during cerebral ischemia-reperfusion injury.
ACS Appl Mater Interfaces. 11:3763–3770. 2019.PubMed/NCBI View Article : Google Scholar
|
|
66
|
Zhang J, Zheng Y, Luo Y, Du Y, Zhang X and
Fu J: Curcumin inhibits LPS-induced neuroinflammation by promoting
microglial M2 polarization via TREM2/TLR4/NF-κB pathways in BV2
cells. Mol Immunol. 116:29–37. 2019.PubMed/NCBI View Article : Google Scholar
|
|
67
|
Demirdağ F, Yavuzer S, Cengiz M, Yavuzer
H, Kara Z, Ayvacı A, Avcı S, Yürüyen M, Uzun H, Altıparmak MR, et
al: The role of NF-κB, PPAR-α, and PPAR-γ in older adults with
metabolic syndrome. Horm Metab Res. 55:733–740. 2023.PubMed/NCBI View Article : Google Scholar
|
|
68
|
Li YF, Ren X, Zhang L, Wang YH and Chen T:
Microglial polarization in TBI: Signaling pathways and influencing
pharmaceuticals. Front Aging Neurosci. 14(901117)2022.PubMed/NCBI View Article : Google Scholar
|
|
69
|
Takuathung MN, Potikanond S, Sookkhee S,
Mungkornasawakul P, Jearanaikulvanich T, Chinda K, Wikan N and
Nimlamool W: Anti-psoriatic and anti-inflammatory effects of
Kaempferia parviflora in keratinocytes and macrophage cells. Biomed
Pharmacother. 143(112229)2021.PubMed/NCBI View Article : Google Scholar
|
|
70
|
Ruan Z, Zhang D, Huang R, Sun W, Hou L,
Zhao J and Wang Q: Microglial activation damages dopaminergic
neurons through MMP-2/-9-mediated increase of blood-brain barrier
permeability in a Parkinson's disease mouse model. Int J Mol Sci.
23(2793)2022.PubMed/NCBI View Article : Google Scholar
|
|
71
|
Guo Y, Dai W, Zheng Y, Qiao W, Chen W,
Peng L, Zhou H, Zhao T, Liu H, Zheng F and Sun P: Mechanism and
regulation of microglia polarization in intracerebral hemorrhage.
Molecules. 27(7080)2022.PubMed/NCBI View Article : Google Scholar
|
|
72
|
Tian J, Liu Y, Wang Z, Zhang S, Yang Y,
Zhu Y and Yang C: LncRNA Snhg8 attenuates microglial inflammation
response and blood-brain barrier damage in ischemic stroke through
regulating miR-425-5p mediated SIRT1/NF-κB signaling. J Biochem Mol
Toxicol. 35(e22724)2021.PubMed/NCBI View Article : Google Scholar
|
|
73
|
Liao Y, Hu J, Guo C, Wen A, Wen L, Hou Q,
Weng Y, Wang J, Ding Y and Yang J: Acteoside alleviates blood-brain
barrier damage induced by ischemic stroke through inhibiting
microglia HMGB1/TLR4/NLRP3 signaling. Biochem Pharmacol.
220(115968)2024.PubMed/NCBI View Article : Google Scholar
|
|
74
|
Chen G, Hou Y, Li X, Pan R and Zhao D:
Sepsis-induced acute lung injury in young rats is relieved by
calycosin through inactivating the HMGB1/MyD88/NF-κB pathway and
NLRP3 inflammasome. Int Immunopharmacol. 96(107623)2021.PubMed/NCBI View Article : Google Scholar
|
|
75
|
Yin N, Zhao Y, Liu C, Yang Y, Wang ZH, Yu
W, Zhang K, Zhang Z, Liu J, Zhang Y and Shi J: Engineered
nanoerythrocytes alleviate central nervous system inflammation by
regulating the polarization of inflammatory microglia. Adv Mater.
34(e2201322)2022.PubMed/NCBI View Article : Google Scholar
|
|
76
|
Chang H, Ma J, Feng K, Feng N, Wang X, Sun
J, Guo T, Wei Y, Xu Y, Wang H, et al: Elevated blood and
cerebrospinal fluid biomarkers of microglial activation and
blood-brain barrier disruption in anti-NMDA receptor encephalitis.
J Neuroinflammation. 20(172)2023.PubMed/NCBI View Article : Google Scholar
|
|
77
|
Yan J, Zhang Y, Wang L, Li Z, Tang S, Wang
Y, Gu N, Sun X and Li L: TREM2 activation alleviates neural damage
via Akt/CREB/BDNF signalling after traumatic brain injury in mice.
J Neuroinflammation. 19(289)2022.PubMed/NCBI View Article : Google Scholar
|
|
78
|
Shi M, Gong Y, Wu M, Gu H, Yu J, Gao F,
Ren Z, Qian M, Dang B and Chen G: Downregulation of TREM2/NF-кB
signaling may damage the blood-brain barrier and aggravate neuronal
apoptosis in experimental rats with surgically injured brain. Brain
Res Bull. 183:116–126. 2022.PubMed/NCBI View Article : Google Scholar
|
|
79
|
Sofroniew MV: Astrocyte barriers to
neurotoxic inflammation. Nat Rev Neurosci. 16:249–263.
2015.PubMed/NCBI View Article : Google Scholar
|
|
80
|
Cheng X, Wang J, Sun X, Shao L, Guo Z and
Li Y: Morphological and functional alterations of astrocytes
responding to traumatic brain injury. J Integr Neurosci.
