Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
July-2025 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2025 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report

  • Authors:
    • Andrei-Ioan Munteanu
    • Delia-Maria Nicoară
    • Iulius Jugănaru
    • Meda-Ada Bugi
    • Otilia Mărginean
  • View Affiliations / Copyright

    Affiliations: Department XI Pediatrics, Discipline I Pediatrics, ‘Victor Babes’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania, 1st Department of Pediatrics, Children's Emergency Hospital ‘Louis Turcanu’, 300011 Timisoara, Romania
    Copyright: © Munteanu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 115
    |
    Published online on: May 13, 2025
       https://doi.org/10.3892/br.2025.1993
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare bone condition included in the spectrum of autoinflammatory pediatric rheumatological diseases. In the present case report, a 9‑year‑old female patient with a personal history of psoriasis since the age of 5 presented with left clavicle pain persisting for ~2 months. Following thorough anamnesis and investigations carried out, a diagnosis of CRMO was established. The present case report discusses a rare pediatric autoinflammatory pathology with autoimmune implications, emphasizing the role of immunostimulation/immune dysfunction. It is possible that immunostimulation with Propionibacterium acnes (also known as Cutibacterium acnes) for psoriasis management may underlie the development of autoinflammatory‑destructive bone lesions. Establishing causal relationships between immunological, bacterial and autoinflammatory factors was challenging during the patient's evaluation in our service.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Kaut S, Van den Wyngaert I, Christiaens D, Wouters C, Noppe N, Herregods N, Dehoorne J and De Somer L: Chronic nonbacterial osteomyelitis in children: A multicentre Belgian cohort of 30 children. Pediatr Rheumatol Online J. 20(41)2022.PubMed/NCBI View Article : Google Scholar

2 

Koné-Paut I, Mannes I and Dusser P: Chronic recurrent multifocal osteomyelitis (CRMO) and juvenile spondyloarthritis (JSpA): To what extent are they related? J Clin Med. 12(453)2023.PubMed/NCBI View Article : Google Scholar

3 

Zhao DY, McCann L, Hahn G and Hedrich CM: Chronic nonbacterial osteomyelitis (CNO) and chronic recurrent multifocal osteomyelitis (CRMO). J Transl Autoimmun. 4(100095)2021.PubMed/NCBI View Article : Google Scholar

4 

Giedion A, Holthusen W, Masel LF and Vischer D: Subacute and chronic ‘symmetrical’ osteomyelitis. Ann Radiol (Paris). 15(32942)1972.PubMed/NCBI(In Multiple languages).

5 

Girschick H, Finetti M, Orlando F, Schalm S, Insalaco A, Ganser G, Nielsen S, Herlin T, Koné-Paut I, Martino S, et al: The multifaceted presentation of chronic recurrent multifocal osteomyelitis: A series of 486 cases from the Eurofever international registry. Rheumatology (Oxford). 57(1504)2018.PubMed/NCBI View Article : Google Scholar

6 

Snipaitiene A, Sileikiene R, Klimaite J, Jasinskiene E, Uktveris R and Jankauskaite L: Unusual case of chronic recurrent multifocal osteomyelitis. Pediatr Rheumatol Online J. 16(49)2018.PubMed/NCBI View Article : Google Scholar

7 

Costi S, Germinario S, Pandolfi M, Pellico MR, Amati A, Gattinara M, Chighizola CB, Caporali R and Marino A: Chronic nonbacterial osteomyelitis and inflammatory bowel disease: A literature review-based cohort. Children (Basel). 10(502)2023.PubMed/NCBI View Article : Google Scholar

8 

Roderick MR, Shah R, Rogers V, Finn A and Ramanan AV: Chronic recurrent multifocal osteomyelitis (CRMO)-advancing the diagnosis. Pediatr Rheumatol Online J. 14(47)2016.PubMed/NCBI View Article : Google Scholar

9 

Sergi CM, Miller E, Demellawy DE, Shen F and Zhang M: Chronic recurrent multifocal osteomyelitis. A narrative and pictorial review. Front Immunol. 13(959575)2022.PubMed/NCBI View Article : Google Scholar

10 

Schneider AM and Nelson AM: Skin microbiota: Friend or foe in pediatric skin health and skin disease. Pediatr Dermatol. 36:815–822. 2019.PubMed/NCBI View Article : Google Scholar

