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Case Report Open Access

Investigation into the casual or causal association of cerebral venous thrombosis and myelin oligodendrocyte glycoprotein antibody‑associated disease: A case report and literature review

  • Authors:
    • Oreste Marsico
    • Angelo Pascarella
    • Roberta Cutellè
    • Denise Tedeschi
    • Alessandro Bulgari
    • Edoardo Ferlazzo
    • Umberto Aguglia
    • Sara Gasparini
  • View Affiliations / Copyright

    Affiliations: Department of Medical and Surgical Sciences, Magna Græcia University, I‑88100 Catanzaro, Italy
    Copyright: © Marsico et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 89
    |
    Published online on: March 19, 2025
       https://doi.org/10.3892/br.2025.1967
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Abstract

Myelin oligodendrocyte glycoprotein antibody‑associated disease (MOGAD) is a central nervous system demyelinating syndrome (DS) typically presenting with optic neuritis or myelitis. The association between cerebral venous thrombosis (CVT) and demyelinating diseases, including multiple sclerosis (MS), is rare. In the present study, a 37‑year‑old man presented with sensory disturbances in the lower limbs and urinary incontinence, consistent with myelitis. The diagnosis of MOGAD was confirmed by spinal magnetic resonance imaging findings and serum anti‑MOG antibody positivity using a cell‑based assay. The patient responded successfully to intravenous corticosteroid therapy. However, shortly after recovery, the patient developed a persistent headache and suffered an epileptic seizure, which was later attributed to CVT. The patient was treated with low molecular weight heparin and lacosamide and subsequently returned to baseline health status without seizure recurrence in the following year. Comprehensive review of the literature on CVT associated with DS, encompassing 15 case reports, two case series and two studies, underscores the rarity of this condition. Most reported cases of CVT have been linked to MS, while only three cases of CVT associated with MOGAD have been documented to date. Additional risk factors, such as lumbar puncture and high‑dose corticosteroid treatment, have been implicated in some instances. Given their shared inflammatory basis, a thrombotic‑inflammatory pathogenic mechanism acting between DS and CVT in predisposed individuals is plausible. However, the exact pathogenic association between these conditions remains largely unclear, and a coincidental association cannot be ruled out. The role of anti‑MOG antibodies in this rare condition also warrants further investigation.
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1 

Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP, Ramanathan S, Waters P, Tenembaum S, Graves JS, et al: Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria. Lancet Neurol. 22:268–282. 2023.PubMed/NCBI View Article : Google Scholar

2 

Al-Ani A, Chen JJ and Costello F: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): Current understanding and challenges. J Neurol. 270:4132–4150. 2023.PubMed/NCBI View Article : Google Scholar

3 

Häußler V, Trebst C, Engels D, Pellkofer H, Havla J, Duchow A, Schindler P, Schwake C, Pakeerathan T, Fischer K, et al: Real-world multicentre cohort study on choices and effectiveness of immunotherapies in NMOSD and MOGAD. J Neurol Neurosurg Psychiatry: jnnp-2024-334764, 2024.

4 

Silvis SM, de Sousa DA, Ferro JM and Coutinho JM: Cerebral venous thrombosis. Nat Rev Neurol. 13:555–565. 2017.PubMed/NCBI View Article : Google Scholar

5 

Koudriavtseva T, Renna R, Plantone D and Mainero C: Demyelinating and thrombotic diseases of the central nervous system: Common pathogenic and triggering factors. Front Neurol. 6(63)2015.PubMed/NCBI View Article : Google Scholar

6 

Vandenberghe N, Debouverie M, Anxionnat R, Clavelou P, Bouly S and Weber M: Cerebral venous thrombosis in four patients with multiple sclerosis. Eur J Neurol. 10:63–66. 2003.PubMed/NCBI View Article : Google Scholar

7 

Kwah LK and Diong J: National institutes of health stroke scale (NIHSS). J Physiother. 60(61)2014.PubMed/NCBI View Article : Google Scholar

8 

Soto-Insuga V, Salvador TA, Martinez LC, Losada del Pozo R, Moreno MR, Gonzalez CO and Catalanet JR: Anti-myelin oligodendrocyte glycoprotein autoantibodies in optic neuritis and venous sinus thrombosis in a girl. J Pediatr Neurol Med. 1:1–3. 2016.