18:203–215. 2019.PubMed/NCBI View Article : Google Scholar
|
|
81
|
Lauranzano E, Rasile M and Matteoli M:
Integrating primary astrocytes in a microfluidic model of the
blood-brain barrier. Methods Mol Biol. 2492:225–240.
2022.PubMed/NCBI View Article : Google Scholar
|
|
82
|
Yosef N, Xi Y and McCarty JH: Isolation
and transcriptional characterization of mouse perivascular
astrocytes. PLoS One. 15(e0240035)2020.PubMed/NCBI View Article : Google Scholar
|
|
83
|
Huang J, Ding J, Wang X, Gu C, He Y, Li Y,
Fan H, Xie Q, Qi X, Wang Z and Qiu P: Transfer of neuron-derived
α-synuclein to astrocytes induces neuroinflammation and blood-brain
barrier damage after methamphetamine exposure: Involving the
regulation of nuclear receptor-associated protein 1. Brain Behav
Immun. 106:247–261. 2022.PubMed/NCBI View Article : Google Scholar
|
|
84
|
Abbott NJ, Rönnbäck L and Hansson E:
Astrocyte-endothelial interactions at the blood-brain barrier. Nat
Rev Neurosci. 7:41–53. 2006.PubMed/NCBI View Article : Google Scholar
|
|
85
|
Weber CM, Moiz B, Zic SM, Alpizar Vargas
V, Li A and Clyne AM: Induced pluripotent stem cell-derived cells
model brain microvascular endothelial cell glucose metabolism.
Fluids Barriers CNS. 19(98)2022.PubMed/NCBI View Article : Google Scholar
|
|
86
|
Wu Z, Parry M, Hou XY, Liu MH, Wang H,
Cain R, Pei ZF, Chen YC, Guo ZY, Abhijeet S and Chen G: Gene
therapy conversion of striatal astrocytes into GABAergic neurons in
mouse models of Huntington's disease. Nat Commun.
11(1105)2020.PubMed/NCBI View Article : Google Scholar
|
|
87
|
Bezzi P, Domercq M, Brambilla L, Galli R,
Schols D, De Clercq E, Vescovi A, Bagetta G, Kollias G, Meldolesi J
and Volterra A: CXCR4-activated astrocyte glutamate release via
TNFalpha: Amplification by microglia triggers neurotoxicity. Nat
Neurosci. 4:702–710. 2001.PubMed/NCBI View
Article : Google Scholar
|
|
88
|
Nedergaard M, Ransom B and Goldman SA: New
roles for astrocytes: Redefining the functional architecture of the
brain. Trends Neurosci. 26:523–530. 2003.PubMed/NCBI View Article : Google Scholar
|
|
89
|
Simard M and Nedergaard M: The
neurobiology of glia in the context of water and ion homeostasis.
Neuroscience. 129:877–896. 2004.PubMed/NCBI View Article : Google Scholar
|
|
90
|
Karve IP, Taylor JM and Crack PJ: The
contribution of astrocytes and microglia to traumatic brain injury.
Br J Pharmacol. 173:692–702. 2016.PubMed/NCBI View Article : Google Scholar
|
|
91
|
Willis EF, MacDonald KPA, Nguyen QH,
Garrido AL, Gillespie ER, Harley SBR, Bartlett PF, Schroder WA,
Yates AG, Anthony DC, et al: Repopulating microglia promote brain
repair in an IL-6-dependent manner. Cell. 180:833–846.e16.
2020.PubMed/NCBI View Article : Google Scholar
|
|
92
|
Lee H and Koh JY: Roles for H+
/K+ -ATPase and zinc transporter 3 in cAMP-mediated
lysosomal acidification in bafilomycin A1-treated astrocytes. Glia.
69:1110–1125. 2021.PubMed/NCBI View Article : Google Scholar
|
|
93
|
Chen Y and Swanson RA: Astrocytes and
brain injury. J Cereb Blood Flow Metab. 23:137–149. 2003.PubMed/NCBI View Article : Google Scholar
|
|
94
|
Burda JE and Sofroniew MV: Reactive
gliosis and the multicellular response to CNS damage and disease.
Neuron. 81:229–248. 2014.PubMed/NCBI View Article : Google Scholar
|
|
95
|
Lee EJ, Hung YC and Lee MY: Early
alterations in cerebral hemodynamics, brain metabolism, and
blood-brain barrier permeability in experimental intracerebral
hemorrhage. J Neurosurg. 91:1013–1019. 1999.PubMed/NCBI View Article : Google Scholar
|
|
96
|
Lee EJ, Chio CC, Chang CH and Chen HH:
Prognostic significance of altered cerebral blood flow velocity in
acute head trauma. J Formos Med Assoc. 96:5–12. 1997.PubMed/NCBI
|
|
97
|
Lien CF, Mohanta SK, Frontczak-Baniewicz
M, Swinny JD, Zablocka B and Górecki DC: Absence of glial
α-dystrobrevin causes abnormalities of the blood-brain barrier and
progressive brain edema. J Biol Chem. 287:41374–41385.
2012.PubMed/NCBI View Article : Google Scholar
|
|
98
|
Wolburg H, Noell S, Wolburg-Buchholz K,
Mack A and Fallier-Becker P: Agrin, aquaporin-4, and astrocyte
polarity as an important feature of the blood-brain barrier.