11 

Rozas M, Hart de Ruijter A, Fabrega MJ, Zorgani A, Guell M, Paetzold B and Brillet F: From dysbiosis to healthy skin: Major contributions of cutibacterium acnes to skin homeostasis. Microorganisms. 9(628)2021.PubMed/NCBI View Article : Google Scholar

12 

Chang HW, Yan D, Singh R, Liu J, Lu X, Ucmak D, Lee K, Afifi L, Fadrosh D, Leech J, et al: Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization. Microbiome. 6(154)2018.PubMed/NCBI View Article : Google Scholar

13 

Swords M, Lakehomer H, McDonald M and Patel J: Symposium-Hindfoot and Ankle Trauma. Indian J Orthopaedics. 52:161–169. 2018.

14 

Kostik MM, Makhova MA, Maletin AS, Magomedova SM, Sorokina LS, Tsukasaki M, Okamoto K, Takayanagi H, Vasiliev DS, Kozlova DI and Mushkin AY: Cytokine profile in patients with chronic non-bacterial osteomyelitis, juvenile idiopathic arthritis, and insulin-dependent diabetes mellitus. Cytokine. 143(155521)2021.PubMed/NCBI View Article : Google Scholar

15 

Hofmann SR, Kapplusch F, Girschick HJ, Morbach H, Pablik J, Ferguson PJ and Hedrich CM: Chronic recurrent multifocal osteomyelitis (CRMO): Presentation, pathogenesis, and treatment. Curr Osteoporos Rep. 15:542–554. 2017.PubMed/NCBI View Article : Google Scholar

16 

Hedrich CM, Hofmann SR, Pablik J, Morbach H and Girschick HJ: Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol. 11(47)2013.PubMed/NCBI View Article : Google Scholar

17 

Zimmermann P and Curtis N: The role of Cutibacterium acnes in auto-inflammatory bone disorders. Eur J Pediatr. 178:89–95. 2019.PubMed/NCBI View Article : Google Scholar

18 

Zaid M, Chavez MR, Carrasco AE, Zimel MN, Zhang AL, Horvai AE, Link TM and O'Donnell RJ: Cutibacterium (formerly Propionibacterium) acnes clavicular infection. J Bone Jt Infect. 4:40–49. 2019.PubMed/NCBI View Article : Google Scholar

19 

Rausch P, Hartmann M, Baines JF and von Bismarck P: Analysis of the fecal and oral microbiota in chronic recurrent multifocal osteomyelitis. Arthritis Res Ther. 24(54)2022.PubMed/NCBI View Article : Google Scholar

20 

Jin Z, Song Y and He L: A review of skin immune processes in acne. Front Immunol. 14(1324930)2023.PubMed/NCBI View Article : Google Scholar

21 

Menter A, Krueger GG, Paek SY, Kivelevitch D, Adamopoulos IE and Langley RG: Interleukin-17 and Interleukin-23: A narrative review of mechanisms of action in psoriasis and associated comorbidities. Dermatol Ther (Heidelb). 11:385–400. 2021.PubMed/NCBI View Article : Google Scholar

22 

Hsu DK, Fung MA and Chen HL: Role of skin and gut microbiota in the pathogenesis of psoriasis, an inflammatory skin disease. Med Microecol. 4(100016)2020.

23 

Nguyen CT, Sah SK, Zouboulis CC and Kim TY: Inhibitory effects of superoxide dismutase 3 on Propionibacterium acnes-induced skin inflammation. Sci Rep. 8(4024)2018.PubMed/NCBI View Article : Google Scholar

24 

Singhal S, Landes C, Shukla R, McCann LJ and Hedrich CM: Classification and management strategies for paediatric chronic nonbacterial osteomyelitis and chronic recurrent multifocal osteomyelitis. Expert Rev Clin Immunol. 19:1101–1116. 2023.PubMed/NCBI View Article : Google Scholar

25 

Quon JS, Dzus AK and Leswick DA: Case study: Chronic recurrent multifocal osteomyelitis in the femoral diaphysis of a young female. Case Rep Radiol. 2012(515761)2012.PubMed/NCBI View Article : Google Scholar

26 

Mandell GA, Contreras SJ, Conard K, Harcke HT and Maas KW: Bone scintigraphy in the detection of chronic recurrent multifocal osteomyelitis. J Nucl Med. 39:1778–1783. 1998.PubMed/NCBI

27 

Villani MF, De Horatio LT, Garganese MC, Casazza I, Savelli S, Pardeo M, Messia V, De Benedetti F and Insalaco A: Whole-Body MRI versus bone scintigraphy: Which is the best diagnostic tool in patients with chronic recurrent multifocal osteomyelitis (CRMO)? Pediatr Rheumatol. 13 (Suppl 1)(P58)2015.

