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Early detection of cardiac impairment and prediction of right ventricular hypertrophy in patients with connective tissue disease

  • Authors:
    • Jiayan Shen
    • Guangrong Xiao
    • Shuqing Fang
    • Haohao Yang
    • Zheren Zhao
    • Yun Xu
    • Meng Jiang
    • Song Zhong
  • View Affiliations / Copyright

    Affiliations: Department of Intensive Care Unit, Renhe Hospital, Shanghai 201999, P.R. China, Department of Cardiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200127, P.R. China
    Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 92
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    Published online on: March 27, 2025
       https://doi.org/10.3892/br.2025.1970
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Abstract

Progressive right ventricle (RV) failure and death in connective tissue disease (CTD) are related to RV hypertrophy (RVH) and dilation, irrespective of pulmonary arterial hypertension (PAH). Therefore, detecting cardiac impairment before RVH and determining RVH predictors is crucial for timely intervention. The present prospective cohort study aimed to identify cardiac markers that occur before RVH and to investigate predictors of RVH. CTD was diagnosed based on clinical features, laboratory findings and imaging data. The cardiac functions of patients with CTD were evaluated using echocardiography, cardiovascular magnetic resonance (CMR) and multi‑modality cardiac imaging studies, including RV wall thickness, systolic functions, late gadolinium enhancement, T1 maps and biventricular strain analysis. A total of 52 patients with CTD with non‑right ventricular hypertrophy (non‑RVH), 34 patients with RVH and 50 healthy individuals were prospectively included. The impaired cardiac indices in patients with RVH included RV ejection fraction, ventricular dimensions, global myocardial deformation, late gadolinium enhancement and ventricular extracellular volume (ECV). The cardiac death rate did not differ significantly between the RVH and non‑RVH groups (P=0.14). Conventional parameters, including serum cardiac markers and the left ventricular ejection fraction, showed no significant changes in the non‑RVH group compared with the control group. Regarding fibrosis assessment using CMR, an elevated native T1 value (1,362±72 msec in the non‑RVH group vs. 1,268±42 in the control group; P<0.001) and ECV (31±4% in the non‑RVH group vs. 25±3% in the control group; P<0.001) were observed. By contrast, T1 myocardium/msec 15 min post‑contrast of the left ventricle in the RVH group was significantly decreased compared with that in the non‑RVH group, indicating an increase in the extracellular matrix at this stage. RVH was predicted by pulmonary arterial pressure (PAP) in patients in the non‑RVH group (t‑statistic, 2.84; P=0.01), whereas after RVH presentation, RV end‑systolic volume (RVESV) became a progression predictor of RVH (t‑statistic, 7.98; P<0.0001). No other cardiac imaging or laboratory findings predicted RVH. To the best of our knowledge, the present study was the first to highlight the non‑invasive detection of cardiac tissue impairment using CMR and provide support for cardiac treatment initiation before RVH detection. The predictors of RVH vary with the heart disease stage. PAP in the non‑RVH stage and incompetence of RVESV in the RVH stage predicted the progression of RVH. The present study was part of a clinical trial (NCT03271385), which was registered on July 1, 2017, and started on September 1, 2017.
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1 

Braun J, Krüger K, Manger B, Schneider M, Specker C and Trappe HJ: Cardiovascular comorbidity in inflammatory rheumatological conditions. Dtsch Arztebl Int. 114:197–203. 2017.PubMed/NCBI View Article : Google Scholar

2 

Dawi J, Affa S, Misakyan Y, Fardeheb S, Kades S, Kiriaki A, Mohan AS, Norris B, Yoon S and Venketaraman V: Exploring cardiovascular implications in systemic lupus erythematosus: A holistic analysis of complications, diagnostic criteria, and therapeutic modalities, encompassing pharmacological and adjuvant approaches. Biomol Concepts. 15:2024.PubMed/NCBI View Article : Google Scholar

3 

Miner JJ and Kim AH: Cardiac manifestations of systemic lupus erythematosus. Rheum Dis Clin North Am. 40:51–60. 2014.PubMed/NCBI View Article : Google Scholar

4 

Schermuly RT, Ghofrani HA, Wilkins MR and Grimminger F: Mechanisms of disease: Pulmonary arterial hypertension. Nat Rev Cardiol. 8:443–455. 2011.PubMed/NCBI View Article : Google Scholar