Neuroscientist. 15:180–193. 2009.PubMed/NCBI View Article : Google Scholar
|
|
99
|
Kim I, Moon SO, Park SK, Chae SW and Koh
GY: Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to
endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin
expression. Circ Res. 89:477–479. 2001.PubMed/NCBI View Article : Google Scholar
|
|
100
|
Liu B and Neufeld AH: Expression of nitric
oxide synthase-2 (NOS-2) in reactive astrocytes of the human
glaucomatous optic nerve head. Glia. 30:178–186. 2000.PubMed/NCBI View Article : Google Scholar
|
|
101
|
Jiang L, Pan CL, Wang CY, Liu BQ, Han Y,
Hu L, Liu L, Yang Y, Qu JW and Liu WT: Selective suppression of the
JNK-MMP2/9 signal pathway by tetramethylpyrazine attenuates
neuropathic pain in rats. J Neuroinflammation.
14(174)2017.PubMed/NCBI View Article : Google Scholar
|
|
102
|
Lu L, Hogan-Cann AD, Globa AK, Lu P, Nagy
JI, Bamji SX and Anderson CM: Astrocytes drive cortical
vasodilatory signaling by activating endothelial NMDA receptors. J
Cereb Blood Flow Metab. 39:481–496. 2019.PubMed/NCBI View Article : Google Scholar
|
|
103
|
Mizee MR, Nijland PG, van der Pol SMA,
Drexhage JAR, van Het Hof B, Mebius R, van der Valk P, van Horssen
J, Reijerkerk A and de Vries HE: Astrocyte-derived retinoic acid: A
novel regulator of blood-brain barrier function in multiple
sclerosis. Acta Neuropathol. 128:691–703. 2014.PubMed/NCBI View Article : Google Scholar
|
|
104
|
Li Y, Xia Y, Wang Y, Mao L, Gao Y, He Q,
Huang M, Chen S and Hu B: Sonic hedgehog (Shh) regulates the
expression of angiogenic growth factors in oxygen-glucose-deprived
astrocytes by mediating the nuclear receptor NR2F2. Mol Neurobiol.
47:967–975. 2013.PubMed/NCBI View Article : Google Scholar
|
|
105
|
Zacharek A, Chen J, Cui X, Li A, Li Y,
Roberts C, Feng Y, Gao Q and Chopp M: Angiopoietin1/Tie2 and
VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and
vascular stabilization after stroke. J Cereb Blood Flow Metab.
27:1684–1691. 2007.PubMed/NCBI View Article : Google Scholar
|
|
106
|
Chen M, Ba H, Lu C, Dai J and Sun J: Glial
cell line-derived neurotrophic factor (GDNF) promotes angiogenesis
through the demethylation of the fibromodulin (FMOD) promoter in
glioblastoma. Med Sci Monit. 24:6137–6143. 2018.PubMed/NCBI View Article : Google Scholar
|
|
107
|
Rodriguez-Perez AI, Borrajo A, Diaz-Ruiz
C, Garrido-Gil P and Labandeira-Garcia JL: Crosstalk between
insulin-like growth factor-1 and angiotensin-II in dopaminergic
neurons and glial cells: Role in neuroinflammation and aging.
Oncotarget. 7:30049–30067. 2016.PubMed/NCBI View Article : Google Scholar
|
|
108
|
Cao F, Jiang Y, Wu Y, Zhong J, Liu J, Qin
X, Chen L, Vitek MP, Li F, Xu L and Sun X: Apolipoprotein E-mimetic
COG1410 reduces acute vasogenic edema following traumatic brain
injury. J Neurotrauma. 33:175–182. 2016.PubMed/NCBI View Article : Google Scholar
|
|
109
|
Leybaert L: Neurobarrier coupling in the
brain: A partner of neurovascular and neurometabolic coupling? J
Cereb Blood Flow Metab. 25:2–16. 2005.PubMed/NCBI View Article : Google Scholar
|
|
110
|
Chen Z, Kelly JR, Morales JE, Sun RC, De
A, Burkin DJ and McCarty JH: The alpha7 integrin subunit in
astrocytes promotes endothelial blood-brain barrier integrity.
Development. 150(dev201356)2023.PubMed/NCBI View Article : Google Scholar
|
|
111
|
Mayer U, Saher GFässler R, Bornemann A,
Echtermeyer F, von der Mark H, Miosge N, Pöschl E and von der Mark
K: Absence of integrin alpha 7 causes a novel form of muscular
dystrophy. Nat Genet. 17:318–323. 1997.PubMed/NCBI View Article : Google Scholar
|
|
112
|
Mielenz D, Hapke S, Pöschl E, von Der Mark
H and von Der Mark K: The integrin alpha 7 cytoplasmic domain
regulates cell migration, lamellipodia formation, and p130CAS/Crk
coupling. J Biol Chem. 276:13417–13426. 2001.PubMed/NCBI View Article : Google Scholar
|
|
113
|
Kim H, Leng K, Park J, Sorets AG, Kim S,
Shostak A, Embalabala RJ, Mlouk K, Katdare KA, Rose IVL, et al:
Reactive astrocytes transduce inflammation in a blood-brain barrier
model through a TNF-STAT3 signaling axis and secretion of alpha
1-antichymotrypsin. Nat Commun. 13(6581)2022.PubMed/NCBI View Article : Google Scholar
|
|
114
|
Lee LL, Aung HH, Wilson DW, Anderson SE,
Rutledge JC and Rutkowsky JM: Triglyceride-rich lipoprotein
lipolysis products increase blood-brain barrier transfer
coefficient and induce astrocyte lipid droplets and cell stress. Am
J Physiol Cell Physiol. 312:C500–C516. 2017.PubMed/NCBI View Article : Google Scholar
|
|
115
|
Malik VA, Zajicek F, Mittmann LA, Klaus J,
Unterseer S, Rajkumar S, Pütz B, Deussing JM, Neumann ID, Rupprecht
R and Di Benedetto B: GDF15 promotes simultaneous astrocyte
remodeling and tight junction strengthening at the blood-brain
barrier. J Neurosci Res. 98:1433–1456. 2020.PubMed/NCBI View Article : Google Scholar
|
|
116
|
Shimizu F, Sano Y, Tominaga O, Maeda T,
Abe MA and Kanda T: Advanced glycation end-products disrupt the
blood-brain barrier by stimulating the release of transforming
growth factor-β by pericytes and vascular endothelial growth factor
and matrix metalloproteinase-2 by endothelial cells in vitro.