9 

Fontana A, Greco F, Smilari P, Praticò AD, Fiumara A, Ruggieri M and Pavone P: Anti-MOG antibody syndrome and cerebral sinovenous thrombosis: A Cause-effect hypothesis. J Pediatric Neurol. 19:127–131. 2021.

10 

Malanga GA and Gangemi E: Intracranial venous thrombosis in a patient with multiple sclerosis. A case report and review of contraceptive alternatives in patients with disabilities. Am J Phys Med Rehabil. 73:283–285. 1994.PubMed/NCBI View Article : Google Scholar

11 

Al Bunyan M and Ogunniyi A: Incidental cerebral venous thrombosis in a patient with multiple sclerosis. J Neurol Sci. 149:191–194. 1997.PubMed/NCBI View Article : Google Scholar

12 

Aidi S, Chaunu MP, Biousse V and Bousser MG: Changing pattern of headache pointing to cerebral venous thrombosis after lumbar puncture and intravenous high-dose corticosteroids. Headache. 39:559–564. 1999.PubMed/NCBI View Article : Google Scholar

13 

Albucher JF, Vuillemin-Azaïs C, Manelfe C, Clanet M, Guiraud-Chaumeil B and Chollet F: Cerebral thrombophlebitis in three patients with probable multiple sclerosis. Role of lumbar puncture or intravenous corticosteroid treatment. Cerebrovasc Dis. 9:298–303. 1999.PubMed/NCBI View Article : Google Scholar

14 

Städler C, Vuadens P, Dewarrat A, Janzer R, Uske A and Bogousslavsky J: Cerebral venous thrombosis after lumbar puncture and intravenous steroids in two patients with multiple sclerosis. Rev Neurol (Paris). 156:155–159. 2000.PubMed/NCBI

15 

Gunal DI, Afsar N, Tuncer N and Aktan S: A case of multiple sclerosis with cerebral venous thrombosis: The role of lumbar puncture and High-dose steroids. Eur Neurol. 47:57–58. 2002.PubMed/NCBI View Article : Google Scholar

16 

Mouraux A, Gille M, Dorban S and Peeters A: Cortical venous thrombosis after lumbar puncture. J Neurol. 249:1313–1315. 2002.PubMed/NCBI View Article : Google Scholar

17 

Kadayifçilar S, Gedik S, Eldem B, Balaban H and Kansu T: Panuveitis associated with multiple sclerosis complicated by cerebral venous thrombosis. Ocul Immunol Inflamm. 12:153–157. 2004.PubMed/NCBI View Article : Google Scholar

18 

Stolz E, Klötzsch C, Schlachetzki F and Rahimi A: High-dose corticosteroid treatment is associated with an increased risk of developing cerebral venous thrombosis. Eur Neurol. 49:247–248. 2003.PubMed/NCBI View Article : Google Scholar

19 

Maurelli M, Bergamaschi R, Candeloro E, Todeschini A and Micieli G: Cerebral venous thrombosis and demyelinating diseases: Report of a case in a clinically isolated syndrome suggestive of multiple sclerosis onset and review of the literature. Mult Scler. 11:242–244. 2005.PubMed/NCBI View Article : Google Scholar

20 

Kalanie H, Harandi AA, Alidaei S, Heidari D, Shahbeigi S and Ghorbani M: Venous thrombosis in multiple sclerosis patients after High-dose intravenous methylprednisolone: The preventive effect of enoxaparin. Thrombosis. 2011(785459)2011.PubMed/NCBI View Article : Google Scholar

21 

Presicci A, Garofoli V, Simone M, Campa MG, Lamanna AL and Margari L: Cerebral venous thrombosis after lumbar puncture and intravenous high dose corticosteroids: A case report of a childhood multiple sclerosis. Brain Dev. 35:602–605. 2013.PubMed/NCBI View Article : Google Scholar

22 

Gazioglu S, Solmaz D and Boz C: Cerebral venous thrombosis after high dose steroid in multiple sclerosis: A case report. Hippokratia. 17:88–90. 2013.PubMed/NCBI