5 

Wigley FM, Lima JAC, Mayes M, McLain D, Chapin JL and Ward-Able C: The prevalence of undiagnosed pulmonary arterial hypertension in subjects with connective tissue disease at the secondary health care level of community-based rheumatologists (the UNCOVER study). Arthritis Rheum. 52:2125–2132. 2005.PubMed/NCBI View Article : Google Scholar

6 

Plazak W, Gryga K, Milewski M, Podolec M, Kostkiewicz M, Podolec P and Musial J: Association of heart structure and function abnormalities with laboratory findings in patients with systemic lupus erythematosus. Lupus. 20:936–944. 2011.PubMed/NCBI View Article : Google Scholar

7 

Hassoun PM: The right ventricle in scleroderma (2013 grover conference series). Pulm Circ. 5:3–14. 2015.PubMed/NCBI View Article : Google Scholar

8 

Alpert MA, Goldberg SH, Singsen BH, Durham JB, Sharp GC, Ahmad M, Madigan NP, Hurst DP and Sullivan WD: Cardiovascular manifestations of mixed connective tissue disease in adults. Circulation. 68:1182–1193. 1983.PubMed/NCBI View Article : Google Scholar

9 

Vegh J, Hegedus I, Szegedi G, Zeher M and Bodolay E: Diastolic function of the heart in mixed connective tissue disease. Clin Rheumatol. 26:176–181. 2007.PubMed/NCBI View Article : Google Scholar

10 

Leal GN, Silva KF, França CMP, Lianza AC, Andrade JL, Campos LMA, Bonfá E and Silva CA: Subclinical right ventricle systolic dysfunction in childhood-onset systemic lupus erythematosus: Insights from two-dimensional speckle-tracking echocardiography. Lupus. 24:613–620. 2015.PubMed/NCBI View Article : Google Scholar

11 

Kawut SM, Barr RG, Lima JAC, Praestgaard A, Johnson WC, Chahal H, Ogunyankin KO, Bristow MR, Kizer JR, Tandri H and Bluemke DA: Right ventricular structure is associated with the risk of heart failure and cardiovascular death: The Multi-Ethnic Study of Atherosclerosis (MESA)-right ventricle study. Circulation. 126:1681–1688. 2012.PubMed/NCBI View Article : Google Scholar

12 

Tang Y, Yang Z, Wen J, Tang D, Luo Y, Xiang C, Huang L and Xia L: Association of serum uric acid with right cardiac chamber remodeling assessed by cardiovascular magnetic resonance feature tracking in patients with connective tissue disease. Front Endocrinol (Lausanne). 15(1351197)2024.PubMed/NCBI View Article : Google Scholar

13 

Vos JL, Butcher SC, Fortuni F, Galloo X, Rodwell L, Vonk MC, Bax JJ, van Leuven SI, de Vries-Bouwstra JK, Snoeren M, et al: The prognostic value of right atrial and right ventricular functional parameters in systemic sclerosis. Front Cardiovasc Med. 9(845359)2022.PubMed/NCBI View Article : Google Scholar

14 

Rich S, Pogoriler J, Husain AN, Toth PT, Gomberg-Maitland M and Archer SL: Long-term effects of epoprostenol on the pulmonary vasculature in idiopathic pulmonary arterial hypertension. Chest. 138:1234–1239. 2010.PubMed/NCBI View Article : Google Scholar

15 

Bell RD, White RJ, Garcia-Hernandez ML, Wu E, Rahimi H, Marangoni RG, Slattery P, Duemmel S, Nuzzo M, Huertas N, et al: Tumor necrosis factor induces obliterative pulmonary vascular disease in a novel model of connective tissue disease-associated pulmonary arterial hypertension. Arthritis Rheumatol. 72:1759–1770. 2020.PubMed/NCBI View Article : Google Scholar

16 

Messroghli DR, Moon JC, Ferreira VM, Grosse-Wortmann L, He T, Kellman P, Mascherbauer J, Nezafat R, Salerno M, Schelbert EB, et al: Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the society for cardiovascular magnetic resonance (SCMR) endorsed by the European association for cardiovascular imaging (EACVI). J Cardiovasc Magn Reson. 19(75)2017.PubMed/NCBI View Article : Google Scholar

17 

White SK, Sado DM, Flett AS and Moon JC: Characterising the myocardial interstitial space: The clinical relevance of non-invasive imaging. Heart. 98:773–779. 2012.PubMed/NCBI View Article : Google Scholar