Neurobiol Aging. 34:1902–1912. 2013.PubMed/NCBI View Article : Google Scholar
|
|
117
|
Senatorov VV Jr, Friedman AR, Milikovsky
DZ, Ofer J, Saar-Ashkenazy R, Charbash A, Jahan N, Chin G, Mihaly
E, Lin JM, et al: Blood-brain barrier dysfunction in aging induces
hyperactivation of TGFβ signaling and chronic yet reversible neural
dysfunction. Sci Transl Med. 11(eaaw8283)2019.PubMed/NCBI View Article : Google Scholar
|
|
118
|
Guo Y, Dong L, Gong A, Zhang J, Jing L,
Ding T, Li PA and Zhang JZ: Damage to the blood-brain barrier and
activation of neuroinflammation by focal cerebral ischemia under
hyperglycemic condition. Int J Mol Med. 48(142)2021.PubMed/NCBI View Article : Google Scholar
|
|
119
|
Wang QS, Ding HG, Chen SL, Liu XQ, Deng
YY, Jiang WQ, Li Y, Huang LQ, Han YL, Wen MY, et al: Hypertonic
saline mediates the NLRP3/IL-1β signaling axis in microglia to
alleviate ischemic blood-brain barrier permeability by
downregulating astrocyte-derived VEGF in rats. CNS Neurosci Ther.
26:1045–1057. 2020.PubMed/NCBI View Article : Google Scholar
|
|
120
|
You L, Yu PP, Dong T, Guo W, Chang S,
Zheng B, Ci Y, Wang F, Yu P, Gao G and Chang YZ: Astrocyte-derived
hepcidin controls iron traffic at the blood-brain-barrier via
regulating ferroportin 1 of microvascular endothelial cells. Cell
Death Dis. 13(667)2022.PubMed/NCBI View Article : Google Scholar
|
|
121
|
Pasti L, Volterra A, Pozzan T and
Carmignoto G: Intracellular calcium oscillations in astrocytes: A
highly plastic, bidirectional form of communication between neurons
and astrocytes in situ. J Neurosci. 17:7817–7830. 1997.PubMed/NCBI View Article : Google Scholar
|
|
122
|
Huber JD, Egleton RD and Davis TP:
Molecular physiology and pathophysiology of tight junctions in the
blood-brain barrier. Trends Neurosci. 24:719–725. 2001.PubMed/NCBI View Article : Google Scholar
|
|
123
|
Cotrina ML, Lin JH, Alves-Rodrigues A, Liu
S, Li J, Azmi-Ghadimi H, Kang J, Naus CC and Nedergaard M:
Connexins regulate calcium signaling by controlling ATP release.
Proc Natl Acad Sci USA. 95:15735–15740. 1998.PubMed/NCBI View Article : Google Scholar
|
|
124
|
Sneyd J, Charles AC and Sanderson MJ: A
model for the propagation of intercellular calcium waves. Am J
Physiol. 266:C293–C302. 1994.PubMed/NCBI View Article : Google Scholar
|
|
125
|
Chapouly C, Tadesse Argaw A, Horng S,
Castro K, Zhang J, Asp L, Loo H, Laitman BM, Mariani JN, Straus
Farber R, et al: Astrocytic TYMP and VEGFA drive blood-brain
barrier opening in inflammatory central nervous system lesions.
Brain. 138:1548–1567. 2015.PubMed/NCBI View Article : Google Scholar
|
|
126
|
Chu H, Yang X, Huang C, Gao Z, Tang Y and
Dong Q: Apelin-13 protects against ischemic blood-brain barrier
damage through the effects of aquaporin-4. Cerebrovasc Dis.
44:10–25. 2017.PubMed/NCBI View Article : Google Scholar
|
|
127
|
Jackson RJ, Meltzer JC, Nguyen H, Commins
C, Bennett RE, Hudry E and Hyman BT: APOE4 derived from astrocytes
leads to blood-brain barrier impairment. Brain. 145:3582–3593.
2022.PubMed/NCBI View Article : Google Scholar
|
|
128
|
Qin X, Wang J, Chen S, Liu G, Wu C, Lv Q,
He X, Bai X, Huang W and Liao H: Astrocytic p75NTR
expression provoked by ischemic stroke exacerbates the blood-brain
barrier disruption. Glia. 70:892–912. 2022.PubMed/NCBI View Article : Google Scholar
|
|
129
|
Lee SW, Kim WJ, Choi YK, Song HS, Son MJ,
Gelman IH, Kim YJ and Kim KW: SSeCKS regulates angiogenesis and
tight junction formation in blood-brain barrier. Nat Med.
9:900–906. 2003.PubMed/NCBI View
Article : Google Scholar
|
|
130
|
Takarada-Iemata M, Yoshikawa A, Ta HM,
Okitani N, Nishiuchi T, Aida Y, Kamide T, Hattori T, Ishii H,
Tamatani T, et al: N-myc downstream-regulated gene 2 protects
blood-brain barrier integrity following cerebral ischemia. Glia.