28 

Schaal MC, Gendler L, Ammann B, Eberhardt N, Janda A, Morbach H, Darge K, Girschick H and Beer M: Imaging in non-bacterial osteomyelitis in children and adolescents: Diagnosis, differential diagnosis and follow-up-an educational review based on a literature survey and own clinical experiences. Insights Imaging. 12(113)2021.PubMed/NCBI View Article : Google Scholar

29 

Chen HC, Wuerdeman MF, Chang JH and Nieves-Robbins NM: The role of whole-body magnetic resonance imaging in diagnosing chronic recurrent multifocal osteomyelitis. Radiol Case Rep. 13:485–489. 2018.PubMed/NCBI View Article : Google Scholar

30 

Sangiorgi E and Rigante D: The clinical chameleon of autoinflammatory diseases in children. Cells. 11(2231)2022.PubMed/NCBI View Article : Google Scholar

31 

Nakanishi H, Yamada S, Kita J, Shinmura D, Hosokawa K, Sahara S and Misawa K: Auditory and vestibular characteristics of NLRP3 inflammasome related autoinflammatory disorders: Monogenic hearing loss can be improved by anti-interleukin-1 therapy. Front Neurol. 13(865763)2022.PubMed/NCBI View Article : Google Scholar

32 

Gregory GE, Munro KJ, Couper KN, Pathmanaban ON and Brough D: The NLRP3 inflammasome as a target for sensorineural hearing loss. Clin Immunol. 249(109287)2023.PubMed/NCBI View Article : Google Scholar

33 

Nakanishi H, Prakash P, Ito T, Kim HJ, Brewer CC, Harrow D, Roux I, Hosokawa S and Griffith AJ: Genetic hearing loss associated with autoinflammation. Front Neurol. 11(141)2020.PubMed/NCBI View Article : Google Scholar

34 

Taddio A, Zennaro F, Pastore S and Cimaz R: An update on the pathogenesis and treatment of chronic recurrent multifocal osteomyelitis in children. Pediatr Drugs. 19:165–172. 2017.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Munteanu A, Nicoară D, Jugănaru I, Bugi M and Mărginean O: Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report. Biomed Rep 23: 115, 2025.
APA
Munteanu, A., Nicoară, D., Jugănaru, I., Bugi, M., & Mărginean, O. (2025). Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report. Biomedical Reports, 23, 115. https://doi.org/10.3892/br.2025.1993
MLA
Munteanu, A., Nicoară, D., Jugănaru, I., Bugi, M., Mărginean, O."Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report". Biomedical Reports 23.1 (2025): 115.
Chicago
Munteanu, A., Nicoară, D., Jugănaru, I., Bugi, M., Mărginean, O."Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report". Biomedical Reports 23, no. 1 (2025): 115. https://doi.org/10.3892/br.2025.1993
Copy and paste a formatted citation
x
Spandidos Publications style
Munteanu A, Nicoară D, Jugănaru I, Bugi M and Mărginean O: Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report. Biomed Rep 23: 115, 2025.
APA
Munteanu, A., Nicoară, D., Jugănaru, I., Bugi, M., & Mărginean, O. (2025). Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report. Biomedical Reports, 23, 115. https://doi.org/10.3892/br.2025.1993
MLA
Munteanu, A., Nicoară, D., Jugănaru, I., Bugi, M., Mărginean, O."Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report". Biomedical Reports 23.1 (2025): 115.
Chicago
Munteanu, A., Nicoară, D., Jugănaru, I., Bugi, M., Mărginean, O."Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report". Biomedical Reports 23, no. 1 (2025): 115. https://doi.org/10.3892/br.2025.1993
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team