18 

Wong TC, Piehler KM, Kang IA, Kadakkal A, Kellman P, Schwartzman DS, Mulukutla SR, Simon MA, Shroff SG, Kuller LH and Schelbert EB: Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in diabetes and associated with mortality and incident heart failure admission. Eur Heart J. 35:657–664. 2014.PubMed/NCBI View Article : Google Scholar

19 

Broberg CS, Chugh SS, Conklin C, Sahn DJ and Jerosch-Herold M: Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease. Circ Cardiovasc Imaging. 3:727–734. 2010.PubMed/NCBI View Article : Google Scholar

20 

Hachulla AL, Launay D, Gaxotte V, de Groote P, Lamblin N, Devos P, Hatron PY, Beregi JP and Hachulla E: Cardiac magnetic resonance imaging in systemic sclerosis: A cross-sectional observational study of 52 patients. Ann Rheum Dis. 68:1878–1884. 2009.PubMed/NCBI View Article : Google Scholar

21 

Mavrogeni S, Sfikakis PP, Karabela G, Stavropoulos E, Spiliotis G, Gialafos E, Panopoulos S, Bournia V, Manolopoulou D, Kolovou G and Kitas G: Cardiovascular magnetic resonance imaging in asymptomatic patients with connective tissue disease and recent onset left bundle branch block. Int J Cardiol. 171:82–87. 2014.PubMed/NCBI View Article : Google Scholar

22 

Zhernakova A, van Diemen CC and Wijmenga C: Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet. 10:43–55. 2009.PubMed/NCBI View Article : Google Scholar

23 

Rudski LG, Lai WW, Afilalo J, Hua L, Handschumacher MD, Chandrasekaran K, Solomon SD, Louie EK and Schiller NB: Guidelines for the echocardiographic assessment of the right heart in adults: A report from the American society of echocardiography endorsed by the European association of echocardiography, a registered branch of the European society of cardiology, and the canadian society of echocardiography. J Am Soc Echocardiogr. 23:685–713, 786-788. 2010.PubMed/NCBI View Article : Google Scholar

24 

Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, Carlsen J, Coats AJS, Escribano-Subias P, Ferrari P, et al: 2022 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 43:3618–3731. 2022.PubMed/NCBI View Article : Google Scholar

25 

Altmayer SPL, Patel AR, Addetia K, Gomberg-Maitland M, Forfia PR and Han Y: Cardiac MRI right ventricle/left ventricle (RV/LV) volume ratio improves detection of RV enlargement. J Magn Reson Imaging. 43:1379–1385. 2016.PubMed/NCBI View Article : Google Scholar

26 

Minegishi S, Kato S, Takase-Minegishi K, Horita N, Azushima K, Wakui H, Ishigami T, Kosuge M, Kimura K and Tamura K: Native T1 time and extracellular volume fraction in differentiation of normal myocardium from non-ischemic dilated and hypertrophic cardiomyopathy myocardium: A systematic review and meta-analysis. Int J Cardiol Heart Vasc. 25(100422)2019.PubMed/NCBI View Article : Google Scholar

27 

Hsu S, Houston BA, Tampakakis E, Bacher AC, Rhodes PS, Mathai SC, Damico RL, Kolb TM, Hummers LK, Shah AA, et al: Right ventricular functional reserve in pulmonary arterial hypertension. Circulation. 133:2413–2422. 2016.PubMed/NCBI View Article : Google Scholar

28 

Li X, Shi K, Yang ZG, Guo YK, Huang S, Xia CC, He S, Li ZL, Li C and He Y: Assessing right ventricular deformation in hypertrophic cardiomyopathy patients with preserved right ventricular ejection fraction: A 3.0-T cardiovascular magnetic resonance study. Sci Rep. 10(1967)2020.PubMed/NCBI View Article : Google Scholar

29 

Konstam MA, Kiernan MS, Bernstein D, Bozkurt B, Jacob M, Kapur NK, Kociol RD, Lewis EF, Mehra MR, Pagani FD, et al: Evaluation and management of right-sided heart failure: A scientific statement from the American heart association. Circulation. 137:e578–e622. 2018.PubMed/NCBI View Article : Google Scholar

30 

Monteagudo-Vela M, Tindale A, Monguió-Santín E, Reyes-Copa G and Panoulas V: Right ventricular failure: Current strategies and future development. Front Cardiovasc Med. 10(998382)2023.PubMed/NCBI View Article : Google Scholar

31 

Ryan JJ and Archer SL: The right ventricle in pulmonary arterial hypertension: Disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure. Circ Res. 115:176–188. 2014.PubMed/NCBI View Article : Google Scholar