66:1432–1446. 2018.PubMed/NCBI View Article : Google Scholar
|
|
131
|
Tian W, Sawyer A, Kocaoglu FB and
Kyriakides TR: Astrocyte-derived thrombospondin-2 is critical for
the repair of the blood-brain barrier. Am J Pathol. 179:860–868.
2011.PubMed/NCBI View Article : Google Scholar
|
|
132
|
Jayakumar AR, Tong XY, Ruiz-Cordero R,
Bregy A, Bethea JR, Bramlett HM and Norenberg MD: Activation of
NF-κB mediates astrocyte swelling and brain edema in traumatic
brain injury. J Neurotrauma. 31:1249–1257. 2014.PubMed/NCBI View Article : Google Scholar
|
|
133
|
Wu M, Gong Y, Jiang L, Zhang M, Gu H, Shen
H and Dang B: VEGF regulates the blood-brain barrier through MMP-9
in a rat model of traumatic brain injury. Exp Ther Med.
24(728)2022.PubMed/NCBI View Article : Google Scholar
|
|
134
|
Wu MY, Gao F, Yang XM, Qin X, Chen GZ, Li
D, Dang BQ and Chen G: Matrix metalloproteinase-9 regulates the
blood brain barrier via the hedgehog pathway in a rat model of
traumatic brain injury. Brain Res. 1727(146553)2020.PubMed/NCBI View Article : Google Scholar
|
|
135
|
Persidsky Y, Ramirez SH, Haorah J and
Kanmogne GD: Blood-brain barrier: Structural components and
function under physiologic and pathologic conditions. J Neuroimmune
Pharmacol. 1:223–236. 2006.PubMed/NCBI View Article : Google Scholar
|
|
136
|
Kassan M, Kwon Y, Munkhsaikhan U, Sahyoun
AM, Ishrat T, Galán M, Gonzalez AA, Abidi AH, Kassan A and
Ait-Aissa K: Protective role of short-chain fatty acids against
Ang-II-induced mitochondrial dysfunction in brain endothelial
cells: A potential role of heme oxygenase 2. Antioxidants (Basel).
12(160)2023.PubMed/NCBI View Article : Google Scholar
|
|
137
|
Wang YI, Abaci HE and Shuler ML:
Microfluidic blood-brain barrier model provides in vivo-like
barrier properties for drug permeability screening. Biotechnol
Bioeng. 114:184–194. 2017.PubMed/NCBI View Article : Google Scholar
|
|
138
|
Min XL, Zou H, Yan J, Lyu Q, He X and
Shang FF: Stress conditions induced circRNAs profile of
extracellular vesicles in brain microvascular endothelial cells.
Metab Brain Dis. 37:1977–1987. 2022.PubMed/NCBI View Article : Google Scholar
|
|
139
|
Furtado D, Björnmalm M, Ayton S, Bush AI,
Kempe K and Caruso F: Overcoming the blood-brain barrier: The role
of nanomaterials in treating neurological diseases. Adv Mater.
30(e1801362)2018.PubMed/NCBI View Article : Google Scholar
|
|
140
|
Grammas P, Martinez J and Miller B:
Cerebral microvascular endothelium and the pathogenesis of
neurodegenerative diseases. Expert Rev Mol Med.
13(e19)2011.PubMed/NCBI View Article : Google Scholar
|
|
141
|
Oldendorf WH, Cornford ME and Brown WJ:
The large apparent work capability of the blood-brain barrier: A
study of the mitochondrial content of capillary endothelial cells
in brain and other tissues of the rat. Ann Neurol. 1:409–417.
1977.PubMed/NCBI View Article : Google Scholar
|
|
142
|
Grutzendler J and Nedergaard M: Cellular
control of brain capillary blood flow: In vivo imaging veritas.
Trends Neurosci. 42:528–536. 2019.PubMed/NCBI View Article : Google Scholar
|
|
143
|
Raut S, Patel R and Al-Ahmad AJ: Presence
of a mutation in PSEN1 or PSEN2 gene is associated with an impaired
brain endothelial cell phenotype in vitro. Fluids Barriers CNS.
18(3)2021.PubMed/NCBI View Article : Google Scholar
|
|
144
|
Lisk C, McCord J, Bose S, Sullivan T,
Loomis Z, Nozik-Grayck E, Schroeder T, Hamilton K and Irwin DC:
Nrf2 activation: A potential strategy for the prevention of acute
mountain sickness. Free Radic Biol Med. 63:264–273. 2013.PubMed/NCBI View Article : Google Scholar
|
|
145
|
Nicolicht-Amorim P, Delgado-Garcia LM,
Nakamura TKE, Courbassier NR, Mosini AC and Porcionatto MA: Simple
and efficient protocol to isolate and culture brain microvascular
endothelial cells from newborn mice. Front Cell Neurosci.
16(949412)2022.PubMed/NCBI View Article : Google Scholar
|
|
146
|
Sawada N: Tight junction-related human
diseases. Pathol Int. 63:1–12. 2013.PubMed/NCBI View Article : Google Scholar
|
|
147
|
González-Mariscal L, Posadas Y, Miranda J,
Uc PY, Ortega-Olvera JM and Hernández S: Strategies that target
tight junctions for enhanced drug delivery. Curr Pharm Des.
22:5313–5346. 2016.PubMed/NCBI View Article : Google Scholar
|
|
148
|
Keaney J and Campbell M: The dynamic
blood-brain barrier. FEBS J. 282:4067–4079. 2015.PubMed/NCBI View Article : Google Scholar
|
|
149
|
Kumar R, Sharma A and Tiwari RK: Can we
predict blood brain barrier permeability of ligands using
computational approaches? Interdiscip Sci. 5:95–101.
2013.PubMed/NCBI View Article : Google Scholar
|
|
150
|
Saxena D, Sharma A, Siddiqui MH and Kumar
R: Blood brain barrier permeability prediction using machine
learning techniques: An update. Curr Pharm Biotechnol.
20:1163–1171. 2019.PubMed/NCBI View Article : Google Scholar
|
|
151
|
Song D, Jiang X, Liu Y, Sun Y, Cao S and
Zhang Z: Asiaticoside attenuates cell growth inhibition and
apoptosis induced by Aβ1-42 via inhibiting the
TLR4/NF-κB signaling pathway in human brain microvascular
endothelial cells. Front Pharmacol. 9(28)2018.PubMed/NCBI View Article : Google Scholar
|
|
152
|
Uraoka M, Ikeda K, Kurimoto-Nakano R,
Nakagawa Y, Koide M, Akakabe Y, Kitamura Y, Ueyama T, Matoba S,
Yamada H, et al: Loss of bcl-2 during the senescence exacerbates
the impaired angiogenic functions in endothelial cells by
deteriorating the mitochondrial redox state. Hypertension.
58:254–263. 2011.PubMed/NCBI View Article : Google Scholar
|
|
153
|
Rajeev V, Fann DY, Dinh QN, Kim HA, De
Silva TM, Lai MKP, Chen CL, Drummond GR, Sobey CG and Arumugam TV:
Pathophysiology of blood brain barrier dysfunction during chronic
cerebral hypoperfusion in vascular cognitive impairment.
Theranostics. 12:1639–1658. 2022.PubMed/NCBI View Article : Google Scholar
|
|
154
|
Sweeney MD, Sagare AP and Zlokovic BV:
Blood-brain barrier breakdown in Alzheimer disease and other
neurodegenerative disorders. Nat Rev Neurol. 14:133–150.
2018.PubMed/NCBI View Article : Google Scholar
|
|
155
|
Bernard-Patrzynski F, Lécuyer MA, Puscas
I, Boukhatem I, Charabati M, Bourbonnière L, Ramassamy C, Leclair
G, Prat A and Roullin VG: Isolation of endothelial cells, pericytes
and astrocytes from mouse brain. PLoS One.
14(e0226302)2019.PubMed/NCBI View Article : Google Scholar
|
|
156
|
Vajtr D, Benada O, Kukacka J, Průša R,
Houstava L, Ťoupalík P and Kizek R: Correlation of ultrastructural
changes of endothelial cells and astrocytes occurring during blood
brain barrier damage after traumatic brain injury with biochemical
markers of BBB leakage and inflammatory response. Physiol Res.
58:263–268. 2009.PubMed/NCBI View Article : Google Scholar
|
|
157
|
Yao X, Uchida K, Papadopoulos MC, Zador Z,
Manley GT and Verkman AS: Mildly reduced brain swelling and
improved neurological outcome in aquaporin-4 knockout mice
following controlled cortical impact brain injury. J Neurotrauma.
32:1458–1464. 2015.PubMed/NCBI View Article : Google Scholar
|
|
158
|
Abbott NJ: Astrocyte-endothelial
interactions and blood-brain barrier permeability. J Anat.
200:629–638. 2002.PubMed/NCBI View Article : Google Scholar
|
|
159
|
Liu H, Wei JY, Li Y, Ban M, Sun Q, Wang
HJ, Zhao D, Tong PG, Wang L, Wang KJ, et al: Endothelial depletion
of Atg7 triggers astrocyte-microvascular disassociation at
blood-brain barrier. J Cell Biol. 222(e202103098)2023.PubMed/NCBI View Article : Google Scholar
|
|
160
|
Wang Y, Wu J, Wang J, He L, Lai H, Zhang
T, Wang X and Li W: Mitochondrial oxidative stress in brain
microvascular endothelial cells: Triggering blood-brain barrier
disruption. Mitochondrion. 69:71–82. 2023.PubMed/NCBI View Article : Google Scholar
|
|
161
|
Sun P, Zhang K, Hassan SH, Zhang X, Tang
X, Pu H, Stetler RA, Chen J and Yin KJ: Endothelium-targeted
deletion of microRNA-15a/16-1 promotes poststroke angiogenesis and
improves long-term neurological recovery. Circ Res. 126:1040–1057.
2020.PubMed/NCBI View Article : Google Scholar
|
|
162
|
Ren C, Li N, Li S, Han R, Huang Q, Hu J,
Jin K and Ji X: Limb ischemic conditioning improved cognitive
deficits via eNOS-dependent augmentation of angiogenesis after
chronic cerebral hypoperfusion in rats. Aging Dis. 9:869–879.
