Open Access

NETosis in myocardial ischemia‑reperfusion injury: From mechanisms to therapies (Review)

  • Authors:
    • Ziyang Zhang
    • Yanxin Wang
    • Tie Li
    • Hongfeng Wang
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  • Published online on: May 13, 2025     https://doi.org/10.3892/br.2025.1991
  • Article Number: 113
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present review describes the mechanisms of NETosis and its role in myocardial ischemia‑reperfusion injury (MIRI), focusing on the release of neutrophil extracellular traps (NETs) by activated neutrophils. NETs, composed of depolymerized chromatin and granule proteins, are crucial for pathogen entrapment, infection control and immune regulation. However, NET formation, linked to neutrophil death (NETosis), exacerbates MIRI by promoting inflammation and tissue damage. To address therapeutic strategies for NETosis in MIRI, several potential clinically significant approaches were explored, including peptidylarginine deaminase 4 inhibition, DNase therapy, antioxidants, inflammation modulation, and antithrombotic treatments, which not only provide novel diagnostic biomarkers and therapeutic targets in MIRI, but are also expected to improve patient prognosis and advance the development of personalised medicine.
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July-2025
Volume 23 Issue 1

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang Z, Wang Y, Li T and Wang H: NETosis in myocardial ischemia‑reperfusion injury: From mechanisms to therapies (Review). Biomed Rep 23: 113, 2025.
APA
Zhang, Z., Wang, Y., Li, T., & Wang, H. (2025). NETosis in myocardial ischemia‑reperfusion injury: From mechanisms to therapies (Review). Biomedical Reports, 23, 113. https://doi.org/10.3892/br.2025.1991
MLA
Zhang, Z., Wang, Y., Li, T., Wang, H."NETosis in myocardial ischemia‑reperfusion injury: From mechanisms to therapies (Review)". Biomedical Reports 23.1 (2025): 113.
Chicago
Zhang, Z., Wang, Y., Li, T., Wang, H."NETosis in myocardial ischemia‑reperfusion injury: From mechanisms to therapies (Review)". Biomedical Reports 23, no. 1 (2025): 113. https://doi.org/10.3892/br.2025.1991