Open Access

Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report

  • Authors:
    • Andrei-Ioan Munteanu
    • Delia-Maria Nicoară
    • Iulius Jugănaru
    • Meda-Ada Bugi
    • Otilia Mărginean
  • View Affiliations

  • Published online on: May 13, 2025     https://doi.org/10.3892/br.2025.1993
  • Article Number: 115
  • Copyright: © Munteanu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare bone condition included in the spectrum of autoinflammatory pediatric rheumatological diseases. In the present case report, a 9‑year‑old female patient with a personal history of psoriasis since the age of 5 presented with left clavicle pain persisting for ~2 months. Following thorough anamnesis and investigations carried out, a diagnosis of CRMO was established. The present case report discusses a rare pediatric autoinflammatory pathology with autoimmune implications, emphasizing the role of immunostimulation/immune dysfunction. It is possible that immunostimulation with Propionibacterium acnes (also known as Cutibacterium acnes) for psoriasis management may underlie the development of autoinflammatory‑destructive bone lesions. Establishing causal relationships between immunological, bacterial and autoinflammatory factors was challenging during the patient's evaluation in our service.
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Spandidos Publications style
Munteanu A, Nicoară D, Jugănaru I, Bugi M and Mărginean O: Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report. Biomed Rep 23: 115, 2025.
APA
Munteanu, A., Nicoară, D., Jugănaru, I., Bugi, M., & Mărginean, O. (2025). Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report. Biomedical Reports, 23, 115. https://doi.org/10.3892/br.2025.1993
MLA
Munteanu, A., Nicoară, D., Jugănaru, I., Bugi, M., Mărginean, O."Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report". Biomedical Reports 23.1 (2025): 115.
Chicago
Munteanu, A., Nicoară, D., Jugănaru, I., Bugi, M., Mărginean, O."Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report". Biomedical Reports 23, no. 1 (2025): 115. https://doi.org/10.3892/br.2025.1993