2018.PubMed/NCBI View Article : Google Scholar
|
|
163
|
Zhu HY, Hong FF and Yang SL: The roles of
nitric oxide synthase/nitric oxide pathway in the pathology of
vascular dementia and related therapeutic approaches. Int J Mol
Sci. 22(4540)2021.PubMed/NCBI View Article : Google Scholar
|
|
164
|
Ungvari Z, Tarantini S, Kiss T, Wren JD,
Giles CB, Griffin CT, Murfee WL, Pacher P and Csiszar A:
Endothelial dysfunction and angiogenesis impairment in the ageing
vasculature. Nat Rev Cardiol. 15:555–565. 2018.PubMed/NCBI View Article : Google Scholar
|
|
165
|
Hübner K, Cabochette P, Diéguez-Hurtado R,
Wiesner C, Wakayama Y, Grassme KS, Hubert M, Guenther S, Belting
HG, Affolter M, et al: Wnt/β-catenin signaling regulates
VE-cadherin-mediated anastomosis of brain capillaries by
counteracting S1pr1 signaling. Nat Commun. 9(4860)2018.PubMed/NCBI View Article : Google Scholar
|
|
166
|
Swaminathan B, Youn SW, Naiche LA, Du J,
Villa SR, Metz JB, Feng H, Zhang C, Kopan R, Sims PA and Kitajewski
JK: Endothelial Notch signaling directly regulates the small GTPase
RND1 to facilitate Notch suppression of endothelial migration. Sci
Rep. 12(1655)2022.PubMed/NCBI View Article : Google Scholar
|
|
167
|
Zhu T, Xie WJ, Wang L, Jin XB, Meng XB,
Sun GB and Sun XB: Notoginsenoside R1 activates the
NAMPT-NAD+-SIRT1 cascade to promote postischemic
angiogenesis by modulating Notch signaling. Biomed Pharmacother.
140(111693)2021.PubMed/NCBI View Article : Google Scholar
|
|
168
|
Ma C, Zhou J, Xu X, Wang L, Qin S, Hu C,
Nie L and Tu Y: The construction of a radiation-induced brain
injury model and preliminary study on the effect of human
recombinant endostatin in treating radiation-induced brain injury.
Med Sci Monit. 25:9392–9401. 2019.PubMed/NCBI View Article : Google Scholar
|
|
169
|
Deng Z, Zhou L, Wang Y, Liao S, Huang Y,
Shan Y, Tan S, Zeng Q, Peng L, Huang H and Lu Z: Astrocyte-derived
VEGF increases cerebral microvascular permeability under high salt
conditions. Aging (Albany NY). 12:11781–11793. 2020.PubMed/NCBI View Article : Google Scholar
|
|
170
|
Lee WH, Warrington JP, Sonntag WE and Lee
YW: Irradiation alters MMP-2/TIMP-2 system and collagen type IV
degradation in brain. Int J Radiat Oncol Biol Phys. 82:1559–1566.
2012.PubMed/NCBI View Article : Google Scholar
|
|
171
|
Kisler K, Nelson AR, Rege SV, Ramanathan
A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, et al:
Pericyte degeneration leads to neurovascular uncoupling and limits
oxygen supply to brain. Nat Neurosci. 20:406–416. 2017.PubMed/NCBI View Article : Google Scholar
|
|
172
|
Kur J, Newman EA and Chan-Ling T: Cellular
and physiological mechanisms underlying blood flow regulation in
the retina and choroid in health and disease. Prog Retin Eye Res.
31:377–406. 2012.PubMed/NCBI View Article : Google Scholar
|
|
173
|
Mae MA, He L, Nordling S, Vazquez-Liebanas
E, Nahar K, Jung B, Li X, Tan BC, Chin Foo J, Cazenave-Gassiot A,
et al: Single-cell analysis of blood-brain barrier response to
pericyte loss. Circ Res. 128:e46–e62. 2021.PubMed/NCBI View Article : Google Scholar
|
|
174
|
Prager O, Kamintsky L, Hasam-Henderson LA,
Schoknecht K, Wuntke V, Papageorgiou I, Swolinsky J, Muoio V,
Bar-Klein G, Vazana U, et al: Seizure-induced microvascular injury
is associated with impaired neurovascular coupling and blood-brain
barrier dysfunction. Epilepsia. 60:322–336. 2019.PubMed/NCBI View Article : Google Scholar
|
|
175
|
Stefanska A, Kenyon C, Christian HC,
Buckley C, Shaw I, Mullins JJ and Péault B: Human kidney pericytes
produce renin. Kidney Int. 90:1251–1261. 2016.PubMed/NCBI View Article : Google Scholar
|
|
176
|
Korte N, James G, You H, Hirunpattarasilp
C, Christie I, Sethi H and Attwell D: Noradrenaline released from
locus coeruleus axons contracts cerebral capillary pericytes via
α2 adrenergic receptors. J Cereb Blood Flow Metab.
43:1142–1152. 2023.PubMed/NCBI View Article : Google Scholar
|
|
177
|
Huang H: Pericyte-endothelial interactions
in the retinal microvasculature. Int J Mol Sci.
21(7413)2020.PubMed/NCBI View Article : Google Scholar
|
|
178
|
Dehouck MP, Tachikawa M, Hoshi Y, Omori K,
Maurage CA, Strecker G, Dehouck L, Boucau MC, Uchida Y, Gosselet F,
et al: Quantitative targeted absolute proteomics for better
characterization of an in vitro human blood-brain barrier model
derived from hematopoietic stem cells. Cells.
11(3963)2022.PubMed/NCBI View Article : Google Scholar
|
|
179
|
Winkler EA, Sengillo JD, Bell RD, Wang J
and Zlokovic BV: Blood-spinal cord barrier pericyte reductions
contribute to increased capillary permeability. J Cereb Blood Flow
Metab. 32:1841–1852. 2012.PubMed/NCBI View Article : Google Scholar
|
|
180
|
Armulik A, Genové G and Betsholtz C:
Pericytes: Developmental, physiological, and pathological
perspectives, problems, and promises. Dev Cell. 21:193–215.
2011.PubMed/NCBI View Article : Google Scholar
|
|
181
|
Figueira I, Galego S, Custódio-Santos T,
Vicente R, Molnár K, Haskó J, Malhó R, Videira M, Wilhelm I,
Krizbai I and Brito MA: Picturing breast cancer brain metastasis
development to unravel molecular players and cellular crosstalk.
Cancers (Basel). 13(910)2021.PubMed/NCBI View Article : Google Scholar
|
|
182
|
Alarcon-Martinez L, Villafranca-Baughman
D, Quintero H, Kacerovsky JB, Dotigny F, Murai KK, Prat A, Drapeau
P and Di Polo A: Interpericyte tunnelling nanotubes regulate
neurovascular coupling. Nature. 585:91–95. 2020.PubMed/NCBI View Article : Google Scholar
|
|
183
|
Lechertier T, Reynolds LE, Kim H, Pedrosa
AR, Gómez-Escudero J, Muñoz-Félix JM, Batista S, Dukinfield M,
Demircioglu F, Wong PP, et al: Pericyte FAK negatively regulates
Gas6/Axl signalling to suppress tumour angiogenesis and tumour
growth. Nat Commun. 11(2810)2020.PubMed/NCBI View Article : Google Scholar
|
|
184
|
Wu Y, Fu J, Huang Y, Duan R, Zhang W, Wang
C, Wang S, Hu X, Zhao H, Wang L, et al: Biology and function of
pericytes in the vascular microcirculation. Animal Model Exp Med.
6:337–345. 2023.PubMed/NCBI View Article : Google Scholar
|
|
185
|
Daneman R, Zhou L, Kebede AA and Barres
BA: Pericytes are required for blood-brain barrier integrity during
embryogenesis. Nature. 468:562–566. 2010.PubMed/NCBI View Article : Google Scholar
|
|
186
|
Bell RD, Winkler EA, Sagare AP, Singh I,
LaRue B, Deane R and Zlokovic BV: Pericytes control key
neurovascular functions and neuronal phenotype in the adult brain
and during brain aging. Neuron. 68:409–427. 2010.PubMed/NCBI View Article : Google Scholar
|
|
187
|
Abramsson A, Kurup S, Busse M, Yamada S,
Lindblom P, Schallmeiner E, Stenzel D, Sauvaget D, Ledin J,
Ringvall M, et al: Defective N-sulfation of heparan sulfate
proteoglycans limits PDGF-BB binding and pericyte recruitment in
vascular development. Genes Dev. 21:316–331. 2007.PubMed/NCBI View Article : Google Scholar
|
|
188
|
Weidenfeller C, Svendsen CN and Shusta EV:
Differentiating embryonic neural progenitor cells induce
blood-brain barrier properties. J Neurochem. 101:555–565.
2007.PubMed/NCBI View Article : Google Scholar
|
|
189
|
Huang Y, Chen S, Luo Y and Han Z:
Crosstalk between inflammation and the BBB in stroke. Curr
Neuropharmacol. 18:1227–1236. 2020.PubMed/NCBI View Article : Google Scholar
|
|
190
|
Thurgur H and Pinteaux E: Microglia in the
neurovascular unit: Blood-brain barrier-microglia interactions
after central nervous system disorders. Neuroscience. 405:55–67.
2019.PubMed/NCBI View Article : Google Scholar
|
|
191
|
Armulik A, Genové G, Mäe M, Nisancioglu
MH, Wallgard E, Niaudet C, He L, Norlin J, Lindblom P, Strittmatter
K, et al: Pericytes regulate the blood-brain barrier. Nature.
468:557–561. 2010.PubMed/NCBI View Article : Google Scholar
|
|
192
|
Hellström M, Kalén M, Lindahl P, Abramsson
A and Betsholtz C: Role of PDGF-B and PDGFR-beta in recruitment of
vascular smooth muscle cells and pericytes during embryonic blood
vessel formation in the mouse. Development. 126:3047–3055.
1999.PubMed/NCBI View Article : Google Scholar
|
|
193
|
Li J, Li M, Ge Y, Chen J, Ma J, Wang C,
Sun M, Wang L, Yao S and Yao C: β-amyloid protein induces
mitophagy-dependent ferroptosis through the CD36/PINK/PARKIN
pathway leading to blood-brain barrier destruction in Alzheimer's
disease. Cell Biosci. 12(69)2022.PubMed/NCBI View Article : Google Scholar
|
|
194
|
Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M,
Owens NC, Verghese PB, Herz J, Holtzman DM and Zlokovic BV:
Blood-brain barrier-associated pericytes internalize and clear
aggregated amyloid-β42 by LRP1-dependent apolipoprotein E
isoform-specific mechanism. Mol Neurodegener. 13(57)2018.PubMed/NCBI View Article : Google Scholar
|
|
195
|
Bongarzone S, Savickas V, Luzi F and Gee
AD: Targeting the receptor for advanced glycation endproducts
(RAGE): A medicinal chemistry perspective. J Med Chem.
60:7213–7232. 2017.PubMed/NCBI View Article : Google Scholar
|
|
196
|
Bell-Temin H, Culver-Cochran AE, Chaput D,
Carlson CM, Kuehl M, Burkhardt BR, Bickford PC, Liu B and Stevens
SM Jr: Novel molecular insights into classical and alternative
activation states of microglia as revealed by stable isotope
labeling by amino acids in cell culture (SILAC)-based proteomics.
Mol Cell Proteomics. 14:3173–3184. 2015.PubMed/NCBI View Article : Google Scholar
|
|
197
|
Becerra-Calixto A and Cardona-Gómez GP:
The role of astrocytes in neuroprotection after brain stroke:
Potential in cell therapy. Front Mol Neurosci.
10(88)2017.PubMed/NCBI View Article : Google Scholar
|
