Investigation into the casual or causal association of cerebral venous thrombosis and myelin oligodendrocyte glycoprotein antibody‑associated disease: A case report and literature review

Marsico,Oreste; Pascarella,Angelo; Cutellè,Roberta; Tedeschi,Denise; Bulgari,Alessandro; Ferlazzo,Edoardo; Aguglia,Umberto; Gasparini,Sara

doi:10.3892/br.2025.1967

Investigation into the casual or causal association of cerebral venous thrombosis and myelin oligodendrocyte glycoprotein antibody‑associated disease: A case report and literature review

Authors:
- Oreste Marsico
- Angelo Pascarella
- Roberta Cutellè
- Denise Tedeschi
- Alessandro Bulgari
- Edoardo Ferlazzo
- Umberto Aguglia
- Sara Gasparini
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Affiliations: Department of Medical and Surgical Sciences, Magna Græcia University, I‑88100 Catanzaro, Italy
Published online on: March 19, 2025 https://doi.org/10.3892/br.2025.1967
Article Number: 89
Copyright: © Marsico et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Myelin oligodendrocyte glycoprotein antibody‑associated disease (MOGAD) is a central nervous system demyelinating syndrome (DS) typically presenting with optic neuritis or myelitis. The association between cerebral venous thrombosis (CVT) and demyelinating diseases, including multiple sclerosis (MS), is rare. In the present study, a 37‑year‑old man presented with sensory disturbances in the lower limbs and urinary incontinence, consistent with myelitis. The diagnosis of MOGAD was confirmed by spinal magnetic resonance imaging findings and serum anti‑MOG antibody positivity using a cell‑based assay. The patient responded successfully to intravenous corticosteroid therapy. However, shortly after recovery, the patient developed a persistent headache and suffered an epileptic seizure, which was later attributed to CVT. The patient was treated with low molecular weight heparin and lacosamide and subsequently returned to baseline health status without seizure recurrence in the following year. Comprehensive review of the literature on CVT associated with DS, encompassing 15 case reports, two case series and two studies, underscores the rarity of this condition. Most reported cases of CVT have been linked to MS, while only three cases of CVT associated with MOGAD have been documented to date. Additional risk factors, such as lumbar puncture and high‑dose corticosteroid treatment, have been implicated in some instances. Given their shared inflammatory basis, a thrombotic‑inflammatory pathogenic mechanism acting between DS and CVT in predisposed individuals is plausible. However, the exact pathogenic association between these conditions remains largely unclear, and a coincidental association cannot be ruled out. The role of anti‑MOG antibodies in this rare condition also warrants further investigation.

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