32 

Mascherbauer J, Marzluf BA, Tufaro C, Pfaffenberger S, Graf A, Wexberg P, Panzenböck A, Jakowitsch J, Bangert C, Laimer D, et al: Cardiac magnetic resonance postcontrast T1 time is associated with outcome in patients with heart failure and preserved ejection fraction. Circ Cardiovasc Imaging. 6:1056–1065. 2013.PubMed/NCBI View Article : Google Scholar

33 

Puntmann VO, Voigt T, Chen Z, Mayr M, Karim R, Rhode K, Pastor A, Carr-White G, Razavi R, Schaeffter T and Nagel E: Native T1 mapping in differentiation of normal myocardium from diffuse disease in hypertrophic and dilated cardiomyopathy. JACC Cardiovasc Imaging. 6:475–484. 2013.PubMed/NCBI View Article : Google Scholar

34 

Yeong CC, Harrop DL, Ng ACT and Wang WYS: Global longitudinal strain manually measured from mid-myocardial lengths is a reliable alternative to speckle tracking global longitudinal strain. J Cardiovasc Imaging. 32(35)2024.PubMed/NCBI View Article : Google Scholar

35 

Seno A, Antiochos P, Lichtenfeld H, Rickers E, Qamar I, Ge Y, Blankstein R, Steigner M, Aghayev A, Jerosch-Herold M and Kwong RY: Prognostic value of T1 mapping and feature tracking by cardiac magnetic resonance in patients with signs and symptoms suspecting heart failure and no clinical evidence of coronary artery disease. J Am Heart Assoc. 11(e020981)2022.PubMed/NCBI View Article : Google Scholar

36 

Korthals D, Chatzantonis G, Bietenbeck M, Meier C, Stalling P and Yilmaz A: CMR-based T1-mapping offers superior diagnostic value compared to longitudinal strain-based assessment of relative apical sparing in cardiac amyloidosis. Sci Rep. 11(15521)2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Shen J, Xiao G, Fang S, Yang H, Zhao Z, Xu Y, Jiang M and Zhong S: Early detection of cardiac impairment and prediction of right ventricular hypertrophy in patients with connective tissue disease. Biomed Rep 22: 92, 2025.
APA
Shen, J., Xiao, G., Fang, S., Yang, H., Zhao, Z., Xu, Y. ... Zhong, S. (2025). Early detection of cardiac impairment and prediction of right ventricular hypertrophy in patients with connective tissue disease. Biomedical Reports, 22, 92. https://doi.org/10.3892/br.2025.1970
MLA
Shen, J., Xiao, G., Fang, S., Yang, H., Zhao, Z., Xu, Y., Jiang, M., Zhong, S."Early detection of cardiac impairment and prediction of right ventricular hypertrophy in patients with connective tissue disease". Biomedical Reports 22.5 (2025): 92.
Chicago
Shen, J., Xiao, G., Fang, S., Yang, H., Zhao, Z., Xu, Y., Jiang, M., Zhong, S."Early detection of cardiac impairment and prediction of right ventricular hypertrophy in patients with connective tissue disease". Biomedical Reports 22, no. 5 (2025): 92. https://doi.org/10.3892/br.2025.1970
Copy and paste a formatted citation
x
Spandidos Publications style
Shen J, Xiao G, Fang S, Yang H, Zhao Z, Xu Y, Jiang M and Zhong S: Early detection of cardiac impairment and prediction of right ventricular hypertrophy in patients with connective tissue disease. Biomed Rep 22: 92, 2025.
APA
Shen, J., Xiao, G., Fang, S., Yang, H., Zhao, Z., Xu, Y. ... Zhong, S. (2025). Early detection of cardiac impairment and prediction of right ventricular hypertrophy in patients with connective tissue disease. Biomedical Reports, 22, 92. https://doi.org/10.3892/br.2025.1970
MLA
Shen, J., Xiao, G., Fang, S., Yang, H., Zhao, Z., Xu, Y., Jiang, M., Zhong, S."Early detection of cardiac impairment and prediction of right ventricular hypertrophy in patients with connective tissue disease". Biomedical Reports 22.5 (2025): 92.
Chicago
Shen, J., Xiao, G., Fang, S., Yang, H., Zhao, Z., Xu, Y., Jiang, M., Zhong, S."Early detection of cardiac impairment and prediction of right ventricular hypertrophy in patients with connective tissue disease". Biomedical Reports 22, no. 5 (2025): 92. https://doi.org/10.3892/br.2025.1970
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