23 

Gasparini S, Russo M, Dattola V, Ferlazzo E and Aguglia U: Cryptogenic cerebral venous thrombosis in a Multiple-sclerosis-patient treated with Alemtuzumab. Mult Scler Relat Disord. 44(102246)2020.PubMed/NCBI View Article : Google Scholar

24 

Zhu M, Cui W, Huang W, Liu Z, Xu Z and Huang H: Cerebral venous thrombosis after High-dose steroid in patient with multiple sclerosis: A case report. Medicine (Baltimore). 102(e34142)2023.PubMed/NCBI View Article : Google Scholar

25 

Virupakshaiah A, Moseley CE, Elicegui S, Gerwitz LM, Spencer CM, George E, Shah M, Cree BAC, Waubant E and Zamvil SS: Life-threatening MOG Antibody-associated hemorrhagic ADEM with elevated CSF IL-6. Neurol Neuroimmunol Neuroinflamm. 11(e200243)2024.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Marsico O, Pascarella A, Cutellè R, Tedeschi D, Bulgari A, Ferlazzo E, Aguglia U and Gasparini S: Investigation into the casual or causal association of cerebral venous thrombosis and myelin oligodendrocyte glycoprotein antibody‑associated disease: A case report and literature review. Biomed Rep 22: 89, 2025.
APA
Marsico, O., Pascarella, A., Cutellè, R., Tedeschi, D., Bulgari, A., Ferlazzo, E. ... Gasparini, S. (2025). Investigation into the casual or causal association of cerebral venous thrombosis and myelin oligodendrocyte glycoprotein antibody‑associated disease: A case report and literature review. Biomedical Reports, 22, 89. https://doi.org/10.3892/br.2025.1967
MLA
Marsico, O., Pascarella, A., Cutellè, R., Tedeschi, D., Bulgari, A., Ferlazzo, E., Aguglia, U., Gasparini, S."Investigation into the casual or causal association of cerebral venous thrombosis and myelin oligodendrocyte glycoprotein antibody‑associated disease: A case report and literature review". Biomedical Reports 22.5 (2025): 89.
Chicago
Marsico, O., Pascarella, A., Cutellè, R., Tedeschi, D., Bulgari, A., Ferlazzo, E., Aguglia, U., Gasparini, S."Investigation into the casual or causal association of cerebral venous thrombosis and myelin oligodendrocyte glycoprotein antibody‑associated disease: A case report and literature review". Biomedical Reports 22, no. 5 (2025): 89. https://doi.org/10.3892/br.2025.1967
Copy and paste a formatted citation
x
Spandidos Publications style
Marsico O, Pascarella A, Cutellè R, Tedeschi D, Bulgari A, Ferlazzo E, Aguglia U and Gasparini S: Investigation into the casual or causal association of cerebral venous thrombosis and myelin oligodendrocyte glycoprotein antibody‑associated disease: A case report and literature review. Biomed Rep 22: 89, 2025.
APA
Marsico, O., Pascarella, A., Cutellè, R., Tedeschi, D., Bulgari, A., Ferlazzo, E. ... Gasparini, S. (2025). Investigation into the casual or causal association of cerebral venous thrombosis and myelin oligodendrocyte glycoprotein antibody‑associated disease: A case report and literature review. Biomedical Reports, 22, 89. https://doi.org/10.3892/br.2025.1967
MLA
Marsico, O., Pascarella, A., Cutellè, R., Tedeschi, D., Bulgari, A., Ferlazzo, E., Aguglia, U., Gasparini, S."Investigation into the casual or causal association of cerebral venous thrombosis and myelin oligodendrocyte glycoprotein antibody‑associated disease: A case report and literature review". Biomedical Reports 22.5 (2025): 89.
Chicago
Marsico, O., Pascarella, A., Cutellè, R., Tedeschi, D., Bulgari, A., Ferlazzo, E., Aguglia, U., Gasparini, S."Investigation into the casual or causal association of cerebral venous thrombosis and myelin oligodendrocyte glycoprotein antibody‑associated disease: A case report and literature review". Biomedical Reports 22, no. 5 (2025): 89. https://doi.org/10.3892/br.2025.